Abstract:
:Competitive divalent (magnesium and calcium) or monovalent (potassium, lithium and sodium) ion exchange and its influence on a membrane potential formation was studied at biological ligands (BL) such as adenosine triphosphate (ATP), asparagine (Asn) and glutamine (Gln) sites. The sites are dispersed electrochemically in membranes made of the conducting polymers (CPs)--poly(N-methylpyrrole) (PMPy) and poly(pyrrole) (PPy). The membranes are made sensitive to calcium and magnesium or to potassium, sodium and lithium by optimized electrodeposition and soaking procedures supported by the study of membrane topography and morphology. Distinctively different electrochemical responses, i.e. electrical potential transients or currents, are observed in the case of "antagonistic" calcium and magnesium or potassium and sodium/lithium ion pairs. Dissimilarity in the responses is ascribed to a difference between on site vs. bulk concentrations of ions, and is dictated by different transport properties of the ions, as shown by using the Nernst-Planck-Poisson (NPP) model and the diffusion-layer model (DLM). The method described allows inspecting potential-dependent competitive ion-exchange processes at the biologically active sites. It is suggested that this approach could be used as an auxiliary tool in study of potential dependent block in realistic membrane channels, such as Mg block in the N-methyl D-aspartate receptor channel (NMDA).
journal_name
Magnes Resjournal_title
Magnesium researchauthors
Paczosa-Bator B,Stepien M,Maj-Zurawska M,Lewenstam Asubject
Has Abstractpub_date
2009-03-01 00:00:00pages
10-20issue
1eissn
0953-1424issn
1952-4021journal_volume
22pub_type
杂志文章abstract::Magnesium (Mg) deficiency strongly affects muscle performance. In judo, many athletes often undergo impressive weight changes associated with severe dehydration. Common practices used by athletes to achieve a target weight can lead to Mg deficit. This study aimed to understand the impact of Mg changes on strength from...
journal_title:Magnesium research
pub_type: 杂志文章
doi:10.1684/mrh.2010.0217
更新日期:2010-09-01 00:00:00
abstract:UNLABELLED:Comprehensive analytical review of 44 human studies in 43 publications of oral Magnesium (Mg) therapy for hypertension (HT) shows Mg supplements may enhance the blood-pressure (BP) lowering effect of anti-hypertensive medications (medications) in Stage 1 HT subjects. 9 studies conducted on subjects treated w...
journal_title:Magnesium research
pub_type: 杂志文章
doi:10.1684/mrh.2010.0198
更新日期:2010-03-01 00:00:00
abstract::The interaction of magnesium ions with biomolecular species is fundamental to the regulation of many biological processes. A mathematical technique to investigate such interactions is described. The concept of a pseudo-formation curve is discussed and the relevance and applicability of such constructions to the study ...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::Traumatic brain injury (TBI) confers a major burden to Western society and effective treatments are urgently required to improve the long-term deficits that inflict TBI survivors. Depletion of intracellular Mg(2+) is a well-known phenomenon occurring after TBI and is associated with poor neurological outcome. However,...
journal_title:Magnesium research
pub_type: 杂志文章,评审
doi:10.1684/mrh.2009.0189
更新日期:2009-12-01 00:00:00
abstract::A protein of approximately 70-kDa was identified as a candidate Na+/Mg2+ exchanger in rumen epithelial cells (REC). Melastatin-related Transient Receptor Potential 7 (TRPM7) and Magnesium Transporter 1 (MagT1) transcripts and, from them, encoded proteins were also detected. The regulation of these Mg transport pathway...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:2009-09-01 00:00:00
abstract::Lactating rats fed a 0.055% Mg diet transferred 5.5 +/- SEM 0.3 mg per day of Mg into milk but remained in a slightly positive Mg balance by increasing both food consumption and fractional intestinal Mg absorption. Urinary Mg excretion increased continually during the course of lactation to values double those of non-...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract::In this study, the effects of oral magnesium supplementation were evaluated on plasma, erythrocyte, and urinary cation levels. The study was carried out with an open, cross-over and randomized design. Healthy subjects received two sachets per day of magnesium (366 mg Mg2+/d) for two 28 d cycles, separated by a 3-week ...
journal_title:Magnesium research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1993-06-01 00:00:00
abstract::The present study was performed to show the molecular identity of functionally characterized Mg transport pathways in rumen epithelial cells (REC) and to investigate the effects of extracellular [Mg] changes on their expression and activity. By using RT- PCR, Western blot, flow cytometry and immunocytochemistry, TRPM7...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:2008-06-01 00:00:00
abstract::More and more studies are accumulating about COVID-19. Some aspects of the pathogenesis of the disease recall events occurring in Mg deficiency, such as a drop of T cells, increased plasma concentration of inflammatory cytokines, and endothelial dysfunction. We hypothesize that a low Mg status, which is rather common,...
journal_title:Magnesium research
pub_type: 杂志文章
doi:10.1684/mrh.2020.0465
更新日期:2020-05-01 00:00:00
abstract::The purpose of the research work was to study the influence of alpha-zearalenol on magnesium concentration in cellular subfractions of certain tissues of female rats and their progeny. Pregnant female rats received alpha-zearalenol at the doses of: 0.05, 0.5 or 1 mg x kg(-1) b.w. After delivery, brain, liver and kidne...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::Age-related human neurodegenerative diseases are a major social and medical problem. It is therefore logical to take into consideration every theory with an overall approach to neurodegenerative diseases. This environmental proposal relies mainly on data concerning the Western Pacific amyotrophic lateral sclerosis-Par...
journal_title:Magnesium research
pub_type: 杂志文章,评审
doi:
更新日期:1997-12-01 00:00:00
abstract::The sudden infant death syndrome (SIDS) remains a leading cause of death during the first year. The common epidemiological and pathological data which characterize SIDS include the curve for age at death (with 3 months as modal age), the stigmata of early maternal intrauterine injury, the seasonal predominance in wint...
journal_title:Magnesium research
pub_type: 杂志文章,评审
doi:
更新日期:1991-09-01 00:00:00
abstract::46 children, aged 2-6 years, with decreased magnesium concentrations in hair, were studied. Magnesium supplementation consisted of Asmag preparation for 3 months and multivitamin Multi-tabs preparation (containing magnesium, but without calcium) for the following 4 months. Control studies were performed again after 7 ...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVES:To examine the cross-sectional associations between serum magnesium (Mg) and hyperuricemia (HU). METHODS:2904 subjects were included in this study. HU was defined as uric acid ≥416 μmol/L for the male population and ≥360 μmol/L for the female population. A multivariable logistic analysis model was applied t...
journal_title:Magnesium research
pub_type: 杂志文章
doi:10.1684/mrh.2015.0384
更新日期:2015-06-01 00:00:00
abstract::Calcium (Ca(2+)) and magnesium (Mg(2+)) are important metal elements that regulate a variety of cellular processes such as proliferation, migration, and apoptosis, in cancer cells. Among the ionic channels mediating intracellular entry, the transient receptor potential melastatin type 7 (TRPM7) channel is of particula...
journal_title:Magnesium research
pub_type: 杂志文章
doi:10.1684/mrh.2014.0367
更新日期:2014-07-01 00:00:00
abstract::Some previous studies have reported the involvement of magnesium (Mg) deficiency in children with ADHD syndrome. In this work, 40 children with clinical symptoms of ADHD were followed clinically and biologically during a magnesium-vitamin B6 (Mg-B6) regimen (6 mg/kg/d Mg, 0.6 mg/kg/d vit-B6) which was set up for at le...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:2006-03-01 00:00:00
abstract::The aim of this work was to compare the possible antinociceptive effect of the intravenous (IV) versus the intrathecal (IT) administration of magnesium sulphate prior to spinal morphine analgesia. This research was conducted in two sets: First; experimentally, to compare the antinociceptive effect of IT magnesium sulp...
journal_title:Magnesium research
pub_type: 杂志文章,随机对照试验
doi:10.1684/mrh.2016.0396
更新日期:2016-03-01 00:00:00
abstract::Idiopathic mitral valve prolapse (IMVP) is a widespread disease. IMVP may be latent, but most patients describe a great variety of symptoms. The clinical pictures of IMVP and of latent tetany are superimposed with regard to Mg deficit. IMVP appears as a late complication of latent tetany due to magnesium deficit (LTMD...
journal_title:Magnesium research
pub_type: 杂志文章,评审
doi:
更新日期:1988-12-01 00:00:00
abstract::Electrolyte abnormalities are a frequent and potentially hazardous complication in the treatment of patients with congestive heart failure. Medical treatment with diuretics and/or digitalis, as well as neurohumoral activation most likely initiated by the compromised cardiac function, contributes to this alteration. Th...
journal_title:Magnesium research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1992-03-01 00:00:00
abstract::The current study assessed the neuroprotective efficacy of magnesium using a FAST-Mag trial treatment protocol alone, and in combination with mild hypothermia, in Sprague Dawley rats subjected to permanent, middle cerebral artery occlusion (MCAO). Treatment with magnesium (MgSO4.7H2O) consisted of an intravenous loadi...
journal_title:Magnesium research
pub_type: 杂志文章
doi:10.1684/mrh.2013.0340
更新日期:2013-04-01 00:00:00
abstract::Pregnancy is marked by a state of hypomagnesaemia but not much is known about the effects of maternal magnesium deprivation on the fetus. The aim of this study was therefore to measure magnesium concentrations in human myometrial and placental tissues and in different body fluids during pregnancy and at term, using at...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract::The consequences of broad-scale alterations in magnesium (Mg2+) levels on learning and memory are poorly understood. We have recently demonstrated that adult male mice maintained on an Mg2+-deficient diet exhibit reduced conditional freezing behavior. The purpose of the present study was to determine if the detrimenta...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:2007-03-01 00:00:00
abstract::Increased white blood cell counts or leukocytosis have been observed primarily in young rats fed diets extremely low in Mg (< 60 ppm) and high in phosphorus (0.5 % P). We investigated the influence that acute and moderate Mg deficiencies have on blood leukocytes at high and low dietary phosphorus levels. For four week...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:2006-06-01 00:00:00
abstract::We measured free intralymphocyte magnesium (Mgi) in 10 hypertensive subjects (HS) before and after treatment with atenolol (A) and in 16 normotensive control subjects (NC). We also carried out in vitro studies on human lymphocytes to test the effect of catecholamines and beta-antagonists on Mgi. Mgi in HS was not stat...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract::Catechol-O-methyltransferase (COMT) is a magnesium-dependent, catecholamine-metabolizing enzyme, whose impaired activity has been positively associated with cardiovascular diseases, particularly hypertension. Consumption of some natural mineral-rich waters has been shown to exert protective effects on cardiovascular r...
journal_title:Magnesium research
pub_type: 杂志文章
doi:10.1684/mrh.2014.0369
更新日期:2014-07-01 00:00:00
abstract::Hypomagnesaemia has been reported among patients undergoing hemodialysis (HD). Recently, a possible correlation between serum magnesium (Mg) and C-reactive protein (CRP) has been stressed. This correlation has been attributed to cytokine production and oxidative stress processes. In this study we aimed to determine th...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
abstract:INTRODUCTION:The present study investigated associations between environmental exposure to magnesium (Mg) and the levels of oxidative stress parameters and selected cytokines, and the antioxidant defense system in the seminal plasma of fertile males. MATERIALS AND METHODS:The study population consisted of 57 healthy, ...
journal_title:Magnesium research
pub_type: 杂志文章
doi:10.1684/mrh.2015.0377
更新日期:2015-01-01 00:00:00
abstract::Ninety-five patients with acute myocardial infarction were followed up for 6 months to 3 years (mean 25.4 months) in a preliminary study to compare the effects of intravenous magnesium (49 patients) with that of intravenous propranolol (44 patients) given immediately after admission to the intensive care unit. There w...
journal_title:Magnesium research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1994-12-01 00:00:00
abstract::Complex fermentable carbohydrates, such as inulin-type fructans have been shown to improve Mg2+ absorption in the hindgut and body stores. The mechanisms for this are not well understood. The newly identified transient receptor potential melastatin 6 and 7 (TRPM6 and TRPM7) channels have been shown to function in acti...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:2008-12-01 00:00:00
abstract::The complex pressure wave (blast) generated by some explosions causes pulmonary pathological changes which resemble the histological findings of the adult respiratory distress syndrome (ARDS). The development of indirect neurotrauma following experimental pulmonary blast injury has been shown previously. The purpose o...
journal_title:Magnesium research
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00