Pathophysiology of affective disorders: functional interaction of stress hormones and hippocampal excitation.

Abstract:

:An important new study by Kvarta, Bradbrook, Dantrassy, Bailey, and Thompson (J Neurophysiol 114: 1713-1724, 2015) examined the effects of persistent stress and excessive glucocorticoid levels on hippocampal function and emotional behavior in rodents. The authors specifically implicate the temporoammonic pathway as being susceptible to reductions in excitatory function in the context of chronic stress. We discuss the importance of this new finding in the broader context of medication development for major depressive disorder.

journal_name

J Neurophysiol

authors

McGinn MA,Pahng AR

doi

10.1152/jn.01065.2015

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

477-479

issue

2

eissn

0022-3077

issn

1522-1598

pii

jn.01065.2015

journal_volume

117

pub_type

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