Abstract：
:This article provides an overview of the increasing number of observations indicating that excitatory amino acids are involved in the control of prolactin secretion. The information available suggests that these amino acids exert a stimulatory action on hypophysial prolactin. Administration of a glutamate receptor agonist induces significant increase in prolactin release in rats, monkeys, and rams. In contrast, noncompetitive antagonists of N-methyl-D-aspartate receptors decrease plasma levels and attenuate the preovulatory surge of prolactin. It appears that the endogenous glutamatergic system participates not only in the regulation of basal secretion of prolactin, but also in the control of physiological prolactin responses induced by the suckling stimulus or by stress. Recent findings suggest that the glutamatergic innervation of the hypothalamic paraventricular nucleus is involved in the mediation of the neural signal of the suckling stimulus-induced prolactin release as well as in the mediation of the stress-induced release of prolactin.
journal_name
Endocrinejournal_title
Endocrineauthors
Nagy GM,Bodnár I,Bánky Z,Halász Bdoi
10.1385/ENDO:28:3:303subject
Has Abstractpub_date
2005-12-01 00:00:00pages
303-8issue
3eissn
1355-008Xissn
1559-0100pii
ENDO:28:3:303journal_volume
28pub_type
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