Minimal liver disease in young persons with homozygous and heterozygous alpha-1-antitrypsin deficiency.

Abstract:

:Of 120 patients who were investigated for moderately elevated liver function tests as the only sign of liver disease, 6 young persons had alpha-1-antitrypsin (AAT) deficiency. Three had a homozygous (Pi ZZ) and three had a heterozygous (Pi MZ) AAT deficiency as measured with isoelectric focusing. An extensive investigation ruled out all other causes of liver disease. The three homozygous patients showed typical periodic acid-Schiff (PAS)-positive globules in their liver biopsies and slight fibrosis, whereas none of the heterozygous patients showed these features. Electron microscopical investigation also showed typical findings in the homozygous but not in the heterozygous patients. Further development of liver disease in these young and apparently healthy AAT-deficient patients with early signs of liver damage is not known. It is possible that these patients will develop severe liver disease later in life. It was possible to detect only the three homozygous patients by histochemical examination of liver tissue, since the heterozygous patients did not show PAS-positive globules in their liver.

journal_name

Scand J Gastroenterol

authors

Hultcrantz R,Jelf E,Nilsson LH

subject

Has Abstract

pub_date

1984-05-01 00:00:00

pages

389-93

issue

3

eissn

0036-5521

issn

1502-7708

journal_volume

19

pub_type

杂志文章
  • Food-stimulated gastroesophageal sphincter pressure in patients with abnormal duodenal loop compared with controls.

    abstract::The gastroesophageal sphincter pressure (GESP) was studied before, during, and after food intake in nine patients with abnormal duodenal loop (AD), six patients with a normal duodenum (controls), and seven healthy volunteers. In normal and control subjects a significant increase in GESP was observed during food intake...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528109182007

    authors: Funch-Jensen P,Oster MJ,Thommesen P

    更新日期:1981-01-01 00:00:00

  • Long-term results with lanreotide in patients with recurrent gastrointestinal angiodysplasias bleeding or obscure gastrointestinal bleeding. Benefits in efficacy and procedures consumption.

    abstract:BACKGROUND:Gastrointestinal angiodysplasias (GIAD) bleeding and obscure gastrointestinal bleeding (OGIB) are increasing health problems. Somatostatin analogues have been proposed as rescue therapy, but data for lanreotide are scarce. OBJECTIVE:To determine the efficacy, safety and resource saving of long-acting lanreo...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1547921

    authors: Frago S,Alcedo J,Martín Pena-Galo E,Lázaro M,Ollero L,de la Llama N

    更新日期:2018-12-01 00:00:00

  • Computer-aided analysis of gastrointestinal pressure recordings. Comparison with manual scoring.

    abstract::The aim of the present study was to compare computer-based and visual/manual scoring of pressure recordings from the gastric antrum and duodenum. The computer system was based on three separate principles of recognition: moving average, tracking base line, and threshold filters. Computer scoring resulted in the detect...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529209011188

    authors: Melsen NC,Andersen MB,Kraglund K,Juhl B

    更新日期:1992-09-01 00:00:00

  • Time course of compromised urea synthesis in patients with alcoholic hepatitis.

    abstract:OBJECTIVES:Alcoholic hepatitis (AH) markedly decreases the urea synthesis capacity. We aimed to investigate the time course of this compromised essential liver function in patients with AH and its relation to treatment and survival. MATERIALS AND METHODS:Thirty patients with AH were included in a prospective cohort st...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/00365521.2017.1399163

    authors: Glavind E,Aagaard NK,Gronbaek H,Orntoft NW,Vilstrup H,Thomsen KL

    更新日期:2018-05-01 00:00:00

  • Analysis of the distribution of human jejunal mast cells including the relation to age, sex, height, weight, and possible allergic manifestations.

    abstract::The median number of mast cells (with 95% confidence interval) in jejunal specimens from 79 individuals was 108 (93-121)/mm2 section area. The distribution was unimodal and slightly skewed to the right. No relation was found between mast cell number and sex, age, height, or weight. A history of possible allergic manif...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509089646

    authors: Selbekk BH,Larsen S,Stadaas J

    更新日期:1985-03-01 00:00:00

  • Influence of alcohol consumption on the association between serum lipids and colorectal adenomas.

    abstract:BACKGROUND:There have been no reports that low serum cholesterol levels increase the risk of colorectal adenoma, although many studies have shown that they do increase the risk of colorectal cancer. Alcohol intake, which is associated with a risk of colorectal adenomas, and serum cholesterol levels are closely related....

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655202761020597

    authors: Fujimori S,Kishida T,Mitsui K,Yonezawa M,Nagata K,Shibata Y,Tanaka S,Tatsuguchi A,Sato J,Yokoi K,Tanaka N,Ohaki Y,Sakamoto C,Kobayashi M

    更新日期:2002-11-01 00:00:00

  • Large-bowel mucosal biotransformation activity in persons at high risk for colorectal cancer. A preliminary report.

    abstract::The transformation of xenobiotics and endogenous compounds to active carcinogens and their subsequent deactivation as an aid to eradication may be important in the etiology of some gastrointestinal cancers. In mammals the gastrointestinal tract has been shown to be an important site of inducible enzyme systems active ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529309098291

    authors: Tobi M,Darmon E,Rozen P,Avigdor S,Rattan J,Santo M,Barnea ER

    更新日期:1993-11-01 00:00:00

  • Role of gender upon basal and postprandial systemic and splanchnic haemodynamics in humans.

    abstract:BACKGROUND:Food intake, accompanied by systemic and splanchnic haemodynamic changes, has only been studied in males. The extent to which splanchnic postprandial hyperaemia shows gender differences is unknown. METHODS:We tested 1) the splanchnic hyperaemic response to food in females and 2) whether postprandial haemody...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201750153458

    authors: Szinnai C,Mottet C,Gutzwiller JP,Drewe J,Beglinger C,Sieber CC

    更新日期:2001-05-01 00:00:00

  • The fate of intravenously injected trypsinogens in dogs.

    abstract::After intravenous injection of autologous purified and radiolabeled anionic and cationic trypsinogens in the dog, there is a multiexponential elimination from serum of the trypsinogens without activation to active trypsins. The results are in agreement with an elimination of the trypsinogens iva glomerular filtration,...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528109181969

    authors: Borgström A

    更新日期:1981-01-01 00:00:00

  • Suppression of anger and gastric emptying in patients with functional dyspepsia.

    abstract::Psychologic distress and gastric motor dysfunction have both been implicated in the pathogenesis of functional (non-ulcer) dyspepsia (FD). This study assesses the association between psychologic factors and gastric emptying in 28 FD patients. Subjects completed an extensive range of psychologic questionnaires and unde...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529209000156

    authors: Bennett EJ,Kellow JE,Cowan H,Scott AM,Shuter B,Langeluddecke PM,Hoschl R,Jones MP,Tennant CC

    更新日期:1992-10-01 00:00:00

  • Comparison of four markers of intestinal permeability in control subjects and patients with coeliac disease.

    abstract:BACKGROUND:Controversy surrounds the issue of intestinal permeability in patients with coeliac disease, polyethylene glycol 400 indicating reduced and di-/mono-saccharide urine excretion ratios and 51Cr-labeled ethylenediaminetetraacetic acid (EDTA) indicating increased permeability. METHODS:We assessed the suitabilit...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409092484

    authors: Bjarnason I,Maxton D,Reynolds AP,Catt S,Peters TJ,Menzies IS

    更新日期:1994-07-01 00:00:00

  • A characterization in childhood inflammatory bowel disease, a new population-based inception cohort from South-Eastern Norway, 2005-07, showing increased incidence in Crohn's disease.

    abstract:OBJECTIVE:Owing to rising incidence rates in inflammatory bowel disease (IBD), there has been increased interest in causal relationships in pediatric disease. The present population-based inception cohort was recruited in the Oslo area from 2005 to 2007, with the aim of conducting a detailed characterization of treatme...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802647434

    authors: Perminow G,Brackmann S,Lyckander LG,Franke A,Borthne A,Rydning A,Aamodt G,Schreiber S,Vatn MH,IBSEN-II Group.

    更新日期:2009-01-01 00:00:00

  • Autoimmune chronic active hepatitis: changing reactivity for antibodies to hepatitis C virus after immunosuppressive treatment.

    abstract::Thirty-three patients fulfilling stringent criteria for autoimmune chronic active hepatitis (CAH) were tested for antibodies against hepatitis C virus (anti-HCV) with an enzyme immunoassay. Eleven of the 33 (33%) patients were anti-HCV-reactive in a serum drawn before initiation of immunosuppressive therapy. Anti-HCV-...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529008998551

    authors: Schvarcz R,von Sydow M,Weiland O

    更新日期:1990-11-01 00:00:00

  • Colonic fermentation of complex dietary carbohydrates in short-bowel patients. No association with hydrogen excretion and fecal and plasma short-chain fatty acids.

    abstract:BACKGROUND:The colonic degradation of carbohydrates (fermentation) to short-chain fatty acids (SCFAs) appears to have major impacts on colonocyte function, sodium and water absorption, and large-bowel energy salvation, but how to quantify the in vivo fermentation in man is still debatable. METHODS:Indicators of coloni...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529509101598

    authors: Nordgaard I,Hansen BS,Mortensen PB

    更新日期:1995-09-01 00:00:00

  • The dependence of the in vitro fermentation of dietary fibre to short-chain fatty acids on the contents of soluble non-starch polysaccharides.

    abstract::The fermentability of cellulose and dietary fibre in common clinical use (Inolaxol, Fiberform, Vi-Siblin, Lunelax, pectin) was measured as the in vitro production of short-chain fatty acids, lactate, and ammonia in 16.6% faecal homogenates from 18 healthy volunteers. The results were compared with the contents of solu...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529309098242

    authors: Mortensen PB,Nordgaard-Andersen I

    更新日期:1993-05-01 00:00:00

  • Subnormal alanine aminotransferase values in blood of patients with Crohn disease.

    abstract:BACKGROUND:It was observed that several patients from the outpatient clinic with Crohn disease (CD) occasionally had subnormal values of alanine aminotransferase (ALAT) in blood. Subnormal ALAT values have previously been reported only in renal failure. METHODS:A retrospective study of clinical chemistry values going ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410005162

    authors: Vadstrup S

    更新日期:2004-06-01 00:00:00

  • Pulmonary hydrogen and methane and plasma ammonia after the administration of lactulose or sorbitol.

    abstract::The gut microfloral metabolism of sorbitol and lactulose was investigated in 10 healthy control subjects and 10 patients with cirrhosis of the liver, by measuring the pulmonary excretion of the fermentational gases hydrogen and methane during 3 h. A possible acute effect on venous plasma ammonia after a single dose of...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528309181604

    authors: Beaven J,Bjørneklett A,Jenssen E,Blomhoff JP,Skrede S

    更新日期:1983-05-01 00:00:00

  • Normal pancreatic secretion in children with progressive familial intrahepatic cholestasis type 1.

    abstract:OBJECTIVE:Progressive familial intrahepatic cholestasis type 1 (PFIC1) is a rare, autosomal, recessive, inherited disease resulting from mutations in the ATP8B1 gene which is expressed at high levels in the small intestine and pancreas and at lower levels in the liver. Given this expression pattern, patients might be e...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600842344

    authors: Walkowiak J,Jankowska I,Pawlowska J,Bull L,Herzig KH,Socha J

    更新日期:2006-12-01 00:00:00

  • The plasma 8-OHdG levels and oxidative stress following cholecystectomy: a randomised multicentre study of patients with minilaparotomy cholecystectomy versus laparoscopic cholecystectomy.

    abstract:OBJECTIVE:The aim of the study was to evaluate the role of 8-OHdG (8-hydroxy-2'-deoxyguanosine) detecting oxidative stress response following cholecystectomy in a randomised multicentre study of patients with minilaparotomy cholecystectomy (MC) versus laparoscopic cholecystectomy (LC). METHODS:Initially, 106 patients ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1080/00365521.2016.1208270

    authors: Aspinen S,Harju J,Juvonen P,Selander T,Kokki H,Pulkki K,Eskelinen MJ

    更新日期:2016-12-01 00:00:00

  • Colorectal endoscopic submucosal dissection (ESD) in the West - when can satisfactory results be obtained? A single-operator learning curve analysis.

    abstract:OBJECTIVES:Up to date we lack a detailed description of the colorectal endoscopic submucosal dissection (ESD) learning curve, that would represent the experience of the Western center. The aim of this study was to define the critical points of the learning curve and to draw up lesions qualification guidelines tailored ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1080/00365521.2017.1379557

    authors: Spychalski M,Skulimowski A,Dziki A,Saito Y

    更新日期:2017-12-01 00:00:00

  • Association between gene polymorphisms of IL-28 and response to lamivudine in Chinese rural patients with chronic hepatitis B.

    abstract:OBJECTIVE:To assess the association between gene polymorphisms (single nucleotide polymorphisms [SNPs]) of rs8099917 and rs12980602 in the IL-28 gene and the response to lamivudine treatment in naïve of Chinese rural patients. MATERIAL AND METHODS:Three hundred and fifty-four naïve chronic hepatitis B (CHB) patients t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2013.779746

    authors: Yu F,Wang Y,Yuan S,Ma J,Ma N,Zhang X,Liu X,Liu D

    更新日期:2013-06-01 00:00:00

  • Dipeptidyl peptidase IV (DP IV, CD26) in patients with inflammatory bowel disease.

    abstract:BACKGROUND:Dipeptidyl peptidase IV (DP IV, CD26), a serine protease with broad tissue distribution and known activity in serum, participates in T cell activation and promotes a Th1 cytokine response, a function in part attributable to its enzymatic activity. We hypothesized that the activity of DP IV in serum and expre...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201750422675

    authors: Hildebrandt M,Rose M,Rüter J,Salama A,Mönnikes H,Klapp BF

    更新日期:2001-10-01 00:00:00

  • Pancreatic dose-response curves to cholecystokinin determined by two techniques in dogs.

    abstract::Dose-response (DR) curves for pancreatic flow rate, bicarbonate and protein output to cholecystokinin (CCK) were determined by two techniques in six conscious dogs with gastric and duodenal Thomas fistulas. With the continuous DR technique G.I.H. CCK was given by intravenous infusion in doses from 0.75 to 24 Ivy dog u...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527809181377

    authors: Singer MV,Sarles H

    更新日期:1978-01-01 00:00:00

  • Carbohydrate intolerance in patients with self-reported food hypersensitivity: comparison of lactulose and glucose.

    abstract:OBJECTIVE:Malabsorption of low-digestible carbohydrates is physiological, but poorly tolerated in some patients. We investigated symptom anticipation and microbial fermentation as possible mechanisms of carbohydrate intolerance in patients with self-reported food hypersensitivity. MATERIAL AND METHODS:In a randomized,...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/00365520903348684

    authors: Valeur J,Morken MH,Norin E,Midtvedt T,Berstad A

    更新日期:2009-01-01 00:00:00

  • The influence of Helicobacter pylori eradication on the gastric mucosal content of epidermal growth factor, transforming growth factor-alpha, and their common receptor.

    abstract:BACKGROUND:The relationship between the expression of epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) and that of their receptor (EGF-R) in the Helicobacter pylori-infected gastric mucosa has not been completely elucidated. The aim of this study was to examine the interplay between H. pyl...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365529850170856

    authors: Russo F,Messa C,Amati L,Caradonna L,Leoci C,Di Matteo G,Jirillo E,Di Leo A

    更新日期:1998-03-01 00:00:00

  • Acetazolamide interferes with the protective effect of prostaglandin E2 in the rat gastric mucosa.

    abstract::Oral prostaglandin E2 protected the gastric mucosa against the damage induced by intraperitoneal indomethacin in the rat. Blocking of the gastric alkaline secretion by subcutaneous acetazolamide potentiated the ulcerogenic action of indomethacin and reduced or abolished the protective effect of a submaximal dose prost...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528109181985

    authors: Kollberg B,Aly A,Rubio C,Johansson C

    更新日期:1981-04-01 00:00:00

  • Long-term follow-up after EMR of large colorectal lesions: metachronous lesions, predictors and surveillance timing.

    abstract::Background: Endoscopic mucosal resection (EMR) is the first-line approach to large colorectal sessile lesions. These patients have been associated with high rates of metachronous lesions (ML), but long-term follow-up (LtFU) data are lacking. We aimed at evaluating the efficacy of an LtFU protocol and analyse the devel...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1694066

    authors: Costa D,Brandão M,Costa R,Gonçalves R,Braga A,Rolanda C

    更新日期:2019-12-01 00:00:00

  • Continuous reaction time in patients with hepatic encephalopathy. A quantitative measure of changes in consciousness.

    abstract::In 14 patients with encephalopathy due to cirrhosis of the liver levels of consciousness were assessed by clinical ratings and continuous reaction time measurements. The observations were compared with similar measurements made in patients with chronic brain syndrome, patients sedated with diazepam, and hospitalized c...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528109181995

    authors: Elsass P,Christensen SE,Ranek L,Theilgaard A,Tygstrup N

    更新日期:1981-04-01 00:00:00

  • The new prophylactic strategy for colon cancer in inflammatory bowel disease by modulating microbiota.

    abstract::It is well understood that intestinal microbiota play an important role in the pathogenesis of inflammatory bowel disease (IBD). In addition, IBD patients are well known to have a higher risk of developing colon cancer due to chronic inflammation. Recent evidence suggests that manipulation of microbiota improves the c...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365521.2012.741617

    authors: Kanauchi O,Mitsuyama K,Andoh A

    更新日期:2013-04-01 00:00:00

  • Protective effects of N-acetyl-L-cysteine and platelet activating factor inhibition are not linked to intercellular adhesion molecule-1 expression after intestinal ischemia and reperfusion injury in rats.

    abstract:BACKGROUND:Intestinal ischemia and reperfusion (I/R) injury may result in development of the systemic inflammatory response syndrome (SIRS). The interactions between activated leukocytes and endothelial cells, mediated by adhesion molecules, seem to be pivotal in these conditions, leading as they do to extravasation of...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310002201

    authors: Olanders K,Börjesson A,Sun ZW,Andersson R

    更新日期:2003-06-01 00:00:00