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Fasting blood levels of gastrin, somatostatin, and pancreatic polypeptide in peptic ulcer disease.

Abstract：

:Fasting plasma levels of immunoreactive gastrin, somatostatin, and pancreatic polypeptide (PP) were determined in 67 patients with an endoscopically proven duodenal, pyloric, or prepyloric ulcer. Pretreatment gastrin (45.6 +/- 53.6 pmol/l, mean +/- S.D.) and somatostatin (54.5 +/- 27.5 pg/ml) did not differ significantly from those in 22 healthy controls (21.8 +/- 20.2 pmol/l and 64.8 +/- 24.7 pg/ml, respectively). The gastrin and somatostatin levels were not changed by 3 weeks of treatment either with propantheline and antacids or with cimetidine and antacids. The mean PP value before treatment was significantly (p less than 0.01) higher in duodenal ulcer patients (0.76 +/- 0.55 ng/ml) than in healthy subjects of similar age (0.36 +/- 0.26 ng/ml). The increased PP level was not lowered significantly by medical treatment even when this resulted in healing of the ulcer.

journal_name

Scand J Gastroenterol

journal_title

Scandinavian journal of gastroenterology

authors

Gustavsson S,Adami HO,Björklund O,Enander LK,Lundqvist G,Lööf L,Nordahl A

doi

10.3109/00365528209181048

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

81-5

issue

1

eissn

0036-5521

issn

1502-7708

journal_volume

17

pub_type

临床试验,杂志文章,随机对照试验

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