Effect of hepatic stimulator substance administration on tissue regeneration due to thioacetamide-induced liver injury in rats.


BACKGROUND:Hepatic stimulator substance (HSS) is a known hepatic growth factor that appears to be organ-specific but species-nonspecific. In the present study we investigated the effect of HSS administration in a rat model of liver injury and regeneration induced by thioacetamide (TAA) injection. METHODS:TAA (300 mg/kg body weight) was injected intraperitoneally in male Wistar rats (group I). HSS (50 mg protein/kg body weight) was administered intraperitoneally either at 24 h (group II) or at 36 h (group III) after TAA treatment. The animals were killed at different time points after TAA injection, and the rate of tritiated thymidine incorporation into hepatic DNA, the activity of the enzyme thymidine kinase in liver, and the assessment of the mitotic index in hepatocytes were used to estimate liver regeneration. RESULTS:The administration of TAA caused severe hepatic injury recognized histopathologically and by increased activities of the serum hepatic enzymes aspartate and alanine aminotransferases. The hepatic injury, which peaked at 24 h and 36 h after TAA injection, was followed by a regenerative process of hepatocytes which presented peaks after 48 h and 60 h (group I). The regenerative process of hepatocytes remained unaffected when HSS was administered 24 h after the injection of TAA (group II). In the case of HSS administration 36 h after the injection of TAA (group III) the examined indices of hepatocyte proliferation were statistically significantly increased at 48 h (P < 0.001), compared with those observed in group I. CONCLUSIONS:The administration of HSS enhanced the hepatocyte proliferative capacity, induced by TAA treatment, depending on the time of its administration.


Scand J Gastroenterol


Theocharis SE,Margeli AP,Agapitos EV,Mykoniatis MG,Kittas CN,Davaris PS




Has Abstract


1998-06-01 00:00:00












  • Transjugular intrahepatic portosystemic shunt placement for refractory ascites: a single-centre experience.

    abstract:BACKGROUND:The presence of refractory ascites is a common indication for transjugular intrahepatic portosystemic shunt (TIPS). Different models have been proposed for the prediction of survival after TIPS. The aim of this study was to evaluate the predictive factors associated with patients' survival after TIPS placeme...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Lodato F,Berzigotti A,Lisotti A,Azzaroli F,Mosconi C,Giampalma E,Renzulli M,Cappelli A,Buonfiglioli F,Calvanese C,Zoli M,Golfieri R,Mazzella G

    更新日期:2012-12-01 00:00:00

  • Interferon alfa-2b alone or combined with recombinant granulocyte-macrophage colony-stimulating factor as treatment of chronic hepatitis C.

    abstract:BACKGROUND:To compare the effect of combination therapy with interferon-alpha (INF-alpha) and granulocyte-macrophage colony-stimulating factor (GM-CSF) to monotherapy with INF-alpha in patients with chronic hepatitis C infection. METHODS:Forty-five consecutive patients with chronic hepatitis C, all presenting with ele...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Grønbaek K,Krarup HB,Ring-Larsen H,Schaffalitzky de Muckadell O,Møller A,Schlichting P,Vyberg M

    更新日期:2002-07-01 00:00:00

  • Effects of short-time somatostatin infusion on the gastric and intestinal propulsion in humans.

    abstract::The effect of short-time somatostatin infusion on gastric and intestinal propulsion of an oral glucose load was examined in healthy subjects by means of a multiple indicator dilution technique. The early gastric emptying rate was enhanced by somatostatin, indicating delayed gastric inhibition. After withdrawal of the ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Johansson C,Efendic S,Wisén O,Uvnäs-Wallensten K,Luft R

    更新日期:1978-01-01 00:00:00

  • The prevalence of gallstone disease in a Dutch population.

    abstract::The prevalence of gallstone disease was studied by ultrasound screening of a hospital population of 424 men and 631 women, admitted to the University Hospital Maastricht (The Netherlands) for elective surgery unrelated to gallstone disease. The prevalence increased with age. In the oldest age category (70 to 79 years)...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Thijs C,Knipschild P,van Engelshoven J

    更新日期:1990-02-01 00:00:00

  • Total colectomy, mucosal proctectomy, and an ileal reservoir to an anal anastomosis. A comparison of short and long efferent legs.

    abstract::In a consecutive series of 46 possible candidates for total colectomy, mucosal proctectomy, and ileal reservoir to an anal anastomosis, we have compared the clinical outcome of group I, with a long efferent leg (12 cm), and group II, with a short efferent leg (3-5 cm). The surgical procedure was done in three steps: f...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Hansen LK,Olsen PR,Simonsen L

    更新日期:1985-11-01 00:00:00

  • Simultaneous measurement of gastric acid and bicarbonate secretion in man.

    abstract::Experiments were performed to validate the computerized pH/PCO2 technique for measurement of HCO3 secretion at a physiologic pH in the human stomach. In bench-side experiments the system detected 103 +/- 2% (mean +/- SE, n = 66) of boluses or infusions of NaHCO3. The standard curve was linear in the physiologic concen...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Sjövall H,Forssell H,Olbe L

    更新日期:1989-12-01 00:00:00

  • Phosphate transport adaptation in rat jejunum and plasma level of 1,25-dihydroxyvitamin D3.

    abstract::Intestinal absorption of inorganic phosphate (Pi) increases in response to a reduction in the dietary supply of Pi. In this work this adaptive response has been characterized in jejunal brush border membrane vesicles and studied in temporal relationship with the change in the plasma level of 1,25(OH)2D3. The results i...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Danisi G,Caverzasio J,Trechsel U,Bonjour JP,Straub RW

    更新日期:1990-03-01 00:00:00

  • Detection of cytomegalovirus by immunohistochemistry of colonic biopsies and quantitative blood polymerase chain reaction: evaluation of agreement in ulcerative colitis.

    abstract:OBJECTIVES:Cytomegalovirus (CMV) often reactivates in ulcerative colitis (UC). In diagnostics, along with immunohistochemistry (IHC) of colonic biopsies, blood CMV polymerase chain reaction (PCR) is gaining increasing application. We aimed to assess agreement between the density of infected colonic cells by IHC and the...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Zagórowicz E,Przybysz A,Szlak J,Magdziak A,Wieszczy P,Mróz A

    更新日期:2018-04-01 00:00:00

  • Gastric blood flow in patients with gastric ulcer measured by endoscopic laser Doppler flowmetry.

    abstract::Gastric blood flow has been studied endoscopically by laser Doppler flowmetry in 15 patients with chronic gastric ulcer. In all patients the ulcer was located at the lesser curvature of the corpus. The blood flow measured in this area was decreased compared with healthy controls, whereas the flow values in other parts...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Lunde OC,Kvernebo K

    更新日期:1988-06-01 00:00:00

  • Serum immunoglobulin G subclasses in patients with ulcerative colitis and Crohn's disease of different disease activities.

    abstract:BACKGROUND:Different concentrations of immunoglobulin G (IgG) subclass-producing cells in the mucosa of patients with ulcerative colitis and Crohn's disease have previously been described. METHODS:To evaluate serum concentration of IgG subclasses as a tool for diagnosis and disease activity in chronic inflammatory bow...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Philipsen EK,Bondesen S,Andersen J,Larsen S

    更新日期:1995-01-01 00:00:00

  • Long-term results with lanreotide in patients with recurrent gastrointestinal angiodysplasias bleeding or obscure gastrointestinal bleeding. Benefits in efficacy and procedures consumption.

    abstract:BACKGROUND:Gastrointestinal angiodysplasias (GIAD) bleeding and obscure gastrointestinal bleeding (OGIB) are increasing health problems. Somatostatin analogues have been proposed as rescue therapy, but data for lanreotide are scarce. OBJECTIVE:To determine the efficacy, safety and resource saving of long-acting lanreo...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Frago S,Alcedo J,Martín Pena-Galo E,Lázaro M,Ollero L,de la Llama N

    更新日期:2018-12-01 00:00:00

  • Helicobacter pylori and bleeding duodenal ulcer: prevalence of the infection and role of non-steroidal anti-inflammatory drugs.

    abstract:BACKGROUND:Several authors have reported low prevalence of Helicobacter pylori infection in patients with upper gastrointestinal bleeding (UGIB). Our aim was to study the prevalence of H. pylori in bleeding duodenal ulcer (DU), with both invasive and non-invasive methods, and to assess the role of non-steroidal anti-in...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Gisbert JP,Gonzalez L,de Pedro A,Valbuena M,Prieto B,Llorca I,Briz R,Khorrami S,Garcia-Gravalos R,Pajares JM

    更新日期:2001-07-01 00:00:00

  • Intestinal bypass. Bacteriological studies from different parts of the small intestine in rats.

    abstract::Forty-five rats were divided into four groups according to type of operation: 1) end-to-side jejunoileal bypass (ES), 10 rats; 2) end-to-end jejunoileal bypass (EE), 10 rats; 3) jejunoileal resection (R), 10 rats; and 4) no operation, 15 rats. The luminal contents from the proximal jejunum and distal ileum, in groups ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Viddal KO,Midtvedt T,Nygaard K

    更新日期:1983-07-01 00:00:00

  • Computer-aided analysis of gastrointestinal pressure recordings. Comparison with manual scoring.

    abstract::The aim of the present study was to compare computer-based and visual/manual scoring of pressure recordings from the gastric antrum and duodenum. The computer system was based on three separate principles of recognition: moving average, tracking base line, and threshold filters. Computer scoring resulted in the detect...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Melsen NC,Andersen MB,Kraglund K,Juhl B

    更新日期:1992-09-01 00:00:00

  • Hepatocellular carcinoma surveillance with liver imaging is not associated with improved survival.

    abstract::Objective: International guidelines recommend hepatocellular carcinoma (HCC) surveillance with ultrasound in high-risk patients with chronic liver diseases. However, there is low-strength evidence about the effects on mortality. The aim of our study was to assess the impact of surveillance on the clinical course and s...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Lang S,Martin A,Kasper P,Schramm C,Kütting F,Goeser T,Steffen HM,Demir M

    更新日期:2020-02-01 00:00:00

  • Serum infliximab concentrations in pediatric inflammatory bowel disease.

    abstract:OBJECTIVE:To study serum infliximab (s-IFX) levels in pediatric patients with inflammatory bowel disease (IBD). SUBJECTS AND METHODS:s-IFX trough levels were measured in a total of 133 blood samples of 37 pediatric IBD patients (Crohn's disease, 23): 48 during the induction phase (weeks 2 and 6) and 85 during maintena...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Hämäläinen A,Sipponen T,Kolho KL

    更新日期:2013-01-01 00:00:00

  • Increased serum levels of vascular endothelial growth factor in patients with inflammatory bowel disease.

    abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is a potent angiogenic, vascular permeability-enhancing, and calcium-dependent enzyme-modulating cytokine with overexpression in various pathologic disorders, including granulomatous inflammation, tissue repair, delayed hypersensitivity reactions, rheumatoid arthriti...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章


    authors: Griga T,Tromm A,Spranger J,May B

    更新日期:1998-05-01 00:00:00

  • Testing strategies to reduce morbidity and mortality from Lynch syndrome.

    abstract:OBJECTIVE:Lynch syndrome (LS) has an autosomal dominant inheritance pattern and is associated with increased risk for colorectal cancer (CRC) and other cancers. Various strategies are used to identify patients at risk and offer surveillance and preventive programs, the cost effectiveness of which is much dependent on t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究


    authors: Keränen A,Ghazi S,Carlson J,Papadogiannakis N,Lagerstedt-Robinson K,Lindblom A

    更新日期:2018-12-01 00:00:00

  • Analysis of the CTLA4 gene in Swedish coeliac disease patients.

    abstract:BACKGROUND:A genetic susceptibility to coeliac disease is well established, involving HLA and non-HLA components. CTLA4 is an important regulator of T-cell function and some studies have suggested that sequence variation in the gene might be a determinant of disease susceptibility, although the evidence is conflicting....

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Popat S,Hearle N,Wixey J,Hogberg L,Bevan S,Lim W,Stenhammar L,Houlston RS

    更新日期:2002-01-01 00:00:00

  • EUS-guided trans-esophageal drainage of a mediastinal necrotic fluid collection using the axios electrocautery enhanced delivery system™.

    abstract::Mediastinal collection secondary to necrotic acute pancreatitis, is an extremely rare event caused by the posterior rupture of the pancreatic duct into the retroperitoneal space with the penetration of the pancreatic fluid through the diaphragmatic orifices. Infection of the necrotic collection may occur with a conseq...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Pizzicannella M,Pandolfi M,Andrisani G,Signoretti M,Martino M,Rea R,Di Matteo FM

    更新日期:2019-02-01 00:00:00

  • Analysis of direct medical care costs of peptic ulcer disease in a Korean tertiary medical center.

    abstract:OBJECTIVES:There have been no reported data on the medical care cost of idiopathic peptic ulcer disease (PUD) compared with H. pylori (+) and/or NSAID (+) cases although H. pylori-negative idiopathic ulcers are increasing. The aim of this study was to investigate the direct medical care costs of PUD based on whether it...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Kang JM,Seo PJ,Kim N,Lee BH,Kwon J,Lee DH,Jung HC

    更新日期:2012-01-01 00:00:00

  • Patients with extraintestinal manifestations have a higher risk of developing pouchitis in ulcerative colitis: multivariate analysis.

    abstract:BACKGROUND:Restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA) have been the surgical treatments of choice for ulcerative colitis (UC). However, the IPAA is sometimes complicated with pouchitis. Furthermore, the cumulative risk and risk factors for developing pouchitis in patients with UC undergoing IPA...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Hata K,Watanabe T,Shinozaki M,Nagawa H

    更新日期:2003-10-01 00:00:00

  • Impaired semen quality in Crohn's disease--drugs, ill health, or undernutrition?

    abstract::Even though abnormalities of semen quality in inflammatory bowel disease have been attributed to sulphasalazine therapy, oligospermia was found in 46% of men with Crohn's disease, none of whom were receiving this drug. Oligospermia occurred more commonly than in men with coeliac disease (6%, P less than 0.02), althoug...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Farthing MJ,Dawson AM

    更新日期:1983-01-01 00:00:00

  • Safety and efficacy of precut needle-knife fistulotomy.

    abstract::OBJECTIVE. Although precut is considered an useful alternative when standard methods of biliary access have failed, there is some controversy about it's safety. The study aim was to evaluate the effectiveness of needle-knife fistulotomy (NKF) after a difficult biliary cannulation and whether common bile duct (CBD) dia...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Lopes L,Dinis-Ribeiro M,Rolanda C

    更新日期:2014-06-01 00:00:00

  • Faecal calprotectin: a novel test for the diagnosis of colorectal cancer?

    abstract::Calprotectin, a prominent cytosol protein in neutrophil granulocytes, was present in increased concentrations in stools from 50 of 53 patients with colorectal cancer, 32 of 40 patients with colorectal polyps, and all of 18 patients with gastric cancer. After radical surgery, faecal calprotectin levels reverted to the ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Røseth AG,Kristinsson J,Fagerhol MK,Schjønsby H,Aadland E,Nygaard K,Roald B

    更新日期:1993-12-01 00:00:00

  • Evaluation of the marker technique for measurement of exocrine pancreatic secretion rate.

    abstract::A secretin-cholecystokinin test was performed in 103 patients, representing both normal and reduced exocrine pancreatic function. The duodenum was intubated with a triple-lumen tube. The gastric and duodenal contents were aspirated separately and sampled in 10-min periods. An inert, water-soluble marker (58Co-vitamin ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章


    authors: Rune SJ,Worning H

    更新日期:1985-05-01 00:00:00

  • Short interferon and ribavirin treatment for HCV genotype 2 or 3 infection: NORDynamIC trial and real-life experience.

    abstract:OBJECTIVE:Interferon-free therapy for hepatitis C virus (HCV) infection is costly, and therefore patients with advanced fibrosis are prioritized. Although coupled with considerable side effects, a large proportion of genotype 2/3 infected patients achieve a sustained virological response (SVR) following interferon-base...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Waldenström J,Färkkilä M,Rembeck K,Norkrans G,Langeland N,Mørch K,Pedersen C,Rauning Buhl M,Nieminen U,Nuutinen H,Alsiö Å,Holmström L,Jungnelius R,Lund K,Rubensson A,Torell E,Westin J,Lagging M

    更新日期:2016-03-01 00:00:00

  • Prevalence of irritable bowel syndrome-like symptoms in ulcerative colitis patients with clinical and endoscopic evidence of remission: prospective multicenter study.

    abstract:OBJECTIVE:Irritable bowel syndrome (IBS)-like symptoms are often found in ulcerative colitis (UC) patients in remission. However, the prevalence of those symptoms in UC patients with endoscopic evidence of remission shown by mucosal healing remains unknown. MATERIAL AND METHODS:IBS diagnosis was evaluated by questionn...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究


    authors: Fukuba N,Ishihara S,Tada Y,Oshima N,Moriyama I,Yuki T,Kawashima K,Kushiyama Y,Fujishiro H,Kinoshita Y

    更新日期:2014-06-01 00:00:00

  • Low liver stiffness among cirrhotic patients with hepatitis B after prolonged treatment with nucleoside analogs.

    abstract:OBJECTIVE:Case reports and short-term clinical trials have suggested that treatment for chronic hepatitis B (CHB) may lead to improvement of cirrhosis. The aim of the present study was to measure liver stiffness in patients diagnosed with advanced fibrosis or cirrhosis prior to prolonged treatment with nucleoside or nu...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究


    authors: Andersen ES,Weiland O,Leutscher P,Krarup H,Westin J,Moessner B,Konopski Z,Frigstad SO,Kjær M,Christensen PB,Weis N

    更新日期:2011-06-01 00:00:00

  • Pancreatic lysosomal enzyme secretion is changed by hepatectomy in rats.

    abstract::To explore the effect of hepatectomy on the secretion of lysosomal enzymes into the pancreatic juice when stimulated by gut hormones, we evaluated the cerulein-stimulated amylase output and cathepsin B output into pancreatic juice, the amylase and cathepsin B content in pancreatic tissue, and the distribution of cathe...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Hirano T,Manabe T,Tobe T

    更新日期:1990-12-01 00:00:00