Bile acid metabolism and vitamin B12 absorption in ulcerative colitis.

Abstract:

:Bile acid and vitamin B12 malabsorption were evaluated in 34 cases of ulcerative colitis. Twenty-four patients were non-operated and 10 patients were colectomized. The postprandial duodenal bile acid concentration was abnormally low in 13 of 24 non-operated cases and found to be correlated to the activity of the disease. Two of six patients subjected to colectomy had a reduced bile acid concentration. Bile acid absorption was assessed by the cholyl-glycine-1-14C breath test combined with faecal analysis. The 14C-excretion in breath was abnormally elevated in only one of the patients in the total material. The faecal 14C-output was related to the disease activity in the non-operated group. Patients colectomized for ulcerative colitis had an extremely high excretion of isotope in the ileal effluent, from 15 to 81 per cent of the dose given. The faecal 14C-output was correlated with the duration of the ileostomy and the mass of ileal discharge. Vitamin B12 malabsorption was only present in five patients. It is concluded that patients with ulcerative colitis during the active phase of the disease have bile acid malabsorption, and patients colectomized for ulcerative colitis have an abnormal high bile acid deconjugation in the ileal effluent.

journal_name

Scand J Gastroenterol

authors

Lenz K

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

769-75

issue

8

eissn

0036-5521

issn

1502-7708

journal_volume

11

pub_type

杂志文章
  • Effect of platelet-derived growth factor-BB on indomethacin-induced gastric lesions in rats.

    abstract::The effect of platelet-derived growth factor-BB (PDGF-BB) was evaluated in rats with indomethacin-induced gastric lesions. Animals were treated with either saline solution or several doses of PDGF-BB given orally. Rats treated with 0.1 nmol/kg PDGF-BB showed a statistically significant reduction of gastric damage. Hig...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529209000138

    authors: Guglietta A,Hervada T,Nardi RV,Lesch CA

    更新日期:1992-08-01 00:00:00

  • Inhibition of epithelial growth factor receptor signalling does not preserve epithelial barrier function after in vitro gliadin insult.

    abstract:OBJECTIVE:In coeliac disease, small-bowel mucosal permeability is increased in response to gluten consumption. However, the signalling routes leading to such a barrier defect remain obscure. As the epidermal growth factor receptor (EGFR) pathway is up-regulated in untreated coeliac disease, and since this cascade has b...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520902898119

    authors: Juuti-Uusitalo K,Lindfors K,Mäki M,Patrikainen M,Isola J,Kaukinen K

    更新日期:2009-01-01 00:00:00

  • Impact of aspirin, NSAIDs, warfarin, corticosteroids and SSRIs on the site and outcome of non-variceal upper and lower gastrointestinal bleeding.

    abstract:OBJECTIVE:To assess the impact of increased use of low-dose aspirin, other non-steroidal anti-inflammatory drugs (NSAIDs), warfarin, corticosteroids and selective serotonin re-uptake inhibitors (SSRIs) on the site and outcome of non-variceal gastrointestinal (GI) bleeds. METHODS:Retrospective review of 731 patients wi...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2010.510567

    authors: Ahsberg K,Höglund P,Kim WH,von Holstein CS

    更新日期:2010-12-01 00:00:00

  • Selective vitamin B12 malabsorption in adult coeliac disease. Report on three cases with associated autoimmune diseases.

    abstract::Three cases of adult coeliac disease with severe vitamin B12 deficiency not accompanied by folate or iron depletion are presented. Two of the patients had the extremely rare combination of coeliac disease and lack of intrinsic factor and autoimmune thrombocytopenic purpura. A close association between coeliac disease ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809090176

    authors: Stene-Larsen G,Mosvold J,Ly B

    更新日期:1988-11-01 00:00:00

  • Eosinophilic diseases of the gastrointestinal tract.

    abstract::Eosinophilic gastrointestinal disorders (EGIDs) are a diverse group of disorders whose diagnosis is on the rise and are characterized by symptoms caused by infiltration by eosinophils of the different sections of the digestive tract. Although little is known of their etiology, it seems to be multifactorial. Alteration...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365521003690251

    authors: Lucendo AJ

    更新日期:2010-09-01 00:00:00

  • The prognosis of chronic aggressive hepatitis. A clinical and morphological follow-up study.

    abstract::In a follow-up study of 85 patients with chronic aggressive (active) hepatitis (CAH) repeated liver biopsies and/or autopsy liver sections were available in 74 cases. The median time of observation was 45 months. Cirrhosis was demonstrated in 38 patients, and cirrhosis was suspected in a further five cases. Fifteen pa...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527709180930

    authors: Dietrichson O,Christoffersen P

    更新日期:1977-01-01 00:00:00

  • Cholecystokinin in the regulation of gastric acid and endocrine pancreatic secretion in humans.

    abstract::In this study, a selective antagonist of cholecystokinin (CCK)-A receptors, loxiglumide, was used to evaluate the role of CCK in the control of the release of gastrin and pancreatic hormones (insulin, glucagon, pancreatic polypeptide (PP), and somatostatin) after stimulation with exogenous CCK and ingestion of a stand...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529309098239

    authors: Konturek JW,Stoll R,Gutwinska-Konturek M,Konturek SJ,Domschke W

    更新日期:1993-05-01 00:00:00

  • Quantitative electron microscopical studies of parietal cells after antral exclusion in the rat.

    abstract::Antral exclusion was performed in seven adult male Sprague-Dawley rats, which were killed 10 weeks later. Fasting serum gastrin concentrations were almost four times higher than in unoperated controls. There was a slight increase in the thickness of the gastric mucosa, but quantitative electron microscopy showed no si...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528209181059

    authors: Helander HF,Liedberg G,Rehfeld JF

    更新日期:1982-01-01 00:00:00

  • Altered bile acid metabolism in patients with constipation-predominant irritable bowel syndrome and functional constipation.

    abstract:OBJECTIVE:Bile acids are derived from cholesterol and are potent physiological laxatives. The aim of this study was to investigate whether bile acid synthesis is altered in constipation. MATERIAL AND METHODS:Female patients with constipation (23 IBS-C, 4 functional constipation (FC)) were studied and compared with non...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802321212

    authors: Abrahamsson H,Ostlund-Lindqvist AM,Nilsson R,Simrén M,Gillberg PG

    更新日期:2008-01-01 00:00:00

  • Non-invasive detection of low-intestinal lactase activity in children by use of a combined 13CO2/H2 breath test.

    abstract:BACKGROUND:The aim of the study was to diagnose hypolactasia with a higher accuracy than with the traditional H2 breath test. METHODS:We used a combined 13C-lactose 13CO2/H2 breath test, which was performed in 33 patients in whom lactase activity was measured. RESULTS:Lactase activity was reduced in 13 cases. The sen...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365529950172808

    authors: Koetse HA,Stellaard F,Bijleveld CM,Elzinga H,Boverhof R,van der Meer R,Vonk RJ,Sauer PJ

    更新日期:1999-01-01 00:00:00

  • Repeated screening for colorectal cancer with fecal occult blood test. A prospective randomized study at Funen, Denmark.

    abstract::Two screenings with Hemoccult-II were performed in a randomized study, allocating 30,970 persons to screening and 30,968 as controls in a population of 140,000 between 45 and 74 years old on the island of Funen, Denmark. The test was completed in 20,672 initially and in 18,779 of these during rescreening 2 years later...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528909093096

    authors: Kronborg O,Fenger C,Olsen J,Bech K,Søndergaard O

    更新日期:1989-06-01 00:00:00

  • IL-1beta and IL-8, matrix metalloproteinase 3, and pepsinogen secretion before and after H. pylori eradication in gastroduodenal phenotypes.

    abstract:OBJECTIVE:Relations between host genetic factors and clinical outcomes of Helicobacter pylori infection are variable among ethnicities. The aim of this study was to examine gastric mucosal cytokines, matrix metalloproteinase 3 (MMP-3), and serum pepsinogen levels before and after eradication of H. pylori according to I...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802130209

    authors: Chang YW,Oh HC,Jang JY,Hwangbo Y,Lee JW,Lee HJ,Joo KR,Dong SH,Kim SS,Kim HJ,Kim BH,Chang R

    更新日期:2008-01-01 00:00:00

  • Helicobacter pylori infection in non-ulcer dyspeptic and ulcer patients. Determinants and consequences in 'real life'.

    abstract:BACKGROUND:Infection rates are high in patients with ulcer disease, but even non-ulcer dyspepsia (NUD) patients have Helicobacter pylori infection. The Notodden Helicobacter study is an 'outcome study' of clinical practice in a local hospital. The study may identify factors associated with infection and evaluate whethe...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529609010345

    authors: Thürmer HL,Flaaten B,Erichsen KE,Lid NO,Solheim SB

    更新日期:1996-08-01 00:00:00

  • The compact Erlangen Active Simulator for Interventional Endoscopy: a prospective comparison in structured team-training courses on "endoscopic hemostasis" for doctors and nurses to the "Endo-Trainer" model.

    abstract:BACKGROUND:In 1997 Hochberger and Neumann presented the "Erlangen Biosimulation Model" (commercialized as the "Erlangen Endo-Trainer") at various national and international meetings. The new compactEASIE is a simplified version of the original "Biosimulation Model" (Endo-Trainer) and is specially designed for easy hand...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410006765

    authors: Hochberger J,Euler K,Naegel A,Hahn EG,Maiss J

    更新日期:2004-09-01 00:00:00

  • Liquid and solid gastric emptying in adults treated for Hirschsprung's disease during early childhood.

    abstract:OBJECTIVE:Dysmotility of the upper gastrointestinal tract has been reported in children with Hirschsprung's disease. In the present study, gastric emptying was studied in adult patients with Hirschsprung's disease to elucidate whether there is a persisting involvement of the upper gastrointestinal tract in this group o...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600842211

    authors: Medhus AW,Bjørnland K,Emblem R,Husebye E

    更新日期:2007-01-01 00:00:00

  • Safety and efficacy of precut needle-knife fistulotomy.

    abstract::OBJECTIVE. Although precut is considered an useful alternative when standard methods of biliary access have failed, there is some controversy about it's safety. The study aim was to evaluate the effectiveness of needle-knife fistulotomy (NKF) after a difficult biliary cannulation and whether common bile duct (CBD) dia...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2014.898085

    authors: Lopes L,Dinis-Ribeiro M,Rolanda C

    更新日期:2014-06-01 00:00:00

  • Gender, having a positive FIT and type of hospital are important factors for colonoscopy experience in colorectal cancer screening - findings from the SCREESCO study.

    abstract:OBJECTIVES:Assessing the experience of screening procedures is crucial for improving the quality and acceptance of colonoscopy in colorectal cancer screening. The aim of the study was to investigate the colonoscopy experience and associated factors among individuals who underwent a colonoscopy in the Screening of Swedi...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1820568

    authors: Fritzell K,Forsberg A,Wangmar J,Wengström Y,Bottai M,Hultcrantz R

    更新日期:2020-11-01 00:00:00

  • The effect of catecholamines on gastric mucosal flow.

    abstract::The effect of intravenous administration of adrenaline, noradrenaline, and isoprenaline on gastric mucosal flow, measured by hydrogen clearance techniques, showed that small doses of adrenaline induced slight mucosal vasodilatation in anaesthetized cats. In both anaesthetized and conscious animals both noradrenaline a...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528209181076

    authors: Semb BK

    更新日期:1982-08-01 00:00:00

  • Assessment of blood flow in the small intestine with laser Doppler flowmetry.

    abstract::Blood flow in the small intestine was assessed in 48 patients by laser Doppler flowmetry. Mucosal and serosal flowmeter signals were compared during 'resting' conditions, vascular occlusion, and reactive hyperemia. Serosal flowmeter recordings were compared with the total blood flow of a bowel segment as measured by v...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528609011131

    authors: Ahn H,Lindhagen J,Nilsson GE,Oberg PA,Lundgren O

    更新日期:1986-09-01 00:00:00

  • Campylobacter pylori in peptic ulcer disease. III. Symptoms and paraclinical and epidemiologic findings.

    abstract::Only a few publications have dealt with the subjective symptoms, the paraclinical findings, or the epidemiology in relation to cultivation of C. pylori. Seventy-two patients answered a questionnaire containing questions about symptoms, dietary habits, smoking, and animal contact. C. pylori was cultivated from the biop...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809093877

    authors: Andersen LP,Elsborg L,Justesen T

    更新日期:1988-04-01 00:00:00

  • Systematic expression profiling of the gastric H+/K+ ATPase in human tissue.

    abstract:OBJECTIVE:The potassium-competitive acid blockers (P-CABs), comprise a new, innovative group of competitive and reversible inhibitors of the gastric H+/K+ ATPase. Our aim was to identify sites of expression of the H+/K+ ATPase that are potential targets of these compounds by examining the expression profile of the gast...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520701405579

    authors: Herrmann M,Selige J,Raffael S,Sachs G,Brambilla A,Klein T

    更新日期:2007-11-01 00:00:00

  • The influence of age, sex, and race on the incidence of esophageal cancer in the United States (1992-2006).

    abstract:BACKGROUND:There is a striking male predominance in esophageal cancer patients. Sex hormones have been suggested as a contributing factor and these are influenced by age and race. In this study, we examined the male-to-female incidence rate ratios of esophageal cancer in the United States. METHODS:We used data from 13...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2011.551890

    authors: Nordenstedt H,El-Serag H

    更新日期:2011-05-01 00:00:00

  • Protectomy in ulcerative colitis. Results in 143 patients.

    abstract::Secondary protectomy caused only one death in 59 patients while 10 deaths in the other 84 patients could be ascribed to simultaneous procedures such as colectomy. The perineal would was closed round a drainage tube. Healing was unrelated to age, primary or later protectomy, and corticosteroid medication. Mean healing ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Grüner OP,Naas R,Flatmark A,Fretheim B,Gjone E

    更新日期:1977-01-01 00:00:00

  • Incidence and prevalence of adult coeliac disease within a defined geographic area in Denmark.

    abstract:BACKGROUND:In childhood coeliac disease highly varying incidence rates have recently been disclosed. Very low incidence rates (0.09/1000) were found in Denmark, in contrast to our neighbouring country Sweden (2.93/1000). Whether this was accounted for by the diagnosis being delayed until adult life was unknown. No stud...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529609009152

    authors: Bodé S,Gudmand-Høyer E

    更新日期:1996-07-01 00:00:00

  • Biochemical gradients in the human gastric and duodenal mucosa in relation to basal acid outputs.

    abstract::The separations and measurements of adenine-adenosine, adenosine monophosphate (AMP), adenosine diphosphate (ADP), adenosine triphosphate (ATP), lipid phosphates (lipid-P), ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) were carried out in the mucosa of the corpus, antrum, and duodenum of patients with decreas...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527709181689

    authors: Mozsik G,Vizi F,Kutas J

    更新日期:1977-01-01 00:00:00

  • Protective effect of lactosucrose on intracolonic indomethacin-induced small-intestinal ulcers in rats.

    abstract:BACKGROUND:Little is known about the role of intestinal microflora in the development of indomethacin-induced enteropathy. The aim of this study was to evaluate the effects of lactosucrose, an indigestible oligosaccharide, on intestinal microflora and on indomethacin-induced enteropathy in rats. METHODS:Male Wistar ra...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365529950173663

    authors: Honda K,Matsumoto T,Kuroki F,Iida M,Oka M,Sawatani I

    更新日期:1999-03-01 00:00:00

  • Implications of gastric topical bioactive peptides in ammonia-induced acute gastric mucosal lesions in rats.

    abstract:BACKGROUND:Ammonia, one of the pathogenic factors in Helicobacter pylori-induced mucosal injury, induces acute mucosal lesions in the rat glandular stomach. METHODS:The effect of ammonia administered intragastrically on gastric peptides was investigated in urethane-anesthetized rats. RESULTS:Gastric mucosal lesions w...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365529850171017

    authors: Mori S,Kaneko H,Mitsuma T,Hayakawa T,Yamaguchi C,Uruma M

    更新日期:1998-04-01 00:00:00

  • Coeliac disease diagnosed by means of duodenoscopy and endoscopic duodenal biopsy.

    abstract::Nineteen patients with suspected coeliac disease were examined by duodenoscopy and biopsy. In all patients a histopathology consistent with coeliac disease was demonstrated in endoscopic biopsies of the duodenal mucosa. On close-up view villous atrophy was seen in vivo. Fourteen patients were re-examined on a gluten-f...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527709181349

    authors: Gillberg R,Ahrén C

    更新日期:1977-01-01 00:00:00

  • Catheter-related septicaemia in patients receiving home parenteral nutrition.

    abstract::Forty-three patients received home parenteral nutrition (HPN) for 4 to 13 months (median, 30 months) with a total treatment period of 153 patient-years. All patients had central venous catheters; 71 PVC subclavian catheters, 138 Broviac catheters, and 16 other catheters were used. Broviac catheters were introduced int...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528609015162

    authors: Rannem T,Ladefoged K,Tvede M,Lorentzen JE,Jarnum S

    更新日期:1986-05-01 00:00:00

  • Isoamylases and their thermolability in serum and cyst fluid from patients with pancreatic pseudocysts.

    abstract::The isoamylase pattern in serum and the amylase thermolability have been suggested as screening tests for the development of pancreatic pseudocysts. To study whether serum reflects the contents of pseudocysts, we have investigated the isoamylases and their thermolability in cyst fluid and in serum from 13 patients wit...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509088833

    authors: Kjaergaard J,Møller P,Henriksen FW,Nielsen VG

    更新日期:1985-09-01 00:00:00