Abstract:
PURPOSE:An increasing body of evidence suggests that dipeptidyl-peptidase 4 (DPP-4) inhibitors could play a role in the development of bullous pemphigoid. The knowledge regarding this association is based on case reports, pharmacovigilance database analyses, and observational studies. Data from randomized clinical trials are a relevant source of information on adverse events. Since no single trial has a sufficient power to assess the risk of very rare adverse events, such as pemphigoid, metanalyses of RCTs could be a useful tool for exploring this issue. METHODS:An extensive Medline, Embase and Cochrane Database search for sitagliptin or vildagliptin, omarigliptin or saxagliptin or alogliptin or trelagliptin or anagliptin or linagliptin or gemigliptin or evogliptin or teneligliptin was performed up to September 30th, 2019. All trials performed on type 2 diabetes, with duration ≥24 weeks, and comparing DPP4i with placebo or active drugs were collected. The study has been registered on PROSPERO (#153344). Mantel-Haenszel odds ratio (MH-OR) with 95% Confidence Interval (95% CI) was calculated for pemphigoid. RESULTS:A total of 138 eligible trials were identified (61,514 patients in DPP-4 inhibitors and 59,661 patients in the control group). Only six trials reported at least one case of pemphigoid (17 and 1 cases in DPP4i and control groups, respectively). DPP-4 inhibitors were associated with an increased risk of pemphigoid (MH-OR 4.44 [1.31, 15.00], p = 0.020). A separate analysis for trials with linagliptin showed a significant increase of BP with the active drug (MH-OR 4.69 [1.09, 20.22]; p = 0.04). CONCLUSIONS:In conclusion, available data from randomized controlled trials seem to confirm the association between DPP-4 inhibitors and bullous pemphigoid. This association could be limited to one molecule of the class (i.e., linagliptin), although data on other DPP4-i (e.g., vildagliptin) are insufficient to rule out similar detrimental effects.
journal_name
Endocrinejournal_title
Endocrineauthors
Silverii GA,Dicembrini I,Nreu B,Montereggi C,Mannucci E,Monami Mdoi
10.1007/s12020-020-02272-xsubject
Has Abstractpub_date
2020-09-01 00:00:00pages
504-507issue
3eissn
1355-008Xissn
1559-0100pii
10.1007/s12020-020-02272-xjournal_volume
69pub_type
杂志文章相关文献
ENDOCRINE文献大全abstract::It is well known that TSH plays a major role in the secretion of thyroid hormones, maintenance of thyroid specific gene expression, and gland growth. In this study, we aimed to evaluate association between tests of thyroid functions (fT3, fT4, TSH) and differentiated thyroid carcinoma. 441 patients operated for nodula...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9316-6
更新日期:2010-04-01 00:00:00
abstract::The objectives of this study were to analyse the results of surgical treatment of multinodular goiter (MG) in a population with under 30 yr of age; (2) to determine the incidence and evolution of related thyroid carcinomas; and (3) to evaluate the rate of relapse. Eighty-one patients operated for MG and under 30 yr of...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:27:3:245
更新日期:2005-08-01 00:00:00
abstract:PURPOSE:The hyperthermal liquid, spray and smog caused by energy-based surgical devices (EBDs) may be the potential risk factors for recurrent laryngeal nerve (RLN) thermal injury, but not been reported previously. We aim to demonstrated it both in thyroid surgeries and animal experiments. METHODS:321 thyroid patients...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02451-w
更新日期:2020-08-10 00:00:00
abstract:BACKGROUND:Wolfram syndrome (WFS) is a rare, monogenic neurodegenerative syndrome characterised by insulin requiring non-autoimmune diabetes mellitus (DM) and optic atrophy which are usually the earliest and commonest manifestations. However, there are other features which are under-recognized, adding to morbidity and ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02320-6
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Thyroid hormone (TH) metabolism can have prognostic significance in brain tumors. We studied the association of common variations in three deiodinase gene single-nucleotide polymorphisms (SNPs) with circulating TH concentrations and prognosis of brain tumor patients. METHODS:Patients admitted for glioma and...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-02016-6
更新日期:2019-12-01 00:00:00
abstract::Thioredoxin-interacting protein (TXNIP) is a known important regulatory protein of islet β-cell biology and function, but the detailed mechanism is not clear. Autophagy plays a pivotal role in maintaining cellular homoeostasis. This study aimed to elucidate the influence of TXNIP on the autophagy of β-cell. In this st...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02471-6
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:to assess bone damage and metabolic abnormalities in patients with Addison's disease given replacement doses of glucocorticoids and mineralocorticoids. METHODS:A total of 87 patients and 81 age-matched and sex-matched healthy controls were studied. The following parameters were measured: urinary cortisol, seru...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1380-8
更新日期:2018-02-01 00:00:00
abstract::To determine whether murine mammary growth is modulated by local insulin-like growth factor-1 (IGF-1) production, expression of recombinant IGF-1 was directed to the mammary glands of transgenic mice using an ovine prepro IGF-1 cDNA under control of the mouse mammary tumor virus-long terminal repeat (MMTV-LTR) promote...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:8:3:251
更新日期:1998-06-01 00:00:00
abstract::Progesterone (P(4)) and estradiol (E(2)) regulate many cell functions through their interaction with specific intracellular receptors, which require the participation of coactivators such as SRC-1 and SRC-3 for enhancing their transcriptional activity. Coactivator expression is altered in many cancers and in some of t...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9288-6
更新日期:2010-02-01 00:00:00
abstract::A mechanism explaining the differential skeletal effects of intermittent and continuous elevation of serum parathyroid hormone (PTH) remains elusive. Intermittent PTH increases bone formation and bone mass and is being investigated as a therapy for osteoporosis. By contrast, chronic hyperparathyroidism results in the ...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:17:1:29
更新日期:2002-02-01 00:00:00
abstract::Recently, the microhistologic evaluation by core needle biopsy (CNB) has been reported as high accurate to diagnose thyroid nodules with previous indeterminate or not adequate fine-needle aspiration cytology. In addition, sparse data have been reported regarding the use of CNB in other conditions. Aim of this review w...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0382-z
更新日期:2015-04-01 00:00:00
abstract::Urocortin 3 (Ucn3) is recognized as a member of the corticotropin-releasing factor (CRF) family, which plays an important role in regulating food intake. We investigated the effects of centrally administered Ucn3 on food intake and gastric emptying in mice. Intracerebroventricular (ICV)administration of Ucn3 (0.1–1 nm...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9420-7
更新日期:2011-04-01 00:00:00
abstract::The goal of the present study was to investigate whether p53 antibodies (Abs) could be a relevant marker for papillary thyroid carcinoma (PTC). Three types of enzyme-linked immunosorbent assay (ELISA) methods were developed for the detection of p53 Abs, including p53-ELISA, phage-SS-ELISA, and phage-SP-ELISA. A total ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0243-9
更新日期:2014-11-01 00:00:00
abstract::Elastosonography (ES) is a newly developed method that is used for the differential diagnosis of benign and malignant thyroid nodules. In different studies, ES scoring has been compared with histopathological findings, and sensitivity and specificity of the scoring were calculated. In this study, it determines the str...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9416-3
更新日期:2011-02-01 00:00:00
abstract::Glucocorticoid hormones potentiate the toxic effects of neuronal stressors. Alteration of gene expression by glucocorticoids could contribute to neuronal susceptibility by downregulating the synthesis of proteins necessary to adapt to challenge. Using heat shock of hippocampal slices as a model for cellular insult, pr...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:8:2:135
更新日期:1998-04-01 00:00:00
abstract:PURPOSE:Angiogenesis has been studied in pituitary neuroendocrine tumours (PitNETs), but the role of the tumour microenvironment (TME) in regulating PitNET angiogenesis remains unknown. We aimed to characterise the role of TME components in determining the angiogenetic PitNET profile, focusing on immune cells and tumou...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02478-z
更新日期:2020-12-01 00:00:00
abstract::Concentrations of immunoreactive (ir-) inhibin in circulation, amniotic fluid, and testes of embryos and newly hatched ducks were determined from d 21 of incubation to d 1 of age. Plasma concentrations of FSH and LH were also determined by chicken radioimmunoassay (RIA) systems. In addition, gene expression and cellul...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:28:2:171
更新日期:2005-11-01 00:00:00
abstract::The A1 adenosine receptor (A1AR) exerts important biological effects in the mammalian biology. To provide insights into the role A1AR action in human physiology, we characterized the pharmacologic properties of the human A1AR, examined somatic sites of A1AR gene expression, and identified the chromosomal location of t...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02746338
更新日期:1995-09-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is linked to increased risk of insulin resistance and diabetes mellitus in patients' later life. The aim of this study was to investigate uptake of deoxy-D-glucose by peripheral blood lymphocytes of PCOS patients with normal fasting plasma glucose and normal glucose tolerance test. The...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0174-5
更新日期:2014-11-01 00:00:00
abstract::Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by tumors of the parathyroid glands, the anterior pituitary, and the endocrine pancreas. Our patient was a 58-year-old man who manifested typical features of MEN-1 including primary hyperparathyroidism, lung carcinoid, and lipom...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9183-1
更新日期:2009-08-01 00:00:00
abstract::Graves' disease (GD) and Hashimoto's thyroiditis (HT) are both common autoimmune diseases of the thyroid gland (AITD). The IL-4 is involved in both humoral and cellular immunity. The aim of this study was to test whether the IL-4 gene could be used as a genetic marker to predict the development of AITD amongst the Chi...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-007-9027-9
更新日期:2007-10-01 00:00:00
abstract:PURPOSE:Various studies in placental tissue suggest that diabetes mellitus alters the expression of glucose transporter (GLUT) proteins, with insulin therapy being a possible modulatory factor. The aim of the present study was quantitative evaluation of the expression of glucose transporters (GLUT-1, GLUT-4, GLUT-9) in...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1202-4
更新日期:2017-03-01 00:00:00
abstract::The aim of the study was to assess the impact of sex hormone-binding globulin (SHBG) on bone mineral density (BMD) and bone turnover among Chinese middle-aged and elderly men. This cross-sectional study was carried out among 404 Chinese men aged over 45 years. BMD was measured with dual-energy X-ray absorptiometry, an...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-013-0155-0
更新日期:2014-11-01 00:00:00
abstract::In order to analyse whether the participation of the dopaminergic system of the preoptic-anterior hypothalamic area (POA-AHA) in the regulation of ovulation is asymmetric and varies during the estrous cycle of the rat, as it occurs with the cholinergic system, the effects of a unilateral implant of haloperidol were st...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02935642
更新日期:1995-06-01 00:00:00
abstract::Prolactinomas are the most common secretory pituitary tumors; however, their pathogenesis is unclear. In order to explore the pathogenesis of prolactinomas, we used fiber-optic BeadArray to examine gene expression profiles in five prolactinomas compared with three normal pituitaries. Three down-regulated genes and one...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9389-2
更新日期:2010-12-01 00:00:00
abstract::This study investigated the impact of incretin on early-phase insulin secretion and glucose excursion. The normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM) groups included 16, 8, and 19 subjects, respectively. Subjects underwent continuous glucose monitoring for 3 d...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9867-9
更新日期:2013-10-01 00:00:00
abstract::First-line treatment of patients with growth hormone secreting adenomas is surgical resection. Disease control can be obtained by surgery (one or multiple steps), in case followed by medical treatment or adjuvant radiation therapy (radiosurgery or radiotherapy). The impact of pre-surgical treatment with somatostatin a...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0619-5
更新日期:2016-03-01 00:00:00
abstract::Aging could be due to the accumulation of oxidative damage. On the other hand, growth hormone (GH) and estrogen deficiency induce deleterious effects on different tissues, and hormonal replacement could counteract these effects. We have investigated whether GH and estrogen administration modify some parameters related...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/endo:26:1:011
更新日期:2005-02-01 00:00:00
abstract::RECK (reversion-inducing cysteine-rich protein with Kazal motifs) is a membrane-anchored glycoprotein which regulates MMP2 and MMP9 activity and has been proposed to play a role in embryo implantation while misexpression of RECK has been associated with a variety of carcinomas. Unfortunately, understanding on the ster...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9614-2
更新日期:2012-08-01 00:00:00
abstract::Altered bone micro-architecture is an important factor in accounting for fragility fractures. Until recently, it has not been possible to gain information about skeletal microstructure in a way that is clinically feasible. Bone biopsy is essentially a research tool. High-resolution peripheral Quantitative Computed Tom...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-014-0280-4
更新日期:2014-11-01 00:00:00