Effect of sulindac on prostaglandin excretion and renal function in cirrhotic patients with ascites.

Abstract:

:The effect of sulindac, a nonsteroidal anti-inflammatory drug, on renal prostaglandin synthesis and renal function variables was investigated in six cirrhotic patients with tense ascites and marked sodium retention. We studied serum thromboxane (TXB2) production, urinary prostaglandin excretion (6-keto-prostaglandin F1 alpha and TXB2) and renal function before and after administration of a therapeutic dose of sulindac (400 mg). After treatment, no significant changes were observed in urinary prostaglandin excretion, serum creatinine concentration, urine volume, or urinary sodium and creatinine clearance, whereas the serum TXB2 concentration was reduced in 89%. In five patients systemic prostaglandins were inhibited, but renal excretion remained unchallenged. However, one patient showed marked reduction of urinary prostaglandins associated with a depression of renal function. The study suggests that sulindac could be a safe substitute for other nonsteroidal anti-inflammatory drugs in cirrhotic patients with ascites. Further pharmacological trials seem to be warranted.

journal_name

Scand J Gastroenterol

authors

Guarner C,Enriquez J,Guarner F,Quiroga J,Just J,Seres I,Prieto J,Vilardell F

doi

10.3109/00365528609034652

subject

Has Abstract

pub_date

1986-03-01 00:00:00

pages

231-4

issue

2

eissn

0036-5521

issn

1502-7708

journal_volume

21

pub_type

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