Centralized registration, prophylactic examination, and treatment results in improved prognosis in familial adenomatous polyposis. Results from the Danish Polyposis Register.

Abstract:

BACKGROUND:Over the last few decades numerous regional and national registers have been established all over the world with the aim of improving survival in familial adenomatous polyposis (FAP). The Danish Polyposis Register was founded in 1971 and coordinates the screening and subsequent prophylactic colectomy of FAP patients. METHODS:The crude cumulative survival in 321 patients (205 probands and 116 call-up cases) with verified FAP was calculated in accordance with the life-table method. RESULTS:At the time of diagnosis of FAP only 2 of 116 (2%) had colorectal cancer versus 142 of 205 probands (69%). The 10-year cumulative survival was 94% (95% confidence limits, 89-99) in call-up cases compared with only 41% (34-49) in probands (p < 0.00001), and survival improved significantly (p < 0.00001) after the establishment of the Danish Polyposis Register. CONCLUSION:The establishment of a centralized polyposis register has resulted in a substantial improvement of the prognosis in FAP.

journal_name

Scand J Gastroenterol

authors

Bülow S,Bülow C,Nielsen TF,Karlsen L,Moesgaard F

doi

10.3109/00365529509096343

subject

Has Abstract

pub_date

1995-10-01 00:00:00

pages

989-93

issue

10

eissn

0036-5521

issn

1502-7708

journal_volume

30

pub_type

杂志文章
  • Unkilned and large amounts of oats in the coeliac disease diet: a randomized, controlled study.

    abstract:OBJECTIVE:There is evidence for the long-term safety of oats as part of a gluten-free diet in coeliac disease (CD). Oats is generally processed by kilning, which theoretically may change its antigenic properties and be the reason that it is tolerated by patients with CD. The aim of this study was to investigate the sui...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/00365520802014858

    authors: Kemppainen TA,Heikkinen MT,Ristikankare MK,Kosma VM,Sontag-Strohm TS,Brinck O,Salovaara HO,Julkunen RJ

    更新日期:2008-01-01 00:00:00

  • Tranexamic acid in massive haemorrhage from the upper gastrointestinal tract: a double-blind study.

    abstract::In a double-blind trial of tranexamic acid in massive upper gastrointestinal haemorrhage, 76 patients were treated with the active drug and 73 patients with placebo. The doses were 1 g intravenously six times daily for a maximum of 3 days, followed by 1.5 g orally four times daily for a maximum of 4 days. The treatmen...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365527909181413

    authors: Engqvist A,Broström O,von Feilitzen F,Halldin M,Nyström B,Ost A,Reichard H,Sandqvist S,Törngren S,Wedlund JE

    更新日期:1979-01-01 00:00:00

  • Ultrasound measurements of calcaneus for estimation of skeletal status in patients with inflammatory bowel disease.

    abstract:BACKGROUND:Patients with inflammatory bowel disease (IBD) are at risk of developing metabolic bone disease. In diagnosing osteoporosis, bone mineral density (BMD) measurements play a key role. Our aims in this study were to assess the skeletal status with quantitative ultrasound (QUS) and to evaluate the ability of thi...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655299750025723

    authors: Jahnsen J,Falch JA,Mowinckel P,Aadland E

    更新日期:1999-08-01 00:00:00

  • Bariatric surgery - time to replace with GLP-1?

    abstract::Obesity with a body mass index (BMI) over 30 kg/m2 represents a significant risk for increased morbidity and mortality, with reduced life expectancy of about 10 years. Until now, surgical treatment has been the only effective longterm intervention. The currently standardized method of bariatric surgery, gastric bypass...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1080/00365521.2017.1293154

    authors: Webb DL,Abrahamsson N,Sundbom M,Hellström PM

    更新日期:2017-01-01 00:00:00

  • Selected bacterial antibodies in Crohn's disease and ulcerative colitis.

    abstract::Agglutinins to four strains of anaerobic gram-positive coccoid rods (species of Eubacterium, Peptostreptococcus and Coprococcus) were found in significantly higher frequency in Crohn's disease (CD) than in ulcerative colitis (UC) and in other diseased control subjects and were virtually absent in apparently healthy su...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528309181586

    authors: Auer IO,Röder A,Wensinck F,van de Merwe JP,Schmidt H

    更新日期:1983-03-01 00:00:00

  • Effects of ebrotidine on aspirin-induced gastric mucosal damage and blood flow in humans.

    abstract::Nonsteroidal anti-inflammatory agents (NSAIDs) such as aspirin (ASA) damage the gastric mucosa both in normal subjects and in arthritic patients. The aim of this study was to investigate the protective action of a new H2-receptor antagonist, ebrotidine, in the prevention of ASA-induced acute mucosal injury in the stom...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365529309098307

    authors: Konturek SJ,Kwiecien N,Sito E,Obtulowicz W,Kaminski K,Oleksy J

    更新日期:1993-12-01 00:00:00

  • Liquid and solid gastric emptying in adults treated for Hirschsprung's disease during early childhood.

    abstract:OBJECTIVE:Dysmotility of the upper gastrointestinal tract has been reported in children with Hirschsprung's disease. In the present study, gastric emptying was studied in adult patients with Hirschsprung's disease to elucidate whether there is a persisting involvement of the upper gastrointestinal tract in this group o...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600842211

    authors: Medhus AW,Bjørnland K,Emblem R,Husebye E

    更新日期:2007-01-01 00:00:00

  • Prevalence of gastrointestinal complaints in runners competing in a long-distance run: an internet-based observational study in 1281 subjects.

    abstract:OBJECTIVE:To assess the prevalence, risk factors and timing of gastrointestinal (GI) complaints in a large group of runners competing in a long-distance run. GI symptoms indicating GI ischaemia were of specific interest. MATERIAL AND METHODS:A questionnaire was sent by e-mail to 2076 athletes who had competed in a rec...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802321170

    authors: ter Steege RW,Van der Palen J,Kolkman JJ

    更新日期:2008-01-01 00:00:00

  • Relation between histologic subtypes and location of gastric cancer and Helicobacter pylori.

    abstract:BACKGROUND:Epidemiologic studies have consistently shown an association between Helicobacter pylori infection and gastric cancer, and it is now widely accepted that this organism plays a role in the pathogenesis of this tumor. Nevertheless, there are discrepant results on its relationship with the histologic type and l...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529709007676

    authors: Martín-de-Argila C,Boixeda D,Redondo C,Alvarez I,Gisbert JP,García Plaza A,Cantón R

    更新日期:1997-04-01 00:00:00

  • Insulin action on glucose transport in isolated skeletal muscle from patients with liver cirrhosis.

    abstract::Insulin resistance, associated with liver cirrhosis, has been suggested to be localized in skeletal muscle. We used an in vitro incubation technique to determine insulin action on glucose transport in skeletal muscle obtained from seven patients with clinically stable alcoholic cirrhosis and seven healthy age- and sex...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409090440

    authors: Johansson U,Eriksson LS,Galuska D,Zierath JR,Wallberg-Henriksson H

    更新日期:1994-01-01 00:00:00

  • The SHA2PE score: a new score for lower gastrointestinal bleeding that predicts low-risk of hospital-based intervention.

    abstract:OBJECTIVES:Lower gastrointestinal bleeding (LGIB) risk scores have mainly focused on identifying high-risk patients. A risk score aimed at predicting which patients will not require hospital-based intervention may reduce unnecessary hospital admissions. The aim of the current study was to develop such a risk score. MA...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1532019

    authors: Hreinsson JP,Sigurdardottir R,Lund SH,Bjornsson ES

    更新日期:2018-12-01 00:00:00

  • Gastric IgA in cystic fibrosis in relation to the migrating motor complex.

    abstract:BACKGROUND:Gastrointestinal symptoms in cystic fibrosis are frequent, but little is known about the underlying pathophysiology. Mucosal secretion of IgA is important for the immunologic function in the human gastrointestinal tract but has not been studied in cystic fibrosis. The aim of this study was to quantify the re...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201750313379

    authors: Hallberg K,Mattsson-Rydberg A,Fändriks L,Strandvik B

    更新日期:2001-08-01 00:00:00

  • Absorption studies after ileal J-pouch anastomosis for ulcerative colitis. A prospective study.

    abstract::Absorption studies were performed in 17 patients with ulcerative colitis operated on with colectomy and an ileal two-limbed J-pouch anastomosis. The patients were studied 3 and greater than or equal to 18 months after closure of the temporary ileostomy. Increased stool mass (median, 609 g/24 h) was found in all patien...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529108996485

    authors: Hylander E,Rannem T,Hegnhøj J,Kirkegaard P,Thale M,Jarnum S

    更新日期:1991-01-01 00:00:00

  • Pregnancy course in patients with intrahepatic cholestasis of pregnancy treated with very low doses of ursodeoxycholic acid.

    abstract:OBJECTIVE:Ursodeoxycholic acid (UDCA) has been proposed as the optimal pharmacological treatment for intrahepatic cholestasis of pregnancy (ICP). The lowest effective dosage of UDCA in women with ICP has not been established. The objective is to determine the risk of adverse pregnancy outcomes resulting from ICP and to...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2015.1064990

    authors: Grymowicz M,Czajkowski K,Smolarczyk R

    更新日期:2016-01-01 00:00:00

  • Protective effects of trolox C, vitamin C, and catalase on bromobenzene-induced damage to rat hepatocytes.

    abstract:BACKGROUND/METHODS:The protective effects of trolox C (water-soluble vitamin E), vitamin C, and catalase on bromobenzene (BB)-induced toxicity to isolated rat hepatocytes were evaluated. The glutathione (GSH) content of the hepatocytes exposed to BB was measured. RESULTS:BB caused acute damage to the cells during 2 h ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529609010355

    authors: Wu J,Karlsson K,Danielsson A

    更新日期:1996-08-01 00:00:00

  • Is transcatheter arterial embolization a safer alternative than surgery when endoscopic therapy fails in bleeding duodenal ulcer?

    abstract:OBJECTIVE:Emergency surgery after unsuccessful endoscopic therapy for bleeding duodenal ulcer has been reported to have a high mortality. Transcatheter arterial embolization (TAE) of the gastroduodenal artery is an alternative strategy when endoscopic therapy fails. This study is a retrospective analysis comparing thes...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365520903486109

    authors: Venclauskas L,Bratlie SO,Zachrisson K,Maleckas A,Pundzius J,Jönson C

    更新日期:2010-03-01 00:00:00

  • The fate of intravenously injected trypsinogens in dogs.

    abstract::After intravenous injection of autologous purified and radiolabeled anionic and cationic trypsinogens in the dog, there is a multiexponential elimination from serum of the trypsinogens without activation to active trypsins. The results are in agreement with an elimination of the trypsinogens iva glomerular filtration,...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528109181969

    authors: Borgström A

    更新日期:1981-01-01 00:00:00

  • Does heparin coating reduce encrustation of biliary plastic endoprostheses? A prospective randomized trial.

    abstract:OBJECTIVE:Common bile duct stenting is widely performed for bridging benign and malignant obstructions. A major limitation is early stent occlusion making regular stent exchange necessary. Covalent binding of glycosaminoglycanes to polyethylene stents proved to reduce encrustation in urological implants. Since developm...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/00365521.2012.711849

    authors: Farnbacher MJ,Lederer R,Blana A,Schneider HT

    更新日期:2012-10-01 00:00:00

  • The compact Erlangen Active Simulator for Interventional Endoscopy: a prospective comparison in structured team-training courses on "endoscopic hemostasis" for doctors and nurses to the "Endo-Trainer" model.

    abstract:BACKGROUND:In 1997 Hochberger and Neumann presented the "Erlangen Biosimulation Model" (commercialized as the "Erlangen Endo-Trainer") at various national and international meetings. The new compactEASIE is a simplified version of the original "Biosimulation Model" (Endo-Trainer) and is specially designed for easy hand...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410006765

    authors: Hochberger J,Euler K,Naegel A,Hahn EG,Maiss J

    更新日期:2004-09-01 00:00:00

  • Expression pattern of T-helper 17 cell signaling pathway and mucosal inflammation in celiac disease.

    abstract:OBJECTIVE:The aim was to investigate the mucosal activation of a broad range of genes associated with the T-helper 17 cell (Th17) signaling pathway in children at different stages of celiac disease (CD), including children with increased risk for CD and children with untreated and gluten-free diet (GFD)-treated CD. MA...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2013.863966

    authors: Lahdenperä AI,Fälth-Magnusson K,Högberg L,Ludvigsson J,Vaarala O

    更新日期:2014-02-01 00:00:00

  • Characterization and clinical course of hepatobiliary carcinoma in patients with primary sclerosing cholangitis.

    abstract:OBJECTIVE:Primary sclerosing cholangitis (PSC) confers a high risk of development of hepatobiliary carcinoma (HBC). The aim of the study was to identify indicators and risk factors for developing HBC in PSC patients. MATERIAL AND METHODS:Thirty-nine PSC patients with HBC at time of HBC diagnosis were compared with 101...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600633495

    authors: Tischendorf JJ,Meier PN,Strassburg CP,Klempnauer J,Hecker H,Manns MP,Krüger M

    更新日期:2006-10-01 00:00:00

  • Prevention of ethanol-induced gastric lesions in rats by natural honey, and its possible mechanism of action.

    abstract::The effects and the mechanism of natural honey on absolute ethanol-induced gastric lesions were studied in rats. Drugs and/or honey were administered subcutaneously or orally to 48-h fasted animals at different time intervals before oral administration of ethanol (0.5 ml/100 g). Mucosal damage and pH were measured 1 h...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529109025043

    authors: Ali AT

    更新日期:1991-03-01 00:00:00

  • Primary treatment of carcinoma of the anus by combined radiotherapy and chemotherapy.

    abstract::Twenty-four patients with carcinoma of the anus were treated with a combined regimen of external irradiation (50 Gy) and mitomycin C and 5-fluorouracil. A relatively large number of patients with locally advanced disease were included. A local complete response rate of 87.5% was obtained. The major acute toxicity was ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528909090794

    authors: Tveit KM,Karlsen KO,Fosså SD,Flokkmann A,Guldvog I,Haffner J

    更新日期:1989-12-01 00:00:00

  • Detection of Helicobacter pylori gene by means of immunomagnetic separation-based polymerase chain reaction in feces.

    abstract:BACKGROUND:Detection of Helicobacter pylori is usually performed by culture, polymerase chain reaction (PCR), histology, or urease test on gastric biopsy samples. Although methods based on feces are non-invasive, their sensitivity has been relatively low. In this study, to improve its sensitivity, immunomagnetic separa...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365529850172476

    authors: Watanabe T,Tomita S,Kudo M,Kurokawa M,Orino A,Todo A,Chiba T

    更新日期:1998-11-01 00:00:00

  • Sclerosing cholangitis in acquired immunodeficiency syndrome. Case reports and review of the literature.

    abstract::Four patients with acquired immunodeficiency syndrome (AIDS) (CDC group IV) were investigated for biliary disease because of the presence of both severe upper abdominal pain and raised levels of serum alkaline phosphatase. None was clinically jaundiced. Upper abdominal ultrasound was abnormal in three. All had endosco...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809090203

    authors: Dowsett JF,Miller R,Davidson R,Vaira D,Polydorou A,Cairns SR,Weller IV

    更新日期:1988-12-01 00:00:00

  • Psychological factors in irritable bowel syndrome: a population-based study of patients, non-patients and controls.

    abstract:BACKGROUND:It has been suggested that psychopathology in irritable bowel syndrome (IBS) patients is a function of patient status rather than of the disease. Although there are many studies comparing IBS patients, IBS non-patients, and controls with each other, no previous study has recruited all three groups from a rep...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Weinryb RM,Osterberg E,Blomquist L,Hultcrantz R,Krakau I,Asberg M

    更新日期:2003-05-01 00:00:00

  • Anti-CagA and anti-VacA antibodies in Helicobacter pylori-infected patients with and without peptic ulcer disease in Serbia and Montenegro.

    abstract:BACKGROUND:The expression of two Helicobacter pylori proteins, CagA and VacA, is associated with more severe pathogenesis and clinical outcomes of the infection. However, this association varies among geographical regions and ethnic groups. We therefore evaluated CagA and VacA seroprevalence in H. pylori-positive dyspe...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310008403

    authors: Sokic-Milutinovic A,Wex T,Todorovic V,Milosavljevic T,Malfertheiner P

    更新日期:2004-03-01 00:00:00

  • Exogenous stem cell factor improves interstitial cells of Cajal restoration after blockade of c-kit signaling pathway.

    abstract:OBJECTIVE:Interstitial cells of Cajal (ICC) have been endowed with considerable intrinsic plasticity. Blockade of the c-kit signaling pathway results in the shift of ICC towards a smooth muscle-like phenotype. Little is known about stem cell factor (SCF), the ligand of c-kit, and the role it plays in the process of res...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521003782371

    authors: Tong W,Jia H,Zhang L,Li C,Ridolfi TJ,Liu B

    更新日期:2010-08-01 00:00:00

  • Selective inhibitors of COX-2--are they safe for the stomach?

    abstract::NSAIDs are widely used and beneficial for patients with inflammatory pain. However, NSAIDs cause significant adverse upper gastrointestinal effects, including increased mortality from serious ulcer complications. NSAIDs exert their anti-inflammatory effects by inhibiting the activity of the COX enzyme, which was recen...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1080/003655200750056565

    authors: Giercksky KE,Haglund U,Rask-Madsen J

    更新日期:2000-11-01 00:00:00

  • Measuring movement and location of the gastroesophageal junction: research and clinical implications.

    abstract::Understanding the physiology of gastroesophageal junction (GEJ) is important as failure of its function is associated with reflux disease, hiatus hernia, and cancer. In recent years, there have been impressive developments in high resolution technologies allowing measurement of luminal pressure, pH, and impedance. One...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365521.2012.746394

    authors: Lee YY,Whiting JG,Robertson EV,Derakhshan MH,Smith D,McColl KE

    更新日期:2013-04-01 00:00:00