Abstract:
OBJECTIVE:In patients with achalasia, little is known about symptoms of the gastrointestinal tract other than the esophagus. The purpose of this study was to determine the prevalence of two functional disorders, functional dyspepsia (FD) and irritable bowel syndrome (IBS), in a group of treated achalasia patients and to assess the additional impact of these disorders on health-related quality of life (HRQoL). MATERIAL AND METHODS:Questionnaires assessing the Rome II criteria for FD and IBS together with the Eckardt clinical symptom score and RAND-36 were sent to 171 treated achalasia patients. RESULTS:Of these patients, 76.6% returned their questionnaires. In the group of achalasia patients, 23% fulfilled the criteria for FD (Dutch general population 13-14%), and 21% fulfilled the criteria for IBS (Dutch general population 1-6%). The prevalence of frequent chest pain (at least weekly) was higher in patients with FD and/or IBS than in those without these symptoms (54.2% versus 28.2%; p=0.004). Female patients with achalasia and with frequent chest pain showed a higher probability of fulfilling the FD and/or IBS criteria (adjusted OR 2.90 (1.18-7.14) and 3.35 (1.4-8.1), respectively; both with p <0.05). Patients fulfilling the FD and/or IBS criteria scored a lower HRQoL on the RAND-36 subscales--pain, social functioning, and vitality--as compared with patients not fulfilling these criteria (p <0.006). CONCLUSIONS; Symptoms of FD and IBS in patients with treated achalasia are common and have a negative impact on HRQoL. Therefore, this has to be included in the standard evaluation of achalasia patients. The association with chest pain suggests a mutual underlying mechanism.
journal_name
Scand J Gastroenteroljournal_title
Scandinavian journal of gastroenterologyauthors
Frankhuisen R,Van Herwaarden MA,Heijkoop R,Baron A,Vermeijden R,Smout AJ,Gooszen HG,Samsom Mdoi
10.1080/00365520902783709subject
Has Abstractpub_date
2009-01-01 00:00:00pages
687-91issue
6eissn
0036-5521issn
1502-7708pii
909225037journal_volume
44pub_type
杂志文章abstract:OBJECTIVE:Prompt and long-standing acid control following once-daily administration of antisecretory drugs is desirable. The objective of this study was to determine whether co-administration of a well-characterized H2-receptor antagonist, famotidine, can be combined with the proton-pump inhibitor omeprazole. MATERIAL...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1080/00365520601026665
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:To study the effect of HLA DQ2, dietary history and development of coeliac disease (CD) on the induction of antibody response to wheat gliadin and cow's milk, beta-lactoglobulin between 1 and 2.5 years of age in children who developed CD and in healthy children. MATERIAL AND METHODS:Infants participating in ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520500535519
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Bile duct and pancreatic cancer (PC) have poor prognoses and treatment options for inoperable patients are scarce. In order to improve outcome for these patients, there is an urgent need for biomarkers predictive of treatment effect. Irinotecan is a topoisomerase 1 (Top1) poison. Top1 protein, TOP1 gene copy...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365521.2014.980318
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:In 1997 Hochberger and Neumann presented the "Erlangen Biosimulation Model" (commercialized as the "Erlangen Endo-Trainer") at various national and international meetings. The new compactEASIE is a simplified version of the original "Biosimulation Model" (Endo-Trainer) and is specially designed for easy hand...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520410006765
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Oral intake (60 ml daily) over 12 days in eight healthy volunteers of an immunostimulatory extract based on the medicinal mushroom Agaricus blazei Murill (AbM (AndoSan™)), reduced the monocyte and granulocyte release of mainly proinflammatory cytokines in vivo, suggesting an anti-inflammatory effect. In this...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365521.2012.660544
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:An association between alpha1-antitrypsin deficiency and chronic pancreatitis (CP) has been reported in several case reports and two systematic studies. However, conflicting results have been shown in other studies of patients with CP. All previous studies were performed by phenotyping or by measurement of s...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/003655202317284282
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Postoperative bacterial infectious complications are frequent in patients with colorectal cancer (CRC), with subsequent increased recurrence rates and poor prognosis. Deficiency of the mannan-binding lectin (MBL) complement activation pathway may cause increased risk of infection in certain patient groups. I...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520410005603
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:To assess the impact of increased use of low-dose aspirin, other non-steroidal anti-inflammatory drugs (NSAIDs), warfarin, corticosteroids and selective serotonin re-uptake inhibitors (SSRIs) on the site and outcome of non-variceal gastrointestinal (GI) bleeds. METHODS:Retrospective review of 731 patients wi...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365521.2010.510567
更新日期:2010-12-01 00:00:00
abstract::In a Swedish-Norwegian multicentre study patients with endoscopically verified duodenal ulcers (greater than 5 mm) were randomized to 2 or 4 weeks of treatment with either 20 mg omeprazole once daily or 300 mg ranitidine once daily. The aim was to evaluate 2 and 4 weeks' treatment with regard to symptomatic improvemen...
journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.3109/00365529109025023
更新日期:1991-02-01 00:00:00
abstract:BACKGROUND:The functional role of the intracellular diacylglycerol/protein kinase C second-messenger pathway in the regulation of gastric acid secretion and the effects on the involved inositotrisphosphate/Ca2+/calmodulin system are not well understood, and contradictory data have been reported. We therefore evaluated ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/003655200750023336
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:Hereditary hemochromatosis has an autosomal recessive inheritance. The C282Y homozygosity is the most common genetic mutation in persons of Northern European descent. A screen of two multiethnic populations in Northern Norway was performed to investigate whether the prevalence of hereditary hemochromatosis wa...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365521.2010.525713
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Duodenal ulcer (DU) is a common problem in patients with chronic liver disease (CLD) and with inadequate response to H2 receptor antagonists. Omeprazole might be more effective. In DU-CLD patients, Helicobacter pylori prevalence is low. Nitric oxide is increased in gastric mucosa in cirrhosis. Oxygen-free ra...
journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1080/003655201750153250
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Growth factors such as epidermal growth factor (EGF) and transforming growth factor alpha (TGF alpha) have been shown to share common receptor (EGFR) and to accelerate ulcer healing due to stimulation of cell proliferation, but the time sequence of expression of EGF and TGF alpha during ulcer healing has not...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529709025056
更新日期:1997-01-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章,评审
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更新日期:2000-08-01 00:00:00
abstract::Previous studies have shown that the small-bowel shunt operation for morbid obesity may be followed by signs of enhanced cell-mediated immunity and polymorphonuclear (PMN) granulocyte bactericidal capacity. In the present study seven patients, operated 4 months--4.5 years previously and exhibiting postoperative arthra...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528009181476
更新日期:1980-01-01 00:00:00
abstract::The effect of moderate congenital hypergastrinemia on the enterochromaffin-like (ECL) cells was investigated in Zucker rats 4 and 18 months of age by combining autoradiography after tritiated thymidine injection and selective immunocytochemistry. In both age groups the serum gastrin concentration was 200% higher in ob...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529409090467
更新日期:1994-03-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.3109/00365529509093246
更新日期:1995-02-01 00:00:00
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doi:10.3109/00365528309181559
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journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00365529108998569
更新日期:1991-05-01 00:00:00
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更新日期:2018-01-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520410003344
更新日期:2004-10-01 00:00:00
abstract::In 14 patients with alcoholic hepatitis an echographic study of the gallbladder was carried out. Nine subjects showed gallbladder wall thickening (thickness greater than 4 mm) and two a 'scanty content gallbladder'. These findings did not correlate with the serum albumin levels. The authors point out the similarity of...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528708991891
更新日期:1987-06-01 00:00:00
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doi:10.1080/00365520410003579
更新日期:2004-12-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365521.2017.1333625
更新日期:2017-09-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529709011201
更新日期:1997-09-01 00:00:00
abstract::Ultrasonography, 99mTc-DIDA cholescintigraphy, and infusion tomography of the gallbladder were compared in a prospective study comprising 45 consecutive patients clinically suspected of having acute cholecystitis. The diagnosis of acute cholecystitis was established or excluded by operation in 35 patients, by oral cho...
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1982-01-01 00:00:00
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doi:10.1080/00365520510012136
更新日期:2005-05-01 00:00:00
abstract::One group of 8 patients with primary biliary cirrhosis and one group of 7 patients with common duct stone both had generally high levels of blood coagulation factors and a wide range of other plasma proteins. In contrast, one group of 6 patients with chronic active hepatitis generally had low levels of the same coagul...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
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更新日期:2019-02-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00