Double-blind randomized trial of bismuth subsalicylate and clindamycin for treatment of Helicobacter pylori infection.

Abstract:

:We evaluated clindamycin and bismuth subsalicylate (Pepto-Bismol) for treatment of Helicobacter pylori infection. Patients with culture or histology positive for H. pylori were randomized to receive two tablets of bismuth subsalicylate four times daily for 4 weeks or bismuth combined with 2 weeks of 300 mg clindamycin four times daily. Clinical symptoms were recorded before and after treatment by means of visual analog scales. Patients in both treatment arms showed improvement in clinical scores for abdominal pain, heartburn, and gas or bloating. Microbiologic cure was achieved in only 1 of 11 patients treated with bismuth alone and in none of 7 treated with bismuth/clindamycin. Successful eradication of H. pylori may require combination of multiple antibiotics, as recommended at the IXth World Congress of Gastroenterology, or pharmacokinetic modulators such as H2-blockers or omeprazole.

journal_name

Scand J Gastroenterol

authors

Westblom TU,Madan E,Subik MA,Duriex DE,Midkiff BR

doi

10.3109/00365529208999958

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

249-52

issue

3

eissn

0036-5521

issn

1502-7708

journal_volume

27

pub_type

临床试验,杂志文章,随机对照试验
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    doi:10.3109/00365527709181722

    authors: Schaffalitzky de Muckadell OB,Fahrenkrug J,Holst JJ,Lauritsen KB

    更新日期:1977-01-01 00:00:00

  • Crohn's disease intestinal CD4+ T cells have impaired interleukin-10 production which is not restored by probiotic bacteria.

    abstract:OBJECTIVE:Crohn's disease (CD) has been associated with low mucosal interleukin (IL)-10 production, but the mechanism behind this deficiency remains unclear. The aim of this study was to investigate IL-10 and interferon (IFN)-gamma production in intestinal CD4+ T cells from CD patients and healthy volunteers (HV) and t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520601013754

    authors: Hvas CL,Kelsen J,Agnholt J,Höllsberg P,Tvede M,Møller JK,Dahlerup JF

    更新日期:2007-05-01 00:00:00

  • Cholesterol saturation of bile after jejunoileal bypass increases more with a 1:3 than with a 3:1 jejunoileal ratio.

    abstract::Previous suggested, surprisingly, that after jejunoileal bypass surgery the lithogenicity of the bile, assessed by its cholesterol saturation and rate of gallstone formation, increases more with a 1:3 than with a 3:1 jejunoileal ratio of the functioning segment. The present study re-evaluates this by examining fasting...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528109181828

    authors: Sørensen TI,Bruusgaard A,Andersen AN,Pedersen LR,Andersen B

    更新日期:1981-01-01 00:00:00

  • The chemotactic function of neutrophils in ulcerative colitis.

    abstract::Neutrophil chemotactic function was investigated in 30 patients with ulcerative colitis (UC) in an active (no. = 15) or an inactive (no. = 15) stage. Peripheral blood neutrophils from active cases had a significantly decreased stimulated migration in modified Boyden chambers. Simultaneously done investigations of neut...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528209182250

    authors: Elmgreen J,Binder V

    更新日期:1982-06-01 00:00:00

  • Covered transjugular intrahepatic portosystemic stents maintain lower portal pressure and require fewer reinterventions than uncovered stents.

    abstract:BACKGROUND:The purpose of this study was to evaluate the patency, functional and haemodynamic results of expanded-polytetrafluoroethylene (ePTFE)-covered transjugular intrahepatic portosystemic shunts in patients with liver cirrhosis. METHODS:Thirteen patients with an ePTFE-covered transjugular intrahepatic portosyste...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410003443

    authors: Ockenga J,Kroencke TJ,Schuetz T,Plauth M,Kasim E,Petersein J,Schmidt HH,Lochs H

    更新日期:2004-10-01 00:00:00

  • Fructose malabsorption is associated with decreased plasma tryptophan.

    abstract:BACKGROUND:Fructose malabsorption is characterized by the inability to absorb fructose efficiently. As a consequence fructose reaches the colon where it is broken down by bacteria to short fatty acids, CO2, H2, CH4 and lactic acid. Bloating, cramps, osmotic diarrhea and other symptoms of irritable bowel syndrome are th...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1080/003655201300051135

    authors: Ledochowski M,Widner B,Murr C,Sperner-Unterweger B,Fuchs D

    更新日期:2001-04-01 00:00:00

  • Managing dyspepsia in the young adult patient: effects of different tests for Helicobacter pylori in a "test-and-scope" approach.

    abstract:AIM:To evaluate how different methods for the detection of Helicobacter pylori influence on a "test, score and scope" decision approach in young dyspeptic patients. RESULTS:Complete data from 341 patients (52.2% males) were analyzed. One hundred and ten (32%) were H. pylori-positive by definition. The rapid serology t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2013.800988

    authors: Valle PC,Breckan RK,Mortensen L,Amin A,Kildahl-Andersen O,Paulssen EJ

    更新日期:2013-08-01 00:00:00

  • Response to jejunal acidification in man. I. Changes in composition of perfusate.

    abstract::The jejunal disposal of perfused acid was studied in 11 control subjects and 12 patients with duodenal ulcer. It was found that the capacity to dispose of acid was saturable and was less than control in patients with duodenal ulcer. When the load of acid was small, all the acid disappeared from the jejunum and sodium ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Thjodleifsson B,Wormsley KG

    更新日期:1976-01-01 00:00:00

  • Role of telaprevir plasma levels for predicting response to antiviral therapy in patients with hepatitis C virus genotype 1 infection.

    abstract:OBJECTIVE:Telaprevir (TVR)-based triple therapy has substantially improved cure rates of hepatitis C virus (HCV) genotype 1 infection but side effects are frequent and often severe. Therefore, response predictors are needed for early identification of patients not responding to TVR-based triple therapy. MATERIAL AND M...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3109/00365521.2014.978363

    authors: Farnik H,Ferreirós N,Labocha S,Geisslinger G,Zeuzem S,Sarrazin C,Vermehren J

    更新日期:2014-12-01 00:00:00

  • Normalization of mucosal cytokine gene expression levels predicts long-term remission after discontinuation of anti-TNF therapy in Crohn's disease.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.758773

    authors: Rismo R,Olsen T,Cui G,Paulssen EJ,Christiansen I,Johnsen K,Florholmen J,Goll R

    更新日期:2013-03-01 00:00:00

  • Intestinal bypass. Bacteriological studies from different parts of the small intestine in rats.

    abstract::Forty-five rats were divided into four groups according to type of operation: 1) end-to-side jejunoileal bypass (ES), 10 rats; 2) end-to-end jejunoileal bypass (EE), 10 rats; 3) jejunoileal resection (R), 10 rats; and 4) no operation, 15 rats. The luminal contents from the proximal jejunum and distal ileum, in groups ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528309181648

    authors: Viddal KO,Midtvedt T,Nygaard K

    更新日期:1983-07-01 00:00:00

  • Phenotypic variance in childhood coeliac disease and the HLA-DQ/DR dose effect.

    abstract:OBJECTIVE:Coeliac disease (CD) is associated with HLA-DQ2 and DQ8. The clinical picture is variable and certain human leucocyte antigen (HLA) DQ/DR combinations have a higher relative risk (RR) for CD than others. Moreover, the HLA-DQ gene-dose effect has an impact on the strength of the gluten-specific T-cell response...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802116422

    authors: Vermeulen BA,Hogen Esch CE,Yuksel Z,Koning F,Verduijn W,Doxiadis II,Schreuder GM,Mearin ML

    更新日期:2009-01-01 00:00:00

  • Incidence and prevalence of adult coeliac disease within a defined geographic area in Denmark.

    abstract:BACKGROUND:In childhood coeliac disease highly varying incidence rates have recently been disclosed. Very low incidence rates (0.09/1000) were found in Denmark, in contrast to our neighbouring country Sweden (2.93/1000). Whether this was accounted for by the diagnosis being delayed until adult life was unknown. No stud...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529609009152

    authors: Bodé S,Gudmand-Høyer E

    更新日期:1996-07-01 00:00:00

  • DNA ploidy, S-phase fraction, and G2 fraction as prognostic determinants in human pancreatic cancer.

    abstract::The DNA ploidy, S-phase fraction (SPF), and G2 fraction of pancreatic cancer tissue was measured by flow cytometry in 95 patients. Forty-nine per cent (n = 47) had a diploid DNA index, and 51% (n = 48) of tumours were aneuploid. Aneuploid tumours and high-grade tumours had significantly higher S-phase and G2-fraction ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529209011164

    authors: Eskelinen M,Lipponen P,Marin S,Haapasalo H,Mäkinen K,Puittinen J,Alhava E,Nordling S

    更新日期:1992-01-01 00:00:00

  • Sexuality in patients with ulcerative colitis before and after restorative proctocolectomy: a prospective study.

    abstract:BACKGROUND:The purpose of this study was to assess sexuality in patients with ulcerative colitis (UC), before and one year after an ileal-pouch anal anastomosis (IPAA). METHODS:Group I comprised 14 medically treated patients (7 M) and Group II comprised 29 patients (18 M), operated with colectomy and ileostomy, with p...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310008449

    authors: Berndtsson I,Oresland T,Hultén L

    更新日期:2004-04-01 00:00:00

  • Epidemiology of pancreatic cancer in Norway: trends in incidence, basis of diagnosis and survival 1965-2007.

    abstract:OBJECTIVE:Pancreatic cancer is the second most frequent gastrointestinal cancer in the Western world. Few reports on concomitant trends in pancreatic cancer incidence, diagnosis, mortality and survival exist at the national level. This study provides a baseline overview of the temporal patterns in these four indicators...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365520903358899

    authors: Søreide K,Aagnes B,Møller B,Westgaard A,Bray F

    更新日期:2010-01-01 00:00:00

  • The relationship between inflammatory bowel disease and Parkinson's disease: true or fiction?

    abstract::Gastrointestinal (GI) symptoms can precede by many years the motor symptoms of Parkinson's disease (PD) and these patients can show some degree of inflammation associated with abnormal aggregates of alpha-synuclein in the GI tract. The abnormal accumulation of alpha-synuclein and the spreading of the aggregates from t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1641739

    authors: Carmona-Abellan M,Rodríguez-Lago I,Cabriada JL,Gómez-Esteban JC

    更新日期:2019-07-01 00:00:00

  • Palliation of oesophagogastric neoplasms with Nd:YAG laser treatment.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529008997629

    authors: Schulze S,Fischerman K

    更新日期:1990-10-01 00:00:00

  • Survival following resection of pancreatic endocrine tumors: importance of R-status and the WHO and TNM classification systems.

    abstract:OBJECTIVE:The aim of this study was to delineate the clinical outcomes and pathological characteristics of surgically resected endocrine tumors of the pancreas and to determine the importance of the World Health Organization (WHO) and tumor-node metastasis (TNM) classifications, resection status, and Ki-67 expression f...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521003782363

    authors: Pomianowska E,Gladhaug IP,Grzyb K,Røsok BI,Edwin B,Bergestuen DS,Mathisen O

    更新日期:2010-08-01 00:00:00

  • Increased serum levels of vascular endothelial growth factor in patients with inflammatory bowel disease.

    abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is a potent angiogenic, vascular permeability-enhancing, and calcium-dependent enzyme-modulating cytokine with overexpression in various pathologic disorders, including granulomatous inflammation, tissue repair, delayed hypersensitivity reactions, rheumatoid arthriti...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1080/00365529850172070

    authors: Griga T,Tromm A,Spranger J,May B

    更新日期:1998-05-01 00:00:00

  • Initial mass screening for colorectal cancer with fecal occult blood test. A prospective randomized study at Funen in Denmark.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528709011142

    authors: Kronborg O,Fenger C,Søndergaard O,Pedersen KM,Olsen J

    更新日期:1987-08-01 00:00:00

  • Gastric cancer confined to the muscularis propria: a possible candidate for laparoscopic surgery or adjuvant therapy.

    abstract:OBJECTIVE:Gastric cancer confined to the muscularis propria (mp) has a favorable prognosis, but still belongs to the advanced category. Many oncologists have difficulties in selecting treatment modalities owing to the confused situation of mp cancer. To clarify the therapeutic strategy, the clinicopathological characte...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410009302

    authors: Park SS,Kim CS,Mok YJ,Kim SJ,Kim HI

    更新日期:2005-04-01 00:00:00

  • Decrease in gastric secretion during the first three months after proximal gastric vagotomy in duodenal ulcer patients.

    abstract::Gastric secretion was stimulated by intravenous infusion of 15 mug/kg/hr of pentagastrin before and 10 and 90 days after proximal gastric vagotomy in 16 duodenal ulcer patients. Postoperatively 15 ug/kg/hr of pentagastrin was also given in combination with 2 mug/kg/hr of carbacholine. Mean acid output in response to p...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Roland M,Berstad A,Liavåg I

    更新日期:1975-01-01 00:00:00

  • Low-dose versus high-dose ursodeoxycholic acid in cystic fibrosis-related cholestatic liver disease. Results of a randomized study with 1-year follow-up.

    abstract:BACKGROUND:Ursodeoxycholic acid (UDCA) is beneficial in cholestasis related to cystic fibrosis (CF). High-dose treatment has been recommended to compensate for bile salt malabsorption. We compared the results of low-dose (10 mg/kg/day) and high-dose (20 mg/kg/day) UDCA treatment on liver biochemistry after 3 and 12 mon...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365529709007686

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    abstract::Seventy-eight young patients with symptoms of chronic inflammatory bowel disease (IBD) of the colon have been investigated to determine to what degree colonoscopy adds important information for the diagnosis of IBD in addition to results of the routine procedures, including rectosigmoidoscopy carried out at the same t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809093915

    authors: Holmquist L,Rudic N,Ahren C,Fällström SP

    更新日期:1988-06-01 00:00:00

  • Postoperative on-line monitoring with intraperitoneal microdialysis is a sensitive clinical method for measuring increased anaerobic metabolism that correlates to the cytokine response.

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    pub_type: 临床试验,杂志文章

    doi:10.1080/00365520310008548

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  • Pain produced by electric stimulation of the rectum in patients with irritable bowel syndrome: further evidence of visceral hyperalgesia.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655299750025101

    authors: Rössel P,Drewes AM,Petersen P,Nielsen J,Arendt-Nielsen L

    更新日期:1999-10-01 00:00:00

  • Acid gastro-oesophageal reflux and oesophageal pressure activity during postprandial and nocturnal periods. A study in subjects with and without pathologic acid gastro-oesophageal reflux.

    abstract::The aim of the investigation was to evaluate the relative quantity of acid gastrooesophageal reflux during different time periods in subjects with and without pathologic reflux. Twenty duodenal ulcer patients, 10 with and 10 without pathologic acid gastro-oesophageal reflux, and 26 asymptomatic volunteers were subject...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528708991937

    authors: Kruse-Anderson S,Wallin L,Madsen T

    更新日期:1987-10-01 00:00:00

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    abstract::Plasma kinetics and biliary excretion of colchicine in patients with chronic liver disease were evaluated after oral administration of a single dose and after long-term treatment. A single oral dose of 1 mg colchicine led to a mean peak concentration of 3.60 +/- 1.04 ng/ml at a peak time of 2.16 +/- 0.34 h and a mean ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409094847

    authors: Rudi J,Raedsch R,Gerteis C,Schlenker T,Plachky J,Walter-Sack I,Sabouraud A,Scherrmann JM,Kommerell B

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,meta分析

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