Abstract:
:Age-related human neurodegenerative diseases are a major social and medical problem. It is therefore logical to take into consideration every theory with an overall approach to neurodegenerative diseases. This environmental proposal relies mainly on data concerning the Western Pacific amyotrophic lateral sclerosis-Parkinsonism-dementia complex (WP ALS-PD) considered as 'a prototypal human neurodegenerative disease' and on extrapolation from it to the bulk of neurodegenerative diseases (NDD). NDD would be due to an accelerated ageing process in certain populations of neurons due to the noxious synergy of (1) increased environmental slow deleterious factors (such as slow toxins) and of (2) decreased environmental protective factors (Mg deficient intake particularly). First, it was observed that three apparently dissimilar conditions occurred at extraordinary high rates in the Guam area: motoneuron disease (ALS), Parkinson's disease (P) and Alzheimer's-like dementia (D). Next, several other foci of endemic ALS-PD were found in Asia and Oceania in three Western Pacific population groups. These included the Chamorro people in Mariana Islands (Guam and Rota), the Auyu and Jakai people of West New Guinea and the Japanese residents of the Kii peninsula (Honshu island). The post-Second World War decline of the occurrence of WP ALS-PD in all three high incidence disease foci coupled with the absence of demonstrable heritable or transmissible factors had led to focus the search for the cause of this degenerative disease on nontransmissible environmental factors that are disappearing as the susceptible population groups acculturate to modern way. Epidemiologic study has shown that preference for traditional Chamorro food is the only one of 23 tested variables significantly associated with an increased risk for PD. An early suggestion incriminated the toxic seed of the false sago palm (Cycas circinalis L) which was used in traditional food and medicine. Laboratory investigation of cycad seed revealed the presence of various toxins and particularly of an 'unusual' non protein aminoacid: L-BMAA (beta-N-methylamino-L-alanine), an excitotoxic aminoacid. This slow toxin presents some structural similarity to another 'unusual' excitotoxic aminoacid: L-BOAA (beta-N-oxalyl-amino-L-alanine), an exogenous neurotoxin present in the grass pea (Lathyrus sativus) whose excessive consumption may cause lathyrism. The excitotoxicity of both L-BMAA and L-BOAA mainly concerns non-NMDA receptors. The neurotoxicity of these aminoacids varies with experimental models failing to induce an experimental model akin to WP ALS-PD or displaying many of the motor-system and behavioral changes of WP ALS-PD. It may be due to the presence of physiological levels of bicarbonate or of various toxic cofactors: bio-organic such as cycasin or inorganic such as pollutant metals e.g. aluminum or manganese, together with the lack of protective factors (e.g. calcium and magnesium deficiencies). Combined Al intoxication with Ca-Mg deficiencies is a reasonable model to investigate the pathogenesis of neurodegenerative diseases and eventually to screen their treatments. It may also be considered as a model of magnesium deficit, but it does not concern simple magnesium deficiency reversible with mere oral physiological magnesium supplementation. Magnesium deficiency cannot result in neurodegenerative disease. Combined Al intoxication with Ca-Mg deficiencies is not reversible through physiological oral magnesium supplementation. It therefore constitutes a type of experimental magnesium depletion model, instrumental in the investigation of the pathogenesis of magnesium depletion and in the screening of its still unknown possible treatments. (ABSTRACT TRUNCATED)
journal_name
Magnes Resjournal_title
Magnesium researchauthors
Durlach J,Bac P,Durlach V,Durlach A,Bara M,Guiet-Bara Asubject
Has Abstractpub_date
1997-12-01 00:00:00pages
339-53issue
4eissn
0953-1424issn
1952-4021journal_volume
10pub_type
杂志文章,评审abstract::Intracellular total Mg2+ and free Mg2+ are compartmentalized between cell organelles and within the cytosol. Different values of [Mg2+]i in the cytosol of the same cell type were measured by various investigators. A main reason for the differences is the uncertainty of the dissociation constants used for the Mg furapt...
journal_title:Magnesium research
pub_type: 杂志文章,评审
doi:
更新日期:2006-12-01 00:00:00
abstract::Epidemiological studies of populations living in areas of low magnesium (Mg) intake have consistently shown a higher cardiovascular morbidity. Several hypotheses have been advanced to explain the cardioprotective properties of magnesium. Few studies, however, have analysed the relation of magnesium to haemostasis. The...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract::The aim of the present study was to determine the effect of an aerobic training on plasma and red blood cells' levels of magnesium, copper, selenium and zinc and on some oxidative stress parameters in a Down syndrome (DS) sample population. Sixteen young male adults with DS participated in the protocol. Among them, ei...
journal_title:Magnesium research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1997-03-01 00:00:00
abstract::Some previous studies have reported the involvement of magnesium (Mg) deficiency in children with ADHD syndrome. In this work, 40 children with clinical symptoms of ADHD were followed clinically and biologically during a magnesium-vitamin B6 (Mg-B6) regimen (6 mg/kg/d Mg, 0.6 mg/kg/d vit-B6) which was set up for at le...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:2006-03-01 00:00:00
abstract::Experimental studies of anxiety in animal models, and evidence of efficacious outcomes of magnesium (Mg) supplementation in the treatment of acute clinical affective disorders, has increased interest in Mg as a potential novel treatment for symptoms of mild/moderate subjective anxiety. This short review examines the e...
journal_title:Magnesium research
pub_type: 杂志文章,评审
doi:10.1684/mrh.2016.0411
更新日期:2016-03-01 00:00:00
abstract::Serum and mononuclear cell magnesium content were determined in a cross-sectional study performed in four groups of hypertensive patients on chronic treatment with atenolol (n = 11), enalapril (n = 10), thiazide diuretics (n = 12), or enalapril + thiazides (n = 11). Our study shows that in patients treated with the th...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:1990-09-01 00:00:00
abstract::In therapy it is known that the combination of vitamin B6 and magnesium is beneficial in the treatment of several forms of primary magnesium deficiency. The purpose of the present study was to investigate the effect of complex magnesium supplementation containing mineral bishofit solution (MgCl2 x 6H2O) and pyridoxine...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract::The present study was performed to show the molecular identity of functionally characterized Mg transport pathways in rumen epithelial cells (REC) and to investigate the effects of extracellular [Mg] changes on their expression and activity. By using RT- PCR, Western blot, flow cytometry and immunocytochemistry, TRPM7...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:2008-06-01 00:00:00
abstract::Traumatic brain injury (TBI) confers a major burden to Western society and effective treatments are urgently required to improve the long-term deficits that inflict TBI survivors. Depletion of intracellular Mg(2+) is a well-known phenomenon occurring after TBI and is associated with poor neurological outcome. However,...
journal_title:Magnesium research
pub_type: 杂志文章,评审
doi:10.1684/mrh.2009.0189
更新日期:2009-12-01 00:00:00
abstract::We evaluated the effects of oral magnesium supplementation on plasma lipid concentrations in patients with non-insulin-dependent diabetes mellitus. Twenty-six persons with non-insulin-dependent diabetes mellitus received 4.5 g magnesium pidolate/d for one month, and 17 persons received placebo. Before and at the end o...
journal_title:Magnesium research
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::Dependency on extracellular calcium influx in contractile response to noradrenaline has been investigated in the thoracic aorta isolated from dietary magnesium (Mg) deficient rats. Adult male Wistar rats were fed with a Mg deficient diet (0.001% Mg) for 30 days, together with control groups (0.07% Mg). The contractile...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
abstract::The consequences of broad-scale alterations in magnesium (Mg2+) levels on learning and memory are poorly understood. We have recently demonstrated that adult male mice maintained on an Mg2+-deficient diet exhibit reduced conditional freezing behavior. The purpose of the present study was to determine if the detrimenta...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:2007-03-01 00:00:00
abstract::The objective of this study was to examine the influence of the endothelium on the extracellular magnesium induced relaxation of basal tension in isolated aortas from both mineralocorticoid-salt (DOCA-salt) hypertensive and control normotensive Sprague Dawley male rats. After incubation in magnesium-free physiological...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract::Electrolyte abnormalities are a frequent and potentially hazardous complication in the treatment of patients with congestive heart failure. Medical treatment with diuretics and/or digitalis, as well as neurohumoral activation most likely initiated by the compromised cardiac function, contributes to this alteration. Th...
journal_title:Magnesium research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1992-03-01 00:00:00
abstract:INTRODUCTION:The present study investigated associations between environmental exposure to magnesium (Mg) and the levels of oxidative stress parameters and selected cytokines, and the antioxidant defense system in the seminal plasma of fertile males. MATERIALS AND METHODS:The study population consisted of 57 healthy, ...
journal_title:Magnesium research
pub_type: 杂志文章
doi:10.1684/mrh.2015.0377
更新日期:2015-01-01 00:00:00
abstract::The purpose of the research work was to study the influence of alpha-zearalenol on magnesium concentration in cellular subfractions of certain tissues of female rats and their progeny. Pregnant female rats received alpha-zearalenol at the doses of: 0.05, 0.5 or 1 mg x kg(-1) b.w. After delivery, brain, liver and kidne...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::The sudden infant death syndrome (SIDS) remains a leading cause of death during the first year. The common epidemiological and pathological data which characterize SIDS include the curve for age at death (with 3 months as modal age), the stigmata of early maternal intrauterine injury, the seasonal predominance in wint...
journal_title:Magnesium research
pub_type: 杂志文章,评审
doi:
更新日期:1991-09-01 00:00:00
abstract::Cerebral vasospasm and delayed cerebral ischemia remain an unsolved problem in patients with aneurysmal subarachnoid hemorrhage (SAH). In theory, high-dose magnesium sulfate (MgSO(4)) therapy offers vascular and neuroprotective benefits and is therefore currently under evaluation. The intensity of the inflammatory res...
journal_title:Magnesium research
pub_type: 临床试验,杂志文章
doi:
更新日期:2012-07-01 00:00:00
abstract::The interaction of magnesium ions with biomolecular species is fundamental to the regulation of many biological processes. A mathematical technique to investigate such interactions is described. The concept of a pseudo-formation curve is discussed and the relevance and applicability of such constructions to the study ...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::Lipid and protein peroxidations were investigated in female patients with magnesium deficit (MD), fibromyalgia (FM) and age matched controls: malondialdehyde and protein carbonyls (PC), as well as serum, leucocyte and erythrocyte magnesium (EMg) were assessed in 20 controls, 25 FM and 16 MD patients. MDA are unchanged...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract::Magnesium deficiency has been linked with cardiac arrhythmias and sudden cardiac death. Antiarrhythmic effects of intravenous magnesium in the patients who are not hypomagnesaemic were mainly demonstrated in the patients with acquired long QT syndrome. Parenteral administration should be considered in this type of ven...
journal_title:Magnesium research
pub_type: 杂志文章,评审
doi:
更新日期:1994-06-01 00:00:00
abstract::Magnesium (Mg) deficiency strongly affects muscle performance. In judo, many athletes often undergo impressive weight changes associated with severe dehydration. Common practices used by athletes to achieve a target weight can lead to Mg deficit. This study aimed to understand the impact of Mg changes on strength from...
journal_title:Magnesium research
pub_type: 杂志文章
doi:10.1684/mrh.2010.0217
更新日期:2010-09-01 00:00:00
abstract::A common use for high doses of oral magnesium salts is to produce a laxative effect to treat constipation. In the intestinal lumen the poorly absorbable magnesium ions (and other ions such as sulphate) exert an osmotic effect and cause water to be retained in the intestinal lumen. This increases the fluidity of the in...
journal_title:Magnesium research
pub_type: 杂志文章,评审
doi:
更新日期:1996-06-01 00:00:00
abstract:UNLABELLED:Comprehensive analytical review of 44 human studies in 43 publications of oral Magnesium (Mg) therapy for hypertension (HT) shows Mg supplements may enhance the blood-pressure (BP) lowering effect of anti-hypertensive medications (medications) in Stage 1 HT subjects. 9 studies conducted on subjects treated w...
journal_title:Magnesium research
pub_type: 杂志文章
doi:10.1684/mrh.2010.0198
更新日期:2010-03-01 00:00:00
abstract::Catechol-O-methyltransferase (COMT) is a magnesium-dependent, catecholamine-metabolizing enzyme, whose impaired activity has been positively associated with cardiovascular diseases, particularly hypertension. Consumption of some natural mineral-rich waters has been shown to exert protective effects on cardiovascular r...
journal_title:Magnesium research
pub_type: 杂志文章
doi:10.1684/mrh.2014.0369
更新日期:2014-07-01 00:00:00
abstract::A tight coupling between ionic currents, intracellular Ca2+ homeostasis, cytosolic [ADP] and deltaG of ATP hydrolysis underlies the regulation of cardiac cell function. As more experimental detail on the biochemistry and biophysics of these complex processes and their interactions accumulates, the intuitive interpreta...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract::To investigate the effects of sex hormones on bone histomorphometry, and bone density (BMD), 10 week old ovariectomized (OVX), orchiectomized (ORX), and sham-operated (SHAM) rats fed a moderately magnesium-deficient fructose diet were studied. One third of the OVX and ORX rats were injected with beta-oestradiol-3-benz...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Changes in plasma matrix metalloproteinase 9 (MMP-9) concentrations and parallel changes in brain magnesium homeostasis have not been examined in cardiac surgery patients. The purpose of the present study was to analyse these relationships in patients undergoing coronary artery bypass surgery (CABG) with ext...
journal_title:Magnesium research
pub_type: 杂志文章
doi:10.1684/mrh.2010.0219
更新日期:2010-12-01 00:00:00
abstract::In clinical practice diabetes mellitus is the most significant cause of hypomagnesemia and Mg depletion. The obese Zucker rat approaches non-insulin-dependent type II diabetes; lean Zucker rats being suitable controls. Using this disease model the influence of dietary Mg deficiency was studied: animals received a diet...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract::Hypomagnesaemia has been reported among patients undergoing hemodialysis (HD). Recently, a possible correlation between serum magnesium (Mg) and C-reactive protein (CRP) has been stressed. This correlation has been attributed to cytokine production and oxidative stress processes. In this study we aimed to determine th...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00