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Primary treatment of carcinoma of the anus by combined radiotherapy and chemotherapy.

Abstract：

:Twenty-four patients with carcinoma of the anus were treated with a combined regimen of external irradiation (50 Gy) and mitomycin C and 5-fluorouracil. A relatively large number of patients with locally advanced disease were included. A local complete response rate of 87.5% was obtained. The major acute toxicity was dermatitis/mucositis, necessitating a split course in 14 cases. After treatment four patients had persistent anal incontinence. After an observation period of 40-70 months 14 of the patients were alive without disease. We conclude that the conservative combined radiotherapy/chemotherapy regimen is an effective treatment also of advanced anal carcinoma, with tolerable toxicity and with promising survival results.

journal_name

Scand J Gastroenterol

journal_title

Scandinavian journal of gastroenterology

authors

Tveit KM,Karlsen KO,Fosså SD,Flokkmann A,Guldvog I,Haffner J

doi

10.3109/00365528909090794

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

1243-7

issue

10

eissn

0036-5521

issn

1502-7708

journal_volume

24

pub_type

杂志文章

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