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Chronic non-A, non-B hepatitis. A long-term follow-up study in 49 patients.

Abstract：

:Forty-nine patients with biopsy-verified chronic non-A, non-B hepatitis (NANBH) of both percutaneously transmitted and sporadic types were followed up for up to 20 years (mean, 62 months +/- 44 months). Drug addicts were not included. Twenty-four patients had chronic persistent hepatitis (CPH), and 25 had chronic active hepatitis (CAH) or cirrhosis on the basis of the first biopsy. Patients with CPH were significantly younger than patients with CAH (mean age, 31 and 51 years, respectively; p less than 0.001). Standard laboratory data (means) correlated with histology, but great variations made liver biopsy essential for the diagnosis. Twenty-one patients were rebiopsied, and 24% had more severe lesions. In total, 16 patients (33%) had signs of cirrhosis. The disease seemed to resolve in eight patients (16%), whereas two patients died of it. Some patients with CPH might progress to CAH, and the frequent finding of cirrhosis in CAH implies the possibility of hepatic failure and fatality in chronic NANBH.

journal_name

Scand J Gastroenterol

journal_title

Scandinavian journal of gastroenterology

authors

Wejstål R,Lindberg J,Lundin P,Norkrans G

doi

10.3109/00365528708991968

subject

Has Abstract

pub_date

1987-11-01 00:00:00

pages

1115-22

issue

9

eissn

0036-5521

issn

1502-7708

journal_volume

22

pub_type

杂志文章

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