Graft-versus-Host disease-like syndrome in malignant thymoma.

Abstract:

:Allogenic transfusion of immunocompetent T lymphocytes into an immunodeficient recipient is necessary for the development of graft-versus-host-disease (GVHD). The gastrointestinal tract is one of the most involved organs in human GVHD, and single-cell necrosis with apoptotic change and crypt abscess are characteristic histopathologic features. The thymus is important in immune regulation, and dysregulation of the immune system can be expected once its microenvironment is disrupted. We report the case of a 38-year-old woman with malignant thymoma without transplantation or transfusion history who initially presented with myasthenia gravis and clinically developed a GVHD-like syndrome with characteristic GVHD-like colitis on colonoscopy. We propose that disruption of the thymic microenvironment caused a dysregulated immune system and development of a GVHD-like syndrome.

journal_name

Scand J Gastroenterol

authors

Wang MH,Wong JM,Wang CY

doi

10.1080/003655200750023660

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

667-70

issue

6

eissn

0036-5521

issn

1502-7708

journal_volume

35

pub_type

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