当前位置： SCI文献检索 > ENDOCRINE期刊下所有文献 > Identification of human somatostatin receptor 2 domains involved in internalization and signaling in QGP-1 pancreatic neuroendocrine tumor cell line.

Identification of human somatostatin receptor 2 domains involved in internalization and signaling in QGP-1 pancreatic neuroendocrine tumor cell line.

Abstract：

:Somatostatin exerts inhibitory effects on hormone secretion and cell proliferation via five receptor subtypes (SST1-SST5), whose internalization is regulated by β-arrestins. The receptor domains involved in these effects have been only partially elucidated. The aim of the study is to characterize the molecular mechanism and determinants responsible for somatostatin receptor 2 internalization and signaling in pancreatic neuroendocrine QGP-1 cell line, focusing on the third intracellular loop and carboxyl terminal domains. We demonstrated that in cells transfected with somatostatin receptor 2 third intracellular loop mutant, no differences in β-arrestins recruitment and receptor internalization were observed after somatostatin receptor 2 activation in comparison with cells bearing wild-type somatostatin receptor 2. Conversely, the truncated somatostatin receptor 2 failed to recruit β-arrestins and to internalize after somatostatin receptor 2 agonist (BIM23120) incubation. Moreover, the inhibitory effect of BIM23120 on cell proliferation, cyclin D1 expression, P-ERK1/2 levels, apoptosis and vascular endothelial growth factor secretion was completely lost in cells transfected with either third intracellular loop or carboxyl terminal mutants. In conclusion, we demonstrated that somatostatin receptor 2 internalization requires intact carboxyl terminal while the effects of SS on cell proliferation, angiogenesis and apoptosis mediated by somatostatin receptor 2 need the integrity of both third intracellular loop and carboxyl terminal.

journal_name

Endocrine

journal_title

Endocrine

authors

Cambiaghi V,Vitali E,Morone D,Peverelli E,Spada A,Mantovani G,Lania AG

doi

10.1007/s12020-016-1026-2

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

146-157

issue

1

eissn

1355-008X

issn

1559-0100

pii

10.1007/s12020-016-1026-2

journal_volume

56

pub_type

杂志文章

相关文献

ENDOCRINE文献大全
  • Activation profiles of monocyte-macrophages and HDL function in healthy women in relation to menstrual cycle and in polycystic ovary syndrome patients.

    abstract：PURPOSE:Hormonal status and menopause affect human macrophage function and cardiometabolic risk. In polycystic ovary syndrome (PCOS) patients the cardiometabolic risk increases through mechanisms that are largely unknown. We tested the hypotheses that macrophage activation is influenced by menstrual cycle and that ovar...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-019-01911-2

    authors： Tedesco S,Adorni MP,Ronda N,Cappellari R,Mioni R,Barbot M,Pinelli S,Plebani M,Bolego C,Scaroni C,Bernini F,Fadini GP,Cignarella A

    更新日期：2019-11-01 00:00:00

  • Molecular analysis of PROP1, POU1F1, LHX3, and HESX1 in Turkish patients with combined pituitary hormone deficiency: a multicenter study.

    abstract：:To investigate the specific mutations in PROP1, POU1F1, LHX3, and HESX1 genes in patients with combined pituitary hormone deficiency (CPHD) in Turkey. Seventy-six patients with CPHD were included in this study. Based on clinical, hormonal, and neuro-radiological data, relevant transcription factor genes were evaluated...

    journal_title：Endocrine

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s12020-014-0498-1

    authors： Baş F,Uyguner ZO,Darendeliler F,Aycan Z,Çetinkaya E,Berberoğlu M,Şiklar Z,Öcal G,Darcan Ş,Gökşen D,Topaloğlu AK,Yüksel B,Özbek MN,Ercan O,Evliyaoğlu O,Çetinkaya S,Şen Y,Atabek E,Toksoy G,Aydin BK,Bundak R

    更新日期：2015-06-01 00:00:00

  • Diurnal rhythmicity in breast-milk glucocorticoids, and infant behavior and sleep at age 3 months.

    abstract：PURPOSE:In previous studies, associations between breast-milk cortisol levels obtained on one occasion and infant neurodevelopment were demonstrated. However, more recent evidence indicates that breast-milk cortisol and cortisone concentrations follow the diurnal rhythm of maternal hypothalamus-pituitary-adrenal axis, ...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-020-02273-w

    authors： Toorop AA,van der Voorn B,Hollanders JJ,Dijkstra LR,Dolman KM,Heijboer AC,Rotteveel J,Honig A,Finken MJJ

    更新日期：2020-06-01 00:00:00

  • Glucocorticoids curtail stimuli-induced CREB phosphorylation in TRH neurons through interaction of the glucocorticoid receptor with the catalytic subunit of protein kinase A.

    abstract：PURPOSE:Corticosterone prevents cold-induced stimulation of thyrotropin-releasing hormone (Trh) expression in rats, and the stimulatory effect of dibutyryl cyclic-adenosine monophosphate (dB-cAMP) on Trh transcription in hypothalamic cultures. We searched for the mechanism of this interference. METHODS:Immunohistochem...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-016-1223-z

    authors： Sotelo-Rivera I,Cote-Vélez A,Uribe RM,Charli JL,Joseph-Bravo P

    更新日期：2017-03-01 00:00:00

  • Could there be a role of serum zonulin increase in the development of hypercalcemia in primary hyperparathyroidism.

    abstract：PURPOSE:To evaluate the serum level of zonulin, which is an intestinal permeability (IP) biomarker, in primary hyperparathyroidism (PHPT) and to investigate the relationship between zonulin, calcium, and parathormone (PTH) levels. METHODS:The study included 34 healthy control (HC) and 39 patients with PHPT. Serum calc...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-020-02504-0

    authors： Korkmaz H,Sirin FB,Torus B

    更新日期：2020-09-28 00:00:00

  • Impact of incretin on early-phase insulin secretion and glucose excursion.

    abstract：:This study investigated the impact of incretin on early-phase insulin secretion and glucose excursion. The normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM) groups included 16, 8, and 19 subjects, respectively. Subjects underwent continuous glucose monitoring for 3 d...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-012-9867-9

    authors： Shen J,Chen Z,Chen C,Zhu X,Han Y

    更新日期：2013-10-01 00:00:00

  • Expression of membrane prostaglandin E synthase in human placenta and fetal membranes and effect of labor.

    abstract：:Initiation and maintenance of labor in humans is associated with an increase in prostaglandin synthesis by intrauterine tissues. The objective of the present study was to characterize the distribution of membrane-bound PGES (mPGES) protein and mPGES mRNA in human placenta, fetal membranes, and decidua at term and to d...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:20:3:219

    authors： Alfaidy N,Sun M,Challis JR,Gibb W

    更新日期：2003-04-01 00:00:00

  • Is autoimmune thyroiditis a risk factor for early atherosclerosis in premenopausal women even if in euthyroid status?

    abstract：:Autoimmune thyroiditis (AIT) is a systemic disease. It is well-known that overt thyroid dysfunction is a cardiovascular risk factor. However, the influence of euthyroid status is unclear. The aim of this study was to evaluate the metabolic parameters and carotid intima-media thickness (CIMT) in euthyroid premenopausal...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-012-9842-5

    authors： Topaloglu O,Gokay F,Kucukler K,Burnik FS,Mete T,Yavuz HC,Berker D,Guler S

    更新日期：2013-08-01 00:00:00

  • Intercellular adhesion molecule 1 gene polymorphisms do not contribute to Graves' disease in Chinese patients.

    abstract：OBJECTIVE:In order to study the association of G241R polymorphism of ICAM-1 gene with an earlier onset of Graves' disease (GD) and the susceptibility of K469E polymorphism to Graves' ophthalmopathy (GO) in Chinese population. STUDY DESIGN:A case-control and replication study was performed in 212 GD patients and 204 he...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-007-0032-9

    authors： Wang S,Sun H,Chen HY,Zhao ZF,Yang Y,Zhao YJ,Cui B,Ning G

    更新日期：2007-04-01 00:00:00

  • Anti-Saccaromyces Cerevisiae antibodies (ASCA) are elevated in autoimmune thyroid disease ASCA in autoimmune thyroid disease.

    abstract：:Environmental factors have been implicated in the development of autoimmune thyroid disease (AITD). Anti-Saccaromyces Cerevisiae Antibodies (ASCA) were shown to be elevated in several autoimmune diseases. The aim of the study was to determine ASCA levels and their relationship with thyroid autoantibodies in patients w...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-010-9372-y

    authors： Yazıcı D,Aydın SZ,Yavuz D,Tarçın O,Deyneli O,Direskeneli H,Akalın S

    更新日期：2010-10-01 00:00:00

  • The human A1 adenosine receptor: ligand binding properties, sites of somatic expression and chromosomal localization.

    abstract：:The A1 adenosine receptor (A1AR) exerts important biological effects in the mammalian biology. To provide insights into the role A1AR action in human physiology, we characterized the pharmacologic properties of the human A1AR, examined somatic sites of A1AR gene expression, and identified the chromosomal location of t...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/BF02746338

    authors： Rivkees SA,Lasbury ME,Stiles GS,Henegariu O,Curtis C,Vance G

    更新日期：1995-09-01 00:00:00

  • An assessment of the relationship between thyroid nodule characteristics, insulin resistance and arterial stiffness in euthyroid nodular goiter.

    abstract：OBJECTIVES:Publications suggesting that thyroid nodule might be associated with insulin resistance and metabolic syndrome are quite interesting. There is a need for studies assessing the relationship between nodule presence and cardiovascular risk in individuals with non-functioning nodular goiter. The purpose of the p...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-018-1701-6

    authors： Aydoğan Y,Altay M,Ünsal O,Kaplanoğlu V,Çağır Y,Yıldız C,Beyan E,Ramadan SU

    更新日期：2018-11-01 00:00:00

  • Effect of low doses of progesterone in the expression of the GABA(A) receptor α4 subunit and procaspase-3 in the hypothalamus of female rats.

    abstract：:Progesterone is a steroid which regulates neural function, thereby modulating neurotransmission, cell survival, and behavior. Previous studies by our group have shown that chronic administration of low doses of progesterone in diestrus II female rats has an antidepressant-like effect in the forced swimming test (FST)....

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-013-0126-5

    authors： Arbo BD,Andrade S,Osterkamp G,Gomez R,Ribeiro MF

    更新日期：2014-08-01 00:00:00

  • Decreased blood activity of glucose-6-phosphate dehydrogenase associates with increased risk for diabetes mellitus.

    abstract：:Glucose-6-phosphate dehydrogenase (G6PD) deficiency predisposes affected individuals highly susceptible to oxidative stress, which is one of the risk factors for diabetes. To evaluate the relationship between blood level of G6PD activity and diabetes in Taiwan, blood G6PD activity was analyzed among 237 patients with ...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:19:2:191

    authors： Wan GH,Tsai SC,Chiu DT

    更新日期：2002-11-01 00:00:00

  • Novel splicing variants of the human thyrotropin receptor encode truncated polypeptides without a membrane-spanning domain.

    abstract：:The thyrotropin receptor is of fundamental importance to normal thyroid function and is considered to be the predominant antigen affected by the autoantibodies of Graves' autoimmune hyperthyroidism. The identification of the epitopes on the receptor to which the autoantibodies bind or the mechanism by which the autoan...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/BF02994449

    authors： Hunt N,Willey KP,Abend N,Balvers M,Jähner D,Northemann W,Ivell R

    更新日期：1995-03-01 00:00:00

  • Atrial conduction times and left atrium mechanical functions in patients with active acromegaly.

    abstract：:The aim of this study was to evaluate atrial electromechanical delay (EMD), P wave dispersion (Pwd), and left atrial (LA) mechanical functions in patients with active acromegaly. Twenty-three patients with active acromegaly and 27 age- and sex-matched controls were included in this study. All atrial electromechanical ...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-014-0348-1

    authors： Ilter A,Kırış A,Kaplan Ş,Kutlu M,Şahin M,Erem C,Civan N,Kangül F

    更新日期：2015-03-01 00:00:00

  • Stimulation by interleukin-6 and inhibition by tumor necrosis factor of cortisol release from bovine adrenal zona fasciculata cells through their receptors.

    abstract：:Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) are synthesized and released from adrenal cells. Therefore, the effects of TNF-alpha and IL-6 on cortisol release from bovine zona fasciculata (ZF) cells were investigated. IL-6 (10-1000 pg/mL) significantly increased basal and adrenocorticotropic hormon...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:13:3:369

    authors： Barney M,Call GB,McIlmoil CJ,Husein OF,Adams A,Balls AG,Oliveira GK,Miner EC,Richards TA,Crawford BK,Heckmann RA,Bell JD,Judd AM

    更新日期：2000-12-01 00:00:00

  • Androgen receptor expression in the testes and epididymides of prenatal and postnatal Sprague-Dawley rats.

    abstract：:The androgen receptor (AR) plays a critical role in sexual differentiation and in the virilization of the male reproductive system. A clear understanding of AR expression at the early stages of sexual development will help elucidate the sensitivity of perinatal animals to endocrine modulation by external agents, such ...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:9:3:253

    authors： You L,Sar M

    更新日期：1998-12-01 00:00:00

  • The effects of experimental hyperthyroidism on hemorheology and plasma fibrinogen concentration.

    abstract：:The present study in female rats determined the effects of experimental hyperthyroidsm on hemorheological parameters and fibrinogen concentration. To induce experimental hyperthyroidism L-thyroxine (0.4 mg/100 g fodder) was added to the fodder of the experimental group rats for 20 d. After experimental duration, T3, T...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:30:2:203

    authors： Ozdemir S,Yücel R,Dariyerli N,Toplan S,Akyolcu MC,Yigit G,Hatemi H

    更新日期：2006-10-01 00:00:00

  • Glucose, cholesterol, and blood pressure: is lower always better for type 2 diabetes?

    abstract：:Diabetes mellitus is a major risk factor for cardiovascular disease. However, the excess risk of death may vary substantially in subgroups of patients with type 2 diabetes, being highest in those younger than 55 years of age. A HbA1c value of 7.0 % or less is recommended for most patients with type 2 diabetes to reduc...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-016-0981-y

    authors： Giugliano D,Maiorino MI,Bellastella G,Esposito K

    更新日期：2016-10-01 00:00:00

  • Diagnostic performance of positron emission tomography using ¹¹C-methionine in patients with suspected parathyroid adenoma: a meta-analysis.

    abstract：:The diagnostic performance of positron emission tomography using ¹¹C-methionine (MET-PET) in detecting parathyroid adenoma has been investigated by several studies with conflicting results. Aim of our study is to meta-analyze published data about this topic. A comprehensive computer literature search of studies publis...

    journal_title：Endocrine

    pub_type： 杂志文章,meta分析

    doi：10.1007/s12020-012-9746-4

    authors： Caldarella C,Treglia G,Isgrò MA,Giordano A

    更新日期：2013-02-01 00:00:00

  • Correction to: Anti-Müllerian hormone serum levels in systemic lupus erythematosus patients: influence of the disease severity and therapy on the ovarian reserve.

    abstract：:The original version of this article unfortunately contained a mistake in given and family names of all the authors. ...

    journal_title：Endocrine

    pub_type： 已发布勘误

    doi：10.1007/s12020-018-1811-1

    authors： Di Mario C,Petricca L,Gigante MR,Barini A,Barini A,Varriano V,Paglionico A,Cattani P,Ferraccioli G,Tolusso B,Gremese E

    更新日期：2019-02-01 00:00:00

  • Low 25 (OH) vitamin D levels are associated with autoimmune thyroid disease in polycystic ovary syndrome.

    abstract：:Low 25(OH) vitamin D levels have been associated with several autoimmune diseases and recently with autoimmune thyroid disease (AITD). The aim of the study was to investigate the association of AITD with 25(OH) vitamin D levels in women with polycystic ovary syndrome (PCOS). Fifty women with PCOS were consecutively en...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-015-0745-0

    authors： Muscogiuri G,Palomba S,Caggiano M,Tafuri D,Colao A,Orio F

    更新日期：2016-08-01 00:00:00

  • Elevated serum RBP4 is associated with insulin resistance in women with polycystic ovary syndrome.

    abstract：:Retinol binding protein 4 (RBP4) is a novel adipocyte-secreted protein that contributes to systemic insulin resistance. Experiments in mice suggest that elevated RBP4 causes insulin resistance. In the present study, we determined serum RBP4 concentration and evaluated its association with insulin resistance in women w...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-006-0006-3

    authors： Weiping L,Qingfeng C,Shikun M,Xiurong L,Hua Q,Xiaoshu B,Suhua Z,Qifu L

    更新日期：2006-12-01 00:00:00

  • Glycemic control in type 2 diabetes: from medication nonadherence to residual vascular risk.

    abstract：:Despite the availability of many new treatment options for type 2 diabetes, the proportion of patients achieving the HbA1c target < 7.0% remains around 50%. We put forward the hypothesis that the unchanged HbA1c results, observed in the last decade in type 2 diabetes patients, are also a consequence of medication nona...

    journal_title：Endocrine

    pub_type： 杂志文章,评审

    doi：10.1007/s12020-017-1517-9

    authors： Giugliano D,Maiorino MI,Bellastella G,Esposito K

    更新日期：2018-07-01 00:00:00

  • The association of obesity with hearing thresholds in women aged 18-40 years.

    abstract：:An elevation in hearing thresholds and decrease in hearing sensitivity in adults, particularly due to aging, are quite common. Recent studies have shown that, apart from aging, various other factors also play a role in auditory changes. Studies on the association of hearing loss (HL) with obesity are limited in advanc...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-015-0755-y

    authors： Üçler R,Turan M,Garça F,Acar İ,Atmaca M,Çankaya H

    更新日期：2016-04-01 00:00:00

  • Development of a metabolic syndrome severity score and its association with incident diabetes in an Asian population-results from a longitudinal cohort in Singapore.

    abstract：PURPOSE:Metabolic syndrome (MetS) is a constellation of clinical factors that indicates elevated risk of diabetes. It is diagnosed based on three or more abnormalities in its components. This does not take into account that MetS can likely present as a continuum of risk. We aim to develop a MetS severity score and asse...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-019-01970-5

    authors： Low S,Khoo KCJ,Wang J,Irwan B,Sum CF,Subramaniam T,Lim SC,Wong TKM

    更新日期：2019-07-01 00:00:00

  • Mitogenic responsiveness of caprine mammary epithelial cells to endocrine and cytokine factors.

    abstract：:Mammary cell mitogenic responsiveness was evaluated with an established nontransformed caprine mammary epithelial cell line (CMEC). As expected, the cells responded to insulin-like growth factor 1 (IGF-1), insulin, and hydrocortisone with an increased number of cells after 3 and 5 d in culture. In combination, insulin...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:10:2:123

    authors： Pantschenko AG,Yang TJ

    更新日期：1999-04-01 00:00:00

  • The impact of peri-operative dexamethasone administration on the normal hypothalamic pituitary adrenal response to major surgical procedures.

    abstract：BACKGROUND:Surgical procedures are associated with activation of the hypothalamic-pituitary-adrenal axis (HPA). Studies examining HPA dynamics peri-operatively are limited and the modulating influence of peri-operatively administered glucocorticoids on that is not well established. This investigation examined alteratio...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-017-1398-y

    authors： El-Sibai K,Rajpal A,Al-Aridi R,Selman WR,Arafah BM

    更新日期：2017-10-01 00:00:00

  • High-resolution-cone beam tomography analysis of bone microarchitecture in patients with acromegaly and radiological vertebral fractures.

    abstract：:Vertebral fractures are an emerging complication of acromegaly but their prediction is still difficult occurring even in patients with normal bone mineral density. In this study we evaluated the ability of high-resolution cone-beam computed tomography to provide information on skeletal abnormalities associated with ve...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-016-1078-3

    authors： Maffezzoni F,Maddalo M,Frara S,Mezzone M,Zorza I,Baruffaldi F,Doglietto F,Mazziotti G,Maroldi R,Giustina A

    更新日期：2016-11-01 00:00:00