Serum concentration of pancreatic polypeptide after infusion of histamine and the effect of cimetidine, trimipramine, and atropine in man.

Abstract:

:Histamine was given intravenously to eight human subjects, and the PP concentration in serum increased significantly from 14.8 (7.2-29.3) pM to 27.5 (9.6-39.3) pM and then decreased to the basal level. This histamine-induced PP release was not altered when trimipramine or cimetidine was given in addition to histamine. This PP release could not mediated through histamine-receptor mechanisms, and since atropine prevented this PP release, we conclude that the release of PP after histamine reflects a cholinergic stimulus.

journal_name

Scand J Gastroenterol

authors

Flaten O,Bohman T,Myren J

doi

10.3109/00365528109181016

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

989-91

issue

8

eissn

0036-5521

issn

1502-7708

journal_volume

16

pub_type

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