Abstract:
BACKGROUND:Low mineral mass and reduced bone strength with increased fracture risk are the main causes of morbidity in Thalassemia Major (TM). The pathogenesis is multifactorial and includes ineffective erythropoiesis with medullary expansion, multiple endocrine dysfunctions, direct iron bone deposition, deferoxamine-induced bone dysplasia, and reduced physical activity associated with disease complications. Dual-energy X-ray absorptiometry (DXA) is the "gold standard" for bone mineral density (BMD) assessment and for bone strength and quality evaluation. This method identifies patients at greater risk of fragility fractures, guiding treatment and monitoring response to therapy. In TM, DXA shows limitations concerning BMD calculation accuracy and fracture risk prediction. One of the main challenges in the assessment of bone health in patients with TM is the accurate interpretation of densitometric results. PURPOSE:This review investigates the major pitfalls in DXA implementation and interpretation in TM. METHODS:Available literature has been assessed. CONCLUSIONS:DXA shows limitations in assessing bone mineral "status" in TM, especially in the paediatric population, due to the peculiar characteristics of bone architecture and deformities associated with the disease. A radiological technique adjustment in this population is mandatory.
journal_name
Endocrinejournal_title
Endocrineauthors
Pellegrino F,Zatelli MC,Bondanelli M,Carnevale A,Cittanti C,Fortini M,Gamberini MR,Giganti M,Ambrosio MRdoi
10.1007/s12020-019-02003-xsubject
Has Abstractpub_date
2019-09-01 00:00:00pages
469-482issue
3eissn
1355-008Xissn
1559-0100pii
10.1007/s12020-019-02003-xjournal_volume
65pub_type
杂志文章,评审相关文献
ENDOCRINE文献大全abstract::The aim of this article is to investigate the effects of Aminoguanidine and vitamin C (VitC) on type IV collagen in diabetic nephropathy rats. Diabetic nephropathy rats were induced by intraperitoneal injection of STZ. Rats were randomly divided into five groups: normal control group (n = 10), diabetes group (n = 10),...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9419-0
更新日期:2011-06-01 00:00:00
abstract::Strict glucose control is a well-proven therapeutic approach for peripheral neuropathies in patients with diabetes. Alpha lipoic acid (ALA) has also been accepted as a therapeutic agent for diabetic peripheral neuropathy (DPN) in the respect of pathogenesis. However, the potential of ALA as a treatment for DPN in comp...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1613-5
更新日期:2018-07-01 00:00:00
abstract::Cytoplasmic calcium ([Ca(2+)](i)) changes evoked by adenosine 5(1)-triphosphate (ATP) were recorded in cultured individual Leydig cells within 10-18 h after cell dispersion. [Ca(2+)](i) was monitored using Fura-2AM loaded cells with a digital ratio imaging system. Five micromolars ATP induced biphasic [Ca(2+)](i) resp...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02738690
更新日期:1996-06-01 00:00:00
abstract::The present study was designed to determine whether an association exists between HPA activity and cytokine production in major depression (MD). In 9 patients with MD and 11 control subjects of both sexes, all drug-free, activity of the HPA axis was evaluated by circadian rhythm of plasma cortisol, 24-h free urinary c...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-006-0016-1
更新日期:2006-12-01 00:00:00
abstract::Glucagon-like peptide-1 (GLP-1) acts as a nutrient-dependent insulin-releasing agent, and its insulinotropic action is enhanced by nutrient secretagogues, such as the dimethyl ester of succinic acid (SAD). In the present study, a primed constant infusion of SAD (0.5 micromol followed by 0.25 micromol/min both per g of...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:15:3:283
更新日期:2001-08-01 00:00:00
abstract::The androgen receptor (AR) plays a critical role in sexual differentiation and in the virilization of the male reproductive system. A clear understanding of AR expression at the early stages of sexual development will help elucidate the sensitivity of perinatal animals to endocrine modulation by external agents, such ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:9:3:253
更新日期:1998-12-01 00:00:00
abstract::The aim of this study was to evaluate atrial electromechanical delay (EMD), P wave dispersion (Pwd), and left atrial (LA) mechanical functions in patients with active acromegaly. Twenty-three patients with active acromegaly and 27 age- and sex-matched controls were included in this study. All atrial electromechanical ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0348-1
更新日期:2015-03-01 00:00:00
abstract::The treatment of acromegaly is based on surgery, drugs, and radiotherapy as a third-line option. Fractionated stereotactic radiotherapy (FSRT) is a new technique with a need for long-term evaluation. The purpose of the study was to evaluate long-term results of FSRT in acromegaly. Overall, 34 patients [sex ratio 1.12,...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0610-1
更新日期:2015-12-01 00:00:00
abstract::Interleukin 15 (IL-15) has recently been proposed as a myokine involved in regulating lipid metabolism. We investigated the effect of exercise training on IL-15 content in skeletal muscle and expression of IL-15 receptor (IL-15R) in adipose tissue of obese rats. After 12 weeks of a high-fat diet, obese rats underwent ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9809-6
更新日期:2013-06-01 00:00:00
abstract::Inflammation is associated with several tumor development and progression. However, these associations are not clear in well-differentiated thyroid carcinomas. We assessed whether NLR is a useful prognostic marker in patients with papillary thyroid carcinomas (PTC). The medical records of all patients who underwent th...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-013-0089-6
更新日期:2014-08-01 00:00:00
abstract::The role of membrane-associated tubulin in TRH receptor-G protein coupling was investigated with the use of compounds that influence tubulin function. TRH-stimulated G protein GTPase activity in GH(3) cell membranes was used to determine receptor-G protein coupling. TRH-stimulated GTPase activity was abolished by G(qα...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02738873
更新日期:1996-02-01 00:00:00
abstract::The prevalence of germ line mutations within the RET-protooncogene and the tumor suppressor genes SDHB, SDHD, and VHL in pheochromocytomas (PC) varies in recent studies from 12 to 24%, if one look at them collectively. DNA was extracted from frozen tumor tissue as well as from blood leukocytes of 36 PC (26 sporadic/10...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9178-y
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:Insulin resistance is an important factor in the pathogenesis of polycystic ovary syndrome (PCOS), which is associated with higher risk of metabolic syndrome (MetS) and cardiovascular complications. Early atherosclerotic lesions may be diagnosed by ultrasonographic parameters: brachial artery flow-mediated dila...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02596-8
更新日期:2021-01-13 00:00:00
abstract:PURPOSE:The primary aim of this study is to isolate cytokines specific for active Graves' orbitopathy (GO) in the tears of affected patients. The secondary aim is to identify other cytokines of interest and to look at the profile of their levels over time. METHODS:This is a prospective pilot study conducted at the Sin...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1467-2
更新日期:2018-02-01 00:00:00
abstract::Studies designed to evaluate the short-term effects of incretin-related drugs in subjects with cardiac disease are still preliminary. In patients with heart failure, two of five studies showed that glucagon-like peptide-1 (GLP-1) infusion was associated with an absolute increase in left ventricular ejection fraction (...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-014-0175-4
更新日期:2014-09-01 00:00:00
abstract::Ovulation and conversion of the follicle into the corpus luteum involve remarkable changes in vascular permeability and neovascularization of the luteinizing granulosa layer. To evaluate the importance of these vascular events in follicle rupture and luteal development, sequential experiments were designed in which ve...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:17:3:199
更新日期:2002-04-01 00:00:00
abstract:PURPOSES:Parathyroid cancer (PC) is rare, but fatal condition. Preoperative prediction of PC remains challenging but meaningful. The aim of this study was to determine an effective model to predict PC in patients with parathyroid lesions >1.5 cm. METHODS:In this retrospective case-control study, we enrolled 30 patient...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-02069-7
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Thyroid hormone (TH) metabolism can have prognostic significance in brain tumors. We studied the association of common variations in three deiodinase gene single-nucleotide polymorphisms (SNPs) with circulating TH concentrations and prognosis of brain tumor patients. METHODS:Patients admitted for glioma and...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-02016-6
更新日期:2019-12-01 00:00:00
abstract::Autoimmune thyroiditis (AIT) is a systemic disease. It is well-known that overt thyroid dysfunction is a cardiovascular risk factor. However, the influence of euthyroid status is unclear. The aim of this study was to evaluate the metabolic parameters and carotid intima-media thickness (CIMT) in euthyroid premenopausal...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9842-5
更新日期:2013-08-01 00:00:00
abstract::Radioiodide ((131)I) is routinely used for the treatment of toxic adenoma, Graves' disease, and for ablation of thyroid remnant after thyroidectomy in patients with thyroid cancer. The toxic effects of ionizing radiations on living cells can be mediated by a necrotic and/or apoptotic process. The involvement of apopto...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-013-9940-z
更新日期:2013-12-01 00:00:00
abstract::The prevalence of adrenal incidentaloma has increased with the increasing use of imaging techniques. While majority are benign adenoma, a small but significant minority may be primary adrenal carcinoma or have endocrine hyper secretion. Existing guidance suggests that excess catecholamine and cortisol secretion should...
journal_title:Endocrine
pub_type: 信件
doi:10.1007/s12020-011-9487-9
更新日期:2011-08-01 00:00:00
abstract::The Metastatic progression of solid tumors, such as thyroid cancer is a complex process which involves various factors. Current understanding on the role of epithelial-mesenchymal transition (EMT) in thyroid carcinomas suggests that EMT is implicated in the progression from follicular thyroid cancer (FTC) and papillar...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-019-02030-8
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:Throughout the SARS-CoV2 pandemic, multiple reports show higher percentages of hospitalization, morbidity, and mortality among men than women, indicating that men are more affected by COVID-19. The pathophysiology of this difference is yet not established, but recent studies suggest that sex hormones may influe...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-020-02536-6
更新日期:2021-01-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Endocrine
pub_type: 已发布勘误
doi:10.1007/s12020-020-02514-y
更新日期:2020-12-01 00:00:00
abstract::Children born large for gestational age (LGA) may be at risk for development of obesity and insulin resistance (IR). The reciprocal relationship of adipokines and proinflammatory cytokines is suggested to play a putative role in fine tuning of insulin secretory dynamics. To evaluate serum interleukin-6 (IL-6), tumor n...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0207-0
更新日期:2014-12-01 00:00:00
abstract::Previous evidence supports the view that insulin, as well as insulin like growth factor-1 (IGF-1) provides neurotropic support for neurons in the central nervous system (CNS) and peripheral nervous system (PNS). In the present study we evaluated the effects of the intravenous infusion of IGF-1 on both necrosis and apo...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-007-0012-0
更新日期:2007-02-01 00:00:00
abstract::We investigated whether 1,25-dihydroxy-vitamin D3 (1,25(OH)2D3) could improve early diabetic nephropathy through the DNA-damage-inducible transcript 4/tuberous sclerosis 2/mammalian target of rapamycin pathway. Rat mesangial cells were cultured in media containing normal glucose or high glucose and were treated with o...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-0999-1
更新日期:2016-11-01 00:00:00
abstract::Steroid hormones regulate levels of gonadotropin mRNA in the pituitary, and gonadotropic hormones in plasma. To determine whether estrogen receptor alpha (ERalpha) mediates steroid negative feedback, wild type (WT) and estrogen receptor alpha knockout (ERalphaKO) mice of both sexes were gonadectomized and implanted wi...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:11:2:137
更新日期:1999-10-01 00:00:00
abstract::Homozygous Klotho mutant (kl-/-) mice exhibit a variety of phenotypes resembling human aging, including arteriosclerosis, infertility, skin atrophy, osteoporosis, and short life span. Calcium abnormality, one of the phenotypes in kl-/- mice, is thought to be due to the elevated gene expression of 25-hydroxyvitamin D3 ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:25:3:229
更新日期:2004-12-01 00:00:00
abstract::Mineralocorticoid and glucocorticoid hormones activate the expression of the Na/K ATPase beta1 through direct binding of the mineralocorticoid receptor (MR) and glucocorticoid receptors (GR) to a mineralocorticoid- and glucocorticoid-responsive element in the beta1 promoter region, but activation of the beta1 promoter...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:13:3:287
更新日期:2000-12-01 00:00:00