Injection of nicotine into the superior colliculus facilitates occurrence of express saccades in monkeys.

Abstract:

:To clarify the role of cholinergic inputs to the intermediate layer of the superior colliculus (SC), we examined the effect of microinjection of nicotine into the SC on visually guided saccades in macaque monkeys. After injection of 0.4-2 microl of 1-100 mM nicotine into the SC, frequency of extremely short latency saccades (express saccades; reaction time = 70-120 ms) dramatically increased, for the saccades the direction and amplitude of which were represented at the location of the injection site on the collicular map. However, no marked change was observed for the relationship between the peak velocities and the amplitudes of saccades. These results suggested that activation of nicotinic acetylcholine receptors in the SC can facilitate initiation but causes no major change in dynamics of visually guided saccades.

journal_name

J Neurophysiol

authors

Aizawa H,Kobayashi Y,Yamamoto M,Isa T

doi

10.1152/jn.1999.82.3.1642

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

1642-6

issue

3

eissn

0022-3077

issn

1522-1598

journal_volume

82

pub_type

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