5-Aminosalicylic acid enemas in patients with active ulcerative colitis. Influence of acidity on the kinetic pattern.

Abstract:

:Enemas containing 1000 mg 5-ASA were administered to patients with active distal colitis in three separate studies: as a single dose in a neutral solution (pH 7.4); as a single dose in a slightly acidic, buffered suspension (pH 4.8); and as multiple doses once a day for 10 days with the acidic enema. 5-ASA was relatively rapidly absorbed from the neutral solution, resulting in plasma concentrations of 5-ASA sometimes two to three times higher than those found after peroral salazosulphapyridine (SASP) treatment. In contrast, absorption from the acidic enema was reduced and/or prolonged, giving plasma concentrations similar to those found during oral SASP treatment. After repeated doses of the acidic enema, plasma concentrations after an enema resembled those seen after the single dose. Urinary excretion was significantly lower, suggesting a reduced fraction of absorption at steady-state conditions. No side effects were observed, and no local irritation was reported. An acidic buffer suspension with 5-ASA seems to be safe for use as enema and deserves further clinical testing for treatment of distal ulcerative colitis.

journal_name

Scand J Gastroenterol

authors

Bondesen S,Nielsen OH,Jacobsen O,Rasmussen SN,Hansen SH,Halskov S,Binder V,Hvidberg EF

subject

Has Abstract

pub_date

1984-07-01 00:00:00

pages

677-82

issue

5

eissn

0036-5521

issn

1502-7708

journal_volume

19

pub_type

临床试验,杂志文章
  • Pro-adrenomedullin in acute decompensation of liver cirrhosis: relationship with acute-on-chronic liver failure and short-term survival.

    abstract::Background and aim: Acute-on-chronic liver failure (ACLF) is characterized by the presence of acute decompensation (AD) of cirrhosis, organ failures, and high short-term mortality rates. In present study, we explored whether Pro-adrenomedullin (Pro-ADM), a biomarker of sepsis, is a potential marker of outcome in patie...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1764616

    authors: Yan H,Jin S,Liang L,Du J,Aithal GP,Li L

    更新日期:2020-05-01 00:00:00

  • Adalimumab trough serum levels and anti-adalimumab antibodies in the long-term clinical outcome of patients with Crohn's disease.

    abstract:OBJECTIVE:Few data are available on the relevance of adalimumab (ADA) trough serum levels and anti-ADA antibodies (AAA) during long-term follow-up of patients with Crohn's Disease (CD), and their association with disease outcome. In this study, our aim was to assess ADA trough serum levels and the presence of AAA accor...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2016.1157894

    authors: Bodini G,Giannini EG,Savarino V,Del Nero L,Pellegatta G,De Maria C,Baldissarro I,Savarino E

    更新日期:2016-09-01 00:00:00

  • Review of the persistence of gastroesophageal reflux disease in children, adolescents and adults: does gastroesophageal reflux disease in adults sometimes begin in childhood?

    abstract:OBJECTIVE:Understanding the natural history and outcomes of gastroesophageal reflux disease (GERD) in children could help to identify patients at risk of having GERD complications during adulthood. This review aimed to assess evidence of whether GERD in children or adolescents persists into adulthood. MATERIAL AND MET...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365521.2011.591425

    authors: Winter HS,Illueca M,Henderson C,Vaezi M

    更新日期:2011-10-01 00:00:00

  • Ultrasonographic findings in patients with peristomal bulging.

    abstract:AIM:The aim of this study was to obtain a classification of peristomal bulging based on findings at ultrasonography in patients with a sigmoid colostomy. METHODS:The patient material comprised 30 men and 33 women. The median age was 69 years (28-90) and the median time between stoma creation and investigation was 68 m...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2011.560681

    authors: Sjödahl RI,Thorelius L,Hallböök OJ

    更新日期:2011-06-01 00:00:00

  • Rectal mucosal adrenergic innervation and enterochromaffin cells in ulcerative colitis and irritable colon.

    abstract::Rectal mucosal biopsies of 13 patients suffering from ulcerative colitis, 7 patients presenting symptomatology typical of irritable colon, and 7 control persons were studied by the recently introduced glyoxylic-acid-induced fluorescence histochemical method. In ulcerative colitis, compared to control specimens: 1) the...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527709180942

    authors: Kyösola K,Penttilä O,Salaspuro M

    更新日期:1977-01-01 00:00:00

  • Tinidazole prophylaxis in appendicectomies. A controlled study of single-dose versus 3-day therapy.

    abstract::The 588 consecutive patients who were operated on on suspicion of appendicitis were randomized into three groups: the control group (no prophylaxis); the single-dose group (preoperatively 500 mg of tinidazole intravenously); and the 3-day group (in addition to the former, a 3-day tinidazole treatment). To discover any...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Viitanen J,Tunturi T,Auvinen O,Pessi T

    更新日期:1984-01-01 00:00:00

  • 31-43 amino acid sequence of the alpha-gliadin induces anti-endomysial antibody production during in vitro challenge.

    abstract:BACKGROUND:Wheat gliadin is the culprit antigen of coeliac disease (CD). Two short sequences of NH2-terminal portion of gliadin seem to be responsible for CD. Antiendomysial antibodies (EMA), highly sensitive and specific for CD, are detectable in the culture media from treated CD patients, after in vitro challenge wit...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655299750024896

    authors: Picarelli A,Di Tola M,Sabbatella L,Anania MC,Di Cello T,Greco R,Silano M,De Vincenzi M

    更新日期:1999-11-01 00:00:00

  • Gastroplasty as a treatment for massive obesity. A clinical and biochemical evaluation.

    abstract::Twenty-four grossly obese patients were operated on with horizontal gastroplasty. One patient died postoperatively of pulmonary embolism. The remaining 23 were extensively studied before and repeatedly after surgery. Eighteen months postoperatively the average weight loss was 34.4 kg (range, 1-71 kg). Seven patients h...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509089660

    authors: Olsson SA,Nilsson-Ehle P,Pettersson BG,Sörbris R

    更新日期:1985-03-01 00:00:00

  • Normalization of mucosal cytokine gene expression levels predicts long-term remission after discontinuation of anti-TNF therapy in Crohn's disease.

    abstract:OBJECTIVE:To investigate mucosal cytokine gene expression levels in healed mucosa after anti-tumor necrosis factor (TNF) therapy in patients with Crohn's disease (CD) as possible risk factors for relapse after discontinuation of therapy. DESIGN:Thirty-seven CD patients treated with anti-TNF agents until complete mucos...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.758773

    authors: Rismo R,Olsen T,Cui G,Paulssen EJ,Christiansen I,Johnsen K,Florholmen J,Goll R

    更新日期:2013-03-01 00:00:00

  • Passage of molecules through the wall of the gastrointestinal tract. Increased passive permeability in rat ileum after exposure to lysolecithin.

    abstract::The interaction between lysolecithin and mucosal cells in the distal ileum has been studied. Using a rat experimental model, we determined the intestinal permeability to fluorescent dextran 3000 after exposure to different amounts of lysolecithin. At pH 7.3, lysolecithin, 10 mg/ml, significantly enhanced the transmura...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528109181820

    authors: Bolin T,Sjödahl R,Sundqvist T,Tagesson C

    更新日期:1981-01-01 00:00:00

  • Isoamylases and their thermolability in serum and cyst fluid from patients with pancreatic pseudocysts.

    abstract::The isoamylase pattern in serum and the amylase thermolability have been suggested as screening tests for the development of pancreatic pseudocysts. To study whether serum reflects the contents of pseudocysts, we have investigated the isoamylases and their thermolability in cyst fluid and in serum from 13 patients wit...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509088833

    authors: Kjaergaard J,Møller P,Henriksen FW,Nielsen VG

    更新日期:1985-09-01 00:00:00

  • Esophageal foreign bodies in adults: systematic review of the literature.

    abstract:OBJECTIVE:Esophageal Foreign Body (FB) impaction represents a major challenge for healthcare providers. Aim of this systematic review was to analyse the current literature evidence on prevalence, presentation, treatment, and outcomes of impacted esophageal FB. MATERIALS AND METHODS:Literature search was conducted betw...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1526317

    authors: Aiolfi A,Ferrari D,Riva CG,Toti F,Bonitta G,Bonavina L

    更新日期:2018-01-01 00:00:00

  • Epidemiological trends in incidence and mortality of hepatobiliary cancers in Germany.

    abstract:OBJECTIVE:While marked changes in the frequency of hepatobiliary malignancies, most notably hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), have been observed in different populations, no such data have been reported for Germany. We aimed to provide epidemiological data on recent trends in liv...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2011.589472

    authors: von Hahn T,Ciesek S,Wegener G,Plentz RR,Weismüller TJ,Wedemeyer H,Manns MP,Greten TF,Malek NP

    更新日期:2011-09-01 00:00:00

  • Delayed mid-ileal perforation secondary to acute-on-chronic ischaemia after a diagnostic colonoscopy.

    abstract::Perforation occurring at a remote site of the bowel after diagnostic colonoscopy is rare. A 61-year-old man presenting with bloody diarrhoea underwent colonoscopy. A dynamic ileus developed in less than 1 day, and mid-ileal perforation occurred 7 days after the procedure. It is suggested that high air pressure during ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655298750027065

    authors: Chau TN,Ng C,Lau LK,Lai ST,Yuen H

    更新日期:1998-09-01 00:00:00

  • Spontaneous splenic rupture precipitated by cough: a case report and a review of the literature.

    abstract::Spontaneous rupture of a normal spleen without a history of trauma is a rare clinical entity. We report on a case of atraumatic splenic rupture in a 61-year-old man who presented to the emergency department for abdominal pain and hypotension. There was no evidence of hematologic or infectious disease involving the spl...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1080/00365520701763472

    authors: Wehbe E,Raffi S,Osborne D

    更新日期:2008-01-01 00:00:00

  • Erratum.

    abstract::PALLE NORDBLAD SCHMIDT, SRDAN NOVOVIC, STINE ROUG & ERIK FELDAGER (2015) Endoscopic, transmural drainage and necrosectomy for walled-off pancreatic and peripancreatic necrosis is associated with low mortality – a single-center experience. http://dx.doi.org/10.3109/0 0365521.2014.946078. When the above article was firs...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 已发布勘误

    doi:10.3109/00365521.2015.1017265

    authors:

    更新日期:2015-05-01 00:00:00

  • Liver fibrosis in hepatitis C patients of Pakistani versus Scandinavian origin.

    abstract:OBJECTIVE:The aim of this study was to examine the significance of native country for the stage of liver fibrosis in a population of HCV patients of Pakistani or Scandinavian origin living in Oslo. PATIENTS AND METHODS:We included 122 consecutive HCV patients at two hepatitis clinics in Oslo, 73 of Scandinavian and 49...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2010.510571

    authors: Midgard H,Bang C,Raknerud N,Dalgard O

    更新日期:2010-12-01 00:00:00

  • Pouch emptying of solid foods after gastroplasty for morbid obesity.

    abstract::To obtain information on possible determinants of weight loss after horizontal gastroplasty, pouch emptying was prospectively investigated in 27 morbidly obese patients. A scintigraphic method was used. Examinations were carried out every 6 months until 2 years after surgery. Pouch emptying was described by means of d...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509089272

    authors: Andersen T,Pedersen BH,Henriksen JH,Uhrenholdt A

    更新日期:1985-12-01 00:00:00

  • Chronic non-specific diarrhea of infancy successfully treated with trimethoprim-sulfamethoxazole.

    abstract::Fifteen children who fulfilled the criteria of chronic non-specific diarrhea of infancy were evaluated for intestinal bacterial overgrowth. In 10 of 11 successfully investigated children we found bacterial overgrowth of the small intestine by upper respiratory tract microflora. In 9 of 10 children (group I) treated wi...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3109/00365528909093094

    authors: Dahlström KA,Danielsson L,Kalin M,Klingspor L

    更新日期:1989-06-01 00:00:00

  • Neuroendocrine differentiation of periodic-acid Schiff and Alcian blue-negative signet-ring cell-like cells and tubular adenocarcinoma cells within a gastric cancer.

    abstract::A case of a Borrmann type 2 advanced gastric cancer with endocrine differentiation is described. Histologically, the cancer was either composed of cells arranged in a tubular pattern or formed solid nests of various sizes. The tubular pattern was composed of a moderately differentiated tubular adenocarcinoma. The hist...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410005775

    authors: Sugihara A,Nakasho K,Yamada N,Nakagomi N,Tsujimura T,Terada N,Tsuji M

    更新日期:2004-08-01 00:00:00

  • Acetazolamide interferes with the protective effect of prostaglandin E2 in the rat gastric mucosa.

    abstract::Oral prostaglandin E2 protected the gastric mucosa against the damage induced by intraperitoneal indomethacin in the rat. Blocking of the gastric alkaline secretion by subcutaneous acetazolamide potentiated the ulcerogenic action of indomethacin and reduced or abolished the protective effect of a submaximal dose prost...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528109181985

    authors: Kollberg B,Aly A,Rubio C,Johansson C

    更新日期:1981-04-01 00:00:00

  • The role of a defunctioning stoma for colonic and perianal Crohn's disease in the biological era.

    abstract:OBJECTIVE:A defunctioning stoma is a therapeutic option for colonic or perianal Crohn's disease. In the pre-biologic era the response rate to defunctioning in our unit was high (86%), but intestinal continuity was only restored in 11-20%. Few data exist on the outcome of defunctioning since the widespread introduction ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2016.1205127

    authors: Martí-Gallostra M,Myrelid P,Mortensen N,Keshav S,Travis SP,George B

    更新日期:2017-03-01 00:00:00

  • Increased colonic permeability in patients with ulcerative colitis: an in vitro study.

    abstract:BACKGROUND:Colonic permeability was studied in vitro in patients subjected to colectomy because of ulcerative colitis and in control patients undergoing colonic resections for cancer. METHODS:The mucosal layer from fresh colonic segments was stripped and mounted in Ussing diffusion chambers containing modified Krebs b...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365529850171701

    authors: Nejdfors P,Wang Q,Ekelund M,Weström BR,Jansson O,Lindström CL,Karlsson B,Jeppsson B

    更新日期:1998-07-01 00:00:00

  • Effect of budesonide enema on remission and relapse rate in distal ulcerative colitis and proctitis.

    abstract:BACKGROUND:Glucocorticosteroid enemas are equally effective as 5-ASA enemas in the treatment of active distal ulcerative colitis (UC). With the introduction of budesonide, the risk of systemic side effects may be reduced. We investigated whether budesonide enema, 2 mg/100 ml, administered twice daily (b.i.d.) could inc...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1080/00365520212512

    authors: Lindgren S,Löfberg R,Bergholm L,Hellblom M,Carling L,Ung KA,Schiöler R,Unge P,Wallin C,Ström M,Persson T,Suhr OB

    更新日期:2002-06-01 00:00:00

  • Mesalazine suppositories versus hydrocortisone foam in patients with distal ulcerative colitis. A comparison of the efficacy and practicality of two topical treatment regimens.

    abstract:BACKGROUND:Topical treatment is effective in patients with distal ulcerative colitis. This trial compares the efficacy, safety, and practicality of 4 weeks' treatment with 500 mg mesalazine suppositories with those of 178 mg hydrocortisone foam, both given twice daily. METHODS:Seventy-nine patients with distal ulcerat...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.3109/00365529509093256

    authors: Farup PG,Hovde O,Halvorsen FA,Raknerud N,Brodin U

    更新日期:1995-02-01 00:00:00

  • EUS-guided trans-esophageal drainage of a mediastinal necrotic fluid collection using the axios electrocautery enhanced delivery system™.

    abstract::Mediastinal collection secondary to necrotic acute pancreatitis, is an extremely rare event caused by the posterior rupture of the pancreatic duct into the retroperitoneal space with the penetration of the pancreatic fluid through the diaphragmatic orifices. Infection of the necrotic collection may occur with a conseq...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1568542

    authors: Pizzicannella M,Pandolfi M,Andrisani G,Signoretti M,Martino M,Rea R,Di Matteo FM

    更新日期:2019-02-01 00:00:00

  • Observer homogeneity in the histologic diagnosis of Helicobacter pylori. Latent class analysis, kappa coefficient, and repeat frequency.

    abstract::Four pathologists independently examined 82 antral mucosal biopsy specimens for the presence of Helicobacter pylori and indicated whether their assessments were certain. The pathologists made a positive diagnosis in from 56% to 84% of the specimens (significant heterogeneity, p < 0.01). The frequency of uncertain diag...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529209000166

    authors: Christensen AH,Gjørup T,Hilden J,Fenger C,Henriksen B,Vyberg M,Ostergaard K,Hansen BF

    更新日期:1992-11-01 00:00:00

  • The effect of cisapride in maintaining symptomatic remission in patients with gastro-oesophageal reflux disease.

    abstract:BACKGROUND:Successful treatment of gastro-oesophageal reflux disease (GORD) has traditionally been assessed as healing of reflux oesophagitis, which may not be relevant in patients with moderate disease. In these patients symptom relief and patient satisfaction with therapy are of fundamental importance. Cisapride has ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.3109/00365529709002988

    authors: Hatlebakk JG,Johnsson F,Vilien M,Carling L,Wetterhus S,Thøgersen T

    更新日期:1997-11-01 00:00:00

  • Increased activity of the mannan-binding lectin complement activation pathway in patients with colorectal cancer.

    abstract:BACKGROUND:Postoperative bacterial infectious complications are frequent in patients with colorectal cancer (CRC), with subsequent increased recurrence rates and poor prognosis. Deficiency of the mannan-binding lectin (MBL) complement activation pathway may cause increased risk of infection in certain patient groups. I...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410005603

    authors: Ytting H,Jensenius JC,Christensen IJ,Thiel S,Nielsen HJ

    更新日期:2004-07-01 00:00:00

  • Radiofrequency ablation versus resection for the treatment of early stage hepatocellular carcinoma: a multicenter Australian study.

    abstract:OBJECTIVES:It remains unclear whether radiofrequency ablation (RFA) provides comparable outcomes to surgical resection (SR). We, therefore, compared survival outcomes of RFA to SR in patients with early stage and very early stage hepatocellular carcinoma (HCC). METHODS:A multicenter retrospective analysis was performe...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3109/00365521.2014.953572

    authors: Gory I,Fink M,Bell S,Gow P,Nicoll A,Knight V,Dev A,Rode A,Bailey M,Cheung W,Kemp W,Roberts SK,Melbourne Liver Group.

    更新日期:2015-05-01 00:00:00