Plasticity in the mediodorsal thalamo-prefrontal cortical transmission in behaving mice.

Abstract:

:We studied changes in thalamo-prefrontal cortical transmission in behaving mice following both low-frequency stimulation of the mediodorsal thalamus (MD) and during extinction of a conditioned fear response. Electrical stimulation of the MD induces a field potential in the medial prefrontal cortex (mPFC) characterized by two initial negative-positive complexes (N1-P1 and N2-P2) followed by two positive-negative complexes (P2-N3 and P3-N4). The N1-P1 and N2-P2 complexes were identified as resulting from orthodromic and antidromic prefrontal activation, respectively. Because the two complexes were not often easily dissociated, plasticity in the prefrontal synaptic transmission was considered to result from changes in N1-P2 amplitude. Low-frequency thalamic stimulation (1, 200 pulses at 2 Hz) produced either long-term (at least 32 min) depression or potentiation of the N1-P2 amplitude. Mice submitted to fear conditioning (tone-shock association), displayed on the first day of extinction (tone-alone presentations) a strong freezing behavior, which decreased progressively, but was still high the following day. Extinction of conditioned fear was accompanied the first day by a depression of prefrontal transmission, which was converted into potentiation the following day. Potentiation of prefrontal transmission lasted at least 24 h following the second day of the fear extinction procedure. In conclusion, low-frequency thalamic stimulation can produce, in behaving mice, either depression or potentiation of prefrontal synaptic transmission. Decrease in prefrontal synaptic transmission observed during the first day of extinction may reflect processing of the high degree of predictiveness of danger (unconditioned stimulus: US) by the aversive conditioned stimulus (CS). However, the subsequent potentiation of transmission in the mPFC may be related to processing of cognitive information such as the CS will no longer be followed by the US, even if emotional response (freezing) to the CS is still high.

journal_name

J Neurophysiol

authors

Herry C,Vouimba RM,Garcia R

doi

10.1152/jn.1999.82.5.2827

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

2827-32

issue

5

eissn

0022-3077

issn

1522-1598

journal_volume

82

pub_type

杂志文章
  • Cerebellar control of saccade dynamics: contribution of the fastigial oculomotor region.

    abstract::The fastigial oculomotor region is the output by which the medioposterior cerebellum influences the generation of saccades. Recent inactivation studies reported observations suggesting an involvement in their dynamics (velocity and duration). In this work, we tested this hypothesis in the head-restrained monkey with t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01021.2014

    authors: Quinet J,Goffart L

    更新日期:2015-05-01 00:00:00

  • Hemispheric differences in the relationship between corticomotor excitability changes following a fine-motor task and motor learning.

    abstract::Motor performance induces a postexercise increase in corticomotor excitability that may be associated with motor learning. We investigated whether there are hemispheric differences in the extent and/or time course of changes in corticomotor excitability following a manipulation task (Purdue pegboard) and their relatio...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00595.2003

    authors: Garry MI,Kamen G,Nordstrom MA

    更新日期:2004-04-01 00:00:00

  • Slow covariations in neuronal resting potentials can lead to artefactually fast cross-correlations in their spike trains.

    abstract::Slow covariations in neuronal resting potentials can lead to artefactually fast cross-correlations in their spike trains. J. Neurophysiol. 80: 3345-3351, 1998. A model of two lateral geniculate nucleus (LGN) cells, which interact only through slow (tens of seconds) covariations in their resting membrane potentials, is...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.6.3345

    authors: Brody CD

    更新日期:1998-12-01 00:00:00

  • Augmented supraorbital skin sympathetic nerve activity responses to symptom trigger events in rosacea patients.

    abstract::Facial flushing in rosacea is often induced by trigger events. However, trigger causation mechanisms are currently unclear. This study tested the central hypothesis that rosacea causes sympathetic and axon reflex-mediated alterations resulting in trigger-induced symptomatology. Twenty rosacea patients and age/sex-matc...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00458.2015

    authors: Metzler-Wilson K,Toma K,Sammons DL,Mann S,Jurovcik AJ,Demidova O,Wilson TE

    更新日期:2015-09-01 00:00:00

  • Tactile detection of slip: surface microgeometry and peripheral neural codes.

    abstract::1. The role of the microgeometry of planar surfaces in the detection of sliding of the surfaces on human and monkey fingerpads was investigated. By the use of a servo-controlled tactile stimulator to press and stroke glass plates on passive fingerpads of human subjects, the ability of humans to discriminate the direct...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1990.63.6.1323

    authors: Srinivasan MA,Whitehouse JM,LaMotte RH

    更新日期:1990-06-01 00:00:00

  • Pathophysiology of affective disorders: functional interaction of stress hormones and hippocampal excitation.

    abstract::An important new study by Kvarta, Bradbrook, Dantrassy, Bailey, and Thompson (J Neurophysiol 114: 1713-1724, 2015) examined the effects of persistent stress and excessive glucocorticoid levels on hippocampal function and emotional behavior in rodents. The authors specifically implicate the temporoammonic pathway as be...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.01065.2015

    authors: McGinn MA,Pahng AR

    更新日期:2017-02-01 00:00:00

  • Multiple T-type Ca2+ current subtypes in electrophysiologically characterized hamster dorsal horn neurons: possible role in spinal sensory integration.

    abstract::Whole cell patch-clamp recordings were used to investigate the contribution of transient, low-threshold calcium currents (I(T)) to firing properties of hamster spinal dorsal horn neurons. I(T) was widely, though not uniformly, expressed by cells in Rexed's laminae I-IV and correlated with the pattern of action potenti...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01083.2010

    authors: Ku WH,Schneider SP

    更新日期:2011-11-01 00:00:00

  • Injection of nicotine into the superior colliculus facilitates occurrence of express saccades in monkeys.

    abstract::To clarify the role of cholinergic inputs to the intermediate layer of the superior colliculus (SC), we examined the effect of microinjection of nicotine into the SC on visually guided saccades in macaque monkeys. After injection of 0.4-2 microl of 1-100 mM nicotine into the SC, frequency of extremely short latency sa...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.82.3.1642

    authors: Aizawa H,Kobayashi Y,Yamamoto M,Isa T

    更新日期:1999-09-01 00:00:00

  • Synaptic physiology and mitochondrial function in crayfish tonic and phasic motor neurons.

    abstract::Phasic and tonic motor neurons of crustaceans differ strikingly in their junctional synaptic physiology. Tonic neurons generally produce small excitatory postsynaptic potentials (EPSPs) that facilitate strongly as stimulation frequency is increased, and normally show no synaptic depression. In contrast, phasic neurons...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.1.281

    authors: Nguyen PV,Marin L,Atwood HL

    更新日期:1997-07-01 00:00:00

  • Basolateral amygdala neurons are activated during threat expectation.

    abstract::Fear conditioning studies have led to the view that the amygdala contains neurons that signal threat and in turn elicit defensive behaviors through their brain stem and hypothalamic targets. In agreement with this model, a prior unit-recording study in rats performing a seminaturalistic foraging task revealed that man...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00807.2018

    authors: Amir A,Kyriazi P,Lee SC,Headley DB,Paré D

    更新日期:2019-05-01 00:00:00

  • Cellular mechanisms underlying spontaneous firing in rat suprachiasmatic nucleus: involvement of a slowly inactivating component of sodium current.

    abstract::Neurons constituting the pacemaker of circadian rhythms, located in the suprachiasmatic nucleus, generate spontaneous firing patterns that change across the day-night cycle. Their average spontaneous firing rate is considered an important functional marker of clock activity because it is highest during daytime and low...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.4.1811

    authors: Pennartz CM,Bierlaagh MA,Geurtsen AM

    更新日期:1997-10-01 00:00:00

  • Motor control hierarchy in joint action that involves bimanual force production.

    abstract::The concept of hierarchical motor control has been viewed as a means of progressively decreasing the number of variables manipulated by each higher control level. We tested the hypothesis that turning an individual bimanual force-production task into a joint (two-participant) force-production task would lead to positi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00313.2015

    authors: Masumoto J,Inui N

    更新日期:2015-06-01 00:00:00

  • Orienting gaze shifts during muscimol inactivation of caudal fastigial nucleus in the cat. I. Gaze dysmetria.

    abstract::The cerebellar control of orienting behavior toward visual targets was studied in the head-unrestrained cat by analyzing the deficits of saccadic gaze shifts after unilateral injection of muscimol in the caudal part of the fastigial nucleus (cFN). Gaze shifts are rendered strongly inaccurate by muscimol cFN inactivati...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.4.1942

    authors: Goffart L,Pélisson D

    更新日期:1998-04-01 00:00:00

  • Anatomy of motor learning. II. Subcortical structures and learning by trial and error.

    abstract::We used positron emission tomography to study motor learning by trial and error. Subjects learned sequences of eight finger movements. Tones generated by a computer told the subjects whether any particular move was correct or incorrect. A control condition was used in which the subjects generated moves, but there was ...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1152/jn.1997.77.3.1325

    authors: Jueptner M,Frith CD,Brooks DJ,Frackowiak RS,Passingham RE

    更新日期:1997-03-01 00:00:00

  • The neural bases of different levels of action understanding.

    abstract::Many have recently questioned whether all levels of actions understanding, from lower kinematic levels to the higher goal or intention levels of action understanding, are processed in the action observation network (a network of neurons that are active during action execution and observation). A recent study by Wurm a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00819.2015

    authors: Marneweck M,Vallence AM

    更新日期:2016-03-01 00:00:00

  • Mechanisms of depolarizing inhibition at the crayfish giant motor synapse. I. Electrophysiology.

    abstract::1. Mechanisms of depolarizing synaptic inhibition were investigated at the crayfish giant motor synapse with the use of two-electrode current- and voltage-clamp techniques. Depolarizing inhibitory postsynaptic potentials (d-IPSPs) of between 5 and 15 mV in amplitude are produced there in the motor giant motoneuron (Mo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1990.64.2.532

    authors: Edwards DH

    更新日期:1990-08-01 00:00:00

  • Spinal cord coordination of hindlimb movements in the turtle: intralimb temporal relationships during scratching and swimming.

    abstract::Spinal cord neuronal circuits generate motor neuron activity patterns responsible for rhythmic hindlimb behaviors such as scratching and swimming. Kinematic analyses of limb movements generated by this motor neuron output reveal important characteristics of these behaviors. Intralimb kinematics of the turtle hindlimb ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.3.1394

    authors: Field EC,Stein PS

    更新日期:1997-09-01 00:00:00

  • A quantitative study of neuronal discharge in areas 5, 2, and 4 of the monkey during fast arm movements.

    abstract::1. The properties of parietal neurons were studied in four adult rhesus monkeys during fast arm movements. The animals were trained to perform flexion or extension of the forearm about the elbow in response to specific auditory cues. Single neuron activity was recorded in 272 area 5 neurons, 81 neurons of the somatose...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.66.2.429

    authors: Burbaud P,Doegle C,Gross C,Bioulac B

    更新日期:1991-08-01 00:00:00

  • Temporal resolution in olfaction II: time course of recovery from adaptation in lobster chemoreceptor cells.

    abstract::1. Adaptation and disadaptation rates determine the temporal response properties of sensory receptor cells. In chemoreception, temporal filter properties of receptor cells are poorly understood. We studied the time course of disadaptation in lobster antennular chemoreceptor cells by using in situ high-resolution stimu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.2.1340

    authors: Gomez G,Atema J

    更新日期:1996-08-01 00:00:00

  • Silent synapses in developing cerebellar granule neurons.

    abstract::Silent synapses are excitatory synapses endowed exclusively with N-methyl-D-aspartate (NMDA) responses that have been proposed to acquire alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) responses during development and after long-term potentiation (LTP). These synapses are functionally silent because o...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00633.2001

    authors: Losi G,Prybylowski K,Fu Z,Luo JH,Vicini S

    更新日期:2002-03-01 00:00:00

  • Premotor neurons B51 and B52 in the buccal ganglia of Aplysia californica: synaptic connections, effects on ongoing motor rhythms, and peptide modulation.

    abstract::1. Two buccal ganglia interneurons, labeled here as B51 and B52, have been identified on the basis of morphological and physiological criteria. 2. These neurons have multipolar cell bodies. B51 extends a major neurite, which arborizes in the neuropil ipsilateral to the soma; extends into the buccal commissure, where i...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1990.63.3.539

    authors: Plummer MR,Kirk MD

    更新日期:1990-03-01 00:00:00

  • Ventral pallidum firing codes hedonic reward: when a bad taste turns good.

    abstract::The ventral pallidum (VP) is a key structure in brain mesocorticolimbic reward circuits that mediate "liking" reactions to sensory pleasures. Do firing patterns in VP actually code sensory pleasure? Strong evidence for hedonic coding requires showing that neural signals track positive increases in sensory pleasure or ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00576.2006

    authors: Tindell AJ,Smith KS,Peciña S,Berridge KC,Aldridge JW

    更新日期:2006-11-01 00:00:00

  • Analysis of postural motoneuron activity in crayfish abdomen. I. Coordination by premotoneuron connections.

    abstract::The activity of the crayfish abdominal postural motoneurons and their associated neurons (the accessory neuron(s) and the MRO(1)) were examined with the aid of techniques for the analysis of simultaneously recorded spike trains. A means of reliably identifying the spikes of the individual motoneurons based on their re...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1975.38.2.313

    authors: Sokolove PG,Tatton WG

    更新日期:1975-03-01 00:00:00

  • Transformation in the neural code for whisker deflection direction along the lemniscal pathway.

    abstract::A prominent characteristic of neurons in the whisker system is their selectivity to the direction in which a whisker is deflected. The aim of this study was to determine how information about whisker direction is encoded at successive levels of the lemniscal pathway. We made extracellular recordings under identical co...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00636.2009

    authors: Bale MR,Petersen RS

    更新日期:2009-11-01 00:00:00

  • Distinct α- and β-band rhythms over rat somatosensory cortex with similar properties as in humans.

    abstract::We demonstrate distinct α- (7-14 Hz) and β-band (15-30 Hz) rhythms in rat somatosensory cortex in vivo using epidural electrocorticography recordings. Moreover, we show in rats that a genuine β-rhythm coexists alongside β-activity that reflects the second harmonic of the arch-shaped somatosensory α-rhythm. This demons...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00507.2015

    authors: Fransen AM,Dimitriadis G,van Ede F,Maris E

    更新日期:2016-06-01 00:00:00

  • Phasic and tonic cell types in the zebra finch auditory caudal mesopallium.

    abstract::The caudal mesopallium (CM) is a cortical-level area in the songbird auditory pathway where selective, invariant responses to familiar songs emerge. To characterize the cell types that perform this computation, we made whole cell recordings from brain slices in juvenile zebra finches ( Taeniopygia guttata) of both sex...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00694.2017

    authors: Chen AN,Meliza CD

    更新日期:2018-03-01 00:00:00

  • Local and propagated dendritic action potentials evoked by glutamate iontophoresis on rat neocortical pyramidal neurons.

    abstract::Iontophoresis of glutamate at sites on the apical dendrite 278-555 microm from the somata of rat neocortical pyramidal neurons evoked low-threshold, small, slow spikes and/or large, fast spikes in 71% of recorded cells. The amplitude of the small, slow spikes recorded at the soma averaged 9.1 mV, and their apparent th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.77.5.2466

    authors: Schwindt PC,Crill WE

    更新日期:1997-05-01 00:00:00

  • Distribution of functional glutamate and GABA receptors on hippocampal pyramidal cells and interneurons.

    abstract::The distribution of functional neurotransmitter receptors is an important determinant of neuronal information processing. To map the location of functional glutamate and GABA receptors on individual hippocampal neurons, we photolyzed "caged" glutamate and GABA while measuring the electrical currents resulting from act...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.84.1.28

    authors: Pettit DL,Augustine GJ

    更新日期:2000-07-01 00:00:00

  • Correlation of fingertip shear force direction with somatosensory cortical activity in monkey.

    abstract::To examine the activity of somatosensory cortex (S1) neurons to self-generated shear forces on the index and thumb, two monkeys were trained to grasp a stationary metal tab with a key grip and exert forces without the fingers slipping in one of four orthogonal directions for 1 s. A majority (∼85%) of slowly adapting a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00749.2014

    authors: Fortier-Poisson P,Langlais JS,Smith AM

    更新日期:2016-01-01 00:00:00

  • Ca2+-induced Ca2+ release in Aplysia bag cell neurons requires interaction between mitochondrial and endoplasmic reticulum stores.

    abstract::Intracellular Ca2+ is influenced by both Ca2+ influx and release. We examined intracellular Ca2+ following action potential firing in the bag cell neurons of Aplysia californica. Following brief synaptic input, these neuroendocrine cells undergo an afterdischarge, resulting in elevated Ca2+ and the secretion of neurop...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90356.2008

    authors: Geiger JE,Magoski NS

    更新日期:2008-07-01 00:00:00