Initial mass screening for colorectal cancer with fecal occult blood test. A prospective randomized study at Funen in Denmark.

Abstract:

:A Danish study allocated at random 30,970 persons to screening with Hemoccult-II and 30,968 as controls in a population of 140,000 between 45 and 74 years old. Persons with known colorectal cancer, adenoma, and distant spread from all types of cancer were excluded. The test was completed in 20,672 persons from August 1985 to September 1986, and 215 (1%) were found to be positive. Colonoscopy in 203 and double-contrast barium enema in 6 detected 37 persons with cancer and 86 with adenomas. Dukes A cancer was detected in 19 in the screening group, in contrast to 2 among controls. Synchronous adenomas were found in 23 with a positive test and 10 controls. Interval cancer was found in nine persons within 1-11 months after a negative test. Eighteen persons got cancer before invitation and six defectors as well. In all, colorectal cancer was detected in 70 persons in the screening group and in 38 controls; the figures for adenomas alone were 103 and 38, respectively. The study is designed to detect a possible reduction in mortality from colorectal cancer of 25% within 5 years after three screenings with intervals of 2 years. The second screening will begin in September 1987. It remains to be shown whether a reduction may be obtained both in mortality and in incidence of colorectal cancer.

journal_name

Scand J Gastroenterol

authors

Kronborg O,Fenger C,Søndergaard O,Pedersen KM,Olsen J

doi

10.3109/00365528709011142

subject

Has Abstract

pub_date

1987-08-01 00:00:00

pages

677-86

issue

6

eissn

0036-5521

issn

1502-7708

journal_volume

22

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,多中心研究

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    authors: Farnbacher MJ,Krause HH,Hagel AF,Raithel M,Neurath MF,Schneider T

    更新日期:2014-03-01 00:00:00

  • The prerequisites for local lysolecithin formation in the human gallbladder. II. Studies on the positional specificity of the phospholipase A activity.

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    doi:10.3109/00365527809181915

    authors: Tagesson C,Norrby S,Sjödahl R

    更新日期:1978-01-01 00:00:00

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    更新日期:2018-04-01 00:00:00

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    pub_type: 杂志文章

    doi:10.3109/00365529609031982

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    pub_type: 杂志文章

    doi:10.3109/00365529609010345

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    doi:10.3109/00365529409092466

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    pub_type: 杂志文章

    doi:10.1080/003655200750023930

    authors: Näslund E,Bogefors J,Grybäck P,Jacobsson H,Hellström PM

    更新日期:2000-04-01 00:00:00

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528909089260

    authors: Leiper JB,Maughan RJ

    更新日期:1989-11-01 00:00:00

  • Palliation of oesophagogastric neoplasms with Nd:YAG laser treatment.

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    pub_type: 杂志文章

    doi:10.3109/00365529008997629

    authors: Schulze S,Fischerman K

    更新日期:1990-10-01 00:00:00

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529709028151

    authors: Capristo E,Mingrone G,Addolorato G,Greco AV,Corazza GR,Gasbarrini G

    更新日期:1997-12-01 00:00:00

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1821764

    authors: Roberts SK,Strasser SI,Nicoll AJ,Kemp W,Majeed A,Mitchell J,Stuart K,Gow P,Sood S,MacQuillan G,George J,Mitchell J,McCaughan GW,ALA Clinical Research Network.

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    pub_type: 杂志文章

    doi:10.3109/00365529209000166

    authors: Christensen AH,Gjørup T,Hilden J,Fenger C,Henriksen B,Vyberg M,Ostergaard K,Hansen BF

    更新日期:1992-11-01 00:00:00

  • The changing histological pattern of gastric polyps in an ethnically heterogeneous population.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.682091

    authors: Peretz A,Fuchs T,Livovsky DM,Turvall E,Pappo O,Ackerman Z

    更新日期:2012-09-01 00:00:00

  • Demonstration of altered cellular DNA content distribution in long-term colon epithelial cell lines with colon cancer genotypes.

    abstract::During prolonged culture (7-40 passages assayed) DNA distribution was constant in IVT-negative lines with FPC genotype and in IVT-negative lines without any known colon cancer genotype, whereas the DNA histograms of the IVT-positive lines with HNPCC genotype showed a marked change. The DNA index (DI) of greater than 1...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809090770

    authors: Danes BS,Deangelis P,Traganos F,Melamed MR,Alm T

    更新日期:1988-09-01 00:00:00

  • Morphology of the pancreatic ductal epithelium after traumatization of the papilla of Vater or endoscopic retrograde pancreatography with various contrast media in cats.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528309181642

    authors: Bub H,Bürner W,Riemann JF,Stolte M

    更新日期:1983-07-01 00:00:00

  • Prognostic factors in patients with gastric adenocarcinoma using competing-risk analysis: a study of cases in the SEER database.

    abstract::Background: Accurate prognostic factors for gastric adenocarcinoma are still lacking in clinical practice, which contributes to inappropriate treatment. Applying the widely used Cox-proportional hazards model to describe survival trends and identify prognostic factors has limitations that result in a risk of bias. A c...

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    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1649456

    authors: Zhang X,Yang J,Huang Q,Lyu J

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  • Comparison of four markers of intestinal permeability in control subjects and patients with coeliac disease.

    abstract:BACKGROUND:Controversy surrounds the issue of intestinal permeability in patients with coeliac disease, polyethylene glycol 400 indicating reduced and di-/mono-saccharide urine excretion ratios and 51Cr-labeled ethylenediaminetetraacetic acid (EDTA) indicating increased permeability. METHODS:We assessed the suitabilit...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409092484

    authors: Bjarnason I,Maxton D,Reynolds AP,Catt S,Peters TJ,Menzies IS

    更新日期:1994-07-01 00:00:00

  • Health care costs associated with Australian tertiary inflammatory bowel disease care.

    abstract:INTRODUCTION:We aimed to describe the total costs of illness for IBD patients and compare the costs of patients with active disease to those with inactive disease. MATERIALS AND METHODS:Resource use for IBD management was itemized for attributable costs (AUD) among all IBD patients over a 12-month period at an Austral...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2017.1323117

    authors: Jackson B,Con D,Ma R,Gorelik A,Liew D,De Cruz P

    更新日期:2017-08-01 00:00:00

  • Inhibition of sulpiride on the cephalic phase of gastric acid and gastrin secretion in duodenal ulcer patients.

    abstract::In 13 patients with duodenal ulceration psychic stimulation with food resulted in a significant rise in gastric acid secretion and in serum gastrin. This rise was abolished when the patients were pre-treated with sulpiride, a non-sedative neuroleptic acting on the hypothalamus. These findings suggest that sulpiride, b...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

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    更新日期:1976-01-01 00:00:00

  • 5-Aminosalicylic acid enemas in patients with active ulcerative colitis. Influence of acidity on the kinetic pattern.

    abstract::Enemas containing 1000 mg 5-ASA were administered to patients with active distal colitis in three separate studies: as a single dose in a neutral solution (pH 7.4); as a single dose in a slightly acidic, buffered suspension (pH 4.8); and as multiple doses once a day for 10 days with the acidic enema. 5-ASA was relativ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Bondesen S,Nielsen OH,Jacobsen O,Rasmussen SN,Hansen SH,Halskov S,Binder V,Hvidberg EF

    更新日期:1984-07-01 00:00:00

  • Constitutive expression of inducible nitric oxide synthase in the normal human colonic epithelium.

    abstract:BACKGROUND:Inducible nitric oxide synthase (iNOS) in the human colon is considered expressed only in inflammatory states such as ulcerative or collagenous colitis. As subtle iNOS labelling was previously observed in some colonic mucosal biopsies from a heterogeneous group of controls with non-inflamed bowel, we studied...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1080/003655202760230919

    authors: Perner A,Andresen L,Normark M,Rask-Madsen J

    更新日期:2002-08-01 00:00:00

  • Reproducibility of ambulatory gastric pH recordings in the corpus and antrum. Effect of food, time, and electrode position.

    abstract::The reproducibility of simultaneous, long-term, ambulatory gastric pH recordings in the antrum and corpus was investigated in nine healthy subjects who underwent three separate, 27-h gastric double pH-metries. Intraindividual reproducibility for the entire 27-h recording period was good in the corpus (Kendall's concor...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529008997637

    authors: Cilluffo T,Armstrong D,Castiglione F,Emde C,Galeazzi R,Gonvers JJ,Blum AL

    更新日期:1990-10-01 00:00:00

  • Role of telaprevir plasma levels for predicting response to antiviral therapy in patients with hepatitis C virus genotype 1 infection.

    abstract:OBJECTIVE:Telaprevir (TVR)-based triple therapy has substantially improved cure rates of hepatitis C virus (HCV) genotype 1 infection but side effects are frequent and often severe. Therefore, response predictors are needed for early identification of patients not responding to TVR-based triple therapy. MATERIAL AND M...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3109/00365521.2014.978363

    authors: Farnik H,Ferreirós N,Labocha S,Geisslinger G,Zeuzem S,Sarrazin C,Vermehren J

    更新日期:2014-12-01 00:00:00

  • Randomized control trials using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused by enterotoxigenic Escherichia coli in volunteers.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/00365521.2011.574726

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    更新日期:2011-07-01 00:00:00

  • Glasgow Blatchford, pre-endoscopic Rockall and AIMS65 scores show no difference in predicting rebleeding rate and mortality in variceal bleeding.

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    pub_type: 杂志文章

    doi:10.1080/00365521.2016.1200138

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    pub_type: 杂志文章

    doi:10.1080/00365520902783709

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365520903486109

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365527909179839

    authors: Faxén A,Rossander L,Kewenter J

    更新日期:1979-01-01 00:00:00

  • In vitro effects of gastrin on the movement of electrolytes across the human colon.

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    doi:10.3109/00365527709181364

    authors: El Masri SH,Lewin MR,Clark CG

    更新日期:1977-01-01 00:00:00