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Ursodeoxycholic acid treatment in patients with primary biliary cirrhosis. A Swedish multicentre, double-blind, randomized controlled study.

Abstract：

BACKGROUND:Ursodeoxycholic acid (UDCA) has been shown to improve serum levels of liver enzymes and bilirubin in primary biliary cirrhosis (PBC). However, it is still uncertain whether UDCA treatment also improves symptoms, liver histology, and survival without liver transplantation. METHODS:We randomized 116 patients with PBC to receive 0.5 g UDCA (n = 60) or placebo (n = 56) daily for 2 years. During the next 2 years, 80% of the UDCA-treated patients and 65% of the placebo-treated patients continued to take UDCA. RESULTS:UDCA improved serum enzyme values but not survival, symptoms, serum bilirubin levels, or liver histology. There was no significant difference in response between initially symptomatic and asymptomatic patients. CONCLUSIONS:UDCA in a dosage of 7.7 mg/kg body weight is of little benefit in PBC. This does not exclude the possibility that larger doses have beneficial effects.

journal_name

Scand J Gastroenterol

journal_title

Scandinavian journal of gastroenterology

authors

Eriksson LS,Olsson R,Glauman H,Prytz H,Befrits R,Rydén BO,Einarsson K,Lindgren S,Wallerstedt S,Wedén M

doi

10.3109/00365529709000190

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

179-86

issue

2

eissn

0036-5521

issn

1502-7708

journal_volume

32

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

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