Abstract：
:A tight coupling between ionic currents, intracellular Ca2+ homeostasis, cytosolic [ADP] and deltaG of ATP hydrolysis underlies the regulation of cardiac cell function. As more experimental detail on the biochemistry and biophysics of these complex processes and their interactions accumulates, the intuitive interpretation of the new findings becomes increasingly impractical. For this reason we developed detailed biophysical model that couples Ca2+ signaling, cell electrophysiology and bioenergetics with the main interactions between phosphorylated species (ATP, ADP, AMP, PCr, Cr, P(i)) and Lewis cytosolic acids (Na+, K+, Mg2+, H+). The results indicate that the increase in free cytosolic Mg2+ (0.2-5 mM) systematically shortens the action potential duration. The analysis suggests that that under physiological conditions a pH decrease accompanied by a free Mg2+ increase tends to counteract an [ADP] increase due to PCr depletion. The model reproduces qualitatively a sequence of events that correlates well with the experimental data.
journal_name
Magnes Resjournal_title
Magnesium researchauthors
Michailova A,McCulloch ADsubject
Has Abstractpub_date
2008-03-01 00:00:00pages
16-28issue
1eissn
0953-1424issn
1952-4021journal_volume
21pub_type
杂志文章abstract：BACKGROUND:Changes in plasma matrix metalloproteinase 9 (MMP-9) concentrations and parallel changes in brain magnesium homeostasis have not been examined in cardiac surgery patients. The purpose of the present study was to analyse these relationships in patients undergoing coronary artery bypass surgery (CABG) with ext...
journal_title：Magnesium research
pub_type： 杂志文章
doi：10.1684/mrh.2010.0219
更新日期：2010-12-01 00:00:00
abstract：:Photosynthetic capacity of chloroplasts is regulated by stromal pH. The pH of the stroma must be maintained higher than external pH during illumination in order to optimize photosynthetic carbon reduction cycle activity. Stromal pH is affected by K+/H+ counterexchange across the chloroplast envelope. Magnesium ion ext...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：1993-09-01 00:00:00
abstract：:Although magnesium (Mg) contents are different between breast milk and formula, few studies have investigated the blood Mg level in breast fed or formula fed preterm infants. We examined the influence of feeding type on serum Mg and whole blood ionized Mg (iMg) levels in preterm infants soon after birth. We included 1...
journal_title：Magnesium research
pub_type： 杂志文章
doi：10.1684/mrh.2019.0444
更新日期：2018-11-01 00:00:00
abstract：:The purpose of the research work was to study the influence of alpha-zearalenol on magnesium concentration in cellular subfractions of certain tissues of female rats and their progeny. Pregnant female rats received alpha-zearalenol at the doses of: 0.05, 0.5 or 1 mg x kg(-1) b.w. After delivery, brain, liver and kidne...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：2003-06-01 00:00:00
abstract：:Increased white blood cell counts or leukocytosis have been observed primarily in young rats fed diets extremely low in Mg (< 60 ppm) and high in phosphorus (0.5 % P). We investigated the influence that acute and moderate Mg deficiencies have on blood leukocytes at high and low dietary phosphorus levels. For four week...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：2006-06-01 00:00:00
abstract：:We have recently demonstrated in the guinea pig that preventive dietary magnesium supplement can significantly reduce impulse noise induced hearing loss by on average 18 dB. The purpose of the present study was to examine whether magnesium might also have a therapeutic effect on noise trauma. Anesthetized guinea pigs ...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:Catechol-O-methyltransferase (COMT) is a magnesium-dependent, catecholamine-metabolizing enzyme, whose impaired activity has been positively associated with cardiovascular diseases, particularly hypertension. Consumption of some natural mineral-rich waters has been shown to exert protective effects on cardiovascular r...
journal_title：Magnesium research
pub_type： 杂志文章
doi：10.1684/mrh.2014.0369
更新日期：2014-07-01 00:00:00
abstract：:Pregnancy is marked by a state of hypomagnesaemia but not much is known about the effects of maternal magnesium deprivation on the fetus. The aim of this study was therefore to measure magnesium concentrations in human myometrial and placental tissues and in different body fluids during pregnancy and at term, using at...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:Dependency on extracellular calcium influx in contractile response to noradrenaline has been investigated in the thoracic aorta isolated from dietary magnesium (Mg) deficient rats. Adult male Wistar rats were fed with a Mg deficient diet (0.001% Mg) for 30 days, together with control groups (0.07% Mg). The contractile...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：:Sodium bicarbonate is used to treat metabolic acidosis, or to induce metabolic alkalosis in sick neonates. The aim of this study was to quantify the decrease in serum concentration of ionized magnesium ([Mg2+]) when sodium bicarbonate is added to neonatal serum in vitro. Sodium bicarbonate was added to 30 cord serum s...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：:The interaction of magnesium ions with biomolecular species is fundamental to the regulation of many biological processes. A mathematical technique to investigate such interactions is described. The concept of a pseudo-formation curve is discussed and the relevance and applicability of such constructions to the study ...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：:Ninety-five patients with acute myocardial infarction were followed up for 6 months to 3 years (mean 25.4 months) in a preliminary study to compare the effects of intravenous magnesium (49 patients) with that of intravenous propranolol (44 patients) given immediately after admission to the intensive care unit. There w...
journal_title：Magnesium research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-12-01 00:00:00
abstract：:There is an important functional link between magnesium and calciotropic hormones. PTH stimulates magnesium reabsorption in the renal tubule, absorption in the gut and release of the ion from bone. Magnesium on the other hand is essential for the normal function of the parathyroid glands, metabolism of vitamin D and a...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：1995-03-01 00:00:00
abstract：:The sudden infant death syndrome (SIDS) remains a leading cause of death during the first year. The common epidemiological and pathological data which characterize SIDS include the curve for age at death (with 3 months as modal age), the stigmata of early maternal intrauterine injury, the seasonal predominance in wint...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：1991-09-01 00:00:00
abstract：:We measured free intralymphocyte magnesium (Mgi) in 10 hypertensive subjects (HS) before and after treatment with atenolol (A) and in 16 normotensive control subjects (NC). We also carried out in vitro studies on human lymphocytes to test the effect of catecholamines and beta-antagonists on Mgi. Mgi in HS was not stat...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:Complex fermentable carbohydrates, such as inulin-type fructans have been shown to improve Mg2+ absorption in the hindgut and body stores. The mechanisms for this are not well understood. The newly identified transient receptor potential melastatin 6 and 7 (TRPM6 and TRPM7) channels have been shown to function in acti...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：2008-12-01 00:00:00
abstract：:Magnesium deficiency has been linked with cardiac arrhythmias and sudden cardiac death. Antiarrhythmic effects of intravenous magnesium in the patients who are not hypomagnesaemic were mainly demonstrated in the patients with acquired long QT syndrome. Parenteral administration should be considered in this type of ven...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：1994-06-01 00:00:00
abstract：UNLABELLED:Comprehensive analytical review of 44 human studies in 43 publications of oral Magnesium (Mg) therapy for hypertension (HT) shows Mg supplements may enhance the blood-pressure (BP) lowering effect of anti-hypertensive medications (medications) in Stage 1 HT subjects. 9 studies conducted on subjects treated w...
journal_title：Magnesium research
pub_type： 杂志文章
doi：10.1684/mrh.2010.0198
更新日期：2010-03-01 00:00:00
abstract：:Ageing constitutes a risk factor for magnesium deficit. Primary magnesium deficit originates from two aetiological mechanisms: deficiency and depletion. Primary magnesium deficiency is due to insufficient magnesium intake. Dietary amounts of magnesium are marginal in the whole population whatever the age. Nutritional ...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：1993-12-01 00:00:00
abstract：:Competitive divalent (magnesium and calcium) or monovalent (potassium, lithium and sodium) ion exchange and its influence on a membrane potential formation was studied at biological ligands (BL) such as adenosine triphosphate (ATP), asparagine (Asn) and glutamine (Gln) sites. The sites are dispersed electrochemically ...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：2009-03-01 00:00:00
abstract：:Mg2+ is known to influence conductance and gating properties of a multitude of ion channels and is thus able to modulate synaptic transmission. Therefore, a tight regulation of the intracellular free Mg2+ concentration ([Mg2+]i) in neurones and glial cells is crucial for maintaining the functions of central nervous sy...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：2000-06-01 00:00:00
abstract：:Ageing is associated with a general decline in physiological functions. Amongst the different aspects of body deterioration, cognitive impairments, and particularly defects in learning and memory, represent one of the most frequent features in the elderly. However, a great variability exists among aged subjects. Clini...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：2006-09-01 00:00:00
abstract：:The goal of this review is to bring to the attention of the readership of Magnesium Research another facet of the importance of magnesium, i.e. magnesium-based biomaterials. A concise history of biomaterials and magnesium are thus presented. In addition, historical and current, clinical magnesium-based applications ar...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：10.1684/mrh.2015.0375
更新日期：2014-10-01 00:00:00
abstract：:Hypomagnesaemia has been reported among patients undergoing hemodialysis (HD). Recently, a possible correlation between serum magnesium (Mg) and C-reactive protein (CRP) has been stressed. This correlation has been attributed to cytokine production and oxidative stress processes. In this study we aimed to determine th...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：:Magnesium (Mg) and nickel (Ni) are biologically active elements in higher animals. Recent studies in vivo as well as in vitro point to interactions of Ni and Mg; non-immunological roles of these elements are reviewed here. Ni and Mg play roles in some of the same enzyme and endocrine systems, body and cell structures,...
journal_title：Magnesium research
pub_type： 杂志文章,评审
doi：
更新日期：1992-09-01 00:00:00
abstract：:Epidemiological studies of populations living in areas of low magnesium (Mg) intake have consistently shown a higher cardiovascular morbidity. Several hypotheses have been advanced to explain the cardioprotective properties of magnesium. Few studies, however, have analysed the relation of magnesium to haemostasis. The...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:Magnesium (Mg) deficiency strongly affects muscle performance. In judo, many athletes often undergo impressive weight changes associated with severe dehydration. Common practices used by athletes to achieve a target weight can lead to Mg deficit. This study aimed to understand the impact of Mg changes on strength from...
journal_title：Magnesium research
pub_type： 杂志文章
doi：10.1684/mrh.2010.0217
更新日期：2010-09-01 00:00:00
abstract：:Lactating rats fed a 0.055% Mg diet transferred 5.5 +/- SEM 0.3 mg per day of Mg into milk but remained in a slightly positive Mg balance by increasing both food consumption and fractional intestinal Mg absorption. Urinary Mg excretion increased continually during the course of lactation to values double those of non-...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：:We studied the voltage dependence of the inhibitory effects of the Ca2+ antagonist Mg2+, compared to nifedipine, on the transsarcolemmal Ca2+ uptake into primary monolayers of smooth muscle cells obtained from pig coronary arteries. The cellular Ca incorporation was analyzed by liquid scintillation. Depolarization was...
journal_title：Magnesium research
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：:Cerebral vasospasm and delayed cerebral ischemia remain an unsolved problem in patients with aneurysmal subarachnoid hemorrhage (SAH). In theory, high-dose magnesium sulfate (MgSO(4)) therapy offers vascular and neuroprotective benefits and is therefore currently under evaluation. The intensity of the inflammatory res...
journal_title：Magnesium research
pub_type： 临床试验,杂志文章
doi：
更新日期：2012-07-01 00:00:00
