Pathophysiology of affective disorders: functional interaction of stress hormones and hippocampal excitation.


:An important new study by Kvarta, Bradbrook, Dantrassy, Bailey, and Thompson (J Neurophysiol 114: 1713-1724, 2015) examined the effects of persistent stress and excessive glucocorticoid levels on hippocampal function and emotional behavior in rodents. The authors specifically implicate the temporoammonic pathway as being susceptible to reductions in excitatory function in the context of chronic stress. We discuss the importance of this new finding in the broader context of medication development for major depressive disorder.


J Neurophysiol


McGinn MA,Pahng AR




Has Abstract


2017-02-01 00:00:00














  • Activity-induced elevations of intracellular calcium concentration in pyramidal and nonpyramidal cells of the CA3 region of rat hippocampal slice cultures.

    abstract::1. Depolarization-induced elevations of intracellular calcium concentration ([Ca2+]i) were examined in slice-cultured hippocampal pyramidal and nonpyramidal cells of the CA3 region by combined intracellular and multisite fura-2 recording techniques. 2. In pyramidal cells, spiking activity induced by depolarizing curre...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Knöpfel T,Gähwiler BH

    更新日期:1992-09-01 00:00:00

  • PKA and PKC enhance excitatory synaptic transmission in human dentate gyrus.

    abstract::cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) are two major modulators of synaptic transmission in the CNS but little is known about how they affect synaptic transmission in the human CNS. In this study, we used forskolin, a PKA activator, and phorbol ester, a PKC activator, to examine the effects of ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Chen HX,Roper SN

    更新日期:2003-05-01 00:00:00

  • Long-term neuromodulatory regulation of a motor pattern-generating network: maintenance of synaptic efficacy and oscillatory properties.

    abstract::Rhythm generation by the pyloric motor network in the stomatogastric ganglion (STG) of the spiny lobster requires permissive neuromodulatory inputs from other central ganglia. When these inputs to the STG are suppressed by cutting the single, mainly afferent stomatogastric nerve (stn), pyloric neurons cease to burst a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Thoby-Brisson M,Simmers J

    更新日期:2002-12-01 00:00:00

  • Cellular mechanisms underlying spontaneous firing in rat suprachiasmatic nucleus: involvement of a slowly inactivating component of sodium current.

    abstract::Neurons constituting the pacemaker of circadian rhythms, located in the suprachiasmatic nucleus, generate spontaneous firing patterns that change across the day-night cycle. Their average spontaneous firing rate is considered an important functional marker of clock activity because it is highest during daytime and low...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Pennartz CM,Bierlaagh MA,Geurtsen AM

    更新日期:1997-10-01 00:00:00

  • Discharge characteristics of biceps brachii motor units at recruitment when older adults sustained an isometric contraction.

    abstract::The purpose of this study was to compare the discharge characteristics of motor units recruited during an isometric contraction that was sustained with the elbow flexor muscles by older adults at target forces that were less than the recruitment threshold force of each isolated motor unit. The discharge times of 27 si...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Pascoe MA,Holmes MR,Enoka RM

    更新日期:2011-02-01 00:00:00

  • Two types of local interneurons are distinguished by morphology, intrinsic membrane properties, and functional connectivity in the moth antennal lobe.

    abstract::Neurons in the silkmoth antennal lobe (AL) are well characterized in terms of their morphology and odor-evoked firing activity. However, their intrinsic electrical properties including voltage-gated ionic currents and synaptic connectivity remain unclear. To address this, whole cell current- and voltage-clamp recordin...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Tabuchi M,Dong L,Inoue S,Namiki S,Sakurai T,Nakatani K,Kanzaki R

    更新日期:2015-11-01 00:00:00

  • Modeling activity-dependent changes of axonal spike conduction in primary afferent C-nociceptors.

    abstract::Action potential initiation and conduction along peripheral axons is a dynamic process that displays pronounced activity dependence. In patients with neuropathic pain, differences in the modulation of axonal conduction velocity by activity suggest that this property may provide insight into some of the pathomechanisms...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Tigerholm J,Petersson ME,Obreja O,Lampert A,Carr R,Schmelz M,Fransén E

    更新日期:2014-05-01 00:00:00

  • Cutaneous masking. II. Geometry of excitatory andinhibitory receptive fields of single units in somatosensory cortex of the cat.

    abstract::1. The responses of single neurons in the primary somatosensory cortex of the cat to brief air-pulse stimuli were quantitatively examined. These controlled natural stimuli activated almost exclusively rapidly adapting hair units which, on systematic movement of the stimulus through the receptive field, gave unit-respo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Laskin SE,Spencer WA

    更新日期:1979-07-01 00:00:00

  • Horizontal vestibuloocular reflex evoked by high-acceleration rotations in the squirrel monkey. III. Responses after labyrinthectomy.

    abstract::The horizontal angular vestibuloocular reflex (VOR) evoked by high-frequency, high-acceleration rotations was studied in four squirrel monkeys after unilateral labyrinthectomy. Spontaneous nystagmus was measured at the beginning and end of each testing session. During the period that animals were kept in darkness (4 d...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Lasker DM,Hullar TE,Minor LB

    更新日期:2000-05-01 00:00:00

  • Binocular 3D otolith-ocular reflexes: responses of normal chinchillas to tilt and translation.

    abstract::Head rotation, translation, and tilt with respect to a gravitational field elicit reflexive eye movements that partially stabilize images of Earth-fixed objects on the retinas of humans and other vertebrates. Compared with the angular vestibulo-ocular reflex, responses to translation and tilt, collectively called the ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Hageman KN,Chow MR,Roberts D,Della Santina CC

    更新日期:2020-01-01 00:00:00

  • Inhibitory responses in Aplysia pleural sensory neurons act to block excitability, transmitter release, and PKC Apl II activation.

    abstract::Expression of the 5-HT(1Apl(a)) receptor in Aplysia pleural sensory neurons inhibited 5-HT-mediated translocation of the novel PKC Apl II in sensory neurons and prevented PKC-dependent synaptic facilitation at sensory to motoneuron synapses (Nagakura et al. 2010). We now demonstrate that the ability of inhibitory rece...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Dunn TW,Farah CA,Sossin WS

    更新日期:2012-01-01 00:00:00

  • Effects of tetanic contraction of motor units of similar type on the initial stiffness to ramp stretch of the cat peroneus longus muscle.

    abstract::1. The stiffness during the initial portion of a ramp stretch was measured in cat peroneus longus muscle at rest and during maximal tetanic contractions produced by increasing numbers of motor units of the same type [slow (S), fast fatigue resistant (FR), or fast fatigable (FF)]. 2. This initial ramp stiffness was def...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


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    更新日期:1990-12-01 00:00:00

  • A combined TMS-EEG study of short-latency afferent inhibition in the motor and dorsolateral prefrontal cortex.

    abstract::Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) enables noninvasive neurophysiological investigation of the human cortex. A TMS paradigm of short-latency afferent inhibition (SAI) is characterized by attenuation of the motor-evoked potential (MEP) and modulation of N100 of the TMS-evoke...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Noda Y,Cash RF,Zomorrodi R,Dominguez LG,Farzan F,Rajji TK,Barr MS,Chen R,Daskalakis ZJ,Blumberger DM

    更新日期:2016-09-01 00:00:00

  • Multimodal sensory responses of nucleus reticularis gigantocellularis and the responses' relation to cortical and motor activation.

    abstract::The connectivity of large neurons of the nucleus reticularis gigantocellularis (NRGc) in the medullary reticular formation potentially allows both for the integration of stimuli, in several modalities, that would demand immediate action, and for coordinated activation of cortical and motoric activity. We have simultan...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Martin EM,Pavlides C,Pfaff D

    更新日期:2010-05-01 00:00:00

  • Neural coupling between homologous muscles during bimanual tasks: effects of visual and somatosensory feedback.

    abstract::While the effects of sensory feedback on bimanual tasks have been studied extensively at two ends of the motor control hierarchy, the cortical and behavioral levels, much less is known about how it affects the intermediate levels, including neural control of homologous muscle groups. We investigated the effects of som...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Nguyen HB,Lee SW,Harris-Love ML,Lum PS

    更新日期:2017-02-01 00:00:00

  • Effects of cerebellar lesions on saccadic eye movements.

    abstract::1. Areas of cerebellar cortex related to saccadic eye movements were ablated in three Macaca mulatta monkeys trained to fixate visual targets. There followed a postoperative dysmetria of saccadic eye movements which appeared to be the result of an impairment specifically within the saccadic system. 2. Convergent evide...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Ritchie L

    更新日期:1976-11-01 00:00:00

  • Receptive-field properties of rat ventral posterior medial neurons before and after selective kainic acid lesions of the trigeminal brain stem complex.

    abstract::Single neurons were recorded from the ventral posteromedial thalamic nucleus (VPM) of urethan-anesthetized rats. Six of these animals were intact, 28 sustained kainic acid (KA) lesions of trigeminal nucleus principalis (PrV), and 9 received similar lesions of trigeminal subnucleus interpolaris (SpVi). Four animals sus...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Rhoades RW,Belford GR,Killackey HP

    更新日期:1987-05-01 00:00:00

  • Activity patterns of the B31/B32 pattern initiators innervating the I2 muscle of the buccal mass during normal feeding movements in Aplysia californica.

    abstract::1. B31 and B32 are pattern-initiator neurons in the buccal ganglia of Aplysia. Along with the B61/B62 neurons, B31/B32 are also motor neurons that innervate the 12 buccal muscle via the I2 nerve. This research was aimed at determining the physiological functions of the B31/B32 and B61/B62 neurons, and of the I2 muscle...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Hurwitz I,Neustadter D,Morton DW,Chiel HJ,Susswein AJ

    更新日期:1996-04-01 00:00:00

  • Cat's medullary reticulospinal and subnucleus reticularis dorsalis noxious neurons form a coupled neural circuit through collaterals of descending axons.

    abstract::Animals and human beings sense and react to real/potential dangerous stimuli. However, the supraspinal mechanisms relating noxious sensing and nocifensive behavior are mostly unknown. The collateralization and spatial organization of interrelated neurons are important determinants of coordinated network function. Here...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Leiras R,Martín-Cora F,Velo P,Liste T,Canedo A

    更新日期:2016-01-01 00:00:00

  • Functional development of a central visual map in cat.

    abstract::1. The onset of visual activity in the superficial layers of the cat superior colliculus begins abruptly at about 6 days postnatal (DPN), just before natural eye opening. Despite the presence of many inactive sites at this time, the systematic nature of the superior colliculus visuotopy is already evident. The number ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Kao CQ,McHaffie JG,Meredith MA,Stein BE

    更新日期:1994-07-01 00:00:00

  • Temporal information can influence spatial localization.

    abstract::To localize objects relative to ourselves, we need to combine various sensory and motor signals. When these signals change abruptly, as information about eye orientation does during saccades, small differences in latency between the signals could introduce localization errors. We examine whether independent temporal i...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Maij F,Brenner E,Smeets JB

    更新日期:2009-07-01 00:00:00

  • Localized adenosine signaling provides fine-tuned negative feedback over a wide dynamic range of neocortical network activities.

    abstract::Although the patterns of activity produced by neocortical networks are now better understood, how these states are activated, sustained, and terminated still remains unclear. Negative feedback by the endogenous neuromodulator adenosine may potentially play an important role, as it can be released by activity and there...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Wall MJ,Richardson MJ

    更新日期:2015-02-01 00:00:00

  • Physiological properties of primary sensory neurons appropriately and inappropriately innervating skin in the adult rat.

    abstract::1. We have studied the physiology of sensory neurons innervating skin of the rat hindlimb, in three groups of animals: 1) normal animals; 2) animals in which the sural nerve (Sn) had regenerated to its original cutaneous target; and 3) animals in which the gastrocnemius muscle nerve (Gn) had previously been cut and cr...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Lewin GR,McMahon SB

    更新日期:1991-10-01 00:00:00

  • Differences in glycinergic mIPSCs in the auditory brain stem of normal and congenitally deaf neonatal mice.

    abstract::We have investigated the fundamental properties of central auditory glycinergic synapses in early postnatal development in normal and congenitally deaf (dn/dn) mice. Glycinergic miniature inhibitory postsynaptic currents (mIPSCs) were recorded using patch-clamp methods in neurons from a brain slice preparation of the ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Leao RN,Oleskevich S,Sun H,Bautista M,Fyffe RE,Walmsley B

    更新日期:2004-02-01 00:00:00

  • Modeling short-term synaptic plasticity at the calyx of Held using in vivo-like stimulation patterns.

    abstract::We measured synaptic responses to complex stimulus trains in the calyx of Held and used the data to test how well several vesicle-release models could capture the observed dynamics. We tested stimulation protocols consisting of Poisson-distributed activity with periodically changing mean frequencies, trains with const...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Hermann J,Grothe B,Klug A

    更新日期:2009-01-01 00:00:00

  • Properties of the GABAA receptor of rat posterior pituitary nerve terminals.

    abstract::1. We investigated gamma-aminobutyric acid (GABA) receptors using thin slice patch-clamp techniques in the swellings along axons of posterior pituitary nerve terminals. 2. Activation of the nerve terminal GABAA receptor induced a mean conductance change of 1.5 nS. Normalizing to area gave a mean conductance density of...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Zhang SJ,Jackson MB

    更新日期:1995-03-01 00:00:00

  • Shared and private variability in the auditory cortex.

    abstract::The high variability of cortical sensory responses is often assumed to impose a major constraint on efficient computation. In the auditory cortex, however, response variability can be very low. We have used in vivo whole cell patch-clamp methods to study the trial-to-trial variability of the subthreshold fluctuations ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Deweese MR,Zador AM

    更新日期:2004-09-01 00:00:00

  • In vivo responses of single olfactory receptor neurons of channel catfish to binary mixtures of amino acids.

    abstract::For the first time in any vertebrate, in vivo responses of single olfactory receptor neurons to odorant mixtures were studied quantitatively. Extracellular electrophysiological response of 54 single olfactory receptor neurons from 23 channel catfish, Ictalurus punctatus, to binary mixtures of amino acids and to their ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Kang J,Caprio J

    更新日期:1997-01-01 00:00:00

  • Microglia-mediated synaptic elimination in neuronal development and disease.

    abstract::It has recently become clear that microglia, the immune cells of the central nervous system, are far more active in the healthy brain than previously thought. Microglia facilitate many stages of brain development by shaping neuronal connectivity via synaptic elimination. Dysfunction of these same processes likely unde...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审


    authors: Whitelaw BS

    更新日期:2018-01-01 00:00:00

  • Breakdown of effective connectivity during slow wave sleep: investigating the mechanism underlying a cortical gate using large-scale modeling.

    abstract::Effective connectivity between cortical areas decreases during slow wave sleep. This decline can be observed in the reduced interareal propagation of activity evoked either directly in cortex by transcranial magnetic stimulation (TMS) or by sensory stimulation. We present here a large-scale model of the thalamocortica...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Esser SK,Hill S,Tononi G

    更新日期:2009-10-01 00:00:00