Abstract:
:As recently as the 1992 Report of the American Thoracic Society Workshop on Lung Transplantation, no QOL facts were given and no knowledge gaps related to QOL outcomes were cited. Even at the present time, the information in that area is based on a relatively small set of preliminary reports. Current information indicates that successful lung transplantation largely reverses the energy and physical mobility deficits reported by transplant candidates and that those improvements are sustained for at least several years after transplant. Recipients report improved health perceptions, fewer problems, and greater life satisfaction than candidates. The type and amount of QOL benefit appear to differ by underlying lung disorder, and recipients who develop obliterative bronchiolitis syndrome experience declines in QOL. Lung transplantation surgery is an expensive procedure initially, and costs remain high during follow-up. Little information is available on long-term QOL outcomes or cost-effectiveness. There is a compelling rationale for QOL research in lung transplantation. At the present time, some of the most challenging problems in transplantation, such as the selection of optimal timing for transplant and choice of immunosuppression medications, do not appear to have clear-cut survival or clinical benefits. Determination of the best approach to such problems is likely to hinge on patients' perceptions of the risk-to-benefit ratio, measured by their perceived QOL. Findings from QOL research need to be developed into interventions to enhance patient outcomes. As noted by Whitehead, QOL and potentially lethal noncompliance may be linked. Can we develop immune suppressive protocols that maintain clinical benefits while minimizing QOL burdens? Pilot studies suggest that QOL can be enhanced prior to transplant, and that health-related QOL prior to transplant may predict survival and clinical outcomes. As noted by Ramsey et al, multicenter studies are needed to achieve sufficient numbers for multivariate and subset analyses and to address issues such as the impact of diagnosis (indication for transplant) on QOL outcomes and cost-effectiveness. QOL and cost measures must be incorporated into large, longitudinal, multicenter clinical trials and observational studies to address those issues.
journal_name
Clin Chest Medjournal_title
Clinics in chest medicineauthors
Gross CR,Raghu Gdoi
10.1016/s0272-5231(05)70387-7subject
Has Abstractpub_date
1997-06-01 00:00:00pages
391-403issue
2eissn
0272-5231issn
1557-8216pii
S0272-5231(05)70387-7journal_volume
18pub_type
杂志文章,评审abstract::To conclude, impairment ratings differ among various diseases and compensation programs. It therefore is important to note, at the outset, which compensation program the patient is eligible for because the requirements of the different programs may vary. The physician report must clearly state an opinion using termino...
journal_title:Clinics in chest medicine
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abstract::In the past decade, there have been more patients with congenital heart disease (CHD) surviving to adulthood; whether due to late repair, or complex underlying CHD, many of these patients will be faced with pulmonary arterial hypertension (PAH) associated with CHD (APAH-CHD). In this review, the authors discuss the mo...
journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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doi:10.1016/j.ccm.2018.07.002
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
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abstract::The long-term ventilated patient is at high risk for developing nosocomial pneumonia or tracheobronchitis. In general, the frequency of infection increases with the duration of mechanical ventilation, but the risk appears to be greatest in the first week of intubation. Although these types of infection are common and ...
journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:10.1016/s0272-5231(05)70026-5
更新日期:2001-03-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:10.1016/s0272-5231(05)70283-5
更新日期:2001-09-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ccm.2015.05.006
更新日期:2015-09-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章
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更新日期:1991-12-01 00:00:00
abstract::Illicit drug users comprise a substantial and growing proportion of the HIV-infected population. Although they develop pulmonary complications common to all HIV transmission groups, they also have unique respiratory illnesses due to the direct effect of the illicit drugs on the lung. Bacterial infections, tuberculosis...
journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:10.1016/s0272-5231(05)70348-8
更新日期:1996-12-01 00:00:00
abstract::Pulmonary thromboembolism is a major cause of maternal mortality. DVT causes significant morbidity in pregnancy and in later life owing to the post-thrombotic syndrome. Obstetricians must have an understanding of the risk factors for VTE, the appropriate use of prophylaxis, the need for objective diagnosis in women wi...
journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
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更新日期:2003-03-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:
更新日期:1990-12-01 00:00:00
abstract::Traditional tuberculosis (TB) infection control focuses on the known patient with TB, usually on appropriate treatment. A refocused, intensified TB infection control approach is presented. Combined with active case finding and rapid molecular diagnostics, an approach called FAST is described as a convenient way to cal...
journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ccm.2019.07.010
更新日期:2019-12-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:10.1016/s0272-5231(03)00092-3
更新日期:2003-12-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:10.1016/s0272-5231(05)70355-5
更新日期:1997-03-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:
更新日期:1981-01-01 00:00:00
abstract::Pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by the accumulation of surfactant in alveoli and terminal airways resulting in respiratory failure. PAP comprises part of a spectrum of disorders of surfactant homeostasis (clearance and production). The surfactant production disorders are caused by...
journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ccm.2016.04.006
更新日期:2016-09-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:
更新日期:1995-12-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) has become a major and growing health problem, with a mortality rate that continues to increase. Several factors, have been identified as individual predictors of mortality in COPD. This article reviews individual predictors for mortality. It also discusses the ability of a...
journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ccm.2007.05.002
更新日期:2007-09-01 00:00:00
abstract::Individualized management of asthma requires consideration of single or combined pharmacologic alternatives. This article reviews experimental and clinical data on the efficacy, safety, mode of action, and therapeutic indications for cromolyn and related inhalational compounds; ketotifen; alpha-adrenergic blockers; ca...
journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:
更新日期:1986-09-01 00:00:00
abstract::Pulmonary embolism remains a leading cause of morbidity and mortality in the United States. However, with improved recognition and diagnosis, the risk of death diminishes. The diagnosis depends on the clinician's suspicion. Pulmonary emboli are categorized into low, intermediate, or high risk based on the scoring scal...
journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ccm.2018.04.013
更新日期:2018-09-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:
更新日期:1994-12-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:
更新日期:1990-09-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:
更新日期:1995-03-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:
更新日期:1995-09-01 00:00:00
abstract::Millions of people worldwide engage in leisure or occupational activities in extreme environments. These environments entail health risks even for normal subjects. The presence of lung disease, or other conditions, further predisposes to illness or injury. Patients who have lung conditions should, but often do not, co...
journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ccm.2005.05.006
更新日期:2005-09-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:
更新日期:1993-03-01 00:00:00
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journal_title:Clinics in chest medicine
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doi:10.1016/j.ccm.2013.08.002
更新日期:2013-12-01 00:00:00
abstract::Current advances in guided bronchoscopy methods permit minimally invasive access to essentially any area of the lungs. This provides a potential means to treat patients with localized lung malignancies who might not otherwise tolerate conventional treatment, which commonly relies on surgical resection. Ablation method...
journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ccm.2017.11.014
更新日期:2018-03-01 00:00:00
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journal_title:Clinics in chest medicine
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