Magnesium, adenosine triphosphate, and catecholamine complexes: application of new means of identifying solute-solute interactions of biological significance using NMR chemical shift data.

Abstract:

:The interaction of magnesium ions with biomolecular species is fundamental to the regulation of many biological processes. A mathematical technique to investigate such interactions is described. The concept of a pseudo-formation curve is discussed and the relevance and applicability of such constructions to the study of solute-solute interactions is outlined. Analysis of curves based on the published variation of chemical shift data of various nuclei of adrenaline and dichloroisoprenaline in aqueous solution, in the presence of increasing concentration of the complex Mg-ATP, is described. Unambiguous indentification of specific interactions and the stability of the species produced is shown to be feasible. Some variation of the values of formation constants deriving from different nuclei reflects the significance of molecular environmental factors on the parameters used.

journal_name

Magnes Res

journal_title

Magnesium research

authors

Hughes MS,Crow DR,Birch NJ

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

89-96

issue

2

eissn

0953-1424

issn

1952-4021

journal_volume

5

pub_type

杂志文章
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    abstract::Traumatic brain injury (TBI) confers a major burden to Western society and effective treatments are urgently required to improve the long-term deficits that inflict TBI survivors. Depletion of intracellular Mg(2+) is a well-known phenomenon occurring after TBI and is associated with poor neurological outcome. However,...

    journal_title:Magnesium research

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    doi:10.1684/mrh.2009.0189

    authors: Cook NL,Van Den Heuvel C,Vink R

    更新日期:2009-12-01 00:00:00

  • Recent data on mitral valve prolapse and magnesium deficit.

    abstract::Idiopathic mitral valve prolapse (IMVP) is a widespread disease. IMVP may be latent, but most patients describe a great variety of symptoms. The clinical pictures of IMVP and of latent tetany are superimposed with regard to Mg deficit. IMVP appears as a late complication of latent tetany due to magnesium deficit (LTMD...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Zeana CD

    更新日期:1988-12-01 00:00:00

  • Biomimetic study of the Ca(2+)-Mg2+ and K(+)-Li+ antagonism on biologically active sites: new methodology to study potential dependent ion exchange.

    abstract::Competitive divalent (magnesium and calcium) or monovalent (potassium, lithium and sodium) ion exchange and its influence on a membrane potential formation was studied at biological ligands (BL) such as adenosine triphosphate (ATP), asparagine (Asn) and glutamine (Gln) sites. The sites are dispersed electrochemically ...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Paczosa-Bator B,Stepien M,Maj-Zurawska M,Lewenstam A

    更新日期:2009-03-01 00:00:00

  • Preliminary communication on intralymphocyte ionized magnesium in hypertensive patients under treatment with beta-blockers.

    abstract::We measured free intralymphocyte magnesium (Mgi) in 10 hypertensive subjects (HS) before and after treatment with atenolol (A) and in 16 normotensive control subjects (NC). We also carried out in vitro studies on human lymphocytes to test the effect of catecholamines and beta-antagonists on Mgi. Mgi in HS was not stat...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Pastori C,Delva P,Degan M,Lechi A

    更新日期:1999-03-01 00:00:00

  • Ageing, hippocampal synaptic activity and magnesium.

    abstract::Ageing is associated with a general decline in physiological functions. Amongst the different aspects of body deterioration, cognitive impairments, and particularly defects in learning and memory, represent one of the most frequent features in the elderly. However, a great variability exists among aged subjects. Clini...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Billard JM

    更新日期:2006-09-01 00:00:00

  • FAST-Mag protocol with or without mild hypothermia (35°C) does not improve outcome after permanent MCAO in rats.

    abstract::The current study assessed the neuroprotective efficacy of magnesium using a FAST-Mag trial treatment protocol alone, and in combination with mild hypothermia, in Sprague Dawley rats subjected to permanent, middle cerebral artery occlusion (MCAO). Treatment with magnesium (MgSO4.7H2O) consisted of an intravenous loadi...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:10.1684/mrh.2013.0340

    authors: Meloni BP,Cross JL,Brookes LM,Clark VW,Campbell K,Knuckey NW

    更新日期:2013-04-01 00:00:00

  • Magnesium and phase angle: a prognostic tool for monitoring cellular integrity in judo athletes.

    abstract::Adequate magnesium (Mg) levels play a vital role in membrane excitability, cell contractility and metabolism, being a key nutrient for sustaining appropriate muscular contraction and performance levels in athletes. Phase angle (PhA), assessed by bioimpedance analysis (BIA), has been reported to be positively associate...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:10.1684/mrh.2015.0389

    authors: Matias CN,Monteiro CP,Santos DA,Martins F,Silva AM,Laires MJ,Sardinha LB

    更新日期:2015-07-01 00:00:00

  • Effect of a natural mineral-rich water on catechol-O-methyltransferase function.

    abstract::Catechol-O-methyltransferase (COMT) is a magnesium-dependent, catecholamine-metabolizing enzyme, whose impaired activity has been positively associated with cardiovascular diseases, particularly hypertension. Consumption of some natural mineral-rich waters has been shown to exert protective effects on cardiovascular r...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:10.1684/mrh.2014.0369

    authors: Bastos P,Araújo JR,Azevedo I,Martins MJ,Ribeiro L

    更新日期:2014-07-01 00:00:00

  • Dietary inulin in mice stimulates Mg2+ absorption and modulates TRPM6 and TRPM7 expression in large intestine and kidney.

    abstract::Complex fermentable carbohydrates, such as inulin-type fructans have been shown to improve Mg2+ absorption in the hindgut and body stores. The mechanisms for this are not well understood. The newly identified transient receptor potential melastatin 6 and 7 (TRPM6 and TRPM7) channels have been shown to function in acti...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Rondón LJ,Rayssiguier Y,Mazur A

    更新日期:2008-12-01 00:00:00

  • Is magnesium content in erythrocytes suitable for evaluating cation retention after oral physiological supplementation in marginally magnesium-deficient subjects?

    abstract::In this study, the effects of oral magnesium supplementation were evaluated on plasma, erythrocyte, and urinary cation levels. The study was carried out with an open, cross-over and randomized design. Healthy subjects received two sachets per day of magnesium (366 mg Mg2+/d) for two 28 d cycles, separated by a 3-week ...

    journal_title:Magnesium research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Borella P,Ambrosini G,Concari M,Bargellini A

    更新日期:1993-06-01 00:00:00

  • Voltage dependence of the pharmacological Mg2+ block of the Ca2+ entry into vascular smooth muscle cells.

    abstract::We studied the voltage dependence of the inhibitory effects of the Ca2+ antagonist Mg2+, compared to nifedipine, on the transsarcolemmal Ca2+ uptake into primary monolayers of smooth muscle cells obtained from pig coronary arteries. The cellular Ca incorporation was analyzed by liquid scintillation. Depolarization was...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Fleckenstein-Grün G,Matyas S,Dumont L

    更新日期:1997-06-01 00:00:00

  • Experimental magnesium depletion in adult rabbits caused by blast overpressure.

    abstract::The complex pressure wave (blast) generated by some explosions causes pulmonary pathological changes which resemble the histological findings of the adult respiratory distress syndrome (ARDS). The development of indirect neurotrauma following experimental pulmonary blast injury has been shown previously. The purpose o...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Cernak I,Radosevic P,Malicevic Z,Savic J

    更新日期:1995-09-01 00:00:00

  • The influence of magnesium supplementation on magnesium and calcium concentrations in hair of children with magnesium shortage.

    abstract::46 children, aged 2-6 years, with decreased magnesium concentrations in hair, were studied. Magnesium supplementation consisted of Asmag preparation for 3 months and multivitamin Multi-tabs preparation (containing magnesium, but without calcium) for the following 4 months. Control studies were performed again after 7 ...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Kozielec T,Sałacka A,Radomska K,Strecker D,Durska G

    更新日期:2001-03-01 00:00:00

  • Magnesium and its relationship to C-reactive protein among hemodialysis patients.

    abstract::Hypomagnesaemia has been reported among patients undergoing hemodialysis (HD). Recently, a possible correlation between serum magnesium (Mg) and C-reactive protein (CRP) has been stressed. This correlation has been attributed to cytokine production and oxidative stress processes. In this study we aimed to determine th...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Pakfetrat M,Malekmakan L,Roozbeh J,Haghpanah S

    更新日期:2008-09-01 00:00:00

  • The effects of magnesium supplementation on subjective anxiety.

    abstract::Experimental studies of anxiety in animal models, and evidence of efficacious outcomes of magnesium (Mg) supplementation in the treatment of acute clinical affective disorders, has increased interest in Mg as a potential novel treatment for symptoms of mild/moderate subjective anxiety. This short review examines the e...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:10.1684/mrh.2016.0411

    authors: Boyle NB,Lawton CL,Dye L

    更新日期:2016-03-01 00:00:00

  • Magnesium, potassium flux and photosynthesis.

    abstract::Photosynthetic capacity of chloroplasts is regulated by stromal pH. The pH of the stroma must be maintained higher than external pH during illumination in order to optimize photosynthetic carbon reduction cycle activity. Stromal pH is affected by K+/H+ counterexchange across the chloroplast envelope. Magnesium ion ext...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Berkowitz GA,Wu W

    更新日期:1993-09-01 00:00:00

  • Effect of bicarbonate on neonatal serum ionized magnesium in vitro.

    abstract::Sodium bicarbonate is used to treat metabolic acidosis, or to induce metabolic alkalosis in sick neonates. The aim of this study was to quantify the decrease in serum concentration of ionized magnesium ([Mg2+]) when sodium bicarbonate is added to neonatal serum in vitro. Sodium bicarbonate was added to 30 cord serum s...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Zaidenberg G,Mimouni FB,Dollberg S

    更新日期:2004-06-01 00:00:00

  • Influence of graded magnesium deficiencies on white blood cell counts and lymphocyte subpopulations in rats.

    abstract::Increased white blood cell counts or leukocytosis have been observed primarily in young rats fed diets extremely low in Mg (< 60 ppm) and high in phosphorus (0.5 % P). We investigated the influence that acute and moderate Mg deficiencies have on blood leukocytes at high and low dietary phosphorus levels. For four week...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Van Orden R,Eggett DL,Franz KB

    更新日期:2006-06-01 00:00:00

  • Magnesium deficiency reduces fear-induced conditional lick suppression in mice.

    abstract::The consequences of broad-scale alterations in magnesium (Mg2+) levels on learning and memory are poorly understood. We have recently demonstrated that adult male mice maintained on an Mg2+-deficient diet exhibit reduced conditional freezing behavior. The purpose of the present study was to determine if the detrimenta...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Bardgett ME,Schultheis PJ,Muzny A,Riddle MD,Wagge JR

    更新日期:2007-03-01 00:00:00

  • Effects of Mg2+, pH and PCr on cardiac excitation-metabolic coupling.

    abstract::A tight coupling between ionic currents, intracellular Ca2+ homeostasis, cytosolic [ADP] and deltaG of ATP hydrolysis underlies the regulation of cardiac cell function. As more experimental detail on the biochemistry and biophysics of these complex processes and their interactions accumulates, the intuitive interpreta...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Michailova A,McCulloch AD

    更新日期:2008-03-01 00:00:00

  • Effects of monovalent cations, pH and temperature on the dissociation constant (KD) for the fluorescent indicator mag-fura-2 at different excitation wavelengths.

    abstract::The use of fluorescent indicators to quantify intracellular magnesium ([Mg(2+)]i) requires accurate determination of the dissociation constant (K(D)). Ideally, the K(D) should be determined intracellularly; however, in practice this is difficult to achieve. An alternative method is to measure the K(D) in solutions whi...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Howarth FC,Singh J,Waring JJ,Hustler BI,Bailey M

    更新日期:1995-12-01 00:00:00

  • The relationship between magnesium and calciotropic hormones.

    abstract::There is an important functional link between magnesium and calciotropic hormones. PTH stimulates magnesium reabsorption in the renal tubule, absorption in the gut and release of the ion from bone. Magnesium on the other hand is essential for the normal function of the parathyroid glands, metabolism of vitamin D and a...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Zofková I,Kancheva RL

    更新日期:1995-03-01 00:00:00

  • Triamterene may preserve lymphocyte magnesium and potassium in patients with congestive heart failure.

    abstract::Electrolyte abnormalities are a frequent and potentially hazardous complication in the treatment of patients with congestive heart failure. Medical treatment with diuretics and/or digitalis, as well as neurohumoral activation most likely initiated by the compromised cardiac function, contributes to this alteration. Th...

    journal_title:Magnesium research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Schwinger RH,Antoni DH

    更新日期:1992-03-01 00:00:00

  • Effect of magnesium supplementation containing mineral bishofit (MgCl2 x 6H2O) solution and pyridoxine hydrochloride on erythrocyte magnesium depletion and behaviour of rats after three-month alcoholization.

    abstract::In therapy it is known that the combination of vitamin B6 and magnesium is beneficial in the treatment of several forms of primary magnesium deficiency. The purpose of the present study was to investigate the effect of complex magnesium supplementation containing mineral bishofit solution (MgCl2 x 6H2O) and pyridoxine...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Iezhitsa IN,Onishchenko NV,Churbakova NV,Parshev VV,Petrov VI,Spasov AA

    更新日期:2002-12-01 00:00:00

  • Histamine metabolism and pinnal hyperaemia during magnesium deficiency in rats.

    abstract::The relation between histamine metabolism and an appearance of pinnal hyperaemia during magnesium (Mg) deficiency, and the effects of some factors on these were studied in 3-week-old Wistar rats. On a Mg-deficient diet (Mg 0.001%), the histamine concentrations in plasma and urine increased after 4-5 d, and reached a m...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Nishio A,Ishiguro S,Ikegaki I,Matsumoto S,Yoshimitsu F,Miyazaki A

    更新日期:1988-12-01 00:00:00

  • Plasma matrix metalloproteinase 9 correlates with disorders of brain magnesium homeostasis in patients undergoing coronary artery bypass surgery.

    abstract:BACKGROUND:Changes in plasma matrix metalloproteinase 9 (MMP-9) concentrations and parallel changes in brain magnesium homeostasis have not been examined in cardiac surgery patients. The purpose of the present study was to analyse these relationships in patients undergoing coronary artery bypass surgery (CABG) with ext...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:10.1684/mrh.2010.0219

    authors: Dabrowski W,Rzecki Z,Czajkowski M,Pilat J,Biernacka J,Kotlinska E,Pasternak K,Stążka K,Sztanke M,Sztanke K

    更新日期:2010-12-01 00:00:00

  • Mechanisms of Mg2+ influx, efflux and intracellular 'muffling' in leech neurones and glial cells.

    abstract::Mg2+ is known to influence conductance and gating properties of a multitude of ion channels and is thus able to modulate synaptic transmission. Therefore, a tight regulation of the intracellular free Mg2+ concentration ([Mg2+]i) in neurones and glial cells is crucial for maintaining the functions of central nervous sy...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Günzel D,Schlue WR

    更新日期:2000-06-01 00:00:00

  • Concentration, compartmentation and metabolic function of intracellular free Mg2+.

    abstract::Intracellular total Mg2+ and free Mg2+ are compartmentalized between cell organelles and within the cytosol. Different values of [Mg2+]i in the cytosol of the same cell type were measured by various investigators. A main reason for the differences is the uncertainty of the dissociation constants used for the Mg furapt...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Günther T

    更新日期:2006-12-01 00:00:00

  • The degree of lymphocytic mitochondrial transmembrane potential and blood magnesium concentrations during coronary artery bypass grafting.

    abstract:UNLABELLED:Magnesium (Mg) plays an important role in lymphocyte function. Low blood concentration of Mg may result in intralymphocyte imbalance and in turn may be associated with intensified apoptosis of peripheral blood lymphocytes. Due to its multistage character; extracorporeal circulation (ECC) may augment Mg disor...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Korycińska A,Dabrowski W,Rzecki Z,Dragan M,Pozarowski P,Wrońska J,Stazka J,Pasternak K,Roliński J

    更新日期:2005-12-01 00:00:00

  • Effects of oral magnesium supplementation on plasma lipid concentrations in patients with non-insulin-dependent diabetes mellitus.

    abstract::We evaluated the effects of oral magnesium supplementation on plasma lipid concentrations in patients with non-insulin-dependent diabetes mellitus. Twenty-six persons with non-insulin-dependent diabetes mellitus received 4.5 g magnesium pidolate/d for one month, and 17 persons received placebo. Before and at the end o...

    journal_title:Magnesium research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Corica F,Allegra A,Di Benedetto A,Giacobbe MS,Romano G,Cucinotta D,Buemi M,Ceruso D

    更新日期:1994-03-01 00:00:00