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Detection of naproxen-induced intestinal permeability change may be facilitated by adding a standardized meal but not by forming marker ratios.

Abstract：

BACKGROUND:We recently compared the intestinal permeability markers polysucrose (PS) 15,000, 51Cr-ethylenediaminetetraacetic acid (EDTA), and 14C-mannitol in healthy humans. We have now studied the ability of these markers to show non-steroidal anti-inflammatory drug (NSAID)-induced intestinal damage, with special regard to the possibility of improving discrimination versus healthy intestine by using a hyperosmolar test solution, adding a standardized liquid meal, calculating paracellular/ transcellular marker excretion ratios, or correcting excretion values for urinary volume. METHODS:Seventeen healthy volunteers ingested a solution containing PS 15,000, 51Cr-EDTA, and 14C-mannitol before and after 1 week of naproxen intake, the solution being isosmolar, hyperosmolar, or isosmolar and followed by a standardized liquid meal. Fractional urinary excretion of the substances was measured over 0-4 h, 4-8 h, and 8-12 h. RESULTS:The excretion of the paracellular permeability markers PS 15,000 and 51Cr-EDTA increased after NSAID pretreatment, whereas that of the transcellular marker 14C-mannitol was unaffected. A standardized liquid meal reduced test variability for all markers and tended to improve differentiation between diseased and healthy intestine. A hyperosmolar test solution tended to improve differentiation for 51Cr-EDTA but not for PS 15,000. Calculating a paracellular/transcellular ratio or correcting excretion values for urinary volume did not improve the differentiation. CONCLUSIONS:A standardized liquid meal may improve the capacity of permeability tests to distinguish between healthy and NSAID-damaged intestine.

journal_name

Scand J Gastroenterol

journal_title

Scandinavian journal of gastroenterology

authors

Oman H,Henriksson AE,Johansson SG,Blomquist L

doi

10.3109/00365529609036908

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

1182-8

issue

12

eissn

0036-5521

issn

1502-7708

journal_volume

31

pub_type

杂志文章

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