Abstract:
:The distribution of functional neurotransmitter receptors is an important determinant of neuronal information processing. To map the location of functional glutamate and GABA receptors on individual hippocampal neurons, we photolyzed "caged" glutamate and GABA while measuring the electrical currents resulting from activation of these receptors. Responses to uncaged neurotransmitters were spatially nonuniform and varied according to the type of receptor and type of neuron. Every region of CA1 pyramidal cells responded to glutamate and GABA, but glutamate and GABA receptors increased in density along the length of their distal dendrites. Similar gradients of glutamate receptors were found in stratum radiatum interneurons, while GABA responses were detectable only in the perisomatic region of these interneurons. These regional variations in receptor distribution indicate the selective targeting of receptors on central neurons and may reflect a mechanism for local regulation of synaptic efficacy.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Pettit DL,Augustine GJdoi
10.1152/jn.2000.84.1.28subject
Has Abstractpub_date
2000-07-01 00:00:00pages
28-38issue
1eissn
0022-3077issn
1522-1598journal_volume
84pub_type
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