Repeated pentagastrin-stimulated gastric acid secretory tests carried out in the evaluation of the pharmacodynamics of a new histamine H2-receptor antagonist, SK&F 93479.


:Single doses of 10 mg or 20 mg intravenously or 25 mg or 40 mg orally of a new histamine H2-receptor antagonist, SK&F 93479, have been administered to 31 patients with peptic ulcer disease. BAO and MAO were measured before and repeated during a 26-h period after drug administration. In a separate group of 17 patients the mean coefficients of variation of BAO and MAO measured in this manner were 53% and 20%, respectively. If this variation in the placebo group is taken into account, BAO was significantly inhibited at all dose levels during the 3rd h after dosing, and a significant effect was still seen during the 25th h after 40 mg orally with a mean reduction of 77%. Mean inhibitions of MAO during the 4th h after dosing of SK&F 93479 were significant at all dose levels, and a significant effect could still be seen during the 26th h for the two oral doses. The mean inhibitions of MAO measured during the 4th and 10th h after dosing were after 10 mg intravenously 44% and 11%, after 20 mg intravenously 59% and 11%, after 25 mg orally 57% and 21%, and after 40 mg orally 75% and 46%. The percentage inhibition of MAO during the 10th h correlated with plasma concentrations (r = 0.64, p less than 0.01). SK&F 93479 is a potent inhibitor of acid secretion with a long duration of action.


Scand J Gastroenterol


Jönsson KA,Bodemar G,Norlander B,Walan A


Has Abstract


1984-03-01 00:00:00












  • Reproducibility of ambulatory gastric pH recordings in the corpus and antrum. Effect of food, time, and electrode position.

    abstract::The reproducibility of simultaneous, long-term, ambulatory gastric pH recordings in the antrum and corpus was investigated in nine healthy subjects who underwent three separate, 27-h gastric double pH-metries. Intraindividual reproducibility for the entire 27-h recording period was good in the corpus (Kendall's concor...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Cilluffo T,Armstrong D,Castiglione F,Emde C,Galeazzi R,Gonvers JJ,Blum AL

    更新日期:1990-10-01 00:00:00

  • Patterns of gastrin components in serum during feeding in normal subjects and duodenal ulcer patients.

    abstract::The contribution of the different gastrin components to the gastrin response to a protein-rich meal was studied. Pooled or individual samples of venous blood drawn at intervals in 12 normal subjects and 16 patients with duodenal ulcers were fractionated on Sephadex G 50 superfine columns of various lengths. Total gast...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Stadil F,Rehfeld JF,Christiansen LA,Malmström

    更新日期:1975-01-01 00:00:00

  • Delayed mid-ileal perforation secondary to acute-on-chronic ischaemia after a diagnostic colonoscopy.

    abstract::Perforation occurring at a remote site of the bowel after diagnostic colonoscopy is rare. A 61-year-old man presenting with bloody diarrhoea underwent colonoscopy. A dynamic ileus developed in less than 1 day, and mid-ileal perforation occurred 7 days after the procedure. It is suggested that high air pressure during ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Chau TN,Ng C,Lau LK,Lai ST,Yuen H

    更新日期:1998-09-01 00:00:00

  • Protective effects of trolox C, vitamin C, and catalase on bromobenzene-induced damage to rat hepatocytes.

    abstract:BACKGROUND/METHODS:The protective effects of trolox C (water-soluble vitamin E), vitamin C, and catalase on bromobenzene (BB)-induced toxicity to isolated rat hepatocytes were evaluated. The glutathione (GSH) content of the hepatocytes exposed to BB was measured. RESULTS:BB caused acute damage to the cells during 2 h ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Wu J,Karlsson K,Danielsson A

    更新日期:1996-08-01 00:00:00

  • Urinary prostaglandins and renal function in chronic liver diseases.

    abstract::Changes in urinary PGE2 and PGF2 alpha excretion in chronic liver diseases were observed in relation to renal hemodynamics and sodium balance. After equilibration on a 110-170-meq sodium diet, daily urine collections were analyzed for PGE2 and PGF2 alpha by a new extraction and radioimmunoassay method. PGE2 was signif...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Uemura M,Tsujii T,Fukui H,Kita K,Takaya A,Tsukamoto N,Nakayama M,Matsumoto M,Tamura M

    更新日期:1986-01-01 00:00:00

  • The CCK-2 receptor is located on the ECL cell, but not on the parietal cell.

    abstract:BACKGROUND:The interrelationship between histamine and gastrin in the physiological regulation of gastric acid secretion is still a matter of dispute. CCK-2 receptors are located on enterochromaffin-like (ECL) cells in corpus mucosa and gastrin stimulates acid production by releasing histamine from the ECL cells, which...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Bakke I,Qvigstad G,Sandvik AK,Waldum HL

    更新日期:2001-11-01 00:00:00

  • Patients and gastroenterologists' perceptions of treatments for inflammatory bowel diseases: do their perspectives match?

    abstract:BACKGROUND:Perceptions of appropriateness of treatments may differ between gastroenterologists (GIs) and inflammatory bowel disease (IBD) patients. The aim of this study was to explore and compare GIs' and patients' perceptions of risks and benefits of treatments and prioritization of expected outcomes. METHODS:Four v...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Vaucher C,Maillard MH,Froehlich F,Burnand B,Michetti P,Pittet V

    更新日期:2016-09-01 00:00:00

  • Fish oil reduces gastric acid secretion.

    abstract:BACKGROUND:The aim of the present investigation was to study gastric acid secretion and release of gastrin, cholecystokinin (CCK), and secretin during intraduodenal perfusion of either fish oil or trioleate. METHODS:Seven healthy volunteers were stimulated on two separate days in random order with intraduodenal perfus...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Riber C,Wøjdemann M,Bisgaard T,Ingels H,Rehfeld JF,Olsen O

    更新日期:1999-09-01 00:00:00

  • Cholecystokinin in the regulation of gastric acid and endocrine pancreatic secretion in humans.

    abstract::In this study, a selective antagonist of cholecystokinin (CCK)-A receptors, loxiglumide, was used to evaluate the role of CCK in the control of the release of gastrin and pancreatic hormones (insulin, glucagon, pancreatic polypeptide (PP), and somatostatin) after stimulation with exogenous CCK and ingestion of a stand...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Konturek JW,Stoll R,Gutwinska-Konturek M,Konturek SJ,Domschke W

    更新日期:1993-05-01 00:00:00

  • Campylobacter pylori in peptic ulcer disease. III. Symptoms and paraclinical and epidemiologic findings.

    abstract::Only a few publications have dealt with the subjective symptoms, the paraclinical findings, or the epidemiology in relation to cultivation of C. pylori. Seventy-two patients answered a questionnaire containing questions about symptoms, dietary habits, smoking, and animal contact. C. pylori was cultivated from the biop...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Andersen LP,Elsborg L,Justesen T

    更新日期:1988-04-01 00:00:00

  • Gastric blood flow in patients with gastric ulcer measured by endoscopic laser Doppler flowmetry.

    abstract::Gastric blood flow has been studied endoscopically by laser Doppler flowmetry in 15 patients with chronic gastric ulcer. In all patients the ulcer was located at the lesser curvature of the corpus. The blood flow measured in this area was decreased compared with healthy controls, whereas the flow values in other parts...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Lunde OC,Kvernebo K

    更新日期:1988-06-01 00:00:00

  • Timing for dose-down of 5-ASA depends on mucosal status with ulcerative colitis.

    abstract:OBJECTIVE:Although aminosalicylic acid (ASA) preparations have been used as first-line drugs for the treatment of ulcerative colitis (UC), no consistent view has been established regarding the ASA dose during the remission-maintenance phase of the disease. In this study, we examined whether the ASA dose should be reduc...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Takahashi F,Tominaga K,Kanamori A,Takenaka K,Hoshino A,Sugaya T,Nakano M,Hiraishi H

    更新日期:2016-07-01 00:00:00

  • Bulk laxatives: their dietary fibre composition, degradation, and faecal bulking capacity in the rat.

    abstract::The intestinal dietary fibre degradation and faecal bulking capacity of various bulk laxatives were investigated by means of balance experiments on rats. Nitrogen, fat, and mineral excretion in faeces was also studied. The dietary fibre content of the various bulk laxatives was quite different (in g/kg dry matter): AC...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Nyman M,Asp NG

    更新日期:1985-09-01 00:00:00

  • Palliation of oesophagogastric neoplasms with Nd:YAG laser treatment.

    abstract::The palliative effect of endoscopic Nd:YAG laser treatment of malignant strictures of the oesophagus and cardia was prospectively evaluated in 30 patients. Most (n = 28) were primarily treated for dysphagia, and swallowing was improved in 21 and normalized in 14 of these patients. Two patients were successfully treate...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Schulze S,Fischerman K

    更新日期:1990-10-01 00:00:00

  • High-grade dysplastic adenoma-like mass lesions are not an indication for colectomy in patients with ulcerative colitis.

    abstract:OBJECTIVE:The management of high-grade dysplasia (HGD) in polypoid lesions in patients with ulcerative colitis (UC) is not well characterized. The purpose of this study was to characterize the clinical course of patients with HGD in adenoma-like dysplasia-associated lesion or masses (DALMs) in the absence of any synchr...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Blonski W,Kundu R,Furth EF,Lewis J,Aberra F,Lichtenstein GR

    更新日期:2008-01-01 00:00:00

  • Gastro-oesophageal reflux in obese subjects: influence of overweight, weight loss and chronic gastric balloon distension.

    abstract:BACKGROUND:Gastro-oesophageal reflux is an obesity-related health risk assumed to improve after weight loss. Prolonged intragastric balloon distension might oppose this. The purpose of the study was to investigate the prevalence of gastro-oesophageal reflux in untreated obese subjects and to study the consequences of w...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Mathus-Vliegen EM,Tygat GN

    更新日期:2002-11-01 00:00:00

  • Gastrointestinal transit of amoxicillin modified-release tablets and a placebo tablet including pharmacokinetic assessments of amoxicillin.

    abstract:BACKGROUND:We have investigated the gastrointestinal transit time of, the influence of food intake on, the disintegration of, and the pharmacokinetics of amoxicillin in a modified-release form. METHODS:Radiolabelled modified-release tablets of amoxicillin and placebo tablets were administered, in an open three-way, ra...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gottfries J,Svenheden A,Alpsten M,Bake B,Larsson A,Idström JP

    更新日期:1996-01-01 00:00:00

  • Granulation and fibrotic esophagus.

    abstract::There is very little information in the medical literature on fibrotic esophageal lesions. These lesions do not appear to be malignant, but are recalcitrant to different treatments including removal, and the use of esophageal stents does not discourage the lesion from continuing to grow. The cause of these lesions rem...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Eslick GD,Sethi S,Kalantar JS

    更新日期:2006-06-01 00:00:00

  • Crohn's disease: Comparison of in vitro ultrasonographic images and histology.

    abstract:OBJECTIVE:To examine some typical histological findings in Crohn's disease using high-frequency ultrasound and to define the echo properties of these findings. MATERIAL AND METHODS:Bowel resection specimens from 14 patients operated on for Crohn's disease were examined with a 10 MHz linear array ultrasound transducer ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Nylund K,Leh S,Immervoll H,Matre K,Skarstein A,Hausken T,Gilja OH,Birger Nesje L,Ødegaard S

    更新日期:2008-01-01 00:00:00

  • Seroreactivity to E. coli outer membrane protein C antibodies in active inflammatory bowel disease; diagnostic value and correlation with phylogroup B2 E. coli infection.

    abstract:BACKGROUND:Several serologic tests, including anti-outer membrane porin C antibody (Omp C), are used for screening and as marker of disease course in inflammatory bowel diseases (IBD). Our aim was to investigate possible differences in Omp C level in patients with active and inactive IBD compared to controls. METHODS:...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Petersen AM,Schou C,Mirsepasi H,Engberg J,Friis-Møller A,Nordgaard-Lassen I,Wildt S,Krogfelt KA

    更新日期:2012-02-01 00:00:00

  • Endoscopic retrograde cholangiography in the diagnosis and treatment of mucobilia.

    abstract:OBJECTIVE:Some biliary neoplasms secrete copious mucin into bile ducts, yet the management of mucobilia is not well known. The objective of this study was to analyze 16 patients with copious mucin in the biliary tract stressing the diagnostic and therapeutic aspects of endoscopic retrograde cholangiography (ERC). MATE...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Tsou YK,Liu NJ,Wu RC,Lee CS,Tang JH,Hung CF,Jan YY

    更新日期:2008-01-01 00:00:00

  • Brown pigment stones in the common bile duct: reduced bilirubinate diconjugate in bile.

    abstract:BACKGROUND:Bilirubin is the main component of most common bile duct stones. Normally, almost all bilirubin in bile is conjugated to glucuronic acid or some other sugar moiety. These conjugates are unstable and liable to deconjugation. Unconjugated bilirubin is insoluble and may precipitate as the calcium salt found in ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Sandstad O,Osnes T,Urdal P,Skar V,Osnes M

    更新日期:2000-02-01 00:00:00

  • Cholecystokinin in the control of gastric acid secretion and gastrin release in response to a meal at low and high pH in healthy subjects and duodenal ulcer patients.

    abstract:OBJECTIVE:In healthy subjects a gastric meal at low pH inhibits gastric acid secretion, possibly by reducing gastrin release, whereas duodenal ulcer (DU) patients have been reported to show a lack of this low pH inhibition of gastric secretion. METHODS:The intragastric pH profiles were measured in seven healthy subjec...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Konturek JW,Konturek SJ,Domschke W

    更新日期:1995-08-01 00:00:00

  • Low-grade elevation of fibrinogen-degradation products is an important parameter to identify acute presentation of autoimmune hepatitis.

    abstract:OBJECTIVE:Diagnosing early-stage acute autoimmune hepatitis (AIH) without pathological findings is difficult. Recent reports indicated that macrophages are not activated during disease development, unlike in other acute liver injuries. We suggest that hepatitis without macrophage activation should lack sinusoidal fibri...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Suzuki H,Harada S,Takao S,Takahashi M,Kato M,Kotoh K

    更新日期:2016-08-01 00:00:00

  • Colonic expression of heme oxygenase-1 is associated with a better long-term survival in patients with colorectal cancer.

    abstract:OBJECTIVE:Heme oxygenase-1 (HO-1) has emerged as a crucial mediator of mucosal defense in the gastrointestinal tract. Its metabolic pathway products, biliverdin/bilirubin and carbon monoxide, can reduce oxidative stress and inflammation, and promote resistance to apoptosis. The role of HO-1 in gastrointestinal malignan...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Becker JC,Fukui H,Imai Y,Sekikawa A,Kimura T,Yamagishi H,Yoshitake N,Pohle T,Domschke W,Fujimori T

    更新日期:2007-07-01 00:00:00

  • Alpha1-antitrypsin genotypes in patients with chronic pancreatitis.

    abstract:BACKGROUND:An association between alpha1-antitrypsin deficiency and chronic pancreatitis (CP) has been reported in several case reports and two systematic studies. However, conflicting results have been shown in other studies of patients with CP. All previous studies were performed by phenotyping or by measurement of s...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Witt H,Kage A,Luck W,Becker M

    更新日期:2002-03-01 00:00:00

  • Inhibitory effects of terbutaline on human esophageal peristalsis and development of tolerance.

    abstract::To investigate the inhibitory influence on esophageal motility of prolonged beta-2-adrenergic stimulation, esophageal peristalsis was studied in 10 volunteers. The beta-2 agonist terbutaline was given orally, 5 mg three times daily, for 10 days, and the subjects were studied before medication (basal), on days 3 and 10...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Lyrenäs E,Sand C,Abrahamsson H

    更新日期:1993-10-01 00:00:00

  • Esophageal motility disorders and their coexistence with pathologic acid reflux in patients with noncardiac chest pain.

    abstract:BACKGROUND:The aim of this study was to determine which motility data of patients with noncardiac chest pain (NCCP) differ from those of controls on the basis of long-term manometry and to evaluate the coexistence of motility disorders and pathologic acid reflux. Further, motility disorders were tested as to whether th...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Adamek RJ,Wegener M,Wienbeck M,Pulte T

    更新日期:1995-09-01 00:00:00

  • Effect of glucagon-like peptide-1 on gastric somatostatin and gastrin secretion in the rat.

    abstract::The effect of glucagon-like peptide-1 (GLP-1) amide on gastric somatostatin and gastrin secretion was investigated in the isolated, vascularly perfused rat stomach preparation. GLP-1 (7-36) amide, 10(-12) to 10(-7)M, dose-dependently increased gastric somatostatin release, achieving maximal stimulation (314 +/- 15% ab...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Eissele R,Koop H,Arnold R

    更新日期:1990-05-01 00:00:00

  • Regional variations in total and nonprotein sulfhydryl compounds in the human gastric mucosa and effects of ethanol.

    abstract::This study evaluated the regional distribution of sulfhydryl compounds in the human gastric mucosa and the effect of ethanol on gastric sulfhydryl tissue levels. Total sulfhydryl, glutathione, and cysteine and their oxidized forms were measured in biopsy specimens taken from the gastric body and antrum of 22 healthy v...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Loguercio C,Romano M,Di Sapio M,Nardi G,Taranto D,Grella A,Del Vecchio Blanco C

    更新日期:1991-10-01 00:00:00