Protective effect of lactosucrose on intracolonic indomethacin-induced small-intestinal ulcers in rats.

Abstract:

BACKGROUND:Little is known about the role of intestinal microflora in the development of indomethacin-induced enteropathy. The aim of this study was to evaluate the effects of lactosucrose, an indigestible oligosaccharide, on intestinal microflora and on indomethacin-induced enteropathy in rats. METHODS:Male Wistar rats were fed either sucrose (SC) or lactosucrose (LS) for 2 weeks. Indomethacin (24 mg/kg/ day) was administered into the colon twice, 24 h apart, and intestinal ulcers in SC and LS groups were compared macroscopically. In another experiment the bacterial composition in the mid-small-intestinal segment was determined in both groups before and after treatment with indomethacin. RESULTS:After indomethacin treatment small-intestinal ulcers were less severe in the LS than in the SC group (ulcer index: median, 0.13 (range, 0.05-0.19) versus 0.23 (0.13-0.34); P < 0.05). Total bacterial count did not differ significantly between the two groups. Indomethacin increased the number of Enterobacteriaceae in both groups, but the increase was less in the LS group. The number of streptococci was also significantly increased in the SC group but not in the LS group. CONCLUSION:These results suggest that LS has some protective effects on indomethacin-induced enteropathy and that this protective effect is in part due to the maintenance of intestinal microflora.

journal_name

Scand J Gastroenterol

authors

Honda K,Matsumoto T,Kuroki F,Iida M,Oka M,Sawatani I

doi

10.1080/00365529950173663

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

264-9

issue

3

eissn

0036-5521

issn

1502-7708

journal_volume

34

pub_type

杂志文章
  • Occurrence of autoantibodies against intrinsic factor, H,K-ATPase, and pepsinogen in atrophic gastritis and rheumatoid arthritis.

    abstract::The occurrence of autoantibodies against intrinsic factor, H,K-ATPase, and pepsinogen was analysed by means of enzyme-linked immunosorbent assay in three groups of sera. Group 1 comprised sera from 14 rheumatoid arthritis patients with normal acid secretion; group 2, sera from 18 rheumatoid arthritis patients with red...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529109003961

    authors: Mårdh S,Ma JY,Song YH,Aly A,Henriksson K

    更新日期:1991-10-01 00:00:00

  • Non-esophageal symptoms cannot differentiate between erosive reflux esophagitis and non-erosive reflux disease in a referred population.

    abstract:BACKGROUND:Non-esophageal symptoms are highly prevalent in non-erosive reflux disease (NERD). However, their prevalence in erosive esophagitis (ErE) is unclear. The aims of this study were to compare patients with pH-positive NERD and ErE in terms of non-esophageal symptoms and to investigate whether such symptoms can ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2011.579997

    authors: Zimmerman J,Hershcovici T

    更新日期:2011-07-01 00:00:00

  • Helicobacter pylori CagA-positive strains affect oxygen free radicals generation by gastric mucosa.

    abstract:BACKGROUND:Helicobacter pylori plays a key role in production of reactive oxygen metabolites (ROMs). However, the importance of virulent CagA-positive H. pylori strains remains to be determined. The aim of this study was to assess ROMs production in gastric biopsies of patients infected by H. pylori. Results were corre...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1080/003655201750074474

    authors: Danese S,Cremonini F,Armuzzi A,Candelli M,Papa A,Ojetti V,Pastorelli A,Di Caro S,Zannoni G,De Sole P,Gasbarrini G,Gasbarrini A

    更新日期:2001-03-01 00:00:00

  • Epidemiology and causes of death in a Swedish cohort of patients with autoimmune hepatitis.

    abstract:BACKGROUND:Epidemiological studies of autoimmune hepatitis (AIH) show varying figures on prevalence and incidence, and data on the long-term prognosis are scarce. Objective To investigate the epidemiology, long-term prognosis and causes of death in a Swedish AIH cohort. MATERIAL AND METHODS:Data collected from 634 AIH...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2017.1335772

    authors: Danielsson Borssén Å,Marschall HU,Bergquist A,Rorsman F,Weiland O,Kechagias S,Nyhlin N,Verbaan H,Nilsson E,Werner M

    更新日期:2017-09-01 00:00:00

  • Age behaviour of gastric acid secretion in males and females with a normal antral and body mucosa.

    abstract::In males with a normal gastric mucosa the acid secretion expressed in terms of fat-free body weight (FFB) shows a random distribution with age, whereas in females there is a significant increase. To explain this sex-related discrepancy, we examined maximal pentagastrin-stimulated gastric acid output (AO) and the parie...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528309181834

    authors: Kekki M,Sipponen P,Siurala M

    更新日期:1983-11-01 00:00:00

  • Dipeptidyl peptidase IV (DP IV, CD26) in patients with inflammatory bowel disease.

    abstract:BACKGROUND:Dipeptidyl peptidase IV (DP IV, CD26), a serine protease with broad tissue distribution and known activity in serum, participates in T cell activation and promotes a Th1 cytokine response, a function in part attributable to its enzymatic activity. We hypothesized that the activity of DP IV in serum and expre...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201750422675

    authors: Hildebrandt M,Rose M,Rüter J,Salama A,Mönnikes H,Klapp BF

    更新日期:2001-10-01 00:00:00

  • Variegate porphyria presenting with acute autonomic dysfunction, intussusception and renal infarction.

    abstract::A 48-year-old man presented with abdominal pain, constipation and irritability one month after starting phenytoin treatment for a generalized seizure. He was hypertensive, tachycardic (BP 174/98, heart rate (HR) 100 bpm supine) and hypovolaemic. Abdominal CT demonstrated transient jejunal intussusception and infarctio...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410008395

    authors: Griffith JC,Jardine DL,Bailey W,Florkowski CM

    更新日期:2004-05-01 00:00:00

  • Symptom profiles in chronic peptic ulcer disease. A detailed study of abdominal and mental symptoms.

    abstract::Abdominal and mental symptoms were assessed in 103 outpatients with chronic peptic ulcer disease. Patients with present symptoms and a history of duodenal or prepyloric ulcer were included if they had no other disorder requiring treatment. A normal female population was used for comparison of mental symptoms. Besides ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3109/00365528509089674

    authors: Sjödin I,Svedlund J,Dotevall G,Gillberg R

    更新日期:1985-05-01 00:00:00

  • The diagnostic value of the D-xylose absorption test in adult coeliac disease.

    abstract::The 25-g D-xylose absorption test was assessed in a total of 40 adult patients with coeliac disease before and after treatment and in 25 control patients. Because of a large overlap neither the urinary excretion rates nor the 1-h blood concentrations were of any use in the assessment of the individual patients. The ov...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528708996467

    authors: Bodé S,Gudmand-Høyer E

    更新日期:1987-12-01 00:00:00

  • Patients' perceptions of faecal calprotectin testing in inflammatory bowel disease: results from a prospective multicentre patient-based survey.

    abstract:INTRODUCTION:Despite its success, there appears to be practical issues with Faecal Calprotectin (FC) testing in Inflammatory Bowel Diseases (IBD), including sample collection, delivery and processing delays. Patients' perception and barriers to FC testing are yet to be explored in clinical practice. METHOD:A prospecti...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1080/00365521.2018.1527394

    authors: Kalla R,Boyapati R,Vatn S,Hijos G,Crooks B,Moore GT,Hall V,Lipscomb G,Gomollón F,Jahnsen J,Singh S

    更新日期:2018-12-01 00:00:00

  • Role of gender upon basal and postprandial systemic and splanchnic haemodynamics in humans.

    abstract:BACKGROUND:Food intake, accompanied by systemic and splanchnic haemodynamic changes, has only been studied in males. The extent to which splanchnic postprandial hyperaemia shows gender differences is unknown. METHODS:We tested 1) the splanchnic hyperaemic response to food in females and 2) whether postprandial haemody...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201750153458

    authors: Szinnai C,Mottet C,Gutzwiller JP,Drewe J,Beglinger C,Sieber CC

    更新日期:2001-05-01 00:00:00

  • Effects of treatment compliance and overnight gastric secretion on outcome of maintenance therapy of duodenal ulcer with ranitidine.

    abstract::Eighty-seven patients with endoscopically healed duodenal ulcers received continuous maintenance treatment with a standard dose of 150 mg ranitidine at night for 6-12 months. The cumulative annual rate of symptomatic reulceration was 24%, whereas a further 25% of asymptomatic relapses were detected with routine endosc...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528309181583

    authors: Boyd EJ,Wilson JA,Wormsley KG

    更新日期:1983-03-01 00:00:00

  • Mice harboring a defective epidermal growth factor receptor (waved-2) have an increased susceptibility to acute dextran sulfate-induced colitis.

    abstract:BACKGROUND:It has been reported that epithelial growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) play an important role in colonic mucosal defense and repair. Waved-2 (wa-2) mice harboring a defect EGF-R and phenotypically similar to TGF-alpha knockout mice provide a novel approach to study the role...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655200750056664

    authors: Egger B,Büchler MW,Lakshmanan J,Moore P,Eysselein VE

    更新日期:2000-11-01 00:00:00

  • Pancreatic duct changes are not associated with early signs of chronic pancreatitis at magnetic resonance imaging (MRI) in patients with primary sclerosing cholangitis.

    abstract:OBJECTIVE:The association between chronic pancreatitis (CP) and primary sclerosing cholangitis (PSC) has been reported previously. The aims of the present study were to evaluate the presence of early pancreatic abnormalities and duct changes, using MRCP/MRI in PSC and to evaluate possible risk factors for these changes...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521003793741

    authors: Said K,Albiin N,Lindberg B,Brismar TB,Karrar A,Permert J,Bergquist A

    更新日期:2010-08-01 00:00:00

  • Pathophysiological basis of pharmacotherapy in the hepatorenal syndrome.

    abstract::Hepatorenal syndrome (HRS) is a functional and reversible impairment of renal function in patients with severe cirrhosis. Major pathophysiological elements include liver dysfunction, a circulatory derangement with central hypovolaemia and neurohumoral activation of potent vasoactive systems leading to a pronounced ren...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1080/00365520510012064

    authors: Møller S,Bendtsen F,Henriksen JH

    更新日期:2005-05-01 00:00:00

  • Impaired lipopolysaccharide-induced interleukin-1-beta production in patients with anti-hepatitis C virus antibody-positive chronic liver disease.

    abstract::The aim of our study was to determine the role of cytokine interleukin-1-beta (IL-1-beta) in patients with chronic hepatitis C virus (HCV) infection. Twenty-eight patients with chronic HCV infection were studied and compared with 18 healthy subjects. IL-1-beta levels were measured with an enzyme-linked immunosorbent a...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409090477

    authors: Ozyilkan E,Tatar G,Hacibektaşoglu A,Kayhan B,Telatar H

    更新日期:1994-03-01 00:00:00

  • Helicobacter pylori eradication in the healing of atrophic gastritis: a one-year prospective study.

    abstract:OBJECTIVE:Whether gastric atrophy or intestinal metaplasia heals after successful treatment of Helicobacter pylori (H. pylori) infection is still a matter of controversy. The aim of this article was to clarify whether, after one year, H. pylori eradication is associated with healing in glandular atrophy and intestinal ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1080/00365520500463175

    authors: Arkkila PE,Seppälä K,Färkkilä MA,Veijola L,Sipponen P

    更新日期:2006-07-01 00:00:00

  • The expression kinetics of CD137 in chronic hepatitis C patients treated with pegylated-interferon and ribavirin.

    abstract:OBJECTIVE:CD137, a member of the tumor necrosis factor receptor family, generates co-stimulatory signals leading to T-cell activation and proliferation for viral eradication. We examined the expression kinetics of CD137 to validate whether it can affect treatment outcomes of chronic hepatitis C (CHC) patients. METHODS...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.668929

    authors: Lee SJ,Shin JW,Park BR,Kim CJ,Jung SW,Kim B,Jeong ID,Bang SJ,Park NH

    更新日期:2012-05-01 00:00:00

  • The effect of catecholamines on gastric mucosal flow.

    abstract::The effect of intravenous administration of adrenaline, noradrenaline, and isoprenaline on gastric mucosal flow, measured by hydrogen clearance techniques, showed that small doses of adrenaline induced slight mucosal vasodilatation in anaesthetized cats. In both anaesthetized and conscious animals both noradrenaline a...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528209181076

    authors: Semb BK

    更新日期:1982-08-01 00:00:00

  • Magnetic resonance imaging of the small bowel in Crohn's disease.

    abstract:OBJECTIVE:There may be advantages in using magnetic resonance imaging (MRI) in small-bowel disease. The aims of this study were to optimize the MRI examination technique and to evaluate the capabilities of MRI compared with those of conventional enteroclysis (CE). MATERIALS AND METHODS:MRI and CE were performed in 36 ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/00365520510015683

    authors: Frøkjaer JB,Larsen E,Steffensen E,Nielsen AH,Drewes AM

    更新日期:2005-07-01 00:00:00

  • Protective effects of trolox C, vitamin C, and catalase on bromobenzene-induced damage to rat hepatocytes.

    abstract:BACKGROUND/METHODS:The protective effects of trolox C (water-soluble vitamin E), vitamin C, and catalase on bromobenzene (BB)-induced toxicity to isolated rat hepatocytes were evaluated. The glutathione (GSH) content of the hepatocytes exposed to BB was measured. RESULTS:BB caused acute damage to the cells during 2 h ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529609010355

    authors: Wu J,Karlsson K,Danielsson A

    更新日期:1996-08-01 00:00:00

  • Staphylococcus aureus in inflammatory bowel disease.

    abstract:BACKGROUND:The potential role of superantigens in inflammatory bowel disease (IBD), particularly Crohn disease, has been broached in studies of the functions of T cell receptors. Staphylococcal cells have been found in intestinal lymph follicles of IBDs. To clarify a role of staphylococcal superantigens in IBD, we atte...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201750163079

    authors: Chiba M,Hoshina S,Kono M,Tobita M,Fukushima T,Iizuka M,Watanabe S

    更新日期:2001-06-01 00:00:00

  • Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer models.

    abstract:OBJECTIVE:Pancreatic cancer continues to be an urgent clinical problem. We used the novel DNA methyltransferase inhibitor Zebularine and the histone deacetylase inhibitor SAHA to investigate the epigenetic influence on viability and differentiation of the pancreatic cancer cell lines YAP C, DAN G and Panc-89 in vitro a...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600874198

    authors: Neureiter D,Zopf S,Leu T,Dietze O,Hauser-Kronberger C,Hahn EG,Herold C,Ocker M

    更新日期:2007-01-01 00:00:00

  • 1- and 4-week cimetidine treatment for duodenal ulcer.

    abstract::Forty-eight patients with symptomatic duodenal ulcer were randomized to 4 weeks' treatment with cimetidine, 1 g/day (C4), or 1 week of cimetidine treatment followed by 3 weeks of placebo (C1 + P). The study was performed double blind. The symptoms were recorded daily on a visual analogue scale. Endoscopy was performed...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528609011103

    authors: Johannessen T,Kristensen P,Fjøsne U,Hafstad PE,Kleveland PM,Løge I,Sandbakken P,Petersen H

    更新日期:1986-08-01 00:00:00

  • Severe jaundice in Sweden in the new millennium: causes, investigations, treatment and prognosis.

    abstract:BACKGROUND:The aims of the study were to assess the causes of jaundice in Gothenburg, Sweden, to study the types of investigations applied in cholestatic and hepatocellular types of jaundice and treatment and to evaluate the prognosis of these patients up to a year from the diagnosis. METHODS:Over a 3-month period, al...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310000492

    authors: Björnsson E,Ismael S,Nejdet S,Kilander A

    更新日期:2003-01-01 00:00:00

  • High-grade dysplastic adenoma-like mass lesions are not an indication for colectomy in patients with ulcerative colitis.

    abstract:OBJECTIVE:The management of high-grade dysplasia (HGD) in polypoid lesions in patients with ulcerative colitis (UC) is not well characterized. The purpose of this study was to characterize the clinical course of patients with HGD in adenoma-like dysplasia-associated lesion or masses (DALMs) in the absence of any synchr...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520801909686

    authors: Blonski W,Kundu R,Furth EF,Lewis J,Aberra F,Lichtenstein GR

    更新日期:2008-01-01 00:00:00

  • Association of polymorphism of the p22PHOX component of NADPH oxidase in gastroduodenal diseases in Japan.

    abstract:OBJECTIVE:Superoxide has been implicated in the pathogenesis of Helicobacter pylori-related diseases through inflammation. NADPH oxidase, a major source of superoxide generation, plays a critical role in H. pylori-related gastric inflammation. The aim of this study was to clarify the effect of the p22PHOX C242T polymor...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520701702348

    authors: Tahara T,Shibata T,Wang F,Nakamura M,Okubo M,Yoshioka D,Sakata M,Nakano H,Hirata I,Arisawa T

    更新日期:2009-01-01 00:00:00

  • Serum concentration of pancreatic polypeptide after infusion of histamine and the effect of cimetidine, trimipramine, and atropine in man.

    abstract::Histamine was given intravenously to eight human subjects, and the PP concentration in serum increased significantly from 14.8 (7.2-29.3) pM to 27.5 (9.6-39.3) pM and then decreased to the basal level. This histamine-induced PP release was not altered when trimipramine or cimetidine was given in addition to histamine....

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528109181016

    authors: Flaten O,Bohman T,Myren J

    更新日期:1981-01-01 00:00:00

  • Effects of omeprazole and eradication of Helicobacter pylori on gastric and duodenal mucosal enzyme activities and DNA in duodenal ulcer patients.

    abstract:BACKGROUND:Duodenal and gastric content of mucosal enzymes in duodenal ulcer (DU) patients differs from that of controls. The purpose of this study has been to examine the effect of omeprazole and eradication of Helicobacter pylori on mucosal enzymes in DU patients. METHODS:The enzyme activities of seven gastric and d...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365529409094876

    authors: Vetvik K,Schrumpf E,Mowinckel P,Aase S,Andersen KJ

    更新日期:1994-11-01 00:00:00

  • Is levofloxacin-based triple therapy an alternative for first-line eradication of Helicobacter pylori? A systematic review and meta-analysis.

    abstract:OBJECTIVES:To evaluate the available data on the efficacy and safety of levofloxacin-based triple therapy compared with standard triple therapy in first-line treatment for Helicobacter pylori infection. METHODS:By searching MEDLINE, The Cochrane Central Register of Controlled Trials, and Web of Knowledge, two independ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3109/00365521.2014.887765

    authors: Xiao SP,Gu M,Zhang GX

    更新日期:2014-05-01 00:00:00