Abstract:
:The transformation of xenobiotics and endogenous compounds to active carcinogens and their subsequent deactivation as an aid to eradication may be important in the etiology of some gastrointestinal cancers. In mammals the gastrointestinal tract has been shown to be an important site of inducible enzyme systems active in mucosal biotransformation, but few data are available in man. The mucosal activity of CYPIA1 (formerly aryl hydrocarbon hydroxylase), a potential carcinogen-activating enzyme, and catechol-O-methyl transferase, a potential carcinogen-inactivating enzyme were determined in colonic tissue obtained by biopsy. There were no significant differences in activity rates in normal mucosa between colorectal cancer and healthy persons, but significant differences are seen in patients with a history of neoplasia with no evidence of recurrence. The levels of activity of these carcinogen-inductive and -protective enzymes may be prognostic markers, in that the balance or imbalance could play a role in the recurrence of neoplasia. This will require confirmation and prospective studies.
journal_name
Scand J Gastroenteroljournal_title
Scandinavian journal of gastroenterologyauthors
Tobi M,Darmon E,Rozen P,Avigdor S,Rattan J,Santo M,Barnea ERdoi
10.3109/00365529309098291subject
Has Abstractpub_date
1993-11-01 00:00:00pages
958-62issue
11eissn
0036-5521issn
1502-7708journal_volume
28pub_type
杂志文章abstract::The clinical pictures of 109 patients with X-ray negative dyspepsia (XND) are described, and a comparison is made with the clinical pictures of 39 gastric ulcer patients and 61 duodenal ulcer patients. In addition it has been attempted to subdivide XND into clinically relevant subgroups by means of a Venn diagram. The...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVE:A reduced risk of perforated diverticular disease among individuals with current statin exposure has been reported. The aim of the present study was to investigate whether statins reduce the risk of acute diverticular disease. MATERIAL AND METHODS:A nation-wide population-based case-control study was perform...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365521.2015.1081274
更新日期:2016-01-01 00:00:00
abstract::An ulcer was induced in the anterior wall of the antrum of cats by local injection of acetic acid solution. Carbonized microspheres, 15 +/- microns in diameter, labelled with 141Ce, 46Sc, and 85Sr, were used to measure blood flow in different regions and layers of the stomach wall. The radioactivity of a blood referen...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:The main disadvantage of endoscopic insertion of an endoprosthesis is the tendency of the stent to clog after a few months. In this study we determined the role of bile viscosity in stent clogging. METHODS:Sixty patients were stented with 10 Fr 11-cm stents. The stents were electively removed after 2 months...
journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00365529409092506
更新日期:1994-08-01 00:00:00
abstract::A case of a Borrmann type 2 advanced gastric cancer with endocrine differentiation is described. Histologically, the cancer was either composed of cells arranged in a tubular pattern or formed solid nests of various sizes. The tubular pattern was composed of a moderately differentiated tubular adenocarcinoma. The hist...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520410005775
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Morphologic, histochemical, and cytoproliferative characteristics differentiate hyperplastic polyps from adenomas. Even so, these polyps are indicators of populations with a high colorectal cancer risk. Since changes in mucosal cell proliferation are highly predictive biomarkers of the adenomacarcinoma seque...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529509093288
更新日期:1995-04-01 00:00:00
abstract::The effect of intravenous administration of adrenaline, noradrenaline, and isoprenaline on gastric mucosal flow, measured by hydrogen clearance techniques, showed that small doses of adrenaline induced slight mucosal vasodilatation in anaesthetized cats. In both anaesthetized and conscious animals both noradrenaline a...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528209181076
更新日期:1982-08-01 00:00:00
abstract::To compare the clinical utility of serum pancreas-specific protein and serum amylase in the diagnosis of acute pancreatitis, the study was conducted in 134 normal subjects and 70 patients (36 with acute pancreatitis and 34 with other acute abdominal diseases as control group). The serum level of pancreas-specific prot...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529409090443
更新日期:1994-01-01 00:00:00
abstract::The gastroesophageal sphincter pressure (GESP) was studied before, during, and after food intake in nine patients with abnormal duodenal loop (AD), six patients with a normal duodenum (controls), and seven healthy volunteers. In normal and control subjects a significant increase in GESP was observed during food intake...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528109182007
更新日期:1981-01-01 00:00:00
abstract::The relationship of fasting serum gastrin (FSG) levels to the histologic state of antral and body mucosa and to the stimulated acid output (PAO) was examined in 860 subjects. The FSG levels correlated with PAO and atrophy of the body mucosa: the FSG increased linearly with an increase in the grade of body atrophy and ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529009095523
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:In coeliac disease, small-bowel mucosal permeability is increased in response to gluten consumption. However, the signalling routes leading to such a barrier defect remain obscure. As the epidermal growth factor receptor (EGFR) pathway is up-regulated in untreated coeliac disease, and since this cascade has b...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520902898119
更新日期:2009-01-01 00:00:00
abstract::Nucleotide pyrophosphatase activity with uridine diphosphoglucose and dephospho-CoA as substrates was demonstrated in normal human serum. The enzyme has a pH-optimum of about 9.6 and is inhibited by EDTA. Phosphodiesterase I (hydrolysis of thymidine-5'-monophospho-p-nitrophenylester) was also found in normal human ser...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVE:To report our endoscopic outcomes and explore the effects of duration of impaction and anesthetic methods on the endoscopic removal of foreign bodies in the upper gastrointestinal tract. METHODS:All consecutive patients with suspected foreign body (FB) ingestion between January 2013 and June 2016 were enroll...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365521.2017.1350284
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Previous studies suggest that E2 prostaglandins and the microflora may participate in the regulation of endocrine cells and of gastrointestinal cell kinetics. Our aim is to examine the actions of endogenous prostaglandins and of the microflora on gastrointestinal cell proliferation and tissue levels of neuro...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529708996520
更新日期:1997-07-01 00:00:00
abstract::A series of 76 patients who have undergone surgical treatment for Crohn's disease is presented. In 14 of the patients surgery was performed for recurrence after previous resection. In total, 91 intestinal resections and one bypass--operation were carried out. Postoperative mortality comprised 4 patients (5.3%), and th...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365527709181336
更新日期:1977-01-01 00:00:00
abstract::In a series of 36 consecutive patients with proved idiopathic hemochromatosis and with a mean follow-up time of 8 years, 10 patients developed 11 carcinomas (30.6%). Five patients had hepatomas and six patients extrahepatic carcinoma involving lungs (four), oral cavity (one), and thyroid (one). The findings suggest a ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528009181523
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Bacterial infections and bacteremia in acute liver failure may at least partly be attributed to translocation of enteric bacteria. Attempts to prevent or treat such infections by the use of antibiotics may instead result in overgrowth of surviving microbes. METHODS:In the present study, normal saline (1.5 m...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529409094897
更新日期:1994-12-01 00:00:00
abstract:OBJECTIVE:To report on survival and complications after insertion of self-expandable stents in patients with malignant oesophageal stenosis. MATERIAL AND METHODS:Data were gathered retrospectively from the medical records of 92 consecutive patients in the period 1994-2003. The study comprised 68 men and 24 women (medi...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520500206350
更新日期:2006-03-01 00:00:00
abstract::To evaluate the usefulness of Courvoisier's sign in ultrasonography, gallbladder size in patients with common hepatic duct dilatation was measured using the ellipsoid method during ultrasonographic examination. During a 6-month period 24 patients with malignant obstructions (6 with carcinoma of the ampulla of Vater, 9...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529409090478
更新日期:1994-03-01 00:00:00
abstract::Non-ulcer dyspepsia (NUD) is defined as dyspepsia in which investigation shows no evidence of focal gastroduodenal disease or oesophagitis. The aim of the present study was to determine the proportion of NUD patients with other identifiable diseases. We interviewed 327 consecutive patients who had at least 1 month of ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528509088842
更新日期:1985-09-01 00:00:00
abstract:OBJECTIVE:Case reports and short-term clinical trials have suggested that treatment for chronic hepatitis B (CHB) may lead to improvement of cirrhosis. The aim of the present study was to measure liver stiffness in patients diagnosed with advanced fibrosis or cirrhosis prior to prolonged treatment with nucleoside or nu...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.3109/00365521.2011.565068
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:Ischemia-reperfusion injury is associated with a high rate of primary organ dysfunction and thereby contributes substantially to morbidity and mortality in the course of liver transplantation. In the present study, the impact of metabolic preconditioning with fructose on ischemia-reperfusion injury in the iso...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365521.2012.741618
更新日期:2013-02-01 00:00:00
abstract::Portal hypertension leads to development of serious complications such as esophageal varices, ascites, renal and cardiovascular dysfunction. The importance of the degree of portal hypertension has been substantiated within recent years. Measurement of the portal pressure is simple and safe and the hepatic venous press...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.3109/00365521.2012.706827
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:Outpatient management without antibiotics has been shown to be safe for selected patients diagnosed with acute uncomplicated diverticulitis (AUD). The aim of this study was to evaluate the impact on admissions, complication rates and health-care costs of the policy of outpatient treatment without using antibiot...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365521.2018.1448887
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is a potent angiogenic, vascular permeability-enhancing, and calcium-dependent enzyme-modulating cytokine with overexpression in various pathologic disorders, including granulomatous inflammation, tissue repair, delayed hypersensitivity reactions, rheumatoid arthriti...
journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1080/00365529850172070
更新日期:1998-05-01 00:00:00
abstract::Of 120 patients who were investigated for moderately elevated liver function tests as the only sign of liver disease, 6 young persons had alpha-1-antitrypsin (AAT) deficiency. Three had a homozygous (Pi ZZ) and three had a heterozygous (Pi MZ) AAT deficiency as measured with isoelectric focusing. An extensive investig...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-05-01 00:00:00
abstract::In an elective gastroscopic series of 3837 patients, gastric mucosal erosions were observed in 404 (10.5%) patients, 215 (5.6%) having only erosions without other endoscopic findings in the upper gastrointestinal tract. The male to female ratio was 1.3:1. The number of patients with erosions was highest in the age gro...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1982-11-01 00:00:00
abstract::The faecal output of chloride, sodium and potassium was studied in 14 patients with active idiopathic proctocolitis, in an attempt to establish a relationship between faecal electrolyte output and acid-base balance data. 7 patients with ileostomy and 8 healthy volunteers were used as controls. The daily faecal excreti...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365527809179829
更新日期:1978-01-01 00:00:00
abstract::Three cases of adult coeliac disease with severe vitamin B12 deficiency not accompanied by folate or iron depletion are presented. Two of the patients had the extremely rare combination of coeliac disease and lack of intrinsic factor and autoimmune thrombocytopenic purpura. A close association between coeliac disease ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528809090176
更新日期:1988-11-01 00:00:00
abstract:OBJECTIVE:The aim was to investigate the mucosal activation of a broad range of genes associated with the T-helper 17 cell (Th17) signaling pathway in children at different stages of celiac disease (CD), including children with increased risk for CD and children with untreated and gluten-free diet (GFD)-treated CD. MA...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365521.2013.863966
更新日期:2014-02-01 00:00:00