Nucleotide pyrophosphatase and phosphodiesterase I. Demonstration of activity in normal serum, and an increase in cholestatic liver disease.

Abstract:

:Nucleotide pyrophosphatase activity with uridine diphosphoglucose and dephospho-CoA as substrates was demonstrated in normal human serum. The enzyme has a pH-optimum of about 9.6 and is inhibited by EDTA. Phosphodiesterase I (hydrolysis of thymidine-5'-monophospho-p-nitrophenylester) was also found in normal human serum, with a pH-optimum of about 9.8 and a Km of 0.20-0.25 mM. Probably both activities should be attributed to one enzyme. Different isoenzymes may exist, however. The activity of nucleotide pyrophosphatase/phosphodiesterase I in normal serum in many respects resembles an enzyme previously isolated from liver plasma membranes. Phosphodiesterase I activity was increased in normal pregnancy, in primary biliary cirrhosis, and in patients with bone lesions, but not in acute viral hepatitis or active chronic hepatitis. In primary biliary cirrhosis, the activity of phosphodiesterase I paralleled an increase of alkaline phosphatases.

journal_name

Scand J Gastroenterol

authors

Haugen HF,Skrede S

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

121-7

issue

2

eissn

0036-5521

issn

1502-7708

journal_volume

11

pub_type

杂志文章
  • Efficacy and safety profile of calcineurin inhibitor salvage therapy in autoimmune hepatitis.

    abstract:BACKGROUND:As data is limited on the outcomes of calcineurin inhibitors (CNI) in autoimmune hepatitis (AIH), we evaluated the efficacy and safety of CNI in AIH patients who failed prior treatment(s). METHODS:A retrospective study was performed of AIH patients who received cyclosporine A (CsA) and/or tacrolimus (TAC) a...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1821764

    authors: Roberts SK,Strasser SI,Nicoll AJ,Kemp W,Majeed A,Mitchell J,Stuart K,Gow P,Sood S,MacQuillan G,George J,Mitchell J,McCaughan GW,ALA Clinical Research Network.

    更新日期:2020-11-01 00:00:00

  • The risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomy.

    abstract:OBJECTIVES:Mismatch repair deficient (dMMR) colorectal cancer (CRC) is caused by inactivation of the MMR DNA repair system, most commonly via epigenetic inactivation of the MLH1 gene, and these tumors occur most frequently in the right colon. The objective was to determine whether cholecystectomy (CCY) increases the ri...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1481997

    authors: Halldorsson MO,Hauptmann M,Snaebjornsson P,Haraldsdóttir KH,Aspelund T,Gudmundsson EF,Gudnason V,Jonasson JG,Haraldsdottir S

    更新日期:2018-08-01 00:00:00

  • Type I and III collagens in human colon cancer and diverticulosis.

    abstract:BACKGROUND:Collagens are major proteins in the extracellular matrix, providing tissues with tensile strength. They are also important for cell adhesion and the invasion of malignant tumours. METHODS:Thirty-nine samples of human colon (24 diverticulosis, 6 malignant tumours, 9 controls) were collected during elective s...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655200750023435

    authors: Bode MK,Karttunen TJ,Mäkelä J,Risteli L,Risteli J

    更新日期:2000-07-01 00:00:00

  • Jejunal morphology and mucosal enzyme activity following intestinal shunt operation for obesity.

    abstract::Jejunal biopsy in 33 patients before and after intestinal shunt operation for obesity has demonstrated that neither surface nor volume of the villi increase after surgery. Specific disaccharidase activity remained unchanged, and specific alkaline phosphatase activity increased slightly. There was a significant decreas...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Danö P,Nielsen OV,Petri M,Jörgensen B

    更新日期:1976-01-01 00:00:00

  • Ultrasonographic findings in patients with peristomal bulging.

    abstract:AIM:The aim of this study was to obtain a classification of peristomal bulging based on findings at ultrasonography in patients with a sigmoid colostomy. METHODS:The patient material comprised 30 men and 33 women. The median age was 69 years (28-90) and the median time between stoma creation and investigation was 68 m...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2011.560681

    authors: Sjödahl RI,Thorelius L,Hallböök OJ

    更新日期:2011-06-01 00:00:00

  • Studies of the choledocho-duodenal sphincter in patients with and without juxta-papillary duodenal diverticula.

    abstract::The function of the choledocho-duodenal sphincter was studied in 16 patients, 8 with juxta-papillary duodenal diverticula. All patients had calculi in the gallbladder. The common bile duct was normal. At cholecystectomy two catheters were introduced into the common bile duct through the stump of the cystic duct and fi...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528009181545

    authors: Løtveit T,Osnes M,Aune S,Larsen S

    更新日期:1980-01-01 00:00:00

  • Collagen metabolites in the peripheral and splanchnic circulation of patients with Crohn disease.

    abstract:BACKGROUND:Fragments of collagen arising during synthesis and breakdown have been suggested as markers of fibrous tissue remodelling in Crohn disease. We compared serum concentrations of the C-terminal propeptide of collagen I (PICP), the N-terminal propeptide of collagen III (PIIINP) and the C-terminal telopeptide of ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520152584833

    authors: Kjeldsen J,Rasmussen M,Schaffalitzky de Muckadell OB,Kronborg O,Junker P

    更新日期:2001-11-01 00:00:00

  • Efficacy of anorectal biofeedback in scleroderma patients with fecal incontinence: a case-control study.

    abstract:OBJECTIVE:To determine whether anorectal biofeedback therapy can improve the symptoms of fecal incontinence (FI) in patients with scleroderma when compared to patients with functional FI, and also whether there is any effect on anorectal physiology or quality of life (QOL). FI in patients with scleroderma is highly pre...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2016.1218537

    authors: Collins J,Mazor Y,Jones M,Kellow J,Malcolm A

    更新日期:2016-12-01 00:00:00

  • Influence of alcohol consumption on the association between serum lipids and colorectal adenomas.

    abstract:BACKGROUND:There have been no reports that low serum cholesterol levels increase the risk of colorectal adenoma, although many studies have shown that they do increase the risk of colorectal cancer. Alcohol intake, which is associated with a risk of colorectal adenomas, and serum cholesterol levels are closely related....

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655202761020597

    authors: Fujimori S,Kishida T,Mitsui K,Yonezawa M,Nagata K,Shibata Y,Tanaka S,Tatsuguchi A,Sato J,Yokoi K,Tanaka N,Ohaki Y,Sakamoto C,Kobayashi M

    更新日期:2002-11-01 00:00:00

  • Patients with cyclic vomiting pattern and diabetic gastropathy have more migraines, abnormal electrogastrograms, and gastric emptying.

    abstract:OBJECTIVE:Some patients with diabetic gastroparesis exhibit cyclical symptoms. The purpose of this work was to study the subset of patients with cyclic vomiting characteristics, described as a cyclic vomiting pattern, in a population of patients with symptoms of diabetic gastroparesis. MATERIAL AND METHODS:Sixty-seven...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802085411

    authors: Christensen CJ,Johnson WD,Abell TL

    更新日期:2008-01-01 00:00:00

  • Eosinophilic gastroenteritis: our recent experience: one-year experience of atypical onset of an uncommon disease.

    abstract::Eosinophilic gastroenteritis is an unusual entity that is rarely found in daily clinical practise. Its aetiology is unknown and diagnosis can be made microscopically with evidence of massive eosinophilic infiltration in patients with chronic gastrointestinal symptoms, excluding entities that may cause such findings (p...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201317097254

    authors: Redondo-Cerezo E,Cabello MJ,González Y,Gómez M,García-Montero M,de Teresa J

    更新日期:2001-12-01 00:00:00

  • Pro-adrenomedullin in acute decompensation of liver cirrhosis: relationship with acute-on-chronic liver failure and short-term survival.

    abstract::Background and aim: Acute-on-chronic liver failure (ACLF) is characterized by the presence of acute decompensation (AD) of cirrhosis, organ failures, and high short-term mortality rates. In present study, we explored whether Pro-adrenomedullin (Pro-ADM), a biomarker of sepsis, is a potential marker of outcome in patie...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1764616

    authors: Yan H,Jin S,Liang L,Du J,Aithal GP,Li L

    更新日期:2020-05-01 00:00:00

  • Centralized registration, prophylactic examination, and treatment results in improved prognosis in familial adenomatous polyposis. Results from the Danish Polyposis Register.

    abstract:BACKGROUND:Over the last few decades numerous regional and national registers have been established all over the world with the aim of improving survival in familial adenomatous polyposis (FAP). The Danish Polyposis Register was founded in 1971 and coordinates the screening and subsequent prophylactic colectomy of FAP ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529509096343

    authors: Bülow S,Bülow C,Nielsen TF,Karlsen L,Moesgaard F

    更新日期:1995-10-01 00:00:00

  • Pancreatic dose-response curves to cholecystokinin determined by two techniques in dogs.

    abstract::Dose-response (DR) curves for pancreatic flow rate, bicarbonate and protein output to cholecystokinin (CCK) were determined by two techniques in six conscious dogs with gastric and duodenal Thomas fistulas. With the continuous DR technique G.I.H. CCK was given by intravenous infusion in doses from 0.75 to 24 Ivy dog u...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527809181377

    authors: Singer MV,Sarles H

    更新日期:1978-01-01 00:00:00

  • Risk and outcome of hepatocellular carcinoma in liver cirrhosis in Southern Sweden: a population-based study.

    abstract::Background and aims: Liver cirrhosis is a risk factor for hepatocellular carcinoma (HCC). While the HCC risk is thought to be highest in hepatitis B and hepatitis C, the risk in other cirrhosis etiologies is not fully established. Therefore, we aimed to study the risk and outcome of HCC in alcoholic cirrhosis compared...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1649454

    authors: Nilsson E,Anderson H,Sargenti K,Lindgren S,Prytz H

    更新日期:2019-08-01 00:00:00

  • Contribution of intraoperative colonoscopy in a colorectal surgery unit.

    abstract:OBJECTIVES:Intraoperative colonoscopy (IC) is routinely used in colorectal surgery procedures, both oncologic and benign ones. Despite its extensive use there is a lack of literature addressing this important issue. The aims of this paper are to determine the contributions of this tool, especially considering changes i...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2017.1362465

    authors: Cerdán Santacruz C,Esteban López-Jamar JM,Sánchez López E,Cerdán Miguel J

    更新日期:2017-11-01 00:00:00

  • Regional vascular influences of vasoactive intestinal polypeptide.

    abstract::Vasoactive intestinal polypeptide (VIP) has powerful vasodilating effects, shown by a striking conductance increase especially in the vertebral artery (+100%), the left descending coronary artery (+200%), the left gastric artery (+550%), the superior pancreaticoduodenal artery (+200%), and the gastroduodenal artery (+...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528309182091

    authors: Blitz W,Charbon GA

    更新日期:1983-09-01 00:00:00

  • Usefulness of the 14C urea breath test as a semi-quantitative monitoring instrument after therapy for Helicobacter pylori infection.

    abstract:BACKGROUND:We evaluated the reliability and usefulness of the 14C urea breath test (UBT) in confirming eradication of Helicobacter pylori 4 to 6 weeks after cessation of antimicrobial therapy. METHODS:We investigated 57 patients, who underwent both an upper endoscopy with multiple biopsy specimens taken for histopatho...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529709000180

    authors: van de Wouw BA,de Boer WA,Hermsen HW,Valkenburg JG,Geuskens LM,Tytgat GN

    更新日期:1997-02-01 00:00:00

  • Crohn's disease intestinal CD4+ T cells have impaired interleukin-10 production which is not restored by probiotic bacteria.

    abstract:OBJECTIVE:Crohn's disease (CD) has been associated with low mucosal interleukin (IL)-10 production, but the mechanism behind this deficiency remains unclear. The aim of this study was to investigate IL-10 and interferon (IFN)-gamma production in intestinal CD4+ T cells from CD patients and healthy volunteers (HV) and t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520601013754

    authors: Hvas CL,Kelsen J,Agnholt J,Höllsberg P,Tvede M,Møller JK,Dahlerup JF

    更新日期:2007-05-01 00:00:00

  • Cytomegalovirus infection in ulcerative colitis.

    abstract:OBJECTIVE:Cytomegalovirus (CMV) infection has been reported as an exacerbating factor in inflammatory bowel disease but the relationship between CMV infection and ulcerative colitis (UC) remains unclear. There has been no detailed research to elucidate the clinicopathologic features of CMV infection in UC using surgica...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520500408584

    authors: Kojima T,Watanabe T,Hata K,Shinozaki M,Yokoyama T,Nagawa H

    更新日期:2006-06-01 00:00:00

  • Diagnosis of Helicobacter pylori infection in patients with atrophic gastritis: comparison of histology, 13C-urea breath test, and serology.

    abstract:BACKGROUND:Atrophic gastritis, a risk factor for gastric cancer, is a late consequence of Helicobacter pylori infection in approximately one-third of the infected patients. It has been suggested that gastric cancer would develop less frequently if H. pylori were eradicated. However, the prevalence of H. pylori infectio...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655200750024290

    authors: Kokkola A,Rautelin H,Puolakkainen P,Sipponen P,Färkkilä M,Haapiainen R,Kosunen TU

    更新日期:2000-02-01 00:00:00

  • Prognostic factors and outcomes of patients with hepatocellular carcinoma in non-cirrhotic liver.

    abstract:OBJECTIVES:To report the outcome of patients with hepatocellular carcinoma (HCC) in non-cirrhotic liver depending on the mode of primary treatment and to define clinicopathological factors influencing patients' prognosis. METHODS:A retrospective analysis of an unselected cohort of 105 patients was performed. Overall s...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.677952

    authors: Wörns MA,Bosslet T,Victor A,Koch S,Hoppe-Lotichius M,Heise M,Hansen T,Pitton MB,Niederle IM,Schuchmann M,Weinmann A,Düber C,Galle PR,Otto G

    更新日期:2012-06-01 00:00:00

  • Transjugular intrahepatic portosystemic shunt placement for refractory ascites: a single-centre experience.

    abstract:BACKGROUND:The presence of refractory ascites is a common indication for transjugular intrahepatic portosystemic shunt (TIPS). Different models have been proposed for the prediction of survival after TIPS. The aim of this study was to evaluate the predictive factors associated with patients' survival after TIPS placeme...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.703239

    authors: Lodato F,Berzigotti A,Lisotti A,Azzaroli F,Mosconi C,Giampalma E,Renzulli M,Cappelli A,Buonfiglioli F,Calvanese C,Zoli M,Golfieri R,Mazzella G

    更新日期:2012-12-01 00:00:00

  • Functional abdominal complaints occurred frequently in living liver donors after donation.

    abstract:BACKGROUND:Donor outcome after living donor liver transplantation has not been examined extensively with regard to postoperative abdominal complaints. We wanted to examine the extent and type of abdominal complaints after removal of a part of the liver and gallbladder in living donors as well as potential similarities ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2010.537685

    authors: Søndenaa K,Gondolesi GE,Roayaie S,Goldman JS,Hausken T,Schwartz ME

    更新日期:2011-05-01 00:00:00

  • A novel one-hour 13C-sorbitol breath test versus the H2-sorbitol breath test for assessment of coeliac disease.

    abstract:OBJECTIVE:The H(2)-sorbitol breath test (H(2)-SBT) has previously been suggested as a screening tool for coeliac disease. We developed an alternative (13)C-sorbitol breath test ((13)C-SBT). The aim of the study was to compare the diagnostic properties of the H(2)-SBT and the (13)C-SBT in a clinical setting. MATERIAL A...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520902846233

    authors: Tveito K,Hetta AK,Askedal M,Brunborg C,Sandvik L,Løberg EM,Skar V

    更新日期:2009-01-01 00:00:00

  • High-grade dysplastic adenoma-like mass lesions are not an indication for colectomy in patients with ulcerative colitis.

    abstract:OBJECTIVE:The management of high-grade dysplasia (HGD) in polypoid lesions in patients with ulcerative colitis (UC) is not well characterized. The purpose of this study was to characterize the clinical course of patients with HGD in adenoma-like dysplasia-associated lesion or masses (DALMs) in the absence of any synchr...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520801909686

    authors: Blonski W,Kundu R,Furth EF,Lewis J,Aberra F,Lichtenstein GR

    更新日期:2008-01-01 00:00:00

  • Effect of platelet-derived growth factor-BB on indomethacin-induced gastric lesions in rats.

    abstract::The effect of platelet-derived growth factor-BB (PDGF-BB) was evaluated in rats with indomethacin-induced gastric lesions. Animals were treated with either saline solution or several doses of PDGF-BB given orally. Rats treated with 0.1 nmol/kg PDGF-BB showed a statistically significant reduction of gastric damage. Hig...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529209000138

    authors: Guglietta A,Hervada T,Nardi RV,Lesch CA

    更新日期:1992-08-01 00:00:00

  • The significance of colocalization of plasminogen activator inhibitor-1 and vitronectin in hepatic fibrosis.

    abstract:BACKGROUND:We examined the relationships among vitronectin (VN), plasminogen activator inhibitor-1 (PAI-1), and transforming growth factor beta 1 (TGF-beta 1) in liver diseases to evaluate the presence of plasmin cascade in human hepatic fibrosis. METHODS:Blood and liver tissues were obtained from 57 patients with liv...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529709011224

    authors: Inuzuka S,Ueno T,Torimura T,Tamaki S,Sugawara H,Sakata R,Kusaba N,Sata M,Tanikawa K

    更新日期:1997-10-01 00:00:00

  • Gastric cancer confined to the muscularis propria: a possible candidate for laparoscopic surgery or adjuvant therapy.

    abstract:OBJECTIVE:Gastric cancer confined to the muscularis propria (mp) has a favorable prognosis, but still belongs to the advanced category. Many oncologists have difficulties in selecting treatment modalities owing to the confused situation of mp cancer. To clarify the therapeutic strategy, the clinicopathological characte...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410009302

    authors: Park SS,Kim CS,Mok YJ,Kim SJ,Kim HI

    更新日期:2005-04-01 00:00:00

  • Detection of Helicobacter pylori gene by means of immunomagnetic separation-based polymerase chain reaction in feces.

    abstract:BACKGROUND:Detection of Helicobacter pylori is usually performed by culture, polymerase chain reaction (PCR), histology, or urease test on gastric biopsy samples. Although methods based on feces are non-invasive, their sensitivity has been relatively low. In this study, to improve its sensitivity, immunomagnetic separa...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365529850172476

    authors: Watanabe T,Tomita S,Kudo M,Kurokawa M,Orino A,Todo A,Chiba T

    更新日期:1998-11-01 00:00:00