FAST-Mag protocol with or without mild hypothermia (35°C) does not improve outcome after permanent MCAO in rats.

Abstract:

:The current study assessed the neuroprotective efficacy of magnesium using a FAST-Mag trial treatment protocol alone, and in combination with mild hypothermia, in Sprague Dawley rats subjected to permanent, middle cerebral artery occlusion (MCAO). Treatment with magnesium (MgSO4.7H2O) consisted of an intravenous loading dose (LD: 360 μmol/kg) and a 24 hour infusion (120 μmol/kg/h), while mild hypothermia at 35°C was maintained for 24 hours. Treatment groups consisted of animals receiving: i) saline; ii) magnesium LD/infusion at 1.5 h/2.5 h post-MCAO; iii) magnesium LD/infusion at 1.5 h/2.5 h post-MCAO and hypothermia commencing at 2.5 h post-MCAO; iv) magnesium LD and hypothermia at 1.5 h and magnesium infusion at 2.5 h post-MCAO; v) hypothermia commencing at 1.5 h post-MCAO and magnesium LD/infusion at 2.5 h post-MCAO; and vi/vii) hypothermia commencing at 1.5 h or 2.5 h post-MCAO. No treatment significantly reduced infarct volumes or improved adhesive tape removal time when measured 48 hours after MCAO. These findings indicate that FAST-Mag treatment alone or with mild hypothermia may not provide benefit after ischemic stroke, associated with permanent cerebral artery occlusion.

journal_name

Magnes Res

journal_title

Magnesium research

authors

Meloni BP,Cross JL,Brookes LM,Clark VW,Campbell K,Knuckey NW

doi

10.1684/mrh.2013.0340

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

67-73

issue

2

eissn

0953-1424

issn

1952-4021

pii

mrh.2013.0340

journal_volume

26

pub_type

杂志文章
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    authors: Scheibe F,Haupt H,Ising H,Cherny L

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    authors: Schweigel M,Kuzinski J,Deiner C,Kolisek M

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    authors: Pages N,Bac P,Maurois P,Durlach J,Agrapart C

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    authors: Bardgett ME,Schultheis PJ,Muzny A,Riddle MD,Wagge JR

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    doi:

    authors: Kozielec T,Sałacka A,Radomska K,Strecker D,Durska G

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    doi:

    authors: Nishio A,Ishiguro S,Ikegaki I,Matsumoto S,Yoshimitsu F,Miyazaki A

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  • Long-term follow-up after acute myocardial infarction in patients randomized to treatment with intravenous magnesium or intravenous propranolol in the acute phase.

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Abraham AS,Balkin J,Rosenmann D,Ilan M,Klutstein M,Zion MM

    更新日期:1994-12-01 00:00:00

  • Are age-related neurodegenerative diseases linked with various types of magnesium depletion?

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    doi:

    authors: Durlach J,Bac P,Durlach V,Durlach A,Bara M,Guiet-Bara A

    更新日期:1997-12-01 00:00:00

  • Preliminary communication on intralymphocyte ionized magnesium in hypertensive patients under treatment with beta-blockers.

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    journal_title:Magnesium research

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    doi:

    authors: Pastori C,Delva P,Degan M,Lechi A

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    journal_title:Magnesium research

    pub_type: 杂志文章

    doi:

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    更新日期:2008-03-01 00:00:00

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    journal_title:Magnesium research

    pub_type: 杂志文章,评审

    doi:

    authors: Berkowitz GA,Wu W

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  • Magnesium therapy for nephrolithiasis.

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    journal_title:Magnesium research

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    journal_title:Magnesium research

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    authors: Paczosa-Bator B,Stepien M,Maj-Zurawska M,Lewenstam A

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    pub_type: 杂志文章

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    authors: Lukácsi L,Lintner F,Gimes G,Zsolnai B,Somogyi J

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  • Effects of oral magnesium supplementation on plasma lipid concentrations in patients with non-insulin-dependent diabetes mellitus.

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    pub_type: 临床试验,杂志文章

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    authors: Corica F,Allegra A,Di Benedetto A,Giacobbe MS,Romano G,Cucinotta D,Buemi M,Ceruso D

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Borella P,Ambrosini G,Concari M,Bargellini A

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  • Magnesium, adenosine triphosphate, and catecholamine complexes: application of new means of identifying solute-solute interactions of biological significance using NMR chemical shift data.

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    journal_title:Magnesium research

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    authors: Hughes MS,Crow DR,Birch NJ

    更新日期:1992-06-01 00:00:00

  • Magnesium deficiency-induced anorexia in hyperphagic obese Zucker rats.

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    journal_title:Magnesium research

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    authors: Rattanatayarom W,Dorfmeister C,Classen UG,Schimatschek HF,Stein U,Classen HG

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    journal_title:Magnesium research

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    journal_title:Magnesium research

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    doi:

    authors: Howarth FC,Singh J,Waring JJ,Hustler BI,Bailey M

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  • Experimental magnesium depletion in adult rabbits caused by blast overpressure.

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    journal_title:Magnesium research

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    doi:

    authors: Cernak I,Radosevic P,Malicevic Z,Savic J

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  • Triamterene may preserve lymphocyte magnesium and potassium in patients with congestive heart failure.

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Schwinger RH,Antoni DH

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  • Antiarrhythmic effect of parenteral magnesium on ventricular tachycardia associated with long QT syndrome.

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    pub_type: 杂志文章,评审

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    authors: Kurita T

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    doi:10.1684/mrh.2010.0198

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    doi:

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    doi:10.1684/mrh.2015.0389

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  • Angiotensin converting enzyme inhibitors, thiazide diuretics and magnesium balance. A preliminary study.

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    doi:

    authors: Malini PL,Strocchi E,Valtancoli G,Ambrosioni E

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    pub_type: 杂志文章

    doi:

    authors: Koh ET,Yeh JK,Bourdeau JE,Chen MM,Om AS

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