Abstract：
OBJECTIVES:Alcoholic hepatitis (AH) markedly decreases the urea synthesis capacity. We aimed to investigate the time course of this compromised essential liver function in patients with AH and its relation to treatment and survival. MATERIALS AND METHODS:Thirty patients with AH were included in a prospective cohort study. We measured the substrate-independent urea synthesis capacity, i.e., the functional hepatic nitrogen clearance (FHNC), in the patients at study entry and again at three months (survivors/available: n = 17). Patients with severe disease (Glasgow Alcoholic Hepatitis Score ≥9, n = 17) were randomized to receive either prednisolone or pentoxifylline and were in addition examined after 14 days (n = 9). RESULTS:FHNC (normal range = 25-45 L/h) was markedly decreased at study entry (median = 5.6 (IQR = 3.0-9.6) L/h) and increased by three-fold in survivors at three months (15.1 (12.0-22.9) L/h; p < .001). In patients with severe AH, FHNC was also increased after 14 days of pharmacologic treatment and showed the greatest increase in the patients taking prednisolone (prednisolone 25.4 (20.6-26.2) L/h vs. pentoxifylline 12.3 (8.0-15.3) L/h; p = .05). FHNC at study entry was lower in 90-day non-survivors than in survivors (p = .04). CONCLUSIONS:The decrease in the urea synthesis capacity in patients with AH was the most marked in short-term non-survivors and partly recovered in survivors at three months. In patients on pharmacologic treatment, recovery was observed already after 14 days, and it was nearly complete in those on prednisolone. Thus, metabolic liver failure in AH seems to be prognostically important, is potentially reversible, and may recover more rapidly following treatment with prednisolone.
journal_name
Scand J Gastroenteroljournal_title
Scandinavian journal of gastroenterologyauthors
Glavind E,Aagaard NK,Gronbaek H,Orntoft NW,Vilstrup H,Thomsen KLdoi
10.1080/00365521.2017.1399163subject
Has Abstractpub_date
2018-05-01 00:00:00pages
592-597issue
5eissn
0036-5521issn
1502-7708journal_volume
53pub_type
杂志文章,随机对照试验abstract：:Perforation occurring at a remote site of the bowel after diagnostic colonoscopy is rare. A 61-year-old man presenting with bloody diarrhoea underwent colonoscopy. A dynamic ileus developed in less than 1 day, and mid-ileal perforation occurred 7 days after the procedure. It is suggested that high air pressure during ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/003655298750027065
更新日期：1998-09-01 00:00:00
abstract：OBJECTIVE:Lynch syndrome (LS) has an autosomal dominant inheritance pattern and is associated with increased risk for colorectal cancer (CRC) and other cancers. Various strategies are used to identify patients at risk and offer surveillance and preventive programs, the cost effectiveness of which is much dependent on t...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章,多中心研究
doi：10.1080/00365521.2018.1542453
更新日期：2018-12-01 00:00:00
abstract：:Seven double-pouch dogs with one vagally innervated Amdrup pouch (AP) and one denervated Heidenhain pouch (HP) made possible comparison of gastric secretion from innervated and denervated mucosa at the same time in the same animal. Stimulation was done by food--a mixture of liver, heart, and bonemeal, 10g/kg. Cimetidi...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Enemas containing 1000 mg 5-ASA were administered to patients with active distal colitis in three separate studies: as a single dose in a neutral solution (pH 7.4); as a single dose in a slightly acidic, buffered suspension (pH 4.8); and as multiple doses once a day for 10 days with the acidic enema. 5-ASA was relativ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 临床试验,杂志文章
doi：
更新日期：1984-07-01 00:00:00
abstract：BACKGROUND:Electronic health (eHealth) solutions may help address the growing pressure on IBD outpatient services as they encompass a component of self-management. However, information regarding patients' attitudes towards the use of eHealth solutions in IBD is lacking. OBJECTIVE:The aim of this study was to evaluate ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365521.2017.1333625
更新日期：2017-09-01 00:00:00
abstract：:Ultrasonography, 99mTc-DIDA cholescintigraphy, and infusion tomography of the gallbladder were compared in a prospective study comprising 45 consecutive patients clinically suspected of having acute cholecystitis. The diagnosis of acute cholecystitis was established or excluded by operation in 35 patients, by oral cho...
journal_title：Scandinavian journal of gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3109/00365528209181047
更新日期：1982-01-01 00:00:00
abstract：BACKGROUND:We recently reported increased intestinal permeability to polysucrose (PS) 15000 in patients with Crohn's disease and in patients treated with non-steroidal anti-inflammatory drugs (NSAIDs). We have now compared this new macromolecular marker (14,700 D) with the conventional markers, 51Cr-labelled ethylenedi...
journal_title：Scandinavian journal of gastroenterology
pub_type： 临床试验,杂志文章
doi：10.3109/00365529509101627
更新日期：1995-12-01 00:00:00
abstract：BACKGROUND:Ultrasound (US)-guided percutaneous acetic acid injection therapy (PAIT) is effective for patients with hepatocellular carcinoma (HCC). This study aimed to determine the occurrence and predictive value of persistent intra-tumoral retention of acetic acid after PAIT. METHODS:We prospectively studied 60 (52 M...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520310008269
更新日期：2004-02-01 00:00:00
abstract：BACKGROUND AND GOALS:Acute non-variceal gastrointestinal bleeding (NVGIB) is one of the most common medical emergencies, leading to significant morbidity and mortality without proper management. This study was to analyze the causes of NVGIB and to evaluate the safety, efficacy, and feasibility of transcatheter arterial...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365521.2020.1790650
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Spontaneous bacterial peritonitis (SBP) is a complication to decompensated cirrhosis. Fluoroquinolones may prevent SBP. However, predictive markers for SBP are wanted. Guidelines suggest that patients with ascitic fluid protein below 15 g/l receive fluoroquinolones to prevent SBP. This study aimed to assess ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365521.2017.1411973
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:The two forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC), are thought to arise because of an interplay of unfavorable genetic and exogenous factors. During a genome-wide linkage study of IBD, we observed a nominal linkage to chromosome 11p12-q13 that was further conf...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520500265166
更新日期：2006-04-01 00:00:00
abstract：:Hepatorenal syndrome (HRS) is a functional and reversible impairment of renal function in patients with severe cirrhosis. Major pathophysiological elements include liver dysfunction, a circulatory derangement with central hypovolaemia and neurohumoral activation of potent vasoactive systems leading to a pronounced ren...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.1080/00365520510012064
更新日期：2005-05-01 00:00:00
abstract：BACKGROUND:Epidemiological studies of autoimmune hepatitis (AIH) show varying figures on prevalence and incidence, and data on the long-term prognosis are scarce. Objective To investigate the epidemiology, long-term prognosis and causes of death in a Swedish AIH cohort. MATERIAL AND METHODS:Data collected from 634 AIH...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365521.2017.1335772
更新日期：2017-09-01 00:00:00
abstract：:Forty-eight patients with symptomatic duodenal ulcer were randomized to 4 weeks' treatment with cimetidine, 1 g/day (C4), or 1 week of cimetidine treatment followed by 3 weeks of placebo (C1 + P). The study was performed double blind. The symptoms were recorded daily on a visual analogue scale. Endoscopy was performed...
journal_title：Scandinavian journal of gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3109/00365528609011103
更新日期：1986-08-01 00:00:00
abstract：BACKGROUND:Restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA) have been the surgical treatments of choice for ulcerative colitis (UC). However, the IPAA is sometimes complicated with pouchitis. Furthermore, the cumulative risk and risk factors for developing pouchitis in patients with UC undergoing IPA...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520310005938
更新日期：2003-10-01 00:00:00
abstract：BACKGROUND AND AIM:Variation in the prevalence of various types of gastric polyps worldwide may reflect different etiologies. Here, the authors report the dynamic changes in histological distribution of gastric polyps over time and by ethnicity for individuals who underwent gastroscopies between 1994 and 2009 at two ho...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365521.2012.682091
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVE:High levels of alanine aminotransferase (ALT) can be a marker of severe liver disease with variable aetiologies and prognosis. Very few prospective studies have been undertaken on the aetiology and prognosis of patients with high ALT levels. No population-based prospective study has systematically evaluated d...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章,多中心研究
doi：10.3109/00365521.2015.1121516
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Duodenal and gastric content of mucosal enzymes in duodenal ulcer (DU) patients differs from that of controls. The purpose of this study has been to examine the effect of omeprazole and eradication of Helicobacter pylori on mucosal enzymes in DU patients. METHODS:The enzyme activities of seven gastric and d...
journal_title：Scandinavian journal of gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3109/00365529409094876
更新日期：1994-11-01 00:00:00
abstract：OBJECTIVES:Systematic screening for chronic hepatitis B and C does not yet exist in Germany. Therefore, the implementation of a screening approach within a preventive medical examination performed by primary care physicians ('Check-Up 35+') was evaluated in a recent prospective multicenter study. The present analysis e...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365521.2017.1390599
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Glucagon-like peptide-2 is formed from proglucagon in the intestinal L-cells and is secreted postprandially in parallel with the insulinotropic hormone GLP-1 (glucagon-like peptide-1), which in addition acts to inhibit gastric motility (enterogastrone effect) by inhibiting central parasympathetic outflow. GL...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365529850171486
更新日期：1998-08-01 00:00:00
abstract：:Nineteen patients with suspected coeliac disease were examined by duodenoscopy and biopsy. In all patients a histopathology consistent with coeliac disease was demonstrated in endoscopic biopsies of the duodenal mucosa. On close-up view villous atrophy was seen in vivo. Fourteen patients were re-examined on a gluten-f...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365527709181349
更新日期：1977-01-01 00:00:00
abstract：:Nucleotide pyrophosphatase activity with uridine diphosphoglucose and dephospho-CoA as substrates was demonstrated in normal human serum. The enzyme has a pH-optimum of about 9.6 and is inhibited by EDTA. Phosphodiesterase I (hydrolysis of thymidine-5'-monophospho-p-nitrophenylester) was also found in normal human ser...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：OBJECTIVE:The mortality associated with malignant complications of gastroesophageal reflux disease (GERD) is well recognized. The aim of this systematic review was to assess the less well-examined mortality associated with GERD and its non-malignant complications, including esophageal erosions, ulcers, bleeding, perfor...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.1080/00365520701785475
更新日期：2008-01-01 00:00:00
abstract：:Eleven adult individuals (aged 24 to 66 years) with severe alpha1-antitrypsin deficiency, Pi Z, and with no clinical signs of liver disease, were investigated with a broad spectrum of liver function tests. Except for low alpha1-antitrypsin levels, no evidence of abnormal hepatic protein synthesis was found. Neither co...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365527709181332
更新日期：1977-01-01 00:00:00
abstract：OBJECTIVE:To investigate the combination therapy, consisting of hyperimmune bovine colostrum, N-acetyl cysteine, zinc and amoxicillin on the eradication of Helicobacter pylori in a mouse model. MATERIAL AND METHODS:C57BL/6 female mice (6 weeks of age) were inoculated with 0.1 ml of 1×10(9) H. pylori via a single oro-g...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365521.2010.506245
更新日期：2010-12-01 00:00:00
abstract：:The following immunologic in vitro tests were applied on peripheral blood mononuclear cells (PBMC) from patients with chronic inflammatory bowel disease (IBD): concanavalin A (Con A)-induced suppressor test, Con A-activated lymphoblast transformation test, and spontaneous lymphoblast transformation test. Concomitant p...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365528708991915
更新日期：1987-09-01 00:00:00
abstract：:The incidence of urolithiasis was registered in 87 patients with chronic inflammatory bowel disease and compared with that of renal oxalate excretion. All patients were studied while on a standardized diet with fixed amounts of fat, calcium, and oxalate. Pyelography had been performed in all. Nine, or 35%, of 26 hyper...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：OBJECTIVES:Mismatch repair deficient (dMMR) colorectal cancer (CRC) is caused by inactivation of the MMR DNA repair system, most commonly via epigenetic inactivation of the MLH1 gene, and these tumors occur most frequently in the right colon. The objective was to determine whether cholecystectomy (CCY) increases the ri...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365521.2018.1481997
更新日期：2018-08-01 00:00:00
abstract：:We investigated the electrogenic transport of glucose in the upper part of the duodenum in 11 healthy subjects by means of simultaneous intestinal perfusion of test solutions and measurement of the corresponding potential differences between blood and the duodenal lumen. The technique entailed continuous perfusion and...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-06-01 00:00:00
abstract：:Pancreatic duct pressure was studied by endoscopic manometry in 12 patients with chronic pancreatitis and in 9 patients with a normal pancreas (suspected biliary dyskinesia). To study the effect of increased intraduodenal concentration of pancreatic enzymes, the duct pressure was measured before and after intraduodena...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365528609015156
更新日期：1986-05-01 00:00:00
