Experimental magnesium depletion in adult rabbits caused by blast overpressure.

Abstract:

:The complex pressure wave (blast) generated by some explosions causes pulmonary pathological changes which resemble the histological findings of the adult respiratory distress syndrome (ARDS). The development of indirect neurotrauma following experimental pulmonary blast injury has been shown previously. The purpose of this study was to evaluate lung and brainstem total tissue magnesium concentrations in adult rabbits following pulmonary blast injury. In order to assess the interrelationship between magnesium and other secondary injury factors, total calcium and high energy phosphate (phosphocreatine, PCr; adenosine triphosphate, ATP) contents were simultaneously measured. Twenty adult male rabbits were divided into two groups. Group C (n = 10) served as control, while group B (n = 10) was subjected to a focused blast wave, generated in laboratory conditions using an air-driven shock tube. Moderate pulmonary blast injury was verified by histological examination in group B. Total tissue magnesium and calcium contents were measured by atomic absorption spectrophotometry in the lungs and brainstem of adult rabbits 30 min following blast overpressure and in their uninjured controls. Simultaneously, PCr and ATP contents were measured by fluorimetric enzymatic analyses in same structures. Lung and brainstem water contents were determined by wet weight to dry weight ratio. Blast overpressure to the lungs induced significant magnesium depletion, increased calcium and decreased the Mg/Ca ratio in lung tissue of injured animals. Increases in water content and PCr/ATP ratio were also observed. Significant correlations between these Mg/Ca and PCr/ATP and between Mg and ATP parameters confirmed the functional relationship between magnesium depletion and impaired bioenergetic state in indirect neurotrauma in adult rabbits through blast overpressure.

journal_name

Magnes Res

journal_title

Magnesium research

authors

Cernak I,Radosevic P,Malicevic Z,Savic J

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

249-59

issue

3

eissn

0953-1424

issn

1952-4021

journal_volume

8

pub_type

杂志文章
  • Influence of endothelium in the in vitro vasorelaxant effect of magnesium on aortic basal tension in DOCA-salt hypertensive rat.

    abstract::The objective of this study was to examine the influence of the endothelium on the extracellular magnesium induced relaxation of basal tension in isolated aortas from both mineralocorticoid-salt (DOCA-salt) hypertensive and control normotensive Sprague Dawley male rats. After incubation in magnesium-free physiological...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Laurant P,Berthelot A

    更新日期:1992-12-01 00:00:00

  • The degree of lymphocytic mitochondrial transmembrane potential and blood magnesium concentrations during coronary artery bypass grafting.

    abstract:UNLABELLED:Magnesium (Mg) plays an important role in lymphocyte function. Low blood concentration of Mg may result in intralymphocyte imbalance and in turn may be associated with intensified apoptosis of peripheral blood lymphocytes. Due to its multistage character; extracorporeal circulation (ECC) may augment Mg disor...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Korycińska A,Dabrowski W,Rzecki Z,Dragan M,Pozarowski P,Wrońska J,Stazka J,Pasternak K,Roliński J

    更新日期:2005-12-01 00:00:00

  • Magnesium therapy for nephrolithiasis.

    abstract:PURPOSE:Critically evaluate the experimental evidence and clinical trial outcomes as the basis for use of magnesium (Mg) supplements as therapy for calcium oxalate nephrolithiasis. MATERIALS AND METHODS:Literature search of MedLine and Web of Science through January 2005; articles cited in papers found by searches. R...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Massey L

    更新日期:2005-06-01 00:00:00

  • Preliminary communication on intralymphocyte ionized magnesium in hypertensive patients under treatment with beta-blockers.

    abstract::We measured free intralymphocyte magnesium (Mgi) in 10 hypertensive subjects (HS) before and after treatment with atenolol (A) and in 16 normotensive control subjects (NC). We also carried out in vitro studies on human lymphocytes to test the effect of catecholamines and beta-antagonists on Mgi. Mgi in HS was not stat...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Pastori C,Delva P,Degan M,Lechi A

    更新日期:1999-03-01 00:00:00

  • Protein peroxidation, magnesium deficiency and fibromyalgia.

    abstract::Lipid and protein peroxidations were investigated in female patients with magnesium deficit (MD), fibromyalgia (FM) and age matched controls: malondialdehyde and protein carbonyls (PC), as well as serum, leucocyte and erythrocyte magnesium (EMg) were assessed in 20 controls, 25 FM and 16 MD patients. MDA are unchanged...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Eisinger J,Zakarian H,Pouly E,Plantamura A,Ayavou T

    更新日期:1996-12-01 00:00:00

  • Magnesium deficiency reduces fear-induced conditional lick suppression in mice.

    abstract::The consequences of broad-scale alterations in magnesium (Mg2+) levels on learning and memory are poorly understood. We have recently demonstrated that adult male mice maintained on an Mg2+-deficient diet exhibit reduced conditional freezing behavior. The purpose of the present study was to determine if the detrimenta...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Bardgett ME,Schultheis PJ,Muzny A,Riddle MD,Wagge JR

    更新日期:2007-03-01 00:00:00

  • Voltage dependence of the pharmacological Mg2+ block of the Ca2+ entry into vascular smooth muscle cells.

    abstract::We studied the voltage dependence of the inhibitory effects of the Ca2+ antagonist Mg2+, compared to nifedipine, on the transsarcolemmal Ca2+ uptake into primary monolayers of smooth muscle cells obtained from pig coronary arteries. The cellular Ca incorporation was analyzed by liquid scintillation. Depolarization was...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Fleckenstein-Grün G,Matyas S,Dumont L

    更新日期:1997-06-01 00:00:00

  • Biomimetic study of the Ca(2+)-Mg2+ and K(+)-Li+ antagonism on biologically active sites: new methodology to study potential dependent ion exchange.

    abstract::Competitive divalent (magnesium and calcium) or monovalent (potassium, lithium and sodium) ion exchange and its influence on a membrane potential formation was studied at biological ligands (BL) such as adenosine triphosphate (ATP), asparagine (Asn) and glutamine (Gln) sites. The sites are dispersed electrochemically ...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Paczosa-Bator B,Stepien M,Maj-Zurawska M,Lewenstam A

    更新日期:2009-03-01 00:00:00

  • No positive effect of oral magnesium supplementation in the decreases of inflammation in subjects with prediabetes: a pilot study.

    abstract::To determine whether oral magnesium supplementation modifies serum levels of high-sensitivity C-reactive protein (hsCRP), TNF-alpha, IL-6, and IL-10 in subjects with prediabetes, inflammation, and hypomagnesemia, a total of 26 subjects men and non-pregnant women were included and randomly allocated to receive 30 ml of...

    journal_title:Magnesium research

    pub_type: 杂志文章,随机对照试验

    doi:10.1684/mrh.2012.0322

    authors: Simental-Mendía LE,Rodríguez-Morán M,Reyes-Romero MA,Guerrero-Romero F

    更新日期:2012-07-01 00:00:00

  • Effects of Mg2+, pH and PCr on cardiac excitation-metabolic coupling.

    abstract::A tight coupling between ionic currents, intracellular Ca2+ homeostasis, cytosolic [ADP] and deltaG of ATP hydrolysis underlies the regulation of cardiac cell function. As more experimental detail on the biochemistry and biophysics of these complex processes and their interactions accumulates, the intuitive interpreta...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Michailova A,McCulloch AD

    更新日期:2008-03-01 00:00:00

  • Effect of a natural mineral-rich water on catechol-O-methyltransferase function.

    abstract::Catechol-O-methyltransferase (COMT) is a magnesium-dependent, catecholamine-metabolizing enzyme, whose impaired activity has been positively associated with cardiovascular diseases, particularly hypertension. Consumption of some natural mineral-rich waters has been shown to exert protective effects on cardiovascular r...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:10.1684/mrh.2014.0369

    authors: Bastos P,Araújo JR,Azevedo I,Martins MJ,Ribeiro L

    更新日期:2014-07-01 00:00:00

  • Antiarrhythmic effect of parenteral magnesium on ventricular tachycardia associated with long QT syndrome.

    abstract::Magnesium deficiency has been linked with cardiac arrhythmias and sudden cardiac death. Antiarrhythmic effects of intravenous magnesium in the patients who are not hypomagnesaemic were mainly demonstrated in the patients with acquired long QT syndrome. Parenteral administration should be considered in this type of ven...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Kurita T

    更新日期:1994-06-01 00:00:00

  • Association between low serum magnesium concentration and hyperuricemia.

    abstract:OBJECTIVES:To examine the cross-sectional associations between serum magnesium (Mg) and hyperuricemia (HU). METHODS:2904 subjects were included in this study. HU was defined as uric acid ≥416 μmol/L for the male population and ≥360 μmol/L for the female population. A multivariable logistic analysis model was applied t...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:10.1684/mrh.2015.0384

    authors: Zeng C,Wang YL,Wei J,Yang T,Li H,Xie DX,Li YS,Lei GH

    更新日期:2015-06-01 00:00:00

  • A review of biointeractions of Ni and Mg. I. Enzyme, endocrine, transport, and skeletal systems.

    abstract::Magnesium (Mg) and nickel (Ni) are biologically active elements in higher animals. Recent studies in vivo as well as in vitro point to interactions of Ni and Mg; non-immunological roles of these elements are reviewed here. Ni and Mg play roles in some of the same enzyme and endocrine systems, body and cell structures,...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Kenney MA,McCoy H

    更新日期:1992-09-01 00:00:00

  • Enhanced contractile response to noradrenaline and calcium influx in thoracic aorta isolated from dietary magnesium deficient rats.

    abstract::Dependency on extracellular calcium influx in contractile response to noradrenaline has been investigated in the thoracic aorta isolated from dietary magnesium (Mg) deficient rats. Adult male Wistar rats were fed with a Mg deficient diet (0.001% Mg) for 30 days, together with control groups (0.07% Mg). The contractile...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Nishio A,Ishiguro S,Shimonishi I,Hirota A

    更新日期:1989-09-01 00:00:00

  • Concentration, compartmentation and metabolic function of intracellular free Mg2+.

    abstract::Intracellular total Mg2+ and free Mg2+ are compartmentalized between cell organelles and within the cytosol. Different values of [Mg2+]i in the cytosol of the same cell type were measured by various investigators. A main reason for the differences is the uncertainty of the dissociation constants used for the Mg furapt...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Günther T

    更新日期:2006-12-01 00:00:00

  • Effect of magnesium supplementation containing mineral bishofit (MgCl2 x 6H2O) solution and pyridoxine hydrochloride on erythrocyte magnesium depletion and behaviour of rats after three-month alcoholization.

    abstract::In therapy it is known that the combination of vitamin B6 and magnesium is beneficial in the treatment of several forms of primary magnesium deficiency. The purpose of the present study was to investigate the effect of complex magnesium supplementation containing mineral bishofit solution (MgCl2 x 6H2O) and pyridoxine...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Iezhitsa IN,Onishchenko NV,Churbakova NV,Parshev VV,Petrov VI,Spasov AA

    更新日期:2002-12-01 00:00:00

  • Magnesium and the inflammatory response: potential pathophysiological implications in the management of patients with aneurysmal subarachnoid hemorrhage?

    abstract::Cerebral vasospasm and delayed cerebral ischemia remain an unsolved problem in patients with aneurysmal subarachnoid hemorrhage (SAH). In theory, high-dose magnesium sulfate (MgSO(4)) therapy offers vascular and neuroprotective benefits and is therefore currently under evaluation. The intensity of the inflammatory res...

    journal_title:Magnesium research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Muroi C,Burkhardt JK,Hugelshofer M,Seule M,Mishima K,Keller E

    更新日期:2012-07-01 00:00:00

  • Rumen epithelial cells adapt magnesium transport to high and low extracellular magnesium conditions.

    abstract::A protein of approximately 70-kDa was identified as a candidate Na+/Mg2+ exchanger in rumen epithelial cells (REC). Melastatin-related Transient Receptor Potential 7 (TRPM7) and Magnesium Transporter 1 (MagT1) transcripts and, from them, encoded proteins were also detected. The regulation of these Mg transport pathway...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Schweigel M,Kuzinski J,Deiner C,Kolisek M

    更新日期:2009-09-01 00:00:00

  • Effect of an aerobic training on magnesium, trace elements and antioxidant systems in a Down syndrome population.

    abstract::The aim of the present study was to determine the effect of an aerobic training on plasma and red blood cells' levels of magnesium, copper, selenium and zinc and on some oxidative stress parameters in a Down syndrome (DS) sample population. Sixteen young male adults with DS participated in the protocol. Among them, ei...

    journal_title:Magnesium research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Monteiro CP,Varela A,Pinto M,Neves J,Felisberto GM,Vaz C,Bicho MP,Laires MJ

    更新日期:1997-03-01 00:00:00

  • Magnesium content of human myometrium and placenta during various stages of gestation, and of different body fluids at term.

    abstract::Pregnancy is marked by a state of hypomagnesaemia but not much is known about the effects of maternal magnesium deprivation on the fetus. The aim of this study was therefore to measure magnesium concentrations in human myometrial and placental tissues and in different body fluids during pregnancy and at term, using at...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Lukácsi L,Lintner F,Gimes G,Zsolnai B,Somogyi J

    更新日期:1993-03-01 00:00:00

  • TRPM7 involvement in cancer: a potential prognostic factor.

    abstract::Calcium (Ca(2+)) and magnesium (Mg(2+)) are important metal elements that regulate a variety of cellular processes such as proliferation, migration, and apoptosis, in cancer cells. Among the ionic channels mediating intracellular entry, the transient receptor potential melastatin type 7 (TRPM7) channel is of particula...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:10.1684/mrh.2014.0367

    authors: Dhennin-Duthille I,Gautier M,Korichneva I,Ouadid-Ahidouch H

    更新日期:2014-07-01 00:00:00

  • The COVID-19 pandemic: is there a role for magnesium? Hypotheses and perspectives.

    abstract::More and more studies are accumulating about COVID-19. Some aspects of the pathogenesis of the disease recall events occurring in Mg deficiency, such as a drop of T cells, increased plasma concentration of inflammatory cytokines, and endothelial dysfunction. We hypothesize that a low Mg status, which is rather common,...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:10.1684/mrh.2020.0465

    authors: Iotti S,Wolf F,Mazur A,Maier JA

    更新日期:2020-05-01 00:00:00

  • Changes in the haemostatic profile during magnesium deficiency in swine.

    abstract::Epidemiological studies of populations living in areas of low magnesium (Mg) intake have consistently shown a higher cardiovascular morbidity. Several hypotheses have been advanced to explain the cardioprotective properties of magnesium. Few studies, however, have analysed the relation of magnesium to haemostasis. The...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Serebruany VL,Herzog WR,Edenbaum LR,Shustov AR,Gurbel PA

    更新日期:1996-10-01 00:00:00

  • Dietary inulin in mice stimulates Mg2+ absorption and modulates TRPM6 and TRPM7 expression in large intestine and kidney.

    abstract::Complex fermentable carbohydrates, such as inulin-type fructans have been shown to improve Mg2+ absorption in the hindgut and body stores. The mechanisms for this are not well understood. The newly identified transient receptor potential melastatin 6 and 7 (TRPM6 and TRPM7) channels have been shown to function in acti...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Rondón LJ,Rayssiguier Y,Mazur A

    更新日期:2008-12-01 00:00:00

  • Magnesium fluxes during lactation in the rat.

    abstract::Lactating rats fed a 0.055% Mg diet transferred 5.5 +/- SEM 0.3 mg per day of Mg into milk but remained in a slightly positive Mg balance by increasing both food consumption and fractional intestinal Mg absorption. Urinary Mg excretion increased continually during the course of lactation to values double those of non-...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Brommage R

    更新日期:1989-12-01 00:00:00

  • Comparison of the antinociceptive effect of systemic versus intrathecal magnesium sulphate on spinal morphine analgesia.

    abstract::The aim of this work was to compare the possible antinociceptive effect of the intravenous (IV) versus the intrathecal (IT) administration of magnesium sulphate prior to spinal morphine analgesia. This research was conducted in two sets: First; experimentally, to compare the antinociceptive effect of IT magnesium sulp...

    journal_title:Magnesium research

    pub_type: 杂志文章,随机对照试验

    doi:10.1684/mrh.2016.0396

    authors: Messeha MM,Boshra V

    更新日期:2016-03-01 00:00:00

  • Expression and functional activity of the Na/Mg exchanger, TRPM7 and MagT1 are changed to regulate Mg homeostasis and transport in rumen epithelial cells.

    abstract::The present study was performed to show the molecular identity of functionally characterized Mg transport pathways in rumen epithelial cells (REC) and to investigate the effects of extracellular [Mg] changes on their expression and activity. By using RT- PCR, Western blot, flow cytometry and immunocytochemistry, TRPM7...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Schweigel M,Kolisek M,Nikolic Z,Kuzinski J

    更新日期:2008-06-01 00:00:00

  • Magnesium and selected parameters of the non-enzymatic antioxidant and immune systems and oxidative stress intensity in the seminal plasma of fertile males.

    abstract:INTRODUCTION:The present study investigated associations between environmental exposure to magnesium (Mg) and the levels of oxidative stress parameters and selected cytokines, and the antioxidant defense system in the seminal plasma of fertile males. MATERIALS AND METHODS:The study population consisted of 57 healthy, ...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:10.1684/mrh.2015.0377

    authors: Kasperczyk A,Dobrakowski M,Zalejska-Fiolka J,Horak S,Birkner E

    更新日期:2015-01-01 00:00:00

  • Bone histomorphometry of ovariectomized or orchiectomized rats fed a moderately magnesium-deficient fructose diet and treated with exogenous oestrogen or testosterone.

    abstract::To investigate the effects of sex hormones on bone histomorphometry, and bone density (BMD), 10 week old ovariectomized (OVX), orchiectomized (ORX), and sham-operated (SHAM) rats fed a moderately magnesium-deficient fructose diet were studied. One third of the OVX and ORX rats were injected with beta-oestradiol-3-benz...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Koh ET,Yeh JK,Bourdeau JE,Chen MM,Om AS

    更新日期:1996-03-01 00:00:00