Mitogenic responsiveness of caprine mammary epithelial cells to endocrine and cytokine factors.

abstract：PURPOSE:Bisphenol-A (BPA) is an endocrine-disrupting chemical that may affect the hormones and their receptors. The aim of this study is to determine whether BPA has an effect on the development of nonfunctional adrenal incidentaloma (NFAI). METHODS:Fifty patients who were admitted to endocrinology outpatient clinics ...

journal_title：Endocrine

authors： Eker F,Gungunes A,Durmaz S,Kisa U,Celik ZR

更新日期：2020-09-23 00:00:00

abstract：:We have shown that gonadotrophs synthesize and secrete immunoreactive calcitonin (CT)-like peptide, and CT is a potent inhibitor of prolactin (PRL) secretion and gene transcription. CT cDNA cloned from LssT2 cells (pit-CT cDNA) exhibits 99% homology with mouse CT cDNA sequence, but exhibits four mismatches in the codi...

journal_title：Endocrine

authors： Kulkarni-Paranjape T,Shah GV

更新日期：2007-06-01 00:00:00

abstract：:Cardiovascular morbidity and mortality are increased in patients with primary hyperparathyroidism (PHPT). We aimed to evaluate left ventricle systolic and diastolic functions with tissue Doppler imaging (TDI) and strain and strain rate echocardiography in patients with PHPT. Thirty-one patients with PHPT and 29 health...

journal_title：Endocrine

authors： Ozdemir D,Kalkan GY,Bayram NA,Onal ED,Ersoy R,Bozkurt E,Cakir B

更新日期：2014-11-01 00:00:00

abstract：:The objective of this study was to assess the prevalence of macroprolactin, a macromolecule with reduced bioactivity, in hyperprolactinemic patients. Prolactin was measured before and after precipitation of macroprolactin by polyethylene glycol in 306 patients. Only patients with prolactin values >700 mIU/L (n = 270) ...

journal_title：Endocrine

authors： Toldy E,Löcsei Z,Szabolcs I,Góth MI,Kneffel P,Szöke D,Kovács GL

更新日期：2003-12-01 00:00:00

abstract：:Studies on the effect of exogenous subclinical thyrotoxicosis on bone mineral density (BMD) in male patients treated with suppressive doses of levothyroxine for differentiated thyroid carcinoma (DTC) are not conclusive. In order to evaluate BMD (in femoral neck, lumbar spine, and distal radius) and bone fractures in m...

journal_title：Endocrine

authors： Reverter JL,Colomé E,Holgado S,Aguilera E,Soldevila B,Mateo L,Sanmartí A

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Conformal, fractionated radiation therapy (XRT) is variably used as a treatment alternative for active acromegaly patients, usually, after failed pituitary surgery. Our objective was to evaluate the long-term efficacy and safety of XRT using strict criteria of biochemical control. SETTING, DESIG...

journal_title：Endocrine

authors： Gonzales-Virla B,Vargas-Ortega G,Martínez-Vázquez KB,de Lo Monteros ALE,Sosa-Erosa E,López-Félix B,Mendoza-Zubieta V,Mercado M

更新日期：2019-08-01 00:00:00

abstract：:Estrogens increase prolactin (PRL) synthesis and release in rats and humans, whereas pituitary-derived calcitonin-like immunoreactive peptide (pit-CT) inhibits PRL gene expression and release. To test the hypothesis that estrogens stimulate lactotrophs by diminishing pit-CT expression, the present studies examined eff...

journal_title：Endocrine

authors： Li Z,Shah GV

更新日期：1995-06-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is linked to increased risk of insulin resistance and diabetes mellitus in patients' later life. The aim of this study was to investigate uptake of deoxy-D-glucose by peripheral blood lymphocytes of PCOS patients with normal fasting plasma glucose and normal glucose tolerance test. The...

journal_title：Endocrine

authors： Oleszczak B,Szablewski L,Pliszka M,Głuszak O,Stopińska-Głuszak U

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:A recent report described a new PCOS-like phenotype in lean older infertile women, and was characterized by high age-specific anti-Müllerian hormone (AMH) but hypo- rather than the expected hyper-androgenism. The hypo-androgenism was, furthermore, characterized of, likely, adrenal origin and autoimmune etiol...

journal_title：Endocrine

authors： Gleicher N,Kushnir VA,Darmon SK,Wang Q,Zhang L,Albertini DF,Barad DH

更新日期：2018-03-01 00:00:00

abstract：:We performed a meta-analysis to analyze the associations of depression with pre-diabetes (PreDM), undiagnosed diabetes (UDM), and previously diagnosed diabetes (PDM), and whether the association was affected by important study characteristics. We searched relevant articles published in PubMed and EMBASE up to August, ...

journal_title：Endocrine

authors： Chen S,Zhang Q,Dai G,Hu J,Zhu C,Su L,Wu X

更新日期：2016-07-01 00:00:00

abstract：:The association between cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) exon-1 +49 A/G polymorphism and Hashimoto's thyroiditis (HT) has been widely studied. The results, however, are mixed. This study provides a comprehensive evaluation of the relationship between the genetic risks of CTLA-4 +49 A/G polymorphism...

journal_title：Endocrine

authors： Qiu H,Tang W,Yin P,Cheng F,Wang L

更新日期：2014-03-01 00:00:00

abstract：:Thymic carcinoid is an important component of the tumor spectrum causing Ectopic ACTH Syndrome (EAS) and usually carries a poor prognosis. Efforts have been focused on exploring the mechanism of the excessive ACTH production in non-pituitary tumors, whereas few studies have reported the molecular events underlying the...

journal_title：Endocrine

authors： Liu RX,Wang WQ,Ye L,Bi YF,Fang H,Cui B,Zhou WW,Dai M,Zhang J,Li XY,Ning G

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:Heparanase, galectin-3, and tissue factor (TF) are overexpressed in solid malignant thyroid tumors. We studied their expression in multinodular goiters (MNGs). DESIGN AND METHODS:Thyroid tissue specimens from 15 MNGs were obtained during surgery. mRNA expression for galectin-3, heparanase, and TF was assesse...

journal_title：Endocrine

authors： Buchs AE,Zehavi S,Sher O,Yeheskely E,Muggia-Sulam M,Sherman Y,Rapoport MJ

更新日期：2003-11-01 00:00:00

abstract：:Prolactinomas are the most common secretory pituitary tumors; however, their pathogenesis is unclear. In order to explore the pathogenesis of prolactinomas, we used fiber-optic BeadArray to examine gene expression profiles in five prolactinomas compared with three normal pituitaries. Three down-regulated genes and one...

journal_title：Endocrine

authors： Jiang Z,Gui S,Zhang Y

更新日期：2010-12-01 00:00:00

abstract：:Insulin pumps operate almost universally in the work environment. Tubeless insulin pumps are a relatively recent development for management of insulin-dependent diabetes. This is the first report of location-dependent failure of insulin pump function, possibly due to external interference, occurring only in the settin...

journal_title：Endocrine

authors： Reiher AE,Gallagher TA,Emanuele MA

更新日期：2009-02-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) acts as a nutrient-dependent insulin-releasing agent, and its insulinotropic action is enhanced by nutrient secretagogues, such as the dimethyl ester of succinic acid (SAD). In the present study, a primed constant infusion of SAD (0.5 micromol followed by 0.25 micromol/min both per g of...

journal_title：Endocrine

authors： Cancelas J,Villanueva-Peñacarrillo ML,Valverde I,Malaisse WJ

更新日期：2001-08-01 00:00:00

abstract：:The cytoplasmic Ca2+ concentration ([Ca2+]i) was measured with dual wavelength fluorometry in glucagon-producing mouse pancreatic alpha-cells loaded with the indicator fura-2. Spontaneous rhythmic activity in terms of slow oscillations from a basal level was observed at 3 mM glucose. Like in the insulin-secreting beta...

journal_title：Endocrine

authors： Berts A,Gylfe E,Hellman B

更新日期：1997-02-01 00:00:00

abstract：:Drugs that act through noradrenergic and serotonergic mechanisms have historically served as the mainstays of pharmacologic treatments for obesity. This review addresses the following three topics: a brief discussion of older weight loss medications approved for short-term use (benzphetamine, phendimetrazine, diethylp...

journal_title：Endocrine

authors： Ryan DH

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:The influence of the dipeptidyl peptidase-IV inhibitor, gemigliptin alone or in combination with metformin on survival, proliferation, and migration of thyroid carcinoma cells was investigated. METHODS:SW1736 and TPC-1 human thyroid carcinoma cells were used. RESULTS:Gemigliptin and metformin caused cell deat...

journal_title：Endocrine

authors： Kim SH,Kang JG,Kim CS,Ihm SH,Choi MG,Yoo HJ,Lee SJ

更新日期：2018-02-01 00:00:00

abstract：:Aging could be due to the accumulation of oxidative damage. On the other hand, growth hormone (GH) and estrogen deficiency induce deleterious effects on different tissues, and hormonal replacement could counteract these effects. We have investigated whether GH and estrogen administration modify some parameters related...

journal_title：Endocrine

authors： Castillo C,Salazar V,Ariznavarreta C,Vara E,Tresguerres JA

更新日期：2005-02-01 00:00:00

abstract：:We aimed to investigate different enhancement patterns of solid thyroid nodules on contrast-enhanced ultrasound (CEUS) and then to evaluate the corresponding diagnostic performance in the differentiation of benign and malignant nodules with and without enhancement. 229 solid thyroid nodules in 196 patients who had und...

journal_title：Endocrine

authors： Wu Q,Wang Y,Li Y,Hu B,He ZY

更新日期：2016-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) have been identified to play important functions during osteoblast proliferation, differentiation, and apoptosis. The miR-17~92 cluster is highly conserved in all vertebrates. Loss-of-function of the miR-17-92 cluster results in smaller embryos and immediate postnatal death of all animals. Germline ...

journal_title：Endocrine

authors： Zhou M,Ma J,Chen S,Chen X,Yu X

更新日期：2014-03-01 00:00:00

abstract：:Hypoxia is well known to decrease appetite and weight gain in growing rats, and to induce weight loss in humans. It has been hypothesized that this is mediated by a change in ghrelin, an orexigenic peptide synthesized and released primarily from the stomach. Rats were exposed to hypoxia for 7 d as neonates (birth-7 d ...

journal_title：Endocrine

authors： Raff H

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:Bone may regulate glucose homeostasis via uncarboxylated bioactive osteocalcin (ucOCN). This study explored whether changes in ucOCN and bone remodeling are associated with change in glucose homeostasis after biliopancreatic diversion (BPD). METHODS:In this secondary exploratory analysis of a 1-year prospectiv...

journal_title：Endocrine

authors： Turcotte AF,Grenier-Larouche T,Lacombe J,Carreau AM,Carpentier AC,Mac-Way F,Tchernof A,Richard D,Biertho L,Lebel S,Marceau S,Ferron M,Gagnon C

更新日期：2020-09-01 00:00:00

abstract：:The main objective of this article is to study the psychosocial profile of patients of Cushing disease (CD) in a developing country setting. Eighteen patients with CD underwent a cross-sectional assessment regarding their socio-demographic and clinical profile, life events, social support, coping, dysfunction, quality...

journal_title：Endocrine

authors： Mattoo SK,Bhansali AK,Gupta N,Grover S,Malhotra R

更新日期：2009-06-01 00:00:00

abstract：INTRODUCTION:Primary autoimmune hypophysitis (PAHs) is a rare inflammatory disease of the pituitary gland. Although largely investigated, the pathogenesis of PAH is not completely clarified. We aimed to investigate the immune response in PAHs. MATERIAL AND METHODS:Serum anti-pituitary and anti-hypothalamus antibodies ...

journal_title：Endocrine

authors： Chiloiro S,Giampietro A,Angelini F,Arena V,Stigliano E,Tartaglione T,Mattogno PP,D'Alessandris QG,Lauretti L,Pontecorvi A,De Marinis L,Bianchi A

更新日期：2021-01-23 00:00:00

abstract：:The purpose of the study was to determine whether impaired beta-cell function exists in Chinese individuals within the normal range of glucose tolerance (NGT), and these individuals are predisposed to diabetes later in life. The cross-sectional study included 843 NGT subjects and 562 isolated impaired glucose toleranc...

journal_title：Endocrine

authors： Lin Z,Zhou J,Li X,Song L,Hou X,Tang J,Wang C,Jia W

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:We exploited the MassARRAY (MA) genotyping platform to develop the "PTC-MA assay", which allows the simultaneous detection of 13 hotspot mutations, in the BRAF, KRAS, NRAS, HRAS, TERT, AKT1, PIK3CA, and EIF1AX genes, and six recurrent genetic rearrangements, involving the RET and TRK genes in papillary thyroid ...

journal_title：Endocrine

authors： Pesenti C,Muzza M,Colombo C,Proverbio MC,Farè C,Ferrero S,Miozzo M,Fugazzola L,Tabano S

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To assess the predictive value of some clinical and biochemical parameters, and of the +49 A/G polymorphism of the CTLA-4 gene, for long-term remission following the withdrawal of antithyroid drugs before starting antithyroid drug therapy. STUDY DESIGN:Observational, prospective and longitudinal study. METH...

journal_title：Endocrine

authors： García-Mayor RV,Álvarez-Vázquez P,Fluiters E,Valverde D,Andrade A

更新日期：2019-02-01 00:00:00

abstract：:Vertebral fractures are an emerging complication of acromegaly but their prediction is still difficult occurring even in patients with normal bone mineral density. In this study we evaluated the ability of high-resolution cone-beam computed tomography to provide information on skeletal abnormalities associated with ve...

journal_title：Endocrine

authors： Maffezzoni F,Maddalo M,Frara S,Mezzone M,Zorza I,Baruffaldi F,Doglietto F,Mazziotti G,Maroldi R,Giustina A

更新日期：2016-11-01 00:00:00