Abstract：
:To examine the activity of somatosensory cortex (S1) neurons to self-generated shear forces on the index and thumb, two monkeys were trained to grasp a stationary metal tab with a key grip and exert forces without the fingers slipping in one of four orthogonal directions for 1 s. A majority (∼85%) of slowly adapting and rapidly adapting (RA) S1 neurons had activity modulated with shear force direction. The cells were recorded mainly in areas 1 and 2 of the S1, although some area 3b neurons also responded to shear direction or magnitude. The preferred shear vectors were distributed in every direction, with tuning arcs varying from 50° to 170°. Some RA neurons sensitive to dynamic shear force direction also responded to static shear force but within a narrower range, suggesting that the direction of the shear force may influence the adaptation rate. Other neurons were modulated with shear forces in diametrically opposite directions. The directional sensitivity of S1 cortical neurons is consistent with recordings from cutaneous afferents showing that shear direction, even without slip, is a powerful stimulus to S1 neurons.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Fortier-Poisson P,Langlais JS,Smith AMdoi
10.1152/jn.00749.2014subject
Has Abstractpub_date
2016-01-01 00:00:00pages
100-11issue
1eissn
0022-3077issn
1522-1598pii
jn.00749.2014journal_volume
115pub_type
杂志文章abstract：:The responses of low-frequency, primary-like neurons of the ventral cochlear nucleus were measured as a function of signal-to-noise ratio for gated tonal signals and noise maskers that were varied in bandwidth and duration. For a given signal-to-noise ratio, each of the maskers is known to produce the same amount of m...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1983.50.6.1516
更新日期：1983-12-01 00:00:00
abstract：:We measured synaptic responses to complex stimulus trains in the calyx of Held and used the data to test how well several vesicle-release models could capture the observed dynamics. We tested stimulation protocols consisting of Poisson-distributed activity with periodically changing mean frequencies, trains with const...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.90243.2008
更新日期：2009-01-01 00:00:00
abstract：:High-frequency stimulation (HFS) is used to treat a variety of neurological diseases, yet its underlying therapeutic action is not fully elucidated. Previously, we reported that HFS-induced elevation in [K(+)](e) or bath perfusion of raised K(e)(+) depressed rat entopeduncular nucleus (EP) neuronal activity via an enh...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.01065.2007
更新日期：2008-05-01 00:00:00
abstract：:N-methyl-d-aspartate receptors (NMDARs) are fundamental coincidence detectors of synaptic activity necessary for the induction of synaptic plasticity and synapse stability. Adjusting NMDAR synaptic content, whether by receptor insertion or lateral diffusion between extrasynaptic and synaptic compartments, could play a...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00458.2019
更新日期：2020-03-01 00:00:00
abstract：:In recent years, electroencephalography and magnetoencephalography (MEG) have both been used to investigate the response in human auditory cortex to musical sounds that are perceived as consonant or dissonant. These studies have typically focused on the transient components of the physiological activity at sound onset...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00876.2018
更新日期：2020-04-01 00:00:00
abstract：:Slow covariations in neuronal resting potentials can lead to artefactually fast cross-correlations in their spike trains. J. Neurophysiol. 80: 3345-3351, 1998. A model of two lateral geniculate nucleus (LGN) cells, which interact only through slow (tens of seconds) covariations in their resting membrane potentials, is...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1998.80.6.3345
更新日期：1998-12-01 00:00:00
abstract：:The distribution of functional neurotransmitter receptors is an important determinant of neuronal information processing. To map the location of functional glutamate and GABA receptors on individual hippocampal neurons, we photolyzed "caged" glutamate and GABA while measuring the electrical currents resulting from act...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.2000.84.1.28
更新日期：2000-07-01 00:00:00
abstract：:A classical question in neuroscience is which features of a stimulus or of an action are represented in brain activity. When several features are interdependent either at a given point in time or at distinct points in time, neural activity related to one feature appears to be correlated with other features. Thus techn...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00981.2005
更新日期：2006-03-01 00:00:00
abstract：:Cervical dystonia (CD) is a movement disorder that involves involuntary turning and twisting of the neck caused by abnormal muscle contraction. Deep brain stimulation (DBS) in the globus pallidus internus (GPi) is used to treat both CD and the motor symptoms of Parkinson's disease (PD). It has been suggested that the ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.01107.2006
更新日期：2007-08-01 00:00:00
abstract：:Skin on the foot sole plays an important role in postural control. Cooling the skin of the foot is often used to induce anesthesia to determine the role of skin in motor and balance control. The effect of cooling on the four classes of mechanoreceptor in the skin is largely unknown, and thus the aim of the present stu...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00381.2012
更新日期：2013-02-01 00:00:00
abstract：:Rhythm generation by the pyloric motor network in the stomatogastric ganglion (STG) of the spiny lobster requires permissive neuromodulatory inputs from other central ganglia. When these inputs to the STG are suppressed by cutting the single, mainly afferent stomatogastric nerve (stn), pyloric neurons cease to burst a...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00482.2001
更新日期：2002-12-01 00:00:00
abstract：:Cold-sensitive and nociceptive neural pathways interact to shape the quality and intensity of thermal and pain perception. Yet the central processing of cold thermosensation in the human brain has not been extensively studied. Here, we used magnetoencephalography and EEG in healthy volunteers to investigate the time c...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00843.2016
更新日期：2017-05-01 00:00:00
abstract：:Long-term potentiation (LTP) of C-fiber-evoked field potentials in spinal dorsal horn may be relevant to pathological pain. Our previous work has shown that the late phase of the spinal LTP is protein synthesis-dependent. Considerable evidence has accumulated that dopamine D1/D5 receptors are important for late-phase ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.01324.2004
更新日期：2005-08-01 00:00:00
abstract：:Responses to repeated auditory stimuli were examined in 103 neurons in the auditory region of the thalamic reticular nucleus (TRN) and in 20 medial geniculate (MGB) neurons of anesthetized rats. A further six TRN neurons were recorded from awake rats. The TRN neurons showed strong responses to the first trial and weak...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.91130.2008
更新日期：2009-02-01 00:00:00
abstract：:1. Responses to pure tones were recorded from single neurons in the anteroventral cochlear nucleus (AVCN) in kittens ranging in age from 4 to 45 days. Different response properties mature at different times after birth. 2. The shapes of response areas of AVCN neurons after the 1st postnatal week resemble those recorde...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1978.41.6.1557
更新日期：1978-11-01 00:00:00
abstract：:The role of the nitric oxide (NO)-cGMP signaling cascade in modulation of peripheral nociception is controversial. Although behavioral studies have suggested both pro- and anti-nociceptive effects, little is known about the direct action of this signaling cascade on primary afferent nociceptive neurons that mediate th...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00058.2004
更新日期：2004-08-01 00:00:00
abstract：:Paired-pulse transcranial magnetic stimulation (TMS) can be used to examine intracortical inhibition in primary motor cortex (M1), termed short-interval intracortical inhibition (SICI). To our knowledge, SICI has only been demonstrated in contralateral motor evoked potentials (MEPs). Ipsilateral MEPs (iMEPs) are assum...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.01139.2015
更新日期：2016-03-01 00:00:00
abstract：:1. In alert macaque monkeys, multiunit activity is encountered in an alternating sequence of silent and spontaneously active zones as an electrode is lowered through the striate cortex (V1). 2. Individual neurons that are spontaneously active in the dark usually have a maintained discharge in the light. Because both t...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1995.74.5.2100
更新日期：1995-11-01 00:00:00
abstract：:1. Our previous study showed that two distinct postural modifications occurred when subjects were instructed to step, rather than maintain stance, in response to a backward surface translation: 1) the automatic postural responses to the surfaces perturbation were reduced in magnitude and 2) the anticipatory postural a...
journal_title：Journal of neurophysiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1152/jn.1996.75.4.1619
更新日期：1996-04-01 00:00:00
abstract：:The properties of the vestibuloocular reflex (VOR) when the axis of rotation is behind the eyes and fixation of a near target is required were studied in the monkey. The magnitude of VOR gain in each eye was found to be above 1.0 and near the ideal value for stabilizing a retinal image. Evidence that this large VOR ga...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1986.56.2.439
更新日期：1986-08-01 00:00:00
abstract：:1. Although it is generally agreed that Ca2+ couples depolarization to the release of neurotransmitters, hypertonic saline and ethanol (ETOH) evoke neurosecretion independent of extracellular Ca2+. One possible explanation is that these agents release Ca2+ from an intracellular store that then stimulates Ca(2+)-depend...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1992.68.4.1229
更新日期：1992-10-01 00:00:00
abstract：:Express saccades represent the fastest possible eye movements to visual targets with reaction times that approach minimum sensory-motor conduction delays. Previous work in monkeys has identified two specific neural signals in the superior colliculus (SC: a midbrain sensorimotor integration structure involved in gaze c...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00047.2015
更新日期：2015-08-01 00:00:00
abstract：:Over the past 3 decades, various algorithms used to decompose the electromyographic (EMG) signal into its constituent motor unit action potentials (MUAPs) have been reported. All are limited to decomposing EMG signals from isometric contraction. In this report, we describe a successful approach to decomposing the surf...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00555.2014
更新日期：2015-03-15 00:00:00
abstract：:Spontaneous negative-going potentials occurring at an average frequency of 0.7 Hz were recorded from the dentate gyrus of slices prepared from the temporal hippocampus of young adult rats. These events (here termed "dentate waves") in several respects resembled the dentate spikes described for freely moving rats durin...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00478.2004
更新日期：2004-12-01 00:00:00
abstract：:Spontaneous calcium oscillations in mushroom bodies of late stage pupal and adult Drosophila brains have been implicated in memory consolidation during olfactory associative learning. This study explores the cellular mechanisms regulating calcium dynamics in Kenyon cells, principal neurons in mushroom bodies. Fura-2 i...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00096.2005
更新日期：2005-07-01 00:00:00
abstract：:We studied the eye movements evoked by applying small amounts of current (2-50 microA) within the oculomotor vermis of two monkeys. We first compared the eye movements evoked by microstimulation applied either during maintained pursuit or during fixation. Smooth, pursuitlike changes in eye velocity caused by the micro...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1998.80.4.2046
更新日期：1998-10-01 00:00:00
abstract：:1. K+ conductances were characterized in isolated, identified superior colliculus-projecting (SCP) rat visual cortical neurons. SCP neurons were identified in vitro under epifluorescence illumination after in vivo retrograde labeling with rhodamine-labeled microspheres or "beads." For experiments, SCP neurons were iso...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1995.73.6.2163
更新日期：1995-06-01 00:00:00
abstract：:In most of the bulbospinal respiratory neurons, threshold depolarization increased during the early period of their spontaneous burst discharge but decreased again at the end of a burst. In some vagal respiratory neurons, however, threshold depolarization increased steadily until the very end of their discharge period...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1975.38.5.1172
更新日期：1975-09-01 00:00:00
abstract：:Unitary pallido-nigral synaptic currents were measured using optogenetic stimulation, which activated up to three unitary synaptic inputs to each substantia nigra pars reticulata (SNr) cell. Episodic barrages of synaptic conductances were generated based on in vivo firing patterns of globus pallidus pars externa (GPe)...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00678.2019
更新日期：2020-02-01 00:00:00
abstract：:The functional and biophysical properties of a persistent sodium current (I(NaP)) previously proposed to participate in the generation of subthreshold oscillations and burst discharge in mesencephalic trigeminal sensory neurons (Mes V) were investigated in brain stem slices (rats, p7-p12) using whole cell patch-clamp ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00636.2004
更新日期：2005-05-01 00:00:00
