Abstract：
:AdipoR1 is one of the adiponectin receptors which are important for adiponectin signaling. Because adiponectin is a candidate gene for common obesity, it is also hypothesized that variations in AdipoR1 may be involved in the development of complex obesity. Therefore, we designed an association study for the AdipoR1 gene. We performed a case-control association study including 1,021 obese subjects (mean age 42 ± 12 years; mean BMI 38.2 ± 6.2 kg/m²) and 226 lean, healthy individuals (mean age 36 ± 7 years; mean BMI 22.1 ± 1.7 kg/m²). Nine tagSNPs were selected to cover the entire AdipoR1 gene and surrounding 7 kb region (based on HapMap data). TagSNPs were genotyped using AcycloPrime-Fluorescence Polarization (FP) SNP Detection kits and TaqMan Pre-Designed SNP Genotyping assays according to manufacturer's protocols. We found that the rs1075399 non-reference allele decreases obesity risk by 45 % in men only [odds ratio (OR) = 0.55, 95 % CI 0.35-0.87, nominal P = 0.010]. However, after Bonferroni correction for multiple testing, this association is lost. None of the other tagSNPs were associated with obesity when studying the entire population, nor when looking at men and women separately. Quantitative analysis of the effect of each SNP on height, weight, and BMI revealed that none of the tagSNPs are associated with weight or BMI. We report here that we found no decisive evidence for association between AdipoR1 tagSNPs and complex obesity in our Belgian Caucasian population.
journal_name
Endocrinejournal_title
Endocrineauthors
Beckers S,de Freitas F,Zegers D,Mertens IL,Verrijken A,Van Camp JK,Van Gaal LF,Van Hul Wdoi
10.1007/s12020-012-9736-6subject
Has Abstractpub_date
2013-02-01 00:00:00pages
120-6issue
1eissn
1355-008Xissn
1559-0100journal_volume
43pub_type
杂志文章相关文献
ENDOCRINE文献大全abstract：PURPOSE:To evaluate the reliability of intermittent intraoperative neuromonitoring (I-IONM) through recurrent laryngeal nerve (RLN) stimulation and laryngeal palpation in predicting postoperative vocal cord palsy and to examine the reliability of this technique in providing useful information in the decision to perform...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-018-1739-5
更新日期：2018-12-01 00:00:00
abstract：:Insulin pumps operate almost universally in the work environment. Tubeless insulin pumps are a relatively recent development for management of insulin-dependent diabetes. This is the first report of location-dependent failure of insulin pump function, possibly due to external interference, occurring only in the settin...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-008-9122-6
更新日期：2009-02-01 00:00:00
abstract：:Stimulation of dopamine D2 receptors inhibits melanotrope pro-opiomelanocortin (POMC) biosynthesis and alpha-melanocyte-stimulating hormone (MSH) secretion. These effects are mediated by G-protein alpha i- and alpha o-subunits and are reversed by stimulating receptors linked to activation of G alpha s protein. Melanot...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/BF02820510
更新日期：1997-06-01 00:00:00
abstract：PURPOSE:The early-life nutritional environment affects long-term glucose homeostasis, we investigated the effects of maternal low-protein diet combined with postnatal early overfeeding on the male offspring's glucose homeostasis in adulthood. METHODS:Only male rats were used, and their delivery was considered postnata...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-018-1719-9
更新日期：2019-01-01 00:00:00
abstract：PURPOSE:Minimally invasive image-guided thermal ablation has been proposed as alternative to surgery for treatment of benign thyroid nodules and recurrent differentiated thyroid carcinoma. Here, we report for the first time the use of radiofrequency ablation (RFA) in a patient with non-metastatic medullary thyroid carc...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-019-01995-w
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:Metastatic disease is common in medullary thyroid carcinoma (MTC) and it is usually detected by raising calcitonin and carcinoembryonic antigen (CEA) levels. Nuclear medicine imaging has an important role in lesion identification/characterisation. We aim to compare 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT perfo...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-019-01846-8
更新日期：2019-05-01 00:00:00
abstract：INTRODUCTION:We retrospectively evaluated all patients with pituitary tumours treated in our department from 1/1/1997 to 01/11/2014. PATIENTS AND METHODS:Two hundred and fifteen patients (124 females, 91 males, mean age 50.9 years) were treated because of pituitary tumours. All patients underwent basal hormonal analys...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-018-1570-z
更新日期：2018-05-01 00:00:00
abstract：:Interactions between testosterone, estradiol, and inhibin in the control of gonadotrophin secretion in males are poorly understood. Castrated rams were treated with steroid-free bovine follicular fluid (bFF), testosterone, or estradiol and for 7 d (2 x 2 x 2 factorial design). Given independently, none of the exogenou...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/BF02778146
更新日期：1997-10-01 00:00:00
abstract：OBJECTIVE:To assess the predictive value of some clinical and biochemical parameters, and of the +49 A/G polymorphism of the CTLA-4 gene, for long-term remission following the withdrawal of antithyroid drugs before starting antithyroid drug therapy. STUDY DESIGN:Observational, prospective and longitudinal study. METH...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-018-1785-z
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:A retrospective analysis was carried out from patients and controls during the past 5 years from a series of studies investigating endothelial microparticles (MP). METHODS:In total, 319 samples from 207 individuals were included in this analysis, from patients with type 2 diabetes (T2D, n = 105), women with...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-019-02059-9
更新日期：2019-11-01 00:00:00
abstract：:PET/CT with (18)F-fluorodeoxyglucose (FDG) or using different radiocompounds has proven accuracy for detection of adrenal metastases in patients undergoing cancer staging. It can assist the diagnostic work-up in oncology patients by identifying distant metastases to the adrenal(s) and defining oligometastatic disease ...
journal_title：Endocrine
pub_type： 杂志文章,评审
doi：10.1007/s12020-014-0440-6
更新日期：2015-05-01 00:00:00
abstract：:We have investigated the effects of different patterns of administration of recombinant human growth hormone (rhGH) on weight gain, organ growth, serum GH binding protein (GHBP) and insulin-like growth factor-l (IGF-1) levels in a series of studies using hypophysectomized (Hx) or GH-deficient dwarf (dw/dw) rats. Anima...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/BF03000203
更新日期：1995-10-01 00:00:00
abstract：PURPOSE:Negative-pressure wound therapy (NPWT) is an adjunct modality in diabetic foot ulcerations (DFUs). Randomized controlled trials (RCTs) have shown its advantage over standard approaches; however, data from observational studies remain scarce.We performed a systematic review of observational non-RCTs evaluating N...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-019-02164-9
更新日期：2020-04-01 00:00:00
abstract：:There are no data about the optimal supplementation therapy in HIV-infected patients with vitamin D (25OHD) deficiency. The aim of this study was to assess the effect of an oral monthly dose of 16,000 IU calcidiol. We performed a longitudinal cohort study of 365 HIV-infected patients (24 % females) was with sequential...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-014-0489-2
更新日期：2015-06-01 00:00:00
abstract：:Molecular chaperones assist proteins to reach their mature and functional conformation. It has become apparent in recent years that chaperones function as part of a multiprotein heterocomplex that is potentially involved not only in protein folding, but also in intracellular trafficking and in targeting proteins for d...
journal_title：Endocrine
pub_type： 杂志文章,评审
doi：10.1385/ENDO:14:2:143
更新日期：2001-03-01 00:00:00
abstract：:Administration of RU486 to late pregnant rats results in preterm delivery 24 h after treatment and the induction of a luteolytic process after labor. We investigated whether functional changes occurring within the corpora lutea after RU486 treatment were associated with morphologic features of apoptotic cell death. Ra...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:15:2:147
更新日期：2001-07-01 00:00:00
abstract：:Homozygous Klotho mutant (kl-/-) mice exhibit a variety of phenotypes resembling human aging, including arteriosclerosis, infertility, skin atrophy, osteoporosis, and short life span. Calcium abnormality, one of the phenotypes in kl-/- mice, is thought to be due to the elevated gene expression of 25-hydroxyvitamin D3 ...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:25:3:229
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND:Surgical procedures are associated with activation of the hypothalamic-pituitary-adrenal axis (HPA). Studies examining HPA dynamics peri-operatively are limited and the modulating influence of peri-operatively administered glucocorticoids on that is not well established. This investigation examined alteratio...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-017-1398-y
更新日期：2017-10-01 00:00:00
abstract：:Riedel's thyroiditis (RT) is a rare type of chronic thyroiditis of unproven etiology and definite treatment. It can be associated with retroperitoneal, mediastinal, orbital, and hepatic fibrosis. Symptoms arise mainly due to compression of neighboring structures. Surgery is usually required for a definite diagnosis an...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-009-9168-0
更新日期：2009-06-01 00:00:00
abstract：:The alpha-subunit is common to the heterodimeric glycoprotein hormones and has been highly conserved throughout vertebrate evolution. In an effort to determine if wild-type and engineered human alpha analogs can serve as agonists or antagonists to the human thyroid-stimulating hormone (TSH) receptor (TSHR), a potent a...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:24:1:025
更新日期：2004-06-01 00:00:00
abstract：:This study tested the hypothesis that aromatization of testosterone to estradiol is necessary for sexual differentiation of the sheep brain. Pregnant ewes (n = 10) were treated with the aromatase inhibitor 1,4,6- androstatriene-3,17-dione (ATD) during the period of gestation when the sheep brain is maximally sensitive...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:29:3:501
更新日期：2006-06-01 00:00:00
abstract：:Urocortin 3 (Ucn3) is recognized as a member of the corticotropin-releasing factor (CRF) family, which plays an important role in regulating food intake. We investigated the effects of centrally administered Ucn3 on food intake and gastric emptying in mice. Intracerebroventricular (ICV)administration of Ucn3 (0.1–1 nm...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-010-9420-7
更新日期：2011-04-01 00:00:00
abstract：:Hypoxia is well known to decrease appetite and weight gain in growing rats, and to induce weight loss in humans. It has been hypothesized that this is mediated by a change in ghrelin, an orexigenic peptide synthesized and released primarily from the stomach. Rats were exposed to hypoxia for 7 d as neonates (birth-7 d ...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:21:2:159
更新日期：2003-07-01 00:00:00
abstract：:Elastosonography (ES) is a newly developed method that is used for the differential diagnosis of benign and malignant thyroid nodules. In different studies, ES scoring has been compared with histopathological findings, and sensitivity and specificity of the scoring were calculated. In this study, it determines the str...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-010-9416-3
更新日期：2011-02-01 00:00:00
abstract：PURPOSE:An increasing body of evidence suggests that dipeptidyl-peptidase 4 (DPP-4) inhibitors could play a role in the development of bullous pemphigoid. The knowledge regarding this association is based on case reports, pharmacovigilance database analyses, and observational studies. Data from randomized clinical tria...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-020-02272-x
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:To systematically evaluate the quality, consistency and the evidence support of guidelines for perioperative diabetes management. METHODS:We retrieved guidelines through systematic search, critically evaluated their quality and compared the recommendations of included guidelines. Five aspects were compared: ta...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-018-1786-y
更新日期：2019-02-01 00:00:00
abstract：:We re-assess the fasting plasma glucose (FPG) and 2-h post-load glucose (2HPG) in the diagnosis of both prediabetes and type 2 diabetes mellitus by developing a gold standard based on beta-cell function. The gold standard was developed in a cohort of 2,152 adult subjects without severe renal or liver dysfunction that ...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-014-0284-0
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:The influence of the dipeptidyl peptidase-IV inhibitor, gemigliptin alone or in combination with metformin on survival, proliferation, and migration of thyroid carcinoma cells was investigated. METHODS:SW1736 and TPC-1 human thyroid carcinoma cells were used. RESULTS:Gemigliptin and metformin caused cell deat...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-017-1503-2
更新日期：2018-02-01 00:00:00
abstract：:Computer analysis of the human placental lactogen-B (hPL-B) enhancer reveals two putative binding sites for the transcription factor NF-IL6, but the role of NF-IL6 in the regulation of the enhancer is unknown. Using gel mobility shift and supershift assays, we demonstrated that NF-IL6 binds to both enhancer sites. Tra...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:12:1:47
更新日期：2000-02-01 00:00:00
abstract：PURPOSE:In morbid obesity nonalcoholic fatty liver disease (NAFLD) is endemic. Aim of this study is to evaluate the diagnostic accuracy of the most common noninvasive methods for identify NAFLD and fibrosis in a cohort of morbid obese population. METHODS:Ninety morbid obese patients undergoing bariatric surgery (BS) a...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-019-02155-w
更新日期：2020-03-01 00:00:00
