Abstract:
:Melatonin, a pineal hormone, is known to be an important neurohormonal factor involved in the timing of reproductive events which occur seasonally in various mammalian species. In order to evaluate the influence of melatonin on neurons which are producing gonadotropin-releasing hormone (GnRH), we studied the effect of light-dark cycle as well as pinealectomy and melatonin administration on GnRH gene expression in the adult male rat medial preoptic area (MPOA) using quantitativein situ hybridization. The animals were kept under artificial light (light on 6:00 h-20:00 h). In animals which were sacrificed at 24:00 h (when endogenous melatonin levels are high), the hybridization signal was higher than that detected in animals sacrificed at 20:00 h (before the onset of darkness). Administration of melatonin during the light period (16:00 h) induced a 15% increase in the amount of GnRH mRNA after 4 h. Three weeks after pinealectomy mRNA levels were decreased by 35%. Injection of melatonin to pinealectomized rats 4 h before sacrifice increase the amount of GnRH mRNA, completely reversing the decrease in mRNA induced by pinealectomy. These results strongly suggest that melatonin produced by the pineal gland exerts a positive influence on GnRH neuronal activity in the male rat.
journal_name
Endocrinejournal_title
Endocrineauthors
Li S,Pelletier Gdoi
10.1007/BF02738829subject
Has Abstractpub_date
1995-07-01 00:00:00pages
533-6issue
7eissn
1355-008Xissn
1559-0100journal_volume
3pub_type
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