Abstract：
BACKGROUND:Changes in plasma matrix metalloproteinase 9 (MMP-9) concentrations and parallel changes in brain magnesium homeostasis have not been examined in cardiac surgery patients. The purpose of the present study was to analyse these relationships in patients undergoing coronary artery bypass surgery (CABG) with extracorporeal circulation (ECC). Additionally, the effect of volatile anaesthetics was considered. PATIENTS AND METHODS:Adult patients undergoing CABG with ECC under general anaesthesia were studied. Plasma MMP-9 and total (tMg) and ionized (iMg) magnesium concentrations were measured during surgery and during the early postoperative period. The plasma arteriovenous (a-v) tMg and iMg differences in the brain circulation were considered to be markers for brain magnesium homeostasis. The Mini-Mental State Examination test and computer tomography were used to diagnose postoperative neuropsychological disorders (PNPDs). RESULTS:In total, 92 patients were examined. PNPDs were noted in 17 cases. Cardiac surgery resulted in increased plasma levels of MMP-9. The highest MMP-9 concentrations were observed in patients with PNPDs. MMP-9 concentrations strongly correlated with a-v tMg and a-v iMg differences. Compared with arterial measurements, venous tMg and iMg concentrations were higher during and immediately after surgery and lower during the early postoperative period. The most severe differences in a-v tMg and iMg were noted in patients with PNPDs. CONCLUSION:1. Cardiac surgery resulted in an increase in plasma MMP-9 concentrations. 2. This increase in MMP-9 was significantly greater in patients with PNPDs. 3. The plasma MMP-9 concentration was correlated with disorders of brain Mg homeostasis.
journal_name
Magnes Resjournal_title
Magnesium researchauthors
Dabrowski W,Rzecki Z,Czajkowski M,Pilat J,Biernacka J,Kotlinska E,Pasternak K,Stążka K,Sztanke M,Sztanke Kdoi
10.1684/mrh.2010.0219subject
Has Abstractpub_date
2010-12-01 00:00:00pages
169-79issue
4eissn
0953-1424issn
1952-4021pii
mrh.2010.0219journal_volume
23pub_type
杂志文章abstract：:Photosynthetic capacity of chloroplasts is regulated by stromal pH. The pH of the stroma must be maintained higher than external pH during illumination in order to optimize photosynthetic carbon reduction cycle activity. Stromal pH is affected by K+/H+ counterexchange across the chloroplast envelope. Magnesium ion ext...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：1993-09-01 00:00:00
abstract：:The complex pressure wave (blast) generated by some explosions causes pulmonary pathological changes which resemble the histological findings of the adult respiratory distress syndrome (ARDS). The development of indirect neurotrauma following experimental pulmonary blast injury has been shown previously. The purpose o...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:Idiopathic mitral valve prolapse (IMVP) is a widespread disease. IMVP may be latent, but most patients describe a great variety of symptoms. The clinical pictures of IMVP and of latent tetany are superimposed with regard to Mg deficit. IMVP appears as a late complication of latent tetany due to magnesium deficit (LTMD...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：1988-12-01 00:00:00
abstract：:Calcium (Ca(2+)) and magnesium (Mg(2+)) are important metal elements that regulate a variety of cellular processes such as proliferation, migration, and apoptosis, in cancer cells. Among the ionic channels mediating intracellular entry, the transient receptor potential melastatin type 7 (TRPM7) channel is of particula...
journal_title：Magnesium research
pub_type： 杂志文章
doi：10.1684/mrh.2014.0367
更新日期：2014-07-01 00:00:00
abstract：:There is an important functional link between magnesium and calciotropic hormones. PTH stimulates magnesium reabsorption in the renal tubule, absorption in the gut and release of the ion from bone. Magnesium on the other hand is essential for the normal function of the parathyroid glands, metabolism of vitamin D and a...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：1995-03-01 00:00:00
abstract：:We studied the voltage dependence of the inhibitory effects of the Ca2+ antagonist Mg2+, compared to nifedipine, on the transsarcolemmal Ca2+ uptake into primary monolayers of smooth muscle cells obtained from pig coronary arteries. The cellular Ca incorporation was analyzed by liquid scintillation. Depolarization was...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：:Ninety-five patients with acute myocardial infarction were followed up for 6 months to 3 years (mean 25.4 months) in a preliminary study to compare the effects of intravenous magnesium (49 patients) with that of intravenous propranolol (44 patients) given immediately after admission to the intensive care unit. There w...
journal_title：Magnesium research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-12-01 00:00:00
abstract：:Intracellular total Mg2+ and free Mg2+ are compartmentalized between cell organelles and within the cytosol. Different values of [Mg2+]i in the cytosol of the same cell type were measured by various investigators. A main reason for the differences is the uncertainty of the dissociation constants used for the Mg furapt...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：2006-12-01 00:00:00
abstract：:Pregnancy is marked by a state of hypomagnesaemia but not much is known about the effects of maternal magnesium deprivation on the fetus. The aim of this study was therefore to measure magnesium concentrations in human myometrial and placental tissues and in different body fluids during pregnancy and at term, using at...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：PURPOSE:Critically evaluate the experimental evidence and clinical trial outcomes as the basis for use of magnesium (Mg) supplements as therapy for calcium oxalate nephrolithiasis. MATERIALS AND METHODS:Literature search of MedLine and Web of Science through January 2005; articles cited in papers found by searches. R...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：2005-06-01 00:00:00
abstract：:Lactating rats fed a 0.055% Mg diet transferred 5.5 +/- SEM 0.3 mg per day of Mg into milk but remained in a slightly positive Mg balance by increasing both food consumption and fractional intestinal Mg absorption. Urinary Mg excretion increased continually during the course of lactation to values double those of non-...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：:Mg2+ is known to influence conductance and gating properties of a multitude of ion channels and is thus able to modulate synaptic transmission. Therefore, a tight regulation of the intracellular free Mg2+ concentration ([Mg2+]i) in neurones and glial cells is crucial for maintaining the functions of central nervous sy...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：2000-06-01 00:00:00
abstract：:Some previous studies have reported the involvement of magnesium (Mg) deficiency in children with ADHD syndrome. In this work, 40 children with clinical symptoms of ADHD were followed clinically and biologically during a magnesium-vitamin B6 (Mg-B6) regimen (6 mg/kg/d Mg, 0.6 mg/kg/d vit-B6) which was set up for at le...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：:Ageing constitutes a risk factor for magnesium deficit. Primary magnesium deficit originates from two aetiological mechanisms: deficiency and depletion. Primary magnesium deficiency is due to insufficient magnesium intake. Dietary amounts of magnesium are marginal in the whole population whatever the age. Nutritional ...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：1993-12-01 00:00:00
abstract：:We evaluated the effects of oral magnesium supplementation on plasma lipid concentrations in patients with non-insulin-dependent diabetes mellitus. Twenty-six persons with non-insulin-dependent diabetes mellitus received 4.5 g magnesium pidolate/d for one month, and 17 persons received placebo. Before and at the end o...
journal_title：Magnesium research
pub_type： 临床试验,杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:The interaction of magnesium ions with biomolecular species is fundamental to the regulation of many biological processes. A mathematical technique to investigate such interactions is described. The concept of a pseudo-formation curve is discussed and the relevance and applicability of such constructions to the study ...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：:The aim of the present study was to determine the effect of an aerobic training on plasma and red blood cells' levels of magnesium, copper, selenium and zinc and on some oxidative stress parameters in a Down syndrome (DS) sample population. Sixteen young male adults with DS participated in the protocol. Among them, ei...
journal_title：Magnesium research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1997-03-01 00:00:00
abstract：:The relation between histamine metabolism and an appearance of pinnal hyperaemia during magnesium (Mg) deficiency, and the effects of some factors on these were studied in 3-week-old Wistar rats. On a Mg-deficient diet (Mg 0.001%), the histamine concentrations in plasma and urine increased after 4-5 d, and reached a m...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：1988-12-01 00:00:00
abstract：:Although magnesium (Mg) contents are different between breast milk and formula, few studies have investigated the blood Mg level in breast fed or formula fed preterm infants. We examined the influence of feeding type on serum Mg and whole blood ionized Mg (iMg) levels in preterm infants soon after birth. We included 1...
journal_title：Magnesium research
pub_type： 杂志文章
doi：10.1684/mrh.2019.0444
更新日期：2018-11-01 00:00:00
abstract：:Magnesium (Mg) and nickel (Ni) are biologically active elements in higher animals. Recent studies in vivo as well as in vitro point to interactions of Ni and Mg; non-immunological roles of these elements are reviewed here. Ni and Mg play roles in some of the same enzyme and endocrine systems, body and cell structures,...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：1992-09-01 00:00:00
abstract：UNLABELLED:Magnesium (Mg) plays an important role in lymphocyte function. Low blood concentration of Mg may result in intralymphocyte imbalance and in turn may be associated with intensified apoptosis of peripheral blood lymphocytes. Due to its multistage character; extracorporeal circulation (ECC) may augment Mg disor...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：2005-12-01 00:00:00
abstract：:Magnesium deficiency has been linked with cardiac arrhythmias and sudden cardiac death. Antiarrhythmic effects of intravenous magnesium in the patients who are not hypomagnesaemic were mainly demonstrated in the patients with acquired long QT syndrome. Parenteral administration should be considered in this type of ven...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：1994-06-01 00:00:00
abstract：INTRODUCTION:The present study investigated associations between environmental exposure to magnesium (Mg) and the levels of oxidative stress parameters and selected cytokines, and the antioxidant defense system in the seminal plasma of fertile males. MATERIALS AND METHODS:The study population consisted of 57 healthy, ...
journal_title：Magnesium research
pub_type： 杂志文章
doi：10.1684/mrh.2015.0377
更新日期：2015-01-01 00:00:00
abstract：:In this study, the effects of oral magnesium supplementation were evaluated on plasma, erythrocyte, and urinary cation levels. The study was carried out with an open, cross-over and randomized design. Healthy subjects received two sachets per day of magnesium (366 mg Mg2+/d) for two 28 d cycles, separated by a 3-week ...
journal_title：Magnesium research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1993-06-01 00:00:00
abstract：:The goal of this review is to bring to the attention of the readership of Magnesium Research another facet of the importance of magnesium, i.e. magnesium-based biomaterials. A concise history of biomaterials and magnesium are thus presented. In addition, historical and current, clinical magnesium-based applications ar...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：10.1684/mrh.2015.0375
更新日期：2014-10-01 00:00:00
abstract：:Cerebral vasospasm and delayed cerebral ischemia remain an unsolved problem in patients with aneurysmal subarachnoid hemorrhage (SAH). In theory, high-dose magnesium sulfate (MgSO(4)) therapy offers vascular and neuroprotective benefits and is therefore currently under evaluation. The intensity of the inflammatory res...
journal_title：Magnesium research
pub_type： 临床试验,杂志文章
doi：
更新日期：2012-07-01 00:00:00
abstract：:The sudden infant death syndrome (SIDS) remains a leading cause of death during the first year. The common epidemiological and pathological data which characterize SIDS include the curve for age at death (with 3 months as modal age), the stigmata of early maternal intrauterine injury, the seasonal predominance in wint...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：1991-09-01 00:00:00
abstract：:To determine whether oral magnesium supplementation modifies serum levels of high-sensitivity C-reactive protein (hsCRP), TNF-alpha, IL-6, and IL-10 in subjects with prediabetes, inflammation, and hypomagnesemia, a total of 26 subjects men and non-pregnant women were included and randomly allocated to receive 30 ml of...
journal_title：Magnesium research
pub_type： 杂志文章,随机对照试验
doi：10.1684/mrh.2012.0322
更新日期：2012-07-01 00:00:00
abstract：:Competitive divalent (magnesium and calcium) or monovalent (potassium, lithium and sodium) ion exchange and its influence on a membrane potential formation was studied at biological ligands (BL) such as adenosine triphosphate (ATP), asparagine (Asn) and glutamine (Gln) sites. The sites are dispersed electrochemically ...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：2009-03-01 00:00:00
abstract：:Electrolyte abnormalities are a frequent and potentially hazardous complication in the treatment of patients with congestive heart failure. Medical treatment with diuretics and/or digitalis, as well as neurohumoral activation most likely initiated by the compromised cardiac function, contributes to this alteration. Th...
journal_title：Magnesium research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1992-03-01 00:00:00
