Centrally administered urocortin 3 inhibits food intake and gastric emptying in mice.

abstract：:Diabetes mellitus is a major risk factor for cardiovascular disease. However, the excess risk of death may vary substantially in subgroups of patients with type 2 diabetes, being highest in those younger than 55 years of age. A HbA1c value of 7.0 % or less is recommended for most patients with type 2 diabetes to reduc...

journal_title：Endocrine

authors： Giugliano D,Maiorino MI,Bellastella G,Esposito K

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:Hyponatremia is the most common electrolyte disorder in hospitalized patients, and its etiopathogenesis is related to an underlying tumor in 14% of cases. Hyponatremia has been associated with a worse outcome in several pathologies, including cancer, in which the leading cause of this electrolyte alteration is ...

journal_title：Endocrine

authors： Marroncini G,Fibbi B,Errico A,Grappone C,Maggi M,Peri A

更新日期：2020-02-01 00:00:00

abstract：:The androgen receptor (AR) plays a critical role in sexual differentiation and in the virilization of the male reproductive system. A clear understanding of AR expression at the early stages of sexual development will help elucidate the sensitivity of perinatal animals to endocrine modulation by external agents, such ...

journal_title：Endocrine

authors： You L,Sar M

更新日期：1998-12-01 00:00:00

abstract：:Skeletal muscle atrophy is associated with type-1 diabetes. Skeletal muscle is the source of pro- and anti-inflammatory cytokines that can mediate muscle hypertrophy and atrophy, while resistance exercise can modulate both muscle mass and muscle cytokine expression. This study determined the effects of a 5-week resist...

journal_title：Endocrine

authors： Molanouri Shamsi M,Hassan ZH,Gharakhanlou R,Quinn LS,Azadmanesh K,Baghersad L,Isanejad A,Mahdavi M

更新日期：2014-05-01 00:00:00

abstract：:In randomized controlled trials (RCTs), more intensive glucose control in patients with type 2 diabetes leads to a modest (9%) reduction in major cardiovascular events (MACE), associated with a 20% reduction of kidney events and 13% reduction of eye events. The FDA issued guidance in 2008 led to the conduct of numerou...

journal_title：Endocrine

authors： Giugliano D,Maiorino MI,Bellastella G,Esposito K

更新日期：2018-05-01 00:00:00

abstract：:Studies on the effect of exogenous subclinical thyrotoxicosis on bone mineral density (BMD) in male patients treated with suppressive doses of levothyroxine for differentiated thyroid carcinoma (DTC) are not conclusive. In order to evaluate BMD (in femoral neck, lumbar spine, and distal radius) and bone fractures in m...

journal_title：Endocrine

authors： Reverter JL,Colomé E,Holgado S,Aguilera E,Soldevila B,Mateo L,Sanmartí A

更新日期：2010-06-01 00:00:00

abstract：:In glucocorticoid-induced osteoporosis (GIO), both bone formation and resorption are altered, however, with a relative prevalence of resorption, consistent with the positive results that have been reported with bisphosphonate treatment. Many studies have investigated the effect of bisphosphonates (BPs), a widely used ...

journal_title：Endocrine

authors： Rossini M,Orsolini G,Viapiana O,Adami S,Gatti D

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Surgical procedures are associated with activation of the hypothalamic-pituitary-adrenal axis (HPA). Studies examining HPA dynamics peri-operatively are limited and the modulating influence of peri-operatively administered glucocorticoids on that is not well established. This investigation examined alteratio...

journal_title：Endocrine

authors： El-Sibai K,Rajpal A,Al-Aridi R,Selman WR,Arafah BM

更新日期：2017-10-01 00:00:00

abstract：:The effect of stress on serum corticosteroid-binding globulin (CBG) was studied in adult male Sprague-Dawley rats. CBG was measured either by a homologous radioimmunoassay (RIA) or by a binding assay (BA) using 3H-corticosterone. Exposure of adult male rats to a severe stressor such as immobilization (IMO) for 1 h did...

journal_title：Endocrine

authors： Martí O,Martín M,Gavaldà A,Giralt M,Hidalgo J,Hsu BR,Kuhn RW,Armario A

更新日期：1997-04-01 00:00:00

abstract：:In order to determine the profiles and sources of inhibin A and inhibin B during pregnancy in Japanese monkeys, serum samples were collected from eight monkeys for measuring concentrations of both inhibins by enzyme-linked immunosorbent assay. The term placenta was used for the localization of inhibin alpha-, betaA-, ...

journal_title：Endocrine

authors： Kojima C,Kondo M,Jin W,Shimizu K,Itoh M,Watanabe G,Groome NP,Taya K

更新日期：2002-06-01 00:00:00

abstract：:AdipoR1 is one of the adiponectin receptors which are important for adiponectin signaling. Because adiponectin is a candidate gene for common obesity, it is also hypothesized that variations in AdipoR1 may be involved in the development of complex obesity. Therefore, we designed an association study for the AdipoR1 ge...

journal_title：Endocrine

authors： Beckers S,de Freitas F,Zegers D,Mertens IL,Verrijken A,Van Camp JK,Van Gaal LF,Van Hul W

更新日期：2013-02-01 00:00:00

abstract：:Diabetes with hypertension is characterized by increased cerebrovascular pathology and poorer outcomes following stroke. In this study we evaluated the effect of global brain ischemia on brain metabolic parameters in normal and diabetic rats treated with a dihydropyridine calcium antagonist, felodipine. Normal and dia...

journal_title：Endocrine

authors： Levy J,Zhu Z,Dunbar JC

更新日期：2004-11-01 00:00:00

abstract：:We validated the effect of prolactin-releasing peptide (PrRP) on prolactin (PRL) secretion from rat anterior pituitary cells in in vitro culture. We found that culture conditions considerably influenced the response of the anterior pituitary cells to PrRP. Longer culture term (4 d) was required to obtain better respon...

journal_title：Endocrine

authors： Kawamata Y,Fujii R,Fukusumi S,Habata Y,Hosoya M,Hinuma S,Kitada C,Onda H,Nishimura O,Fujino M

更新日期：2000-06-01 00:00:00

abstract：:The process of homo- and/or heterodimerization of G-protein coupled receptors (GPCRs) and receptor tyrosine kinase (RTK) families are crucial for implicating the fundamental properties of receptor proteins including receptor expression, trafficking, and desensitization as well as signal transduction. The members of GP...

journal_title：Endocrine

authors： Kumar U

更新日期：2011-10-01 00:00:00

abstract：:The cytoplasmic Ca2+ concentration ([Ca2+]i) was measured with dual wavelength fluorometry in glucagon-producing mouse pancreatic alpha-cells loaded with the indicator fura-2. Spontaneous rhythmic activity in terms of slow oscillations from a basal level was observed at 3 mM glucose. Like in the insulin-secreting beta...

journal_title：Endocrine

authors： Berts A,Gylfe E,Hellman B

更新日期：1997-02-01 00:00:00

abstract：:The treatment of acromegaly is based on surgery, drugs, and radiotherapy as a third-line option. Fractionated stereotactic radiotherapy (FSRT) is a new technique with a need for long-term evaluation. The purpose of the study was to evaluate long-term results of FSRT in acromegaly. Overall, 34 patients [sex ratio 1.12,...

journal_title：Endocrine

authors： Diallo AM,Colin P,Litre CF,Diallo MM,Decoudier B,Bertoin F,Higel B,Patey M,Rousseaux P,Delemer B

更新日期：2015-12-01 00:00:00

abstract：:We aimed to investigate different enhancement patterns of solid thyroid nodules on contrast-enhanced ultrasound (CEUS) and then to evaluate the corresponding diagnostic performance in the differentiation of benign and malignant nodules with and without enhancement. 229 solid thyroid nodules in 196 patients who had und...

journal_title：Endocrine

authors： Wu Q,Wang Y,Li Y,Hu B,He ZY

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:PTEN and KLLN are two tumor suppressor genes located in 10q23, share a bidirectional promoter and have roles in carcinogenesis. Formerly, the role of PTEN mutations and KLLN epimutations were identified in incidence of thyroid lesions in individuals with Cowden syndrome, a rare autosomal dominant inherited diso...

journal_title：Endocrine

authors： Razavi SA,Modarressi MH,Yaghmaei P,Tavangar SM,Hedayati M

更新日期：2017-09-01 00:00:00

abstract：:Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are relatively rare and heterogenous malignancies. Recent advances in histopathological classification according to the anatomical site of origin, proliferation rate, and extend of the disease have created a valid and powerful tool for the prognostic stratificati...

journal_title：Endocrine

authors： Alexandraki KI,Kaltsas G

更新日期：2012-02-01 00:00:00

abstract：:To assess how early can estrogens induce female mating behaviors, rat pups 8-29 days old (D8-D29, respectively) were injected twice daily with estradiol benzoate (E) or oil (O) followed by progesterone (P) or oil, and then observed for the estrogen-dependent ear wiggling (EW) and lordosis in response to natural stimul...

journal_title：Endocrine

authors： Kow LM,Bogun M,Zhang Q,Pfaff DW

更新日期：2007-12-01 00:00:00

abstract：:Insulin pumps operate almost universally in the work environment. Tubeless insulin pumps are a relatively recent development for management of insulin-dependent diabetes. This is the first report of location-dependent failure of insulin pump function, possibly due to external interference, occurring only in the settin...

journal_title：Endocrine

authors： Reiher AE,Gallagher TA,Emanuele MA

更新日期：2009-02-01 00:00:00

abstract：:Concentrations of immunoreactive (ir-) inhibin in circulation, amniotic fluid, and testes of embryos and newly hatched ducks were determined from d 21 of incubation to d 1 of age. Plasma concentrations of FSH and LH were also determined by chicken radioimmunoassay (RIA) systems. In addition, gene expression and cellul...

journal_title：Endocrine

authors： Yang P,Medan MS,Arai KY,Jin W,Watanabe G,Taya K

更新日期：2005-11-01 00:00:00

abstract：:Various factors influence quality of life (QoL) in acromegaly. Whether disease control and treatment approach are related to QoL is still a matter of debate. The aim of the present study was to evaluate QoL in patients with acromegaly using the disease-specific Acromegaly Quality of Life Questionnaire in respect to di...

journal_title：Endocrine

authors： Vandeva S,Yaneva M,Natchev E,Elenkova A,Kalinov K,Zacharieva S

更新日期：2015-08-01 00:00:00

abstract：:We hypothesized that in nonectopic Cushing syndrome there is an insufficient activity of type II (renal) 11beta-hydroxysteroid dehydrogenase (11beta-HSD2) that is related to cortisol excess, rather than to corticotropin (adrenocorticotropic hormone [ACTH]) levels. We measured plasma ACTH and urinary-free cortisol (UFF...

journal_title：Endocrine

authors： Stiefel P,García-Morillo JS,Jimenez L,Pamies E,Miranda ML,Carneado J,Villar J,Leal-Cerro A

更新日期：2002-08-01 00:00:00

abstract：:Alendronate is a well-established treatment for osteoporosis and suppresses bone resorption by a direct effect on osteoclasts and their precursors. The effect of alendronate on osteoclasts is produced, at least in part, by the receptor activator of nuclear factor kappaB ligand (RANKL) and the osteoprotegerin (OPG) syn...

journal_title：Endocrine

authors： Enjuanes A,Ruiz-Gaspà S,Peris P,Ozalla D,Alvarez L,Combalia A,Martínez de Osaba MJ,Monegal A,Pares A,Guañabens N

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:We aimed to evaluate the performance of structural magnetic resonance imaging (MRI)-based quantitative measurements at extraocular muscle (EOM), orbital fat (OF), and especially lacrimal gland (LG) in predicting response to glucocorticoid (GC) in patients with active and moderate-severe thyroid-associated ophth...

journal_title：Endocrine

authors： Hu H,Xu XQ,Chen L,Chen W,Wu Q,Chen HH,Zhu H,Shi HB,Wu FY

更新日期：2020-11-01 00:00:00

abstract：:Variations in the fat mass and obesity-associated (FTO) gene have recently been associated with obesity and type 2 diabetes mellitus among different ethnic populations. Given that the phenotype of polycystic ovary syndrome (PCOS) overlaps with obesity and type 2 diabetes, we hypothesize that the common rs9939609 varia...

journal_title：Endocrine

authors： Yan Q,Hong J,Gu W,Zhang Y,Liu Q,Su Y,Zhang Y,Li X,Cui B,Ning G

更新日期：2009-12-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare tumour which frequently occurs in the context of the multiple endocrine neoplasia syndromes, where it coexists with other usually benign tumours. The clinical picture varies and distant metastases are frequently present at diagnosis. Calcitonin levels are elevated in the pre...

journal_title：Endocrine

authors： Alevizaki M,Kyratzoglou E,Bamias A,Tzanela M,Dimopoulos MA,Saltiki K

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:A large number of studies has investigated proopiomelanocortin processing in anterior pituitary corticotropes but little is known on proopiomelanocortin/ACTH degradation within these cells. The ubiquitin-proteasome system is an intracellular protein degradation pathway which has garnered considerable interest i...

journal_title：Endocrine

authors： Sesta A,Cassarino MF,Cavagnini F,Pecori Giraldi F

更新日期：2018-09-01 00:00:00

abstract：:A substantial number of pregnancies are complicated by gestational diabetes mellitus (GDM) and up to 70 % of women with GDM go on to develop type 2 diabetes. Given the extensive body of research suggesting physical activity reduces the risk of type 2 diabetes, facilitating physical activity, and reducing sedentary tim...

journal_title：Endocrine

authors： Johnson ST,Lynch B,Vallance J,Davenport MH,Gardiner PA,Butalia S

更新日期：2016-04-01 00:00:00