Abstract:
:Erectile dysfunction (ED) is commonly associated with risk factors for cardiovascular disease, including diabetes. The prevalence of ED in diabetic patients is high--about 75% of diabetic men 60 yr of age or older had ED in one study. Endothelial dysfunction, accelerated atherosclerosis, and diabetic neuropathy likely contribute to ED in diabetics. As silent ischemia is common in the diabetic patient, and diabetes is now often thought of as a coronary heart disease risk equivalent, diabetic men seeking therapy for ED may be considered candidates for exercise stress testing. Phosphodiesterase 5 (PDE5) inhibitors improve erectile function in diabetic men with ED; however, efficacy rates may be somewhat lower than in nondiabetic men. Studies to date have suggested that PDE5 inhibitors per se do not cause an increase in myocardial infarction rates in men being treated for ED.
journal_name
Endocrinejournal_title
Endocrineauthors
Kloner RAdoi
10.1385/ENDO:23:2-3:125subject
Has Abstractpub_date
2004-03-01 00:00:00pages
125-9issue
2-3eissn
1355-008Xissn
1559-0100pii
ENDO:23:2-3:125journal_volume
23pub_type
杂志文章,评审相关文献
ENDOCRINE文献大全abstract::Progesterone (P(4)) and estradiol (E(2)) regulate many cell functions through their interaction with specific intracellular receptors, which require the participation of coactivators such as SRC-1 and SRC-3 for enhancing their transcriptional activity. Coactivator expression is altered in many cancers and in some of t...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9288-6
更新日期:2010-02-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is linked to increased risk of insulin resistance and diabetes mellitus in patients' later life. The aim of this study was to investigate uptake of deoxy-D-glucose by peripheral blood lymphocytes of PCOS patients with normal fasting plasma glucose and normal glucose tolerance test. The...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0174-5
更新日期:2014-11-01 00:00:00
abstract::Diabetes mellitus is a major risk factor for cardiovascular disease. However, the excess risk of death may vary substantially in subgroups of patients with type 2 diabetes, being highest in those younger than 55 years of age. A HbA1c value of 7.0 % or less is recommended for most patients with type 2 diabetes to reduc...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-0981-y
更新日期:2016-10-01 00:00:00
abstract::Fifty children ages 4-10 yr with type 1 diabetes mellitus volunteered to participate in a study to evaluate and compare a new needle-free device developed for growth hormone delivery. Children answered descriptive questions related to nervousness and worry, hurt or pain, redness or bleeding, and stinging and wetness. ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:15:1:015
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:This study aimed to analyze the clinical and genetic characteristics of Chinese children with congenital hyperinsulinemia (CHI) that is spontaneously relieved. METHODS:The patient group comprised 200 children with CHI that were treated at the Beijing Children's Hospital from January 2006 to December 2018. Th...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02585-x
更新日期:2021-01-27 00:00:00
abstract::Renal or hepatic impairment, often encountered in patients with type 2 diabetes, influences the pharmacokinetics and bioavailability of antihyperglycemic agents. An emerging concern is whether pharmacotherapy with incretin-based agents, the most recent drug classes to be introduced for type 2 diabetes, can be safely u...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-014-0179-0
更新日期:2014-08-01 00:00:00
abstract::The process of homo- and/or heterodimerization of G-protein coupled receptors (GPCRs) and receptor tyrosine kinase (RTK) families are crucial for implicating the fundamental properties of receptor proteins including receptor expression, trafficking, and desensitization as well as signal transduction. The members of GP...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-011-9524-8
更新日期:2011-10-01 00:00:00
abstract::Studies designed to evaluate the short-term effects of incretin-related drugs in subjects with cardiac disease are still preliminary. In patients with heart failure, two of five studies showed that glucagon-like peptide-1 (GLP-1) infusion was associated with an absolute increase in left ventricular ejection fraction (...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-014-0175-4
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Surgical procedures are associated with activation of the hypothalamic-pituitary-adrenal axis (HPA). Studies examining HPA dynamics peri-operatively are limited and the modulating influence of peri-operatively administered glucocorticoids on that is not well established. This investigation examined alteratio...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1398-y
更新日期:2017-10-01 00:00:00
abstract::Estrogens regulate gene expression and cell proliferation in target tissues. In studies of estrogen-regulated gene expression, identification of appropriate housekeeping genes (HKGs), reference genes whose expression is not altered by treatment, is difficult. The goal of this study was to define HKGs unaltered by estr...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9154-6
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:In previous studies, associations between breast-milk cortisol levels obtained on one occasion and infant neurodevelopment were demonstrated. However, more recent evidence indicates that breast-milk cortisol and cortisone concentrations follow the diurnal rhythm of maternal hypothalamus-pituitary-adrenal axis, ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02273-w
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:Multiple endocrine neoplasia type 1 is a rare tumor syndrome caused by germline mutations of MEN1 gene. Phenotype varies widely, and no definitive correlation with the genotype has been observed. Mutation-negative patients with MEN1-associated tumors represent phenocopies. By comparing mutation-positive and mut...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01932-x
更新日期:2019-08-01 00:00:00
abstract::This study examined the interrelationship between transforming growth factor-beta1 (TGF-beta1) and 17beta-estradiol (E2) in the regulation of growth plate chondrocytes. To determine whether TGF-beta1 modulates chondrocyte response to E2, we used cells isolated from the resting zone (RC) and growth zone (GC) of costoch...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:11:3:241
更新日期:1999-12-01 00:00:00
abstract::To investigate the adrenal effect of a phytosterol (PS) additive, 80 male Japanese quail were divided into four sub-groups and fed 0, 40, 400, and 4,000 ppm of PS, respectively, for 21 days. Subsequently, 50% of the birds from each dosage group were subjected to a 6-day adrenal function test, whereby they were injecte...
journal_title:Endocrine
pub_type: 信件
doi:10.1007/s12020-011-9590-y
更新日期:2012-04-01 00:00:00
abstract::A substantial number of pregnancies are complicated by gestational diabetes mellitus (GDM) and up to 70 % of women with GDM go on to develop type 2 diabetes. Given the extensive body of research suggesting physical activity reduces the risk of type 2 diabetes, facilitating physical activity, and reducing sedentary tim...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-015-0828-y
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:Metabolic syndrome (MetS) is a constellation of clinical factors that indicates elevated risk of diabetes. It is diagnosed based on three or more abnormalities in its components. This does not take into account that MetS can likely present as a continuum of risk. We aim to develop a MetS severity score and asse...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01970-5
更新日期:2019-07-01 00:00:00
abstract::We investigated the expression and activity of cytosolic phospholipase A2 (cPLA2) in the corpus luteum during spontaneous and induced luteolysis in pseudopregnant rats. In both models, luteal PLA2 activity rose in association with functional regression and persisted during the following structural regression. Tissue c...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:14:3:337
更新日期:2001-04-01 00:00:00
abstract::The alpha-subunit is common to the heterodimeric glycoprotein hormones and has been highly conserved throughout vertebrate evolution. In an effort to determine if wild-type and engineered human alpha analogs can serve as agonists or antagonists to the human thyroid-stimulating hormone (TSH) receptor (TSHR), a potent a...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:24:1:025
更新日期:2004-06-01 00:00:00
abstract::Inflammation is associated with several tumor development and progression. However, these associations are not clear in well-differentiated thyroid carcinomas. We assessed whether NLR is a useful prognostic marker in patients with papillary thyroid carcinomas (PTC). The medical records of all patients who underwent th...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-013-0089-6
更新日期:2014-08-01 00:00:00
abstract::A cohort of nine patients, mostly young adults, presented with a new sign/symptom of pheochromocytoma/paraganglioma: exercise-induced nausea and vomiting. The aims of this article are to introduce this sign/symptom and offer a possible hypothesis for the observation. Following a 2000 report from a paraganglioma patien...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9319-3
更新日期:2010-06-01 00:00:00
abstract::Giant prolactinomas are rare tumors characterized by their large size, compressive symptoms, and extremely high prolactin secretion. The aim of this study is to describe our experience with a series of 16 giant prolactinomas cases in terms of clinical presentation, therapeutic decisions, and final outcomes. Retrospect...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1129-9
更新日期:2017-01-01 00:00:00
abstract::Environmental factors have been implicated in the development of autoimmune thyroid disease (AITD). Anti-Saccaromyces Cerevisiae Antibodies (ASCA) were shown to be elevated in several autoimmune diseases. The aim of the study was to determine ASCA levels and their relationship with thyroid autoantibodies in patients w...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9372-y
更新日期:2010-10-01 00:00:00
abstract::Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism. Thirty-six subjects with hyperthyroidism and 30 healthy controls were enrolled in t...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-011-9472-3
更新日期:2011-10-01 00:00:00
abstract::FKBP5 encodes a co-chaperone of HSP90 protein that regulates intracellular glucocorticoid receptor sensitivity. When it is bound to the glucocorticoid receptor complex, cortisol binds with lower affinity to glucocorticoid receptor. Cushing's syndrome is associated with memory deficits, smaller hippocampal volumes, and...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1083-6
更新日期:2016-12-01 00:00:00
abstract::The objective of this study was to assess the prevalence of macroprolactin, a macromolecule with reduced bioactivity, in hyperprolactinemic patients. Prolactin was measured before and after precipitation of macroprolactin by polyethylene glycol in 306 patients. Only patients with prolactin values >700 mIU/L (n = 270) ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:22:3:267
更新日期:2003-12-01 00:00:00
abstract::Lactogen-dependent Nb2 lymphoma cells, widely employed for studying prolactin (PRL) mitogenic mechanisms, are also useful for investigations of apoptosis in T-lineage lymphocytes. Utilizing PRL-dependent Nb2-11 cultures, apoptosis-regulatory genes were evaluated for participation in dexamethasone- (DEX) provoked cell ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:9:2:163
更新日期:1998-10-01 00:00:00
abstract:PURPOSE:Anti-Müllerian hormone (AMH) is crucial for folliculogenesis. Prenatal exposure to AMH in mice produces a phenocopy of polycystic ovary syndrome (PCOS) in the adult female offspring. The aim of this study was to determine whether genetic variation in AMH gene contribute to PCOS in women of Chinese ancestry. ME...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02538-4
更新日期:2020-11-09 00:00:00
abstract:PURPOSE:Acute porphyrias are metabolic disorders of heme biosynthesis characterized by acute life-threatening attacks. The diagnosis is often missed since clinical presentation is aspecific mimicking other medical and surgical conditions. Variegate porphyria (VP) is an autosomal dominant inherited disease with incomple...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1569-5
更新日期:2018-09-01 00:00:00
abstract::AdipoR1 is one of the adiponectin receptors which are important for adiponectin signaling. Because adiponectin is a candidate gene for common obesity, it is also hypothesized that variations in AdipoR1 may be involved in the development of complex obesity. Therefore, we designed an association study for the AdipoR1 ge...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9736-6
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the effect of combining human parathyroid hormone (1-34) (PTH1-34; PTH) and menaquinone-4 (MK-4) on calvarial bone defect repair in osteopenic rats. METHODS:Fourteen week olds were subject to craniotomy for the establishment of osteopenic animal models fed through a chroni...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1761-7
更新日期:2019-02-01 00:00:00