Preliminary communication on intralymphocyte ionized magnesium in hypertensive patients under treatment with beta-blockers.

Abstract:

:We measured free intralymphocyte magnesium (Mgi) in 10 hypertensive subjects (HS) before and after treatment with atenolol (A) and in 16 normotensive control subjects (NC). We also carried out in vitro studies on human lymphocytes to test the effect of catecholamines and beta-antagonists on Mgi. Mgi in HS was not statistically different before and after the treatment with A (M +/- SD, basal: 227 +/- 31 + mumol/l; A: 236 +/- 47 mumol/l; NS). Mgi in NC proved not statistically different as compared to HS without treatment (M +/- SD, NC: 232 +/- 35 mumol/l; HS before treatment: 227 +/- 31 mumol/l; NS). The Mgi of the lymphocytes treated in vitro with noradrenaline (NA) significantly decreased in comparison with the control (M +/- SD, basal: 244 +/- 26 mumol/l; NA: 198 +/- 25 mumol/l; p = 0.0001), whereas it did not change after incubation with NA and propranolol (P) (M +/- SD, basal: 238 +/- 32 mumol/l; NA + P: 239 +/- 30 mumol/l; NS). On the other hand Mgi decreased significantly after incubation with NA and A (M +/- SD, basal: 255 +/- 21 mumol/l; NA + A: 202 +/- 34 mumol/l). Our in vivo data show that the Mgi of HS remains unvaried after treatment with A, and that there is not statistical difference between Mgi of NC and of HS before treatment. The in vitro study demonstrated that catecholamines cause a significant reduction in Mgi. This effect is only inhibited by a non-selective beta-blocker such as P. These results seem to explain the ineffectiveness of treatment with atenolol on our patients' Mgi.

journal_name

Magnes Res

journal_title

Magnesium research

authors

Pastori C,Delva P,Degan M,Lechi A

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

49-55

issue

1

eissn

0953-1424

issn

1952-4021

journal_volume

12

pub_type

杂志文章
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    authors: Günzel D,Schlue WR

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  • Concentration, compartmentation and metabolic function of intracellular free Mg2+.

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    authors: Günther T

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  • Angiotensin converting enzyme inhibitors, thiazide diuretics and magnesium balance. A preliminary study.

    abstract::Serum and mononuclear cell magnesium content were determined in a cross-sectional study performed in four groups of hypertensive patients on chronic treatment with atenolol (n = 11), enalapril (n = 10), thiazide diuretics (n = 12), or enalapril + thiazides (n = 11). Our study shows that in patients treated with the th...

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    authors: Malini PL,Strocchi E,Valtancoli G,Ambrosioni E

    更新日期:1990-09-01 00:00:00

  • Effects of monovalent cations, pH and temperature on the dissociation constant (KD) for the fluorescent indicator mag-fura-2 at different excitation wavelengths.

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    authors: Howarth FC,Singh J,Waring JJ,Hustler BI,Bailey M

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  • Effect of an aerobic training on magnesium, trace elements and antioxidant systems in a Down syndrome population.

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    authors: Monteiro CP,Varela A,Pinto M,Neves J,Felisberto GM,Vaz C,Bicho MP,Laires MJ

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  • Histamine metabolism and pinnal hyperaemia during magnesium deficiency in rats.

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    authors: Nishio A,Ishiguro S,Ikegaki I,Matsumoto S,Yoshimitsu F,Miyazaki A

    更新日期:1988-12-01 00:00:00

  • Magnesium and thermoregulation. I. Newborn and infant. Is sudden infant death syndrome a magnesium-dependent disease of the transition from chemical to physical thermoregulation?

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    pub_type: 杂志文章,评审

    doi:

    authors: Durlach J,Durlach V,Rayssiguier Y,Ricquier D,Goubern M,Bertin R,Bara M,Guiet-Bara A,Olive G,Mettey R

    更新日期:1991-09-01 00:00:00

  • Magnesium, adenosine triphosphate, and catecholamine complexes: application of new means of identifying solute-solute interactions of biological significance using NMR chemical shift data.

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    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Hughes MS,Crow DR,Birch NJ

    更新日期:1992-06-01 00:00:00

  • The effects of magnesium supplementation on subjective anxiety.

    abstract::Experimental studies of anxiety in animal models, and evidence of efficacious outcomes of magnesium (Mg) supplementation in the treatment of acute clinical affective disorders, has increased interest in Mg as a potential novel treatment for symptoms of mild/moderate subjective anxiety. This short review examines the e...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:10.1684/mrh.2016.0411

    authors: Boyle NB,Lawton CL,Dye L

    更新日期:2016-03-01 00:00:00

  • Magnesium fluxes during lactation in the rat.

    abstract::Lactating rats fed a 0.055% Mg diet transferred 5.5 +/- SEM 0.3 mg per day of Mg into milk but remained in a slightly positive Mg balance by increasing both food consumption and fractional intestinal Mg absorption. Urinary Mg excretion increased continually during the course of lactation to values double those of non-...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Brommage R

    更新日期:1989-12-01 00:00:00

  • Magnesium deficiency reduces fear-induced conditional lick suppression in mice.

    abstract::The consequences of broad-scale alterations in magnesium (Mg2+) levels on learning and memory are poorly understood. We have recently demonstrated that adult male mice maintained on an Mg2+-deficient diet exhibit reduced conditional freezing behavior. The purpose of the present study was to determine if the detrimenta...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

    authors: Bardgett ME,Schultheis PJ,Muzny A,Riddle MD,Wagge JR

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  • Magnesium supplements may enhance the effect of antihypertensive medications in stage 1 hypertensive subjects.

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    doi:10.1684/mrh.2010.0198

    authors: Rosanoff A

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  • Influence of graded magnesium deficiencies on white blood cell counts and lymphocyte subpopulations in rats.

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    journal_title:Magnesium research

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    authors: Van Orden R,Eggett DL,Franz KB

    更新日期:2006-06-01 00:00:00

  • Comparison of the antinociceptive effect of systemic versus intrathecal magnesium sulphate on spinal morphine analgesia.

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    journal_title:Magnesium research

    pub_type: 杂志文章,随机对照试验

    doi:10.1684/mrh.2016.0396

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  • The influence of magnesium supplementation on magnesium and calcium concentrations in hair of children with magnesium shortage.

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    authors: Kozielec T,Sałacka A,Radomska K,Strecker D,Durska G

    更新日期:2001-03-01 00:00:00

  • Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. I. Attention deficit hyperactivity disorders.

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    authors: Mousain-Bosc M,Roche M,Polge A,Pradal-Prat D,Rapin J,Bali JP

    更新日期:2006-03-01 00:00:00

  • The COVID-19 pandemic: is there a role for magnesium? Hypotheses and perspectives.

    abstract::More and more studies are accumulating about COVID-19. Some aspects of the pathogenesis of the disease recall events occurring in Mg deficiency, such as a drop of T cells, increased plasma concentration of inflammatory cytokines, and endothelial dysfunction. We hypothesize that a low Mg status, which is rather common,...

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    doi:10.1684/mrh.2020.0465

    authors: Iotti S,Wolf F,Mazur A,Maier JA

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  • Effects of Mg2+, pH and PCr on cardiac excitation-metabolic coupling.

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    journal_title:Magnesium research

    pub_type: 杂志文章

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    authors: Michailova A,McCulloch AD

    更新日期:2008-03-01 00:00:00

  • Protein peroxidation, magnesium deficiency and fibromyalgia.

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    authors: Eisinger J,Zakarian H,Pouly E,Plantamura A,Ayavou T

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  • Antiarrhythmic effect of parenteral magnesium on ventricular tachycardia associated with long QT syndrome.

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    pub_type: 杂志文章,评审

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    authors: Kurita T

    更新日期:1994-06-01 00:00:00

  • No positive effect of oral magnesium supplementation in the decreases of inflammation in subjects with prediabetes: a pilot study.

    abstract::To determine whether oral magnesium supplementation modifies serum levels of high-sensitivity C-reactive protein (hsCRP), TNF-alpha, IL-6, and IL-10 in subjects with prediabetes, inflammation, and hypomagnesemia, a total of 26 subjects men and non-pregnant women were included and randomly allocated to receive 30 ml of...

    journal_title:Magnesium research

    pub_type: 杂志文章,随机对照试验

    doi:10.1684/mrh.2012.0322

    authors: Simental-Mendía LE,Rodríguez-Morán M,Reyes-Romero MA,Guerrero-Romero F

    更新日期:2012-07-01 00:00:00

  • Magnesium and strength in elite judo athletes according to intracellular water changes.

    abstract::Magnesium (Mg) deficiency strongly affects muscle performance. In judo, many athletes often undergo impressive weight changes associated with severe dehydration. Common practices used by athletes to achieve a target weight can lead to Mg deficit. This study aimed to understand the impact of Mg changes on strength from...

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    doi:10.1684/mrh.2010.0217

    authors: Matias CN,Santos DA,Monteiro CP,Silva AM,Raposo Mde F,Martins F,Sardinha LB,Bicho M,Laires MJ

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  • Therapeutic effect of parenteral magnesium on noise-induced hearing loss in the guinea pig.

    abstract::We have recently demonstrated in the guinea pig that preventive dietary magnesium supplement can significantly reduce impulse noise induced hearing loss by on average 18 dB. The purpose of the present study was to examine whether magnesium might also have a therapeutic effect on noise trauma. Anesthetized guinea pigs ...

    journal_title:Magnesium research

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    doi:

    authors: Scheibe F,Haupt H,Ising H,Cherny L

    更新日期:2002-03-01 00:00:00

  • The relationship between magnesium and calciotropic hormones.

    abstract::There is an important functional link between magnesium and calciotropic hormones. PTH stimulates magnesium reabsorption in the renal tubule, absorption in the gut and release of the ion from bone. Magnesium on the other hand is essential for the normal function of the parathyroid glands, metabolism of vitamin D and a...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Zofková I,Kancheva RL

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  • Is magnesium content in erythrocytes suitable for evaluating cation retention after oral physiological supplementation in marginally magnesium-deficient subjects?

    abstract::In this study, the effects of oral magnesium supplementation were evaluated on plasma, erythrocyte, and urinary cation levels. The study was carried out with an open, cross-over and randomized design. Healthy subjects received two sachets per day of magnesium (366 mg Mg2+/d) for two 28 d cycles, separated by a 3-week ...

    journal_title:Magnesium research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Borella P,Ambrosini G,Concari M,Bargellini A

    更新日期:1993-06-01 00:00:00

  • Acute myocardial infarction severity, complications, and mortality associated with lack of magnesium intake through consumption of desalinated seawater.

    abstract::Drinking water (DW) is an important dietary source of magnesium. Israel has recently increased desalinated seawater (DSW) production for DW, but negligible magnesium content in DSW may pose a risk of hypomagnesemia and consequential adverse cardiovascular effects. Consecutive acute myocardial infarction (AMI) patients...

    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:10.1684/mrh.2019.0449

    authors: Shlezinger M,Amitai Y,Goldenberg I,Atar S,Shechter M

    更新日期:2019-05-01 00:00:00

  • Magnesium and ageing. II. Clinical data: aetiological mechanisms and pathophysiological consequences of magnesium deficit in the elderly.

    abstract::Ageing constitutes a risk factor for magnesium deficit. Primary magnesium deficit originates from two aetiological mechanisms: deficiency and depletion. Primary magnesium deficiency is due to insufficient magnesium intake. Dietary amounts of magnesium are marginal in the whole population whatever the age. Nutritional ...

    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Durlach J,Durlach V,Bac P,Rayssiguier Y,Bara M,Guiet-Bara A

    更新日期:1993-12-01 00:00:00

  • Magnesium and phase angle: a prognostic tool for monitoring cellular integrity in judo athletes.

    abstract::Adequate magnesium (Mg) levels play a vital role in membrane excitability, cell contractility and metabolism, being a key nutrient for sustaining appropriate muscular contraction and performance levels in athletes. Phase angle (PhA), assessed by bioimpedance analysis (BIA), has been reported to be positively associate...

    journal_title:Magnesium research

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    doi:10.1684/mrh.2015.0389

    authors: Matias CN,Monteiro CP,Santos DA,Martins F,Silva AM,Laires MJ,Sardinha LB

    更新日期:2015-07-01 00:00:00

  • Association between low serum magnesium concentration and hyperuricemia.

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    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:10.1684/mrh.2015.0384

    authors: Zeng C,Wang YL,Wei J,Yang T,Li H,Xie DX,Li YS,Lei GH

    更新日期:2015-06-01 00:00:00

  • Ageing, hippocampal synaptic activity and magnesium.

    abstract::Ageing is associated with a general decline in physiological functions. Amongst the different aspects of body deterioration, cognitive impairments, and particularly defects in learning and memory, represent one of the most frequent features in the elderly. However, a great variability exists among aged subjects. Clini...

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    pub_type: 杂志文章,评审

    doi:

    authors: Billard JM

    更新日期:2006-09-01 00:00:00