Effect of platelet-derived growth factor-BB on indomethacin-induced gastric lesions in rats.

Abstract:

:The effect of platelet-derived growth factor-BB (PDGF-BB) was evaluated in rats with indomethacin-induced gastric lesions. Animals were treated with either saline solution or several doses of PDGF-BB given orally. Rats treated with 0.1 nmol/kg PDGF-BB showed a statistically significant reduction of gastric damage. Higher doses did not produce any further reduction of gastric damage, and a return toward control values was observed. The effect on lesions was independent of inhibition of gastric acid secretion, since a dose of 0.1 nmol/kg of this growth factor failed to modify gastric acid secretion stimulated by pylorus ligation.

journal_name

Scand J Gastroenterol

authors

Guglietta A,Hervada T,Nardi RV,Lesch CA

doi

10.3109/00365529209000138

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

673-6

issue

8

eissn

0036-5521

issn

1502-7708

journal_volume

27

pub_type

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