Voltage dependence of the pharmacological Mg2+ block of the Ca2+ entry into vascular smooth muscle cells.

Abstract:

:We studied the voltage dependence of the inhibitory effects of the Ca2+ antagonist Mg2+, compared to nifedipine, on the transsarcolemmal Ca2+ uptake into primary monolayers of smooth muscle cells obtained from pig coronary arteries. The cellular Ca incorporation was analyzed by liquid scintillation. Depolarization was produced by elevation of K+0. The data suggest that depolarization known to improve the inhibition by organic Ca2+ antagonists of L-type voltage-gated Ca2+ channels attenuates the Ca2+ antagonism of Mg2+ at vascular smooth muscle cells.

journal_name

Magnes Res

journal_title

Magnesium research

authors

Fleckenstein-Grün G,Matyas S,Dumont L

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

101-6

issue

2

eissn

0953-1424

issn

1952-4021

journal_volume

10

pub_type

杂志文章
  • Magnesium therapy for nephrolithiasis.

    abstract:PURPOSE:Critically evaluate the experimental evidence and clinical trial outcomes as the basis for use of magnesium (Mg) supplements as therapy for calcium oxalate nephrolithiasis. MATERIALS AND METHODS:Literature search of MedLine and Web of Science through January 2005; articles cited in papers found by searches. R...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Massey L

    更新日期:2005-06-01 00:00:00

  • Influence of endothelium in the in vitro vasorelaxant effect of magnesium on aortic basal tension in DOCA-salt hypertensive rat.

    abstract::The objective of this study was to examine the influence of the endothelium on the extracellular magnesium induced relaxation of basal tension in isolated aortas from both mineralocorticoid-salt (DOCA-salt) hypertensive and control normotensive Sprague Dawley male rats. After incubation in magnesium-free physiological...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Laurant P,Berthelot A

    更新日期:1992-12-01 00:00:00

  • Effect of an aerobic training on magnesium, trace elements and antioxidant systems in a Down syndrome population.

    abstract::The aim of the present study was to determine the effect of an aerobic training on plasma and red blood cells' levels of magnesium, copper, selenium and zinc and on some oxidative stress parameters in a Down syndrome (DS) sample population. Sixteen young male adults with DS participated in the protocol. Among them, ei...

    journal_title:Magnesium research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Monteiro CP,Varela A,Pinto M,Neves J,Felisberto GM,Vaz C,Bicho MP,Laires MJ

    更新日期:1997-03-01 00:00:00

  • Magnesium and selected parameters of the non-enzymatic antioxidant and immune systems and oxidative stress intensity in the seminal plasma of fertile males.

    abstract:INTRODUCTION:The present study investigated associations between environmental exposure to magnesium (Mg) and the levels of oxidative stress parameters and selected cytokines, and the antioxidant defense system in the seminal plasma of fertile males. MATERIALS AND METHODS:The study population consisted of 57 healthy, ...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:10.1684/mrh.2015.0377

    authors: Kasperczyk A,Dobrakowski M,Zalejska-Fiolka J,Horak S,Birkner E

    更新日期:2015-01-01 00:00:00

  • Recent data on mitral valve prolapse and magnesium deficit.

    abstract::Idiopathic mitral valve prolapse (IMVP) is a widespread disease. IMVP may be latent, but most patients describe a great variety of symptoms. The clinical pictures of IMVP and of latent tetany are superimposed with regard to Mg deficit. IMVP appears as a late complication of latent tetany due to magnesium deficit (LTMD...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Zeana CD

    更新日期:1988-12-01 00:00:00

  • The degree of lymphocytic mitochondrial transmembrane potential and blood magnesium concentrations during coronary artery bypass grafting.

    abstract:UNLABELLED:Magnesium (Mg) plays an important role in lymphocyte function. Low blood concentration of Mg may result in intralymphocyte imbalance and in turn may be associated with intensified apoptosis of peripheral blood lymphocytes. Due to its multistage character; extracorporeal circulation (ECC) may augment Mg disor...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Korycińska A,Dabrowski W,Rzecki Z,Dragan M,Pozarowski P,Wrońska J,Stazka J,Pasternak K,Roliński J

    更新日期:2005-12-01 00:00:00

  • Long-term follow-up after acute myocardial infarction in patients randomized to treatment with intravenous magnesium or intravenous propranolol in the acute phase.

    abstract::Ninety-five patients with acute myocardial infarction were followed up for 6 months to 3 years (mean 25.4 months) in a preliminary study to compare the effects of intravenous magnesium (49 patients) with that of intravenous propranolol (44 patients) given immediately after admission to the intensive care unit. There w...

    journal_title:Magnesium research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Abraham AS,Balkin J,Rosenmann D,Ilan M,Klutstein M,Zion MM

    更新日期:1994-12-01 00:00:00

  • Magnesium, potassium flux and photosynthesis.

    abstract::Photosynthetic capacity of chloroplasts is regulated by stromal pH. The pH of the stroma must be maintained higher than external pH during illumination in order to optimize photosynthetic carbon reduction cycle activity. Stromal pH is affected by K+/H+ counterexchange across the chloroplast envelope. Magnesium ion ext...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Berkowitz GA,Wu W

    更新日期:1993-09-01 00:00:00

  • Acute myocardial infarction severity, complications, and mortality associated with lack of magnesium intake through consumption of desalinated seawater.

    abstract::Drinking water (DW) is an important dietary source of magnesium. Israel has recently increased desalinated seawater (DSW) production for DW, but negligible magnesium content in DSW may pose a risk of hypomagnesemia and consequential adverse cardiovascular effects. Consecutive acute myocardial infarction (AMI) patients...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:10.1684/mrh.2019.0449

    authors: Shlezinger M,Amitai Y,Goldenberg I,Atar S,Shechter M

    更新日期:2019-05-01 00:00:00

  • Magnesium, adenosine triphosphate, and catecholamine complexes: application of new means of identifying solute-solute interactions of biological significance using NMR chemical shift data.

    abstract::The interaction of magnesium ions with biomolecular species is fundamental to the regulation of many biological processes. A mathematical technique to investigate such interactions is described. The concept of a pseudo-formation curve is discussed and the relevance and applicability of such constructions to the study ...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Hughes MS,Crow DR,Birch NJ

    更新日期:1992-06-01 00:00:00

  • Magnesium deficiency reduces fear-induced conditional lick suppression in mice.

    abstract::The consequences of broad-scale alterations in magnesium (Mg2+) levels on learning and memory are poorly understood. We have recently demonstrated that adult male mice maintained on an Mg2+-deficient diet exhibit reduced conditional freezing behavior. The purpose of the present study was to determine if the detrimenta...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Bardgett ME,Schultheis PJ,Muzny A,Riddle MD,Wagge JR

    更新日期:2007-03-01 00:00:00

  • Effect of a natural mineral-rich water on catechol-O-methyltransferase function.

    abstract::Catechol-O-methyltransferase (COMT) is a magnesium-dependent, catecholamine-metabolizing enzyme, whose impaired activity has been positively associated with cardiovascular diseases, particularly hypertension. Consumption of some natural mineral-rich waters has been shown to exert protective effects on cardiovascular r...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:10.1684/mrh.2014.0369

    authors: Bastos P,Araújo JR,Azevedo I,Martins MJ,Ribeiro L

    更新日期:2014-07-01 00:00:00

  • The COVID-19 pandemic: is there a role for magnesium? Hypotheses and perspectives.

    abstract::More and more studies are accumulating about COVID-19. Some aspects of the pathogenesis of the disease recall events occurring in Mg deficiency, such as a drop of T cells, increased plasma concentration of inflammatory cytokines, and endothelial dysfunction. We hypothesize that a low Mg status, which is rather common,...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:10.1684/mrh.2020.0465

    authors: Iotti S,Wolf F,Mazur A,Maier JA

    更新日期:2020-05-01 00:00:00

  • Enhanced contractile response to noradrenaline and calcium influx in thoracic aorta isolated from dietary magnesium deficient rats.

    abstract::Dependency on extracellular calcium influx in contractile response to noradrenaline has been investigated in the thoracic aorta isolated from dietary magnesium (Mg) deficient rats. Adult male Wistar rats were fed with a Mg deficient diet (0.001% Mg) for 30 days, together with control groups (0.07% Mg). The contractile...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Nishio A,Ishiguro S,Shimonishi I,Hirota A

    更新日期:1989-09-01 00:00:00

  • Magnesium and its relationship to C-reactive protein among hemodialysis patients.

    abstract::Hypomagnesaemia has been reported among patients undergoing hemodialysis (HD). Recently, a possible correlation between serum magnesium (Mg) and C-reactive protein (CRP) has been stressed. This correlation has been attributed to cytokine production and oxidative stress processes. In this study we aimed to determine th...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Pakfetrat M,Malekmakan L,Roozbeh J,Haghpanah S

    更新日期:2008-09-01 00:00:00

  • Rumen epithelial cells adapt magnesium transport to high and low extracellular magnesium conditions.

    abstract::A protein of approximately 70-kDa was identified as a candidate Na+/Mg2+ exchanger in rumen epithelial cells (REC). Melastatin-related Transient Receptor Potential 7 (TRPM7) and Magnesium Transporter 1 (MagT1) transcripts and, from them, encoded proteins were also detected. The regulation of these Mg transport pathway...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Schweigel M,Kuzinski J,Deiner C,Kolisek M

    更新日期:2009-09-01 00:00:00

  • Magnesium fluxes during lactation in the rat.

    abstract::Lactating rats fed a 0.055% Mg diet transferred 5.5 +/- SEM 0.3 mg per day of Mg into milk but remained in a slightly positive Mg balance by increasing both food consumption and fractional intestinal Mg absorption. Urinary Mg excretion increased continually during the course of lactation to values double those of non-...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Brommage R

    更新日期:1989-12-01 00:00:00

  • The influence of alpha-zearalenol on magnesium concentration in cellular subfractions of certain tissues of female rats and their progeny.

    abstract::The purpose of the research work was to study the influence of alpha-zearalenol on magnesium concentration in cellular subfractions of certain tissues of female rats and their progeny. Pregnant female rats received alpha-zearalenol at the doses of: 0.05, 0.5 or 1 mg x kg(-1) b.w. After delivery, brain, liver and kidne...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Pasternak K,Kiełczykowska M,Sztanke M,Borzecki A

    更新日期:2003-06-01 00:00:00

  • Antiarrhythmic effect of parenteral magnesium on ventricular tachycardia associated with long QT syndrome.

    abstract::Magnesium deficiency has been linked with cardiac arrhythmias and sudden cardiac death. Antiarrhythmic effects of intravenous magnesium in the patients who are not hypomagnesaemic were mainly demonstrated in the patients with acquired long QT syndrome. Parenteral administration should be considered in this type of ven...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Kurita T

    更新日期:1994-06-01 00:00:00

  • Ageing, hippocampal synaptic activity and magnesium.

    abstract::Ageing is associated with a general decline in physiological functions. Amongst the different aspects of body deterioration, cognitive impairments, and particularly defects in learning and memory, represent one of the most frequent features in the elderly. However, a great variability exists among aged subjects. Clini...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Billard JM

    更新日期:2006-09-01 00:00:00

  • Correlations between feeding type and blood ionized magnesium levels in Japanese preterm infants.

    abstract::Although magnesium (Mg) contents are different between breast milk and formula, few studies have investigated the blood Mg level in breast fed or formula fed preterm infants. We examined the influence of feeding type on serum Mg and whole blood ionized Mg (iMg) levels in preterm infants soon after birth. We included 1...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:10.1684/mrh.2019.0444

    authors: Watanabe A,Shoji H,Awaji A,Ikeda N,Ohkawa N,Suganuma H,Kantake M,Shimizu T

    更新日期:2018-11-01 00:00:00

  • Are age-related neurodegenerative diseases linked with various types of magnesium depletion?

    abstract::Age-related human neurodegenerative diseases are a major social and medical problem. It is therefore logical to take into consideration every theory with an overall approach to neurodegenerative diseases. This environmental proposal relies mainly on data concerning the Western Pacific amyotrophic lateral sclerosis-Par...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Durlach J,Bac P,Durlach V,Durlach A,Bara M,Guiet-Bara A

    更新日期:1997-12-01 00:00:00

  • Magnesium and ageing. II. Clinical data: aetiological mechanisms and pathophysiological consequences of magnesium deficit in the elderly.

    abstract::Ageing constitutes a risk factor for magnesium deficit. Primary magnesium deficit originates from two aetiological mechanisms: deficiency and depletion. Primary magnesium deficiency is due to insufficient magnesium intake. Dietary amounts of magnesium are marginal in the whole population whatever the age. Nutritional ...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Durlach J,Durlach V,Bac P,Rayssiguier Y,Bara M,Guiet-Bara A

    更新日期:1993-12-01 00:00:00

  • Comparison of the antinociceptive effect of systemic versus intrathecal magnesium sulphate on spinal morphine analgesia.

    abstract::The aim of this work was to compare the possible antinociceptive effect of the intravenous (IV) versus the intrathecal (IT) administration of magnesium sulphate prior to spinal morphine analgesia. This research was conducted in two sets: First; experimentally, to compare the antinociceptive effect of IT magnesium sulp...

    journal_title:Magnesium research

    pub_type: 杂志文章,随机对照试验

    doi:10.1684/mrh.2016.0396

    authors: Messeha MM,Boshra V

    更新日期:2016-03-01 00:00:00

  • Experimental magnesium depletion in adult rabbits caused by blast overpressure.

    abstract::The complex pressure wave (blast) generated by some explosions causes pulmonary pathological changes which resemble the histological findings of the adult respiratory distress syndrome (ARDS). The development of indirect neurotrauma following experimental pulmonary blast injury has been shown previously. The purpose o...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Cernak I,Radosevic P,Malicevic Z,Savic J

    更新日期:1995-09-01 00:00:00

  • Concentration, compartmentation and metabolic function of intracellular free Mg2+.

    abstract::Intracellular total Mg2+ and free Mg2+ are compartmentalized between cell organelles and within the cytosol. Different values of [Mg2+]i in the cytosol of the same cell type were measured by various investigators. A main reason for the differences is the uncertainty of the dissociation constants used for the Mg furapt...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Günther T

    更新日期:2006-12-01 00:00:00

  • Magnesium and thermoregulation. I. Newborn and infant. Is sudden infant death syndrome a magnesium-dependent disease of the transition from chemical to physical thermoregulation?

    abstract::The sudden infant death syndrome (SIDS) remains a leading cause of death during the first year. The common epidemiological and pathological data which characterize SIDS include the curve for age at death (with 3 months as modal age), the stigmata of early maternal intrauterine injury, the seasonal predominance in wint...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Durlach J,Durlach V,Rayssiguier Y,Ricquier D,Goubern M,Bertin R,Bara M,Guiet-Bara A,Olive G,Mettey R

    更新日期:1991-09-01 00:00:00

  • Effects of oral magnesium supplementation on plasma lipid concentrations in patients with non-insulin-dependent diabetes mellitus.

    abstract::We evaluated the effects of oral magnesium supplementation on plasma lipid concentrations in patients with non-insulin-dependent diabetes mellitus. Twenty-six persons with non-insulin-dependent diabetes mellitus received 4.5 g magnesium pidolate/d for one month, and 17 persons received placebo. Before and at the end o...

    journal_title:Magnesium research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Corica F,Allegra A,Di Benedetto A,Giacobbe MS,Romano G,Cucinotta D,Buemi M,Ceruso D

    更新日期:1994-03-01 00:00:00

  • Magnesium deficiency-induced anorexia in hyperphagic obese Zucker rats.

    abstract::In clinical practice diabetes mellitus is the most significant cause of hypomagnesemia and Mg depletion. The obese Zucker rat approaches non-insulin-dependent type II diabetes; lean Zucker rats being suitable controls. Using this disease model the influence of dietary Mg deficiency was studied: animals received a diet...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Rattanatayarom W,Dorfmeister C,Classen UG,Schimatschek HF,Stein U,Classen HG

    更新日期:2001-09-01 00:00:00

  • Magnesium-based implants: a mini-review.

    abstract::The goal of this review is to bring to the attention of the readership of Magnesium Research another facet of the importance of magnesium, i.e. magnesium-based biomaterials. A concise history of biomaterials and magnesium are thus presented. In addition, historical and current, clinical magnesium-based applications ar...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:10.1684/mrh.2015.0375

    authors: Luthringer BJ,Feyerabend F,Willumeit-Römer R

    更新日期:2014-10-01 00:00:00