Abstract:
:To clarify the role of cholinergic inputs to the intermediate layer of the superior colliculus (SC), we examined the effect of microinjection of nicotine into the SC on visually guided saccades in macaque monkeys. After injection of 0.4-2 microl of 1-100 mM nicotine into the SC, frequency of extremely short latency saccades (express saccades; reaction time = 70-120 ms) dramatically increased, for the saccades the direction and amplitude of which were represented at the location of the injection site on the collicular map. However, no marked change was observed for the relationship between the peak velocities and the amplitudes of saccades. These results suggested that activation of nicotinic acetylcholine receptors in the SC can facilitate initiation but causes no major change in dynamics of visually guided saccades.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Aizawa H,Kobayashi Y,Yamamoto M,Isa Tdoi
10.1152/jn.1999.82.3.1642subject
Has Abstractpub_date
1999-09-01 00:00:00pages
1642-6issue
3eissn
0022-3077issn
1522-1598journal_volume
82pub_type
杂志文章abstract::Nicotine evokes pain in the skin and oral mucosa and excites a subpopulation of cutaneous nociceptors, but little is known about the central transmission of chemogenic pain. We have investigated the responses of lumbar spinal wide dynamic range (WDR)-type dorsal horn neurons to intracutaneous (ic) microinjection of ni...
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