Metronidazole in Crohn's disease. A double blind cross-over clinical trial.

Abstract:

:Twenty-two patients with active Crohn's disease treated with salazosulfapyridin or prednisone, were in addition given metronidazole 1.000 mg daily or placebo for two months each in a double-blind cross-over study. No statistically significant effect was observed on the overall clinical condition in the 20 patients who completed the trial, although haemoglobin rose and ESR fell significantly in the metronidazole periods. In the 6 patients with colonic involvement only an improvement was registered both in symptoms and laboratory values.

journal_name

Scand J Gastroenterol

authors

Blichfeldt P,Blomhoff JP,Myhre E,Gjone E

doi

10.3109/00365527809179816

subject

Has Abstract

pub_date

1978-01-01 00:00:00

pages

123-7

issue

1

eissn

0036-5521

issn

1502-7708

journal_volume

13

pub_type

临床试验,杂志文章,随机对照试验
  • Helicobacter pylori in functional dyspepsia and normal controls.

    abstract:BACKGROUND:The aim of this study was to examine whether Helicobacter pylori status can identify a specific subset of patients with functional dyspepsia (FD) and erosive prepyloric changes (EPC). METHODS:Anamnestic, somatic, and psychologic data were collected from 87 patients with functional dyspepsia and 77 normal co...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409092466

    authors: Wilhelmsen I,Tangen Haug T,Sipponen P,Berstad A

    更新日期:1994-06-01 00:00:00

  • Ascites as the first manifestation of polyarteritis nodosa.

    abstract::Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis that affects numerous organs, particularly the digestive tract (33-52% of cases). However, isolated ascites has rarely been described in patients with PAN. We observed a patient who had developed ascites revealing PAN, and because of suspected malignancy ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600575670

    authors: Hervé F,Héron F,Levesque H,Marie I

    更新日期:2006-04-01 00:00:00

  • Endogenous prostaglandins and microflora modulate DNA synthesis and neuroendocrine peptides in the rat gastrointestinal tract.

    abstract:BACKGROUND:Previous studies suggest that E2 prostaglandins and the microflora may participate in the regulation of endocrine cells and of gastrointestinal cell kinetics. Our aim is to examine the actions of endogenous prostaglandins and of the microflora on gastrointestinal cell proliferation and tissue levels of neuro...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529708996520

    authors: Uribe A,Alam M,Midtvedt T,Smedfors B,Theodorsson E

    更新日期:1997-07-01 00:00:00

  • Effects on peritoneal proteolysis and hemodynamics of prophylactic infusion with C1 inhibitor in experimental acute pancreatitis.

    abstract::Acute pancreatitis was induced in pigs by manual retrograde injection of Na-taurocholate into the pancreatic duct. Chromogenic peptide substrate assays showed increased trypsin (TRY) and plasma kallikrein activities (KK), parallel with a reduction of prekallikrein (PKK) levels and functional plasma kallikrein inhibiti...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528608996414

    authors: Ruud TE,Aasen AO,Pillgram-Larsen J,Stadaas JO

    更新日期:1986-10-01 00:00:00

  • Insulin enhances epidermal growth factor- and transforming growth factor-alpha-stimulated growth in primary cultures of guinea pig gastric mucous epithelial cells.

    abstract::The effect of insulin on epidermal growth factor (EGF)- and transforming growth factor-alpha (TGF alpha)-induced cell proliferation was examined in primary cultures of gastric surface mucous epithelial cells by using changes in cell counts and DNA as indices of cell growth. With 1.0% fetal bovine serum and Dulbecco's ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529108996250

    authors: Rutten MJ,Harmon P,Campbell DR

    更新日期:1991-09-01 00:00:00

  • Eosinophilic gastroenteritis: our recent experience: one-year experience of atypical onset of an uncommon disease.

    abstract::Eosinophilic gastroenteritis is an unusual entity that is rarely found in daily clinical practise. Its aetiology is unknown and diagnosis can be made microscopically with evidence of massive eosinophilic infiltration in patients with chronic gastrointestinal symptoms, excluding entities that may cause such findings (p...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201317097254

    authors: Redondo-Cerezo E,Cabello MJ,González Y,Gómez M,García-Montero M,de Teresa J

    更新日期:2001-12-01 00:00:00

  • Effectiveness of antibiotic prophylaxis in cholecystectomy: a prospective population-based study of 1171 cholecystectomies.

    abstract:BACKGROUND:The aim of this study was to assess the benefit from antibiotic prophylaxis (AP) during cholecystectomy in a population-based cohort study. METHODS:All cholecystectomies performed in Uppsala County, 2003-2005, were registered prospectively according to a standardized protocol. High-risk procedures (HP) were...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.711850

    authors: Darkahi B,Videhult P,Sandblom G,Liljeholm H,Ljungdahl M,Rasmussen IC

    更新日期:2012-10-01 00:00:00

  • Short stricture of the rectum regressing on discontinuation of hormone replacement therapy: endoscopic appearance, multiple biopsies and clinical improvement insufficient for diagnosis.

    abstract::A short, benign-looking stricture of the rectum presented itself clinically as subileus in a middle-aged woman after 5 years on hormone replacement therapy (HRT) and 8 years after curative surgery for cancer of the ovaries. Radiological work-up and multiple, repeated biopsies supported the endoscopically appearing ben...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520510011614

    authors: Hoff G,Wiig J,Reed W,Hole KH,Scheistrøen M,Henriksen H

    更新日期:2005-03-01 00:00:00

  • Gastroesophageal sphincter pressure and serum gastrin: reaction to food stimulation in normal subjects and in patients with gastric or duodenal ulcer.

    abstract::Gastroesophageal sphincter pressure and serum gastrin concentration were determined in the fasting state and after the intake of a protein food in 6 normal subjects, 6 patients with gastric ulcer, and in 6 patients with duodenal ulcer. No significant differences in the fasting state were found. After the food intake, ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527809182207

    authors: Csendes A,Oster M,Brandsborg O,Möller J,Brandsborg M,Amdrup E

    更新日期:1978-01-01 00:00:00

  • Clinical practice and evidence in endoscopic treatment of bleeding peptic gastroduodenal ulcer.

    abstract:OBJECTIVE:To investigate treatment practice in non-variceal upper gastrointestinal bleeding (NVUGIB) caused by gastroduodenal ulcer and how it adheres to the best evidence as documented in randomized studies and meta-analyses. MATERIAL AND METHODS:The literature was surveyed to identify appropriate practices, and a st...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600880989

    authors: Adamsen S,Bendix J,Kallehave F,Moesgaard F,Nilsson T,Wille-Jørgensen P

    更新日期:2007-03-01 00:00:00

  • Managing dyspepsia in the young adult patient: effects of different tests for Helicobacter pylori in a "test-and-scope" approach.

    abstract:AIM:To evaluate how different methods for the detection of Helicobacter pylori influence on a "test, score and scope" decision approach in young dyspeptic patients. RESULTS:Complete data from 341 patients (52.2% males) were analyzed. One hundred and ten (32%) were H. pylori-positive by definition. The rapid serology t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2013.800988

    authors: Valle PC,Breckan RK,Mortensen L,Amin A,Kildahl-Andersen O,Paulssen EJ

    更新日期:2013-08-01 00:00:00

  • Gastric acid responses to adequate and modified sham feeding and to insulin hypoglycemia in duodenal ulcer patients.

    abstract::In duodenal ulcer patients the effect of vagal activation of gastric acid secretion by the intricate procedure of adequate sham feeding for 15 min has been compared with the effects of vagal stimulation induced by more easily accomplishable methods. The comparison involved modified sham feeding for 15 min by a 'chew-a...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527809179834

    authors: Stenquist B,Knutson U,Olbe L

    更新日期:1978-01-01 00:00:00

  • A characterization in childhood inflammatory bowel disease, a new population-based inception cohort from South-Eastern Norway, 2005-07, showing increased incidence in Crohn's disease.

    abstract:OBJECTIVE:Owing to rising incidence rates in inflammatory bowel disease (IBD), there has been increased interest in causal relationships in pediatric disease. The present population-based inception cohort was recruited in the Oslo area from 2005 to 2007, with the aim of conducting a detailed characterization of treatme...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802647434

    authors: Perminow G,Brackmann S,Lyckander LG,Franke A,Borthne A,Rydning A,Aamodt G,Schreiber S,Vatn MH,IBSEN-II Group.

    更新日期:2009-01-01 00:00:00

  • Effect of mental stress and cisapride on autonomic nerve functions in functional dyspepsia.

    abstract:BACKGROUND:Disordered autonomic nerve function is frequently present in patients with functional dyspepsia (FD). In this study we investigated whether the prokinetic cisapride, which acts via acetylcholine receptors, and stress may modulate these abnormalities. METHODS:Nineteen patients (6 men, 13 women) with FD and 1...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/00365529850166824

    authors: Hveem K,Svebak S,Hausken T,Berstad A

    更新日期:1998-02-01 00:00:00

  • Gastrointestinal transit of amoxicillin modified-release tablets and a placebo tablet including pharmacokinetic assessments of amoxicillin.

    abstract:BACKGROUND:We have investigated the gastrointestinal transit time of, the influence of food intake on, the disintegration of, and the pharmacokinetics of amoxicillin in a modified-release form. METHODS:Radiolabelled modified-release tablets of amoxicillin and placebo tablets were administered, in an open three-way, ra...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365529609031626

    authors: Gottfries J,Svenheden A,Alpsten M,Bake B,Larsson A,Idström JP

    更新日期:1996-01-01 00:00:00

  • Influence of ampicillin, clindamycin, and metronidazole on faecal excretion of short-chain fatty acids in healthy subjects.

    abstract::The faecal excretion of short-chain fatty acids (SCFAs) has been measured in groups of six healthy subjects before, during, and after they received the antibiotics clindamycin, ampicillin, or metronidazole perorally for 6 days. Intake of clindamycin reduced the median total concentration of SCFAs from 62.9 mmol/kg fae...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528609003109

    authors: Høverstad T,Carlstedt-Duke B,Lingaas E,Midtvedt T,Norin KE,Saxerholt H,Steinbakk M

    更新日期:1986-06-01 00:00:00

  • Gastric emptying: comparison of scintigraphic, polyethylene glycol dilution, and paracetamol tracer assessment techniques.

    abstract:BACKGROUND:The method of choice for studying gastric emptying is dependent on several factors. The aim of the present study was to assess the concordance between solid gastric emptying, using a scintigraphic technique as gold standard, and gastric emptying as measured with parcetamol tracer and polyethylene glycol (PEG...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655200750023930

    authors: Näslund E,Bogefors J,Grybäck P,Jacobsson H,Hellström PM

    更新日期:2000-04-01 00:00:00

  • Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C-linked familial diarrhea.

    abstract:OBJECTIVE:Activating mutations in the GUCY2C gene, which encodes the epithelial receptor guanylate cyclase C, cause diarrhea due to increased loss of sodium chloride to the intestinal lumen. Patients with familial GUCY2C diarrhea syndrome (FGDS) are predisposed to inflammatory bowel disease (IBD). We investigated wheth...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1521867

    authors: Tronstad RR,Polushina T,Brattbakk HR,Stansberg C,von Volkmann HL,Hanevik K,Ellinghaus E,Jørgensen SF,Ersland KM,Pham KD,Gilja OH,Hovdenak N,Hausken T,Vatn MH,Franke A,Knappskog PM,Le Hellard S,Karlsen TH,Fiskerstrand

    更新日期:2018-01-01 00:00:00

  • Quality of life study in a regional group of patients with Crohn disease. A structured interview study.

    abstract:BACKGROUND:The course and prognosis of Crohn disease has previously been described in a regional group of patients in Copenhagen County. The aim of the present study was to reveal the quality of life. as judged by the patients, and compared to age- and sex-matched healthy controls. METHODS:Out of 100 consecutive out-p...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655200451199

    authors: Guassora AD,Kruuse C,Thomsen OO,Binder V

    更新日期:2000-10-01 00:00:00

  • Percutaneous transgallbladder rendezvous for enteroscopic management of choledocholithiasis in patients with surgically altered anatomy.

    abstract:INTRODUCTION:Endoscopic retrograde cholangiopancreatography (ERCP) in patients with surgically altered upper gastrointestinal anatomy (SAA) is generally challenging despite the use of enteroscopy. After failed biliary cannulation, rendezvous technique (RV) can be an option to assist the biliary access. However, proper ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2013.805812

    authors: Okuno M,Iwashita T,Yasuda I,Mabuchi M,Uemura S,Nakashima M,Doi S,Adachi S,Mukai T,Moriwaki H

    更新日期:2013-08-01 00:00:00

  • Simultaneous measurement of gastric acid and bicarbonate secretion in man.

    abstract::Experiments were performed to validate the computerized pH/PCO2 technique for measurement of HCO3 secretion at a physiologic pH in the human stomach. In bench-side experiments the system detected 103 +/- 2% (mean +/- SE, n = 66) of boluses or infusions of NaHCO3. The standard curve was linear in the physiologic concen...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528909090782

    authors: Sjövall H,Forssell H,Olbe L

    更新日期:1989-12-01 00:00:00

  • Chronic pancreatitis in patients with sclerosing cholangitis and ulcerative colitis.

    abstract::In the 4-year period 1980-83 sclerosing cholangitis was demonstrated in 7 out of 151 patients with ulcerative colitis hospitalized in our department. Total ulcerative colitis was demonstrated in all patients with sclerosing cholangitis, whereas abnormal pancreatograms compatible with chronic pancreatitis were seen in ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509089693

    authors: Børkje B,Vetvik K,Odegaard S,Schrumpf E,Larssen TB,Kolmannskog F

    更新日期:1985-05-01 00:00:00

  • Absence of pseudomembranes in Clostridium difficile-associated diarrhea in patients using immunosuppression agents.

    abstract:OBJECTIVE:Clostridium difficile is a major cause of diarrhea in hospitalized patients. Although pseudomembranes are crucial evidence for diagnosis of C. difficile-associated diarrhea (CDAD), some cases do not show any pseudomembranes. The aim of this study was to verify the hypothesis that pseudomembranes are not gener...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802321238

    authors: Nomura K,Fujimoto Y,Yamashita M,Morimoto Y,Ohshiro M,Sato K,Oyake T,Kowata S,Konishi H,Yoshikawa T,Ishida Y,Taniwaki M,Japan Hematology\/Oncology Study (J-HOST) Group Kyoto.

    更新日期:2009-01-01 00:00:00

  • Stenting and extracorporeal shock wave lithotripsy in chronic pancreatitis.

    abstract:BACKGROUND:Early observational studies of endoscopic treatment and extracorporeal shock wave lithotripsy (ESWL) reported considerable or complete relief of pain in 50%-80% of patients with chronic pancreatitis. There is no consensus on the measurement of pain, making comparison of observational studies difficult, and l...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310000663a

    authors: Holm M,Matzen P

    更新日期:2003-03-01 00:00:00

  • Chronic non-A, non-B hepatitis. A long-term follow-up study in 49 patients.

    abstract::Forty-nine patients with biopsy-verified chronic non-A, non-B hepatitis (NANBH) of both percutaneously transmitted and sporadic types were followed up for up to 20 years (mean, 62 months +/- 44 months). Drug addicts were not included. Twenty-four patients had chronic persistent hepatitis (CPH), and 25 had chronic acti...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528708991968

    authors: Wejstål R,Lindberg J,Lundin P,Norkrans G

    更新日期:1987-11-01 00:00:00

  • Alpha-fetoprotein and carcinoembryonic antigen in patients with primary liver carcinoma, metastatic liver disease, and alcoholic liver disease.

    abstract::Alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), alkaline phosphatase (ALP) and gamma-glutamyltranspeptidase (GT) were determined in three groups of patients: 21 with primary liver carcinoma (PLC), 106 with metastatic liver disease, and 110 with various degrees of alcoholic liver diseases. AFP was elevated in ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528209181112

    authors: Bell H

    更新日期:1982-10-01 00:00:00

  • Cholecystokinin in the regulation of gastric acid and endocrine pancreatic secretion in humans.

    abstract::In this study, a selective antagonist of cholecystokinin (CCK)-A receptors, loxiglumide, was used to evaluate the role of CCK in the control of the release of gastrin and pancreatic hormones (insulin, glucagon, pancreatic polypeptide (PP), and somatostatin) after stimulation with exogenous CCK and ingestion of a stand...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529309098239

    authors: Konturek JW,Stoll R,Gutwinska-Konturek M,Konturek SJ,Domschke W

    更新日期:1993-05-01 00:00:00

  • Association between gene polymorphisms of IL-28 and response to lamivudine in Chinese rural patients with chronic hepatitis B.

    abstract:OBJECTIVE:To assess the association between gene polymorphisms (single nucleotide polymorphisms [SNPs]) of rs8099917 and rs12980602 in the IL-28 gene and the response to lamivudine treatment in naïve of Chinese rural patients. MATERIAL AND METHODS:Three hundred and fifty-four naïve chronic hepatitis B (CHB) patients t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2013.779746

    authors: Yu F,Wang Y,Yuan S,Ma J,Ma N,Zhang X,Liu X,Liu D

    更新日期:2013-06-01 00:00:00

  • Is transcatheter arterial embolization a safer alternative than surgery when endoscopic therapy fails in bleeding duodenal ulcer?

    abstract:OBJECTIVE:Emergency surgery after unsuccessful endoscopic therapy for bleeding duodenal ulcer has been reported to have a high mortality. Transcatheter arterial embolization (TAE) of the gastroduodenal artery is an alternative strategy when endoscopic therapy fails. This study is a retrospective analysis comparing thes...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365520903486109

    authors: Venclauskas L,Bratlie SO,Zachrisson K,Maleckas A,Pundzius J,Jönson C

    更新日期:2010-03-01 00:00:00

  • Lack of association between appendectomy and primary biliary cirrhosis.

    abstract:OBJECTIVE:In view of the possible implication of various environmental factors in the pathogenesis of primary biliary cirrhosis (PBC), the role of appendectomy in patients with PBC and other chronic liver diseases from Central Greece was investigated. MATERIAL AND METHODS:The medical files of 68 patients with PBC and ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520500319633

    authors: Rigopoulou EI,Georgiadou SP,Barbanis S,Dalekos GN

    更新日期:2006-05-01 00:00:00