Abstract：
BACKGROUND/METHODS:The protective effects of trolox C (water-soluble vitamin E), vitamin C, and catalase on bromobenzene (BB)-induced toxicity to isolated rat hepatocytes were evaluated. The glutathione (GSH) content of the hepatocytes exposed to BB was measured. RESULTS:BB caused acute damage to the cells during 2 h of incubation (short) when BB was added directly to the culture wells, whereas a late-occurring and time-dependent increase in lactate dehydrogenase (LDH) leakage rate was observed during 24 h of incubation (long) when BB was dissolved in a different way. Incubation of the cells with trolox C (0.5-2.0 mM) prevented the hepatocellular damage induced by BB at 2.4 mM during the long-term incubation. Vitamin C (0.1-1.0 mM) had a protective effect on BB-induced toxicity during both the short- (BB, 1.6 mM) and the long- (BB, 2.4 mM) term incubations. Catalase (3200 U/ml) also showed a beneficial effect on the cells during the short-term BB exposure. Trolox C (2.0 mM) and vitamin C (0.5 mM) restored BB-induced GSH depletion in the cells. CONCLUSIONS:BB induced two patterns of LDH leakage from isolated hepatocytes on the basis of different ways of BB exposure and incubation periods. Trolox C, vitamin C, and catalase exerted protective effects on BB-induced toxicity during short- or/and long-term incubations. The effects were concentration-dependent. Restoration of GSH content in BB-exposed hepatocytes suggests that trolox C and vitamin C could reduce GSH consumption during BB metabolism and exert an antioxidant effect.
journal_name
Scand J Gastroenteroljournal_title
Scandinavian journal of gastroenterologyauthors
Wu J,Karlsson K,Danielsson Adoi
10.3109/00365529609010355subject
Has Abstractpub_date
1996-08-01 00:00:00pages
797-803issue
8eissn
0036-5521issn
1502-7708journal_volume
31pub_type
杂志文章abstract：:The jejunal disposal of perfused acid was studied in 11 control subjects and 12 patients with duodenal ulcer. It was found that the capacity to dispose of acid was saturable and was less than control in patients with duodenal ulcer. When the load of acid was small, all the acid disappeared from the jejunum and sodium ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Basal, meal-stimulated, and insulin-stimulated secretion of pancreatic polypeptide (PP) has been measured before and 3 and 12 months after gastric bypass surgery in 10 obese patients. The basal serum concentration of PP was significantly reduced after the operation. After a meal there was a significant increase in PP ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365528109181020
更新日期：1981-01-01 00:00:00
abstract：OBJECTIVE:Morbidity and mortality following perforated peptic ulcer (PPU) remain substantial. In the recently published PULP trial, 30-day mortality in patients surgically treated for PPU decreased from 27% to 17% following the implementation of a perioperative care protocol based on The Surviving Sepsis Guidelines. Th...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章,多中心研究
doi：10.3109/00365521.2012.746393
更新日期：2013-02-01 00:00:00
abstract：INTRODUCTION:The incidence of acute pancreatitis (AP) in children has increased significantly in the past two decades. OBJECTIVE:All cases of AP, acute recurrent pancreatitis (ARP), and chronic pancreatitis examined between May 2002 and May 2012 at Hospital de Braga, Portugal, were reviewed. MATERIAL AND METHODS:Pati...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365521.2014.882403
更新日期：2014-05-01 00:00:00
abstract：:Forty-eight patients with symptomatic duodenal ulcer were randomized to 4 weeks' treatment with cimetidine, 1 g/day (C4), or 1 week of cimetidine treatment followed by 3 weeks of placebo (C1 + P). The study was performed double blind. The symptoms were recorded daily on a visual analogue scale. Endoscopy was performed...
journal_title：Scandinavian journal of gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3109/00365528609011103
更新日期：1986-08-01 00:00:00
abstract：:The separations and measurements of adenine-adenosine, adenosine monophosphate (AMP), adenosine diphosphate (ADP), adenosine triphosphate (ATP), lipid phosphates (lipid-P), ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) were carried out in the mucosa of the corpus, antrum, and duodenum of patients with decreas...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365527709181689
更新日期：1977-01-01 00:00:00
abstract：:Tryptophan absorption was studied in 32 patients with Crohn's disease and 16 healthy controls. A non-parametric sorting process identified two distinct groups of patients; 19 with normal tryptophan absorption values and 13 with distinctly subnormal results. The patients with impaired tryptophan absorption ate less, ha...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:In a 5-year clinicopathological study of acute colitis involving 238 adults, 42 patients were found to have 'transient colitis syndrome'. This is a term we have developed to describe those patients who have a short-duration self-limiting acute colitis of abrupt onset and negative bacteriology and which does not recur....
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365528209181107
更新日期：1982-10-01 00:00:00
abstract：:190 patients with elevated serum amylase levels were tested for macroamylasemia and the amylase to creatinine clearance ratio. Macroamylasemia was found in 3 patients. In these patients macroamylasemia persisted after the total activity of serum amylase had fallen to nearly normal levels. The Cam/Ccr-ratios were deter...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365527709181707
更新日期：1977-01-01 00:00:00
abstract：OBJECTIVE:Acute pancreatitis starts as an autodigestive process restricted to the pancreas and progresses to a systemic inflammation via cytokine release into the blood stream. Several inhibitors of the coagulation cascade, including active-site-inactivated factor VIIa, have shown anti-inflammatory properties in other ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520701295632
更新日期：2007-06-01 00:00:00
abstract：:Our aim was to study the cell kinetics and epithelial structure in the ileum and colon of conventional and germfree AGUS rats by means of a classic stathmokinetic technique. A slight hyperplasia was observed in the villi of germfree animals (p < 0.05), associated with a comparatively short cell cycle time. The crypt c...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529409096836
更新日期：1994-05-01 00:00:00
abstract：OBJECTIVE:The management of high-grade dysplasia (HGD) in polypoid lesions in patients with ulcerative colitis (UC) is not well characterized. The purpose of this study was to characterize the clinical course of patients with HGD in adenoma-like dysplasia-associated lesion or masses (DALMs) in the absence of any synchr...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520801909686
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to evaluate the role of 8-OHdG (8-hydroxy-2'-deoxyguanosine) detecting oxidative stress response following cholecystectomy in a randomised multicentre study of patients with minilaparotomy cholecystectomy (MC) versus laparoscopic cholecystectomy (LC). METHODS:Initially, 106 patients ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1080/00365521.2016.1208270
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVE:To compare natural course and treatment results of various types of choledochal cysts. MATERIAL AND METHODS:Complication rate in treated (T) and natural course in not treated (NT) patients with choledochal cysts were compared. The level of bilioenteric anastomosis after cyst resection was categorized and the...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365521003675054
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND AND AIM:Variation in the prevalence of various types of gastric polyps worldwide may reflect different etiologies. Here, the authors report the dynamic changes in histological distribution of gastric polyps over time and by ethnicity for individuals who underwent gastroscopies between 1994 and 2009 at two ho...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365521.2012.682091
更新日期：2012-09-01 00:00:00
abstract：:Gastric blood flow has been studied endoscopically by laser Doppler flowmetry in 15 patients with chronic gastric ulcer. In all patients the ulcer was located at the lesser curvature of the corpus. The blood flow measured in this area was decreased compared with healthy controls, whereas the flow values in other parts...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365528809093909
更新日期：1988-06-01 00:00:00
abstract：OBJECTIVE:Three CAspase Recruitment Domain (CARD15) mutations have shown to predispose to Crohn's disease in Caucasian populations. The aim of this study was to investigate the mutation frequency in patients with inflammatory bowel disease and in healthy controls in Denmark. MATERIAL AND METHODS:Genotyping of the thre...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520701427102
更新日期：2007-12-01 00:00:00
abstract：:Allogenic transfusion of immunocompetent T lymphocytes into an immunodeficient recipient is necessary for the development of graft-versus-host-disease (GVHD). The gastrointestinal tract is one of the most involved organs in human GVHD, and single-cell necrosis with apoptotic change and crypt abscess are characteristic...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/003655200750023660
更新日期：2000-06-01 00:00:00
abstract：OBJECTIVE:Ursodeoxycholic acid (UDCA) has been proposed as the optimal pharmacological treatment for intrahepatic cholestasis of pregnancy (ICP). The lowest effective dosage of UDCA in women with ICP has not been established. The objective is to determine the risk of adverse pregnancy outcomes resulting from ICP and to...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365521.2015.1064990
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:In neurophysiological studies, P300, is well known for reflecting early cognitive impairment in minimal hepatic encephalopathy (MHE). Although P300 is investigated extensively, other early event-related potential (ERP) parameters have not been studied in MHE. METHODS:The subjects were 21 adult cirrhotic pat...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365521.2013.878382
更新日期：2014-05-01 00:00:00
abstract：:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. So far, surgical resection has been the only curative treatment, but new options became available with the application of imatinib (Glivec) as a specific molecular inhibitor. Even after complete resection, GIS...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520310008845
更新日期：2004-06-01 00:00:00
abstract：:The transformation of xenobiotics and endogenous compounds to active carcinogens and their subsequent deactivation as an aid to eradication may be important in the etiology of some gastrointestinal cancers. In mammals the gastrointestinal tract has been shown to be an important site of inducible enzyme systems active ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529309098291
更新日期：1993-11-01 00:00:00
abstract：:After intravenous injection of autologous purified and radiolabeled anionic and cationic trypsinogens in the dog, there is a multiexponential elimination from serum of the trypsinogens without activation to active trypsins. The results are in agreement with an elimination of the trypsinogens iva glomerular filtration,...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365528109181969
更新日期：1981-01-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to evaluate the patency, functional and haemodynamic results of expanded-polytetrafluoroethylene (ePTFE)-covered transjugular intrahepatic portosystemic shunts in patients with liver cirrhosis. METHODS:Thirteen patients with an ePTFE-covered transjugular intrahepatic portosyste...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520410003443
更新日期：2004-10-01 00:00:00
abstract：:Four patients with acquired immunodeficiency syndrome (AIDS) (CDC group IV) were investigated for biliary disease because of the presence of both severe upper abdominal pain and raised levels of serum alkaline phosphatase. None was clinically jaundiced. Upper abdominal ultrasound was abnormal in three. All had endosco...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365528809090203
更新日期：1988-12-01 00:00:00
abstract：:Aprotinin was found to inhibit the amplitude of electrically stimulated contractions of the isolated guinea pig ileum with an ID50 of 6.75 X 10(-6) M. Aprotinin inhibited pentagastrin-stimulated gastric acid secretion in the rat, cat, and pig after oral or intraventricular administration. No inhibition of gastric acid...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-11-01 00:00:00
abstract：BACKGROUND:Controversy surrounds the issue of intestinal permeability in patients with coeliac disease, polyethylene glycol 400 indicating reduced and di-/mono-saccharide urine excretion ratios and 51Cr-labeled ethylenediaminetetraacetic acid (EDTA) indicating increased permeability. METHODS:We assessed the suitabilit...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529409092484
更新日期：1994-07-01 00:00:00
abstract：:Objectives: Very few data on the incidence, predictors, and clinical outcomes of lupus-like reactions (LLRs) in patients with inflammatory bowel disease (IBD) treated with anti-TNFs have been reported. Materials and methods: All records of consecutive IBD patients who started a treatment with an anti-TNF from January ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365521.2019.1663260
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:On 16 December 2006, most Eurotransplant countries changed waiting time oriented liver allocation policy to the urgency oriented Model for End-stage Liver Disease (MELD) system. There are limited data on the effects of this policy change within the Eurotransplant community. PATIENTS AND METHODS:A total of 15...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365521.2011.568521
更新日期：2011-07-01 00:00:00
abstract：:Antral exclusion was performed in seven adult male Sprague-Dawley rats, which were killed 10 weeks later. Fasting serum gastrin concentrations were almost four times higher than in unoperated controls. There was a slight increase in the thickness of the gastric mucosa, but quantitative electron microscopy showed no si...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365528209181059
更新日期：1982-01-01 00:00:00
