当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY期刊下所有文献 > Screening of tumor necrosis factor receptor-associated factor 6 as a candidate gene for inflammatory bowel disease.

Screening of tumor necrosis factor receptor-associated factor 6 as a candidate gene for inflammatory bowel disease.

Abstract：

OBJECTIVE:The two forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC), are thought to arise because of an interplay of unfavorable genetic and exogenous factors. During a genome-wide linkage study of IBD, we observed a nominal linkage to chromosome 11p12-q13 that was further confirmed upon fine density mapping. This chromosomal region contains a functional IBD candidate gene coding for tumor necrosis factor receptor-associated factor 6 (TRAF6), a signal transducer regulating innate and adaptive immunity as well as bone homeostasis. MATERIAL AND METHODS:Using denaturing high-performance liquid chromatography (dHPLC) and DNA sequencing, all exons and exon-intron boundaries of the TRAF6 gene in probands of 95 IBD families were initially screened; this material comprised 20 CD, 39 UC and 36 mixed families. RESULTS:No nucleotide changes in the coding sequence of TRAF6 were detected, but a single-base insertion/deletion polymorphism in a polythymine stretch (containing 8 or 7 thymines, respectively) in intron 3 was identified. However, examination of an extended material of 290 unrelated CD patients, 416 UC patients and 320 healthy blood donors failed to show any association with this 7T/8T variation and IBD, nor was this polymorphism related to specific clinical features in IBD. CONCLUSIONS:Our study tends to exclude a good positional and functional candidate gene, TRAF6, as an IBD predisposing gene and lends support to the idea that the function of TRAF6 is important enough not to permit structural alterations of this mediator.

journal_name

Scand J Gastroenterol

journal_title

Scandinavian journal of gastroenterology

authors

Lappalainen M,Paavola-Sakki P,Halme L,Turunen U,Heliö T,Färkkilä M,Kontula K

doi

10.1080/00365520500265166

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

424-9

issue

4

eissn

0036-5521

issn

1502-7708

pii

M774212086L46445

journal_volume

41

pub_type

杂志文章

相关文献

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY文献大全
  • Crohn's disease intestinal CD4+ T cells have impaired interleukin-10 production which is not restored by probiotic bacteria.

    abstract：OBJECTIVE:Crohn's disease (CD) has been associated with low mucosal interleukin (IL)-10 production, but the mechanism behind this deficiency remains unclear. The aim of this study was to investigate IL-10 and interferon (IFN)-gamma production in intestinal CD4+ T cells from CD patients and healthy volunteers (HV) and t...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365520601013754

    authors： Hvas CL,Kelsen J,Agnholt J,Höllsberg P,Tvede M,Møller JK,Dahlerup JF

    更新日期：2007-05-01 00:00:00

  • Dynamics and localization of activin A expression in rat gastric ulcers.

    abstract：BACKGROUND:Activin A, the homodimer of the activin/inhibin betaA subunit, has been shown to participate in cutaneous wound healing. In this study we intended to determine its part in gastric ulceration. METHODS:Activin A expression was studied by immunohistochemistry and in situ hybridization in acetic-acid-induced ch...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365520310000636a

    authors： Becker JC,Hertel M,Markmann A,Shahin M,Werner S,Domschke W,Pohle T

    更新日期：2003-03-01 00:00:00

  • Correlation between exocrine pancreatic secretion and serum concentration of human pancreatic polypeptide in chronic pancreatitis.

    abstract：:Concentrations of human pancreatic polypeptide (HPP) in serum were measured in the fasting state and after a meal in 19 control subjects and 24 patients with chronic pancreatitis (CP). The severity of CP was characterized on the basis of the duodenal lipase concentration after a test meal (Lundh test). Basal and postp...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365528009181517

    authors： Andersen BN,Hagen C,Klein HC,Stadil F,Worning H

    更新日期：1980-01-01 00:00:00

  • Primary sclerosing cholangitis and the microbiota: current knowledge and perspectives on etiopathogenesis and emerging therapies.

    abstract：:Primary sclerosing cholangitis (PSC) is a chronic, fibroinflammatory, cholestatic liver disease of unknown etiopathogenesis. PSC generally progresses to liver cirrhosis, is a major risk factor for hepatobiliary and colonic neoplasia, and confers a median survival to death or liver transplantation of only 12 years. Alt...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.3109/00365521.2014.913189

    authors： Tabibian JH,O'Hara SP,Lindor KD

    更新日期：2014-08-01 00:00:00

  • The fate of intravenously injected trypsinogens in dogs.

    abstract：:After intravenous injection of autologous purified and radiolabeled anionic and cationic trypsinogens in the dog, there is a multiexponential elimination from serum of the trypsinogens without activation to active trypsins. The results are in agreement with an elimination of the trypsinogens iva glomerular filtration,...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365528109181969

    authors： Borgström A

    更新日期：1981-01-01 00:00:00

  • Mucosal enzyme activities in the functioning intestine one and six months after jejuno-ileal by-pass operation for obesity.

    abstract：:Enzyme activity changes in the functioning segment (the shunt) of the small intestine during the first 6 months after by-pass operation for obesity were investigated. At the ligament of Treitz no significant changes in disaccharidase activities occurred, whereas two intracellular beta-galactosidases showed increased a...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Asp NG,Gudmand-Høyer G,Andersen B

    更新日期：1979-01-01 00:00:00

  • Effects of short-time somatostatin infusion on the gastric and intestinal propulsion in humans.

    abstract：:The effect of short-time somatostatin infusion on gastric and intestinal propulsion of an oral glucose load was examined in healthy subjects by means of a multiple indicator dilution technique. The early gastric emptying rate was enhanced by somatostatin, indicating delayed gastric inhibition. After withdrawal of the ...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365527809181925

    authors： Johansson C,Efendic S,Wisén O,Uvnäs-Wallensten K,Luft R

    更新日期：1978-01-01 00:00:00

  • Antibodies to oat prolamines (avenins) in children with coeliac disease.

    abstract：BACKGROUND:The use of oats in a gluten-free diet for children with coeliac disease is presently under investigation. In this study we measured the content of antibodies to oat prolamines (avenin) in sera from coeliac children and reference children. METHODS:Crude avenin was prepared by extraction with ethanol and salt...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365520310003156

    authors： Hollén E,Högberg L,Stenhammar L,Fälth-Magnusson K,Magnusson KE

    更新日期：2003-07-01 00:00:00

  • Comparison of 5-aminosalicylic acid (3 g) and prednisolone phosphate sodium enemas (30 mg) in the treatment of distal ulcerative colitis. A prospective, randomized, double-blind trial.

    abstract：:Twenty-nine patients with attacks of distal ulcerative colitis were treated randomly with 3 g 5-aminosalicylic acid (5-ASA) or 30 mg of prednisolone phosphate sodium (PP) enemas (40 ml). Endoscopic, clinical, and histologic improvement were comparable in the two treatment groups. Our study showed that topical treatmen...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.3109/00365528809090161

    authors： Mulder CJ,Tytgat GN,Wiltink EH,Houthoff HJ

    更新日期：1988-10-01 00:00:00

  • Effect of sulindac on prostaglandin excretion and renal function in cirrhotic patients with ascites.

    abstract：:The effect of sulindac, a nonsteroidal anti-inflammatory drug, on renal prostaglandin synthesis and renal function variables was investigated in six cirrhotic patients with tense ascites and marked sodium retention. We studied serum thromboxane (TXB2) production, urinary prostaglandin excretion (6-keto-prostaglandin F...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365528609034652

    authors： Guarner C,Enriquez J,Guarner F,Quiroga J,Just J,Seres I,Prieto J,Vilardell F

    更新日期：1986-03-01 00:00:00

  • Non-specific abdominal pain remains as the most common reason for acute abdomen: 26-year retrospective audit in one emergency unit.

    abstract：OBJECTIVE:Distribution of diagnoses causing acute abdominal pain (AAP) may change because of population aging, increased obesity, advanced diagnostic imaging and changes in nutritional habits. Our aim was to evaluate the diagnoses causing AAP during a 26-year period. MATERIALS AND METHODS:This was a retrospective cros...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365521.2017.1342140

    authors： Fagerström A,Paajanen P,Saarelainen H,Ahonen-Siirtola M,Ukkonen M,Miettinen P,Paajanen H

    更新日期：2017-10-01 00:00:00

  • Faecal calprotectin and lactoferrin as markers of acute radiation proctitis: a pilot study of eight stool markers.

    abstract：BACKGROUND:Non-invasive diagnostic tools to evaluate the severity of acute, radiation-induced proctitis are not readily available. The faecal excretion of eight markers of gut inflammation was therefore examined. Five proteins and three lipid derivates were analysed in sequential stool samples taken before and during r...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365520410003614

    authors： Larsen A,Hovdenak N,Karlsdottir A,Wentzel-Larsen T,Dahl O,Fagerhol MK

    更新日期：2004-11-01 00:00:00

  • Cholecystokinin in the control of gastric acid secretion and gastrin release in response to a meal at low and high pH in healthy subjects and duodenal ulcer patients.

    abstract：OBJECTIVE:In healthy subjects a gastric meal at low pH inhibits gastric acid secretion, possibly by reducing gastrin release, whereas duodenal ulcer (DU) patients have been reported to show a lack of this low pH inhibition of gastric secretion. METHODS:The intragastric pH profiles were measured in seven healthy subjec...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365529509096321

    authors： Konturek JW,Konturek SJ,Domschke W

    更新日期：1995-08-01 00:00:00

  • Role of miR-19a targeting TNF-α in mediating ulcerative colitis.

    abstract：OBJECTIVE:Ulcerative colitis (UC) is a widely studied inflammatory disease associated with differential expression of genes involved in immune function, wound healing, and tissue remodeling. MicroRNAs have been reported to play a role in various cancer types. However, the mechanism of how microRNAs regulate UC remains ...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365521.2013.800991

    authors： Chen B,She S,Li D,Liu Z,Yang X,Zeng Z,Liu F

    更新日期：2013-07-01 00:00:00

  • Yersinia infection mimicking recurrence of gastrointestinal stromal tumor.

    abstract：:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. So far, surgical resection has been the only curative treatment, but new options became available with the application of imatinib (Glivec) as a specific molecular inhibitor. Even after complete resection, GIS...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365520310008845

    authors： Luedde T,Tacke F,Chavan A,Länger F,Klempnauer J,Manns MP

    更新日期：2004-06-01 00:00:00

  • Myofibroblast-like cells produce mRNA for type I and III procollagens in chronic active hepatitis.

    abstract：:In chronic active hepatitis the rate of collagen biosynthesis is largely determined by intracellular mRNA concentrations. To localize procollagen mRNA-producing cells, we investigated biopsy specimens from five patients with hepatitis B surface antigen-positive chronic active hepatitis and five patients without liver ...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365529309096093

    authors： Högemann B,Gillessen A,Böcker W,Rauterberg J,Domschke W

    更新日期：1993-07-01 00:00:00

  • Acetazolamide interferes with the protective effect of prostaglandin E2 in the rat gastric mucosa.

    abstract：:Oral prostaglandin E2 protected the gastric mucosa against the damage induced by intraperitoneal indomethacin in the rat. Blocking of the gastric alkaline secretion by subcutaneous acetazolamide potentiated the ulcerogenic action of indomethacin and reduced or abolished the protective effect of a submaximal dose prost...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365528109181985

    authors： Kollberg B,Aly A,Rubio C,Johansson C

    更新日期：1981-04-01 00:00:00

  • Helicobacter pylori inhibits activity of cdc2 kinase and delays G2/M to G1 progression in gastric adenocarcinoma cell line.

    abstract：BACKGROUND:Helicobacter pylori is a bacterial pathogen strongly associated with ulcer diseases and gastric cancer. The bacterial-induced alteration of cell-cycle control in host cells may play a role in the pathogenetic mechanisms. The aims of this study were to define the effect of H. pylori on the G2/M to G1 transiti...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365520310000627

    authors： Chiou CC,Chan CC,Kuo YP,Chan EC

    更新日期：2003-02-01 00:00:00

  • Polymorphonuclear function in patients with skin and joint symptoms after small-intestinal shunt operations.

    abstract：:Previous studies have shown that the small-bowel shunt operation for morbid obesity may be followed by signs of enhanced cell-mediated immunity and polymorphonuclear (PMN) granulocyte bactericidal capacity. In the present study seven patients, operated 4 months--4.5 years previously and exhibiting postoperative arthra...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365528009181476

    authors： Palmblad J,Engstedt L,Hallberg D,Norberg R,Udén AM

    更新日期：1980-01-01 00:00:00

  • Glasgow Blatchford, pre-endoscopic Rockall and AIMS65 scores show no difference in predicting rebleeding rate and mortality in variceal bleeding.

    abstract：OBJECTIVE:To compare the performance of the Glasgow Blatchford score (GBS), pre-endoscopic Rockall score (PRS) and AIMS65 score in predicting specific clinical endpoints following variceal upper gastrointestinal hemorrhage (UGIH). MATERIAL AND METHODS:Between January 2008 and December 2013, we retrospectively analyzed...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365521.2016.1200138

    authors： Budimir I,Gradišer M,Nikolić M,Baršić N,Ljubičić N,Kralj D,Budimir I Jr

    更新日期：2016-11-01 00:00:00

  • Endoscopic findings, Helicobacter pylori status, and dyspeptic complaints in vagotomized or medically treated peptic ulcer patients and healthy community controls.

    abstract：BACKGROUND:The recommendation that Helicobacter pylori be eradicated in surgically treated peptic ulcer patients, regardless of complaints and ongoing ulceration, is controversial. To explore possible endoscopic changes associated with vagotomy and long-term acid suppression, the objectives of this study were to compar...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 评论,杂志文章

    doi：10.1080/003655299750026173

    authors： Lindsetmo RO,Johnsen R,Revhaug A

    更新日期：1999-05-01 00:00:00

  • Stenting and extracorporeal shock wave lithotripsy in chronic pancreatitis.

    abstract：BACKGROUND:Early observational studies of endoscopic treatment and extracorporeal shock wave lithotripsy (ESWL) reported considerable or complete relief of pain in 50%-80% of patients with chronic pancreatitis. There is no consensus on the measurement of pain, making comparison of observational studies difficult, and l...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365520310000663a

    authors： Holm M,Matzen P

    更新日期：2003-03-01 00:00:00

  • Effect of omeprazole, a substituted benzimidazole, on 24-h intragastric acidity in patients with peptic ulcer disease.

    abstract：:Intragastric pH was measured during physiological conditions over 24-h periods in patients with peptic ulcer disease. After single oral doses of 20, 40, and 80 mg omeprazole we found a dose-dependent reduction in mean intragastric acidity ranging from 38% to 99%. After treatment for 1 week with omeprazole, 40 mg daily...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Naesdal J,Bodemar G,Walan A

    更新日期：1984-10-01 00:00:00

  • Acute biliary pancreatitis: focus on recurrence rate and costs when current guidelines are not complied.

    abstract：BACKGROUND:International guidelines recommend cholecystectomy within 2-4 weeks after mild to moderate acute biliary pancreatitis (ABP) to prevent recurrence. We aimed to investigate the compliance to guidelines concerning early cholecystectomy and the associated costs. METHODS:Admissions for ABP 2011-2013 were retrosp...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365521.2016.1243258

    authors： Ragnarsson T,Andersson R,Ansari D,Persson U,Andersson B

    更新日期：2017-03-01 00:00:00

  • Teprenone for the prevention of low-dose aspirin-induced gastric mucosal injury in Helicobacter pylori-negative patients.

    abstract：:Objectives: Low-dose aspirin is the standard treatment for the prevention of cardiovascular events in at-risk patients. We performed a randomized, placebo-controlled study to determine the efficacy of teprenone for primary prevention of gastrointestinal injury in patients taking LDA for vascular protection.Methods: Pa...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章,随机对照试验

    doi：10.1080/00365521.2019.1672781

    authors： Chitapanarux T,Lertprasertsuke N,Kongnak A

    更新日期：2019-10-01 00:00:00

  • Pregnancy course in patients with intrahepatic cholestasis of pregnancy treated with very low doses of ursodeoxycholic acid.

    abstract：OBJECTIVE:Ursodeoxycholic acid (UDCA) has been proposed as the optimal pharmacological treatment for intrahepatic cholestasis of pregnancy (ICP). The lowest effective dosage of UDCA in women with ICP has not been established. The objective is to determine the risk of adverse pregnancy outcomes resulting from ICP and to...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365521.2015.1064990

    authors： Grymowicz M,Czajkowski K,Smolarczyk R

    更新日期：2016-01-01 00:00:00

  • Campylobacter pylori in peptic ulcer disease. III. Symptoms and paraclinical and epidemiologic findings.

    abstract：:Only a few publications have dealt with the subjective symptoms, the paraclinical findings, or the epidemiology in relation to cultivation of C. pylori. Seventy-two patients answered a questionnaire containing questions about symptoms, dietary habits, smoking, and animal contact. C. pylori was cultivated from the biop...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365528809093877

    authors： Andersen LP,Elsborg L,Justesen T

    更新日期：1988-04-01 00:00:00

  • Biochemical gradients in the human gastric and duodenal mucosa in relation to basal acid outputs.

    abstract：:The separations and measurements of adenine-adenosine, adenosine monophosphate (AMP), adenosine diphosphate (ADP), adenosine triphosphate (ATP), lipid phosphates (lipid-P), ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) were carried out in the mucosa of the corpus, antrum, and duodenum of patients with decreas...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365527709181689

    authors： Mozsik G,Vizi F,Kutas J

    更新日期：1977-01-01 00:00:00

  • "12 weeks' stopping rule" in the treatment of genotype 1 chronic hepatitis C: two prognostic categories under the same label?

    abstract：OBJECTIVE:The current guidelines recommend maintenance of combined therapy for hepatitis C virus (HCV) genotype-1 chronic hepatitis when HCV-RNA is undetectable or < or = 2 log10 of baseline after 12 weeks of therapy. The aim of this study was to investigate whether the probability of obtaining sustained viral (SVR) re...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365520801989969

    authors： Ladero JM,López-Alonso G,Devesa MJ,Cuenca F,Agreda M,Ortega L,Suárez A,Díaz-Rubio M

    更新日期：2008-08-01 00:00:00

  • Nephrotic syndrome in ulcerative colitis.

    abstract：:Complicating disorders in various organs outside the intestinal tract are common in ulcerative colitis. This report deals with the occurrence of nephrotic syndrome in two patients with long-standing ulcerative colitis. In the patient studied in most detail, 2 episodes have taken place, the first developing into uremia...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Stokke KT,Teisberg PA,Myhre E,Hovig T,Flatmark A,Gjone E

    更新日期：1976-01-01 00:00:00