Abstract:
:Primate head-free saccade generator implements a desired (post-VOR) eye position command by anticipating intended head motion. J. Neurophysiol. 78: 2811-2816, 1997. When we glance between objects, the brain ultimately controls gaze direction in space. However, it is currently unclear how this is allocated into separate commands for eye and head movement. To determine the role of desired final eye position commands, and their coordination with intended head movement, we trained three monkeys to make large gaze shifts while wearing opaque goggles with a monocular 8 degrees aperture. Animals eventually developed a new set of context-dependent eye-head coordination strategies, in particular expanding the head range and compressing the eye-in-head range toward the aperture (while wearing the goggles). However, when we shifted the location of the aperture to a different subsection of the normal head-free oculomotor range (by covering the original aperture and creating a new one), eye-head saccades failed to acquire visual targets, because they continued to drive the eye ultimately toward the now occluded original aperture. Even when a head-stationary saccade acquired the new aperture, subsequent head-free saccades drove the eye eccentrically toward a point that anticipated the intended head movement, such that the subsequent vestibuloocular reflex slow phase brought the eye onto the location of the original aperture. Animals could only acquire the new aperture consistently after several days of retraining. These results suggest that 1) eye-head coordination is achieved by a plastic, context-dependent neural operator that uses information about initial eye/head position and intended movement to compute desired combinations of final eye/head position and 2) acquisition of these positions involves sophisticated anticipatory compensations for subsequent movement components, akin to those observed previously in complex oral and manual behaviors.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Crawford JD,Guitton Ddoi
10.1152/jn.1997.78.5.2811subject
Has Abstractpub_date
1997-11-01 00:00:00pages
2811-6issue
5eissn
0022-3077issn
1522-1598journal_volume
78pub_type
杂志文章abstract::The amino acid sequence of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B from the brown ghost knife fish Apteronotus leptorhynchus has been determined and compared with the sequence of the murine NR2B. This comparison revealed high levels of sequence conservation throughout the ligand binding and membrane span...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00629.2002
更新日期:2003-02-01 00:00:00
abstract::The neural organization of the superior colliculus (SC) projection to horizontal ocular motoneurons was analyzed in anesthetized cats using intracellular recording and transneuronal labeling. Intracellular responses to SC stimulation were analyzed in lateral rectus (LR) and medial rectus (MR) motoneurons and internucl...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.6.2597
更新日期:1999-06-01 00:00:00
abstract::1. Axonal transection triggers a cascade of pathological processes that frequently lead to the degeneration of the injured neuron. It is generally believed that the degenerative process is triggered by an overwhelming influx of calcium through the cut end of the axon. 2. Theoretical considerations and indirect observa...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.74.6.2625
更新日期:1995-12-01 00:00:00
abstract::1. We have stimulated responses of stellate cells in the anteroventral cochlear nucleus (AVCN) to single-formant stimuli (SFSs) with the use of recorded auditory-nerve fiber (ANF) responses as inputs. In particular, two important features of temporal discharge patterns, the phase locking to best frequency (BF) tones a...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.73.4.1600
更新日期:1995-04-01 00:00:00
abstract::We used laser scanning photostimulation through a focused UV laser of caged glutamate in an in vitro slice preparation through the rat's somatosensory thalamus to study topography and connectivity between the thalamic reticular nucleus and ventral posterior lateral nucleus. This enabled us to focally stimulate the som...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00206.2005
更新日期:2005-10-01 00:00:00
abstract::Subjects were asked to track, with their eyes or their hand, the movement of a target that maintained a constant speed and made a single, abrupt change in direction. The tracking speed and direction of motion after the step change in target direction were compared for the eyes and the hand. After removal of the saccad...
journal_title:Journal of neurophysiology
pub_type: 临床试验,杂志文章
doi:10.1152/jn.2000.84.3.1149
更新日期:2000-09-01 00:00:00
abstract::1. The effects of dorsal raphe (DR) stimulation on neural activity in the rat lateral hypothalamic area (LHA), including specific glucose-sensitive neurons, were investigated by extracellular and intracellular recording in vivo, and the neurotransmitters involved were determined. 2. In 67 adult male anesthetized rats,...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1988.60.2.524
更新日期:1988-08-01 00:00:00
abstract::Gonadotropin-releasing hormone (GnRH) controls mammalian reproduction via the hypothalamic-pituitary-gonadal (hpg) axis, acting on gonadotrope cells in the pituitary gland that express the GnRH receptor (GnRHR). Cells expressing the GnRHR have also been identified in the brain. However, the mechanism by which GnRH act...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00357.2015
更新日期:2015-08-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.73.3.1135
更新日期:1995-03-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1988.60.2.645
更新日期:1988-08-01 00:00:00
abstract::The neurons in the intermediate layers of the monkey superior colliculus (SC) that discharge before saccadic eye movements can be divided into at least two types, burst and buildup neurons, and the differences in their characteristics are compatible with different functional contributions of the two cell types. It has...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.4.2082
更新日期:1998-04-01 00:00:00
abstract::1. Reflex responses were elicited in muscles that act at the ankle by electrical stimulation of low-threshold afferents from the foot in human subjects who were reclining supine. During steady voluntary contractions, stimulus trains (5 pulses at 300 Hz) were delivered at two intensities to the sural nerve (1.2-4.0 tim...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.67.5.1375
更新日期:1992-05-01 00:00:00
abstract::Prefrontal cortex (PFC) dopamine D1/5 receptors modulate long- and short-term neuronal plasticity that may contribute to cognitive functions. Synergistic to synaptic strength modulation, direct postsynaptic D1/5 receptor activation also modulates voltage-dependent ionic currents that regulate spike firing, thus alteri...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00317.2006
更新日期:2007-03-01 00:00:00
abstract::The high variability of cortical sensory responses is often assumed to impose a major constraint on efficient computation. In the auditory cortex, however, response variability can be very low. We have used in vivo whole cell patch-clamp methods to study the trial-to-trial variability of the subthreshold fluctuations ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00197.2004
更新日期:2004-09-01 00:00:00
abstract::When sensory feedback is perturbed, accurate movement is restored by a combination of implicit processes and deliberate reaiming to strategically compensate for errors. Here, we directly compare two methods used previously to dissociate implicit from explicit learning on a trial-by-trial basis: 1) asking participants ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1981.45.3.501
更新日期:1981-03-01 00:00:00
abstract::1. We examined excitation and the facilitatory effect on the heat responses induced by histamine in visceral polymodal receptors with the use of the canine testis-spermatic nerve preparation in vitro. 2. The proportion of units that showed excitation (> 10 impulses 1 min after application of histamine was initiated) i...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.76.3.1396
更新日期:1996-09-01 00:00:00
abstract::Single-unit activity was recorded from the caudate nucleus (CD), globus pallidus, and entopeduncular nucleus (GP-ENTO) in awake, partially restrained kittens. The purpose of this experiment was to assess the ability of developing basal ganglia structures to process natural facial somatosensory information and compare ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1985.54.1.143
更新日期:1985-07-01 00:00:00
abstract::The objectives of this study were 1) to probe the effects of visual motion adaptation on early visual and V5/MT cortical excitability and 2) to investigate whether changes in cortical excitability following visual motion adaptation are related to the degree of visual dependency, i.e., an overreliance on visual cues co...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
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更新日期:2017-03-01 00:00:00
abstract::The ability of a spatial population of cutaneous, Adelta, and C mechano-nociceptors to encode the location and intensity of a noxious, cutaneous indentation was examined using an isolated preparation in a rat model. Skin and its intact innervation were harvested from the medial thigh of the rat hindlimb and placed in ...
journal_title:Journal of neurophysiology
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更新日期:2000-05-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
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更新日期:1989-06-01 00:00:00
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更新日期:2006-02-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1991.65.6.1517
更新日期:1991-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1979-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
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更新日期:2004-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.1.496
更新日期:1998-01-01 00:00:00
abstract::1. Responses of single units and multiunit clusters were recorded in the ferret primary auditory cortex (AI) with the use of broadband complex dynamic spectra. Previous work has demonstrated that simpler spectra consisting of single moving ripples (i.e., sinusoidally modulated spectral profiles that travel at a consta...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
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更新日期:1996-11-01 00:00:00